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Report error Found 179 Enz. Inhib. hit(s) with Target = 'Homeodomain-interacting protein kinase 2'
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50: 3nMAssay Description:Inhibition of HIPK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50563555(CHEMBL4750420)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant HIPK2 using myelin substrate by radiometric scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of human HIPK2 using myelin basic protein as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 12...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  7.30nMAssay Description:Binding constant for HIPK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM81551(Furan thiazolidinediones, A64)
Affinity DataIC50: 74nM Kd:  9.5nMAssay Description:In vitro biochemical assays were performed in parallel to determine the most potent tool compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2011
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50563556(CHEMBL4743939)
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant HIPK2 using myelin substrate by radiometric scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50388783(CHEMBL2062565)
Affinity DataIC50: 20nMAssay Description:Inhibition of HipK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50563557(CHEMBL4790791)
Affinity DataIC50: 28nMAssay Description:Inhibition of human recombinant HIPK2 using myelin substrate by radiometric scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50560704(CHEMBL4754195)
Affinity DataIC50: 29nMAssay Description:Inhibition of human HIPK2 by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50560704(CHEMBL4754195)
Affinity DataIC50: 29nMAssay Description:Inhibition of human recombinant HIPK2 using myelin substrate by radiometric scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50563539(CHEMBL4762964)
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant HIPK2 using myelin substrate by radiometric scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50507430(CHEMBL3937369)
Affinity DataIC50: 30nMAssay Description:Inhibition recombinant human HIPK2 (165 to 564 residues) after 5 mins in presence of [33P] ATP by Topcount methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50388786(CHEMBL2062563)
Affinity DataIC50: 30nMAssay Description:Inhibition of HipK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  31nMAssay Description:Binding affinity to HIPK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  31nMAssay Description:Binding constant for HIPK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 31nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged HIPK2 (165 to 564 residues) expressed in baculovirus infected Sf21 insect cells using MBP as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 31nMAssay Description:Inhibition of HIPK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50437434(CHEMBL2409175)
Affinity DataIC50: 40nMAssay Description:Inhibition of Hipk-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50172243(CHEMBL3103192)
Affinity DataIC50: 40nMAssay Description:Inhibition of Hipk2 (unknown origin) by quantitative PCRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2017
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50563541(CHEMBL4743730)
Affinity DataIC50: 41nMAssay Description:Inhibition of human recombinant HIPK2 using myelin substrate by radiometric scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50563554(CHEMBL4790030)
Affinity DataIC50: 42nMAssay Description:Inhibition of human recombinant HIPK2 using myelin substrate by radiometric scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50388782(CHEMBL2062564)
Affinity DataIC50: 50nMAssay Description:Inhibition of HipK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50388784(CHEMBL2062575)
Affinity DataIC50: 60nMAssay Description:Inhibition of HipK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50563540(CHEMBL4740998)
Affinity DataIC50: 68nMAssay Description:Inhibition of human recombinant HIPK2 using myelin substrate by radiometric scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50563538(CHEMBL4797457)
Affinity DataIC50: 70nMAssay Description:Inhibition of human recombinant HIPK2 using myelin substrate by radiometric scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50563559(CHEMBL4587433)
Affinity DataIC50: 74nMAssay Description:Inhibition of HIPK2 (unknown origin) by selectscreen kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  92nMAssay Description:Binding constant for HIPK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50399540(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Affinity DataIC50: 100nMAssay Description:Inhibition of HIPK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM17055((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...)
Affinity DataIC50: 100nMAssay Description:Inhibition of HIPK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 100nMAssay Description:Inhibition of HIPK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50242737((R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimet...)
Affinity DataIC50: 100nMAssay Description:Inhibition of HIPK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50563537(CHEMBL4789951)
Affinity DataIC50: 102nMAssay Description:Inhibition of human recombinant HIPK2 using myelin substrate by radiometric scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50563533(CHEMBL4777288)
Affinity DataIC50: 119nMAssay Description:Inhibition of human recombinant HIPK2 using myelin substrate by radiometric scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50242737((R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimet...)
Affinity DataKd:  120nMAssay Description:Binding constant for HIPK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50563534(CHEMBL4778153)
Affinity DataIC50: 123nMAssay Description:Inhibition of human recombinant HIPK2 using myelin substrate by radiometric scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM17055((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...)
Affinity DataKd:  140nMAssay Description:Binding constant for HIPK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 146nMAssay Description:Inhibition of human HIPK2 using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50563544(CHEMBL4778370)
Affinity DataIC50: 172nMAssay Description:Inhibition of human recombinant HIPK2 using myelin substrate by radiometric scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50563535(CHEMBL4791451)
Affinity DataIC50: 179nMAssay Description:Inhibition of human recombinant HIPK2 using myelin substrate by radiometric scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  190nMAssay Description:Binding constant for HIPK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM15138(Biochemistry 469551 Compound 11 | 5-indazolyl pyri...)
Affinity DataKd:  220nMAssay Description:Binding constant for HIPK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50355504(CHEMBL1908393)
Affinity DataKd:  220nMAssay Description:Binding constant for HIPK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50563536(CHEMBL4741919)
Affinity DataIC50: 260nMAssay Description:Inhibition of human recombinant HIPK2 using myelin substrate by radiometric scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM25045(CHEMBL538346 | mTOR Inhibitor, PI103 | PI-103 | 3-...)
Affinity DataKd:  290nMAssay Description:Binding constant for HIPK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50355496(CHEMBL1908397)
Affinity DataKd:  300nMAssay Description:Binding constant for HIPK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM658709(Sodium 1-amino-6-bromobenzo[h]isoquinoline-8- carb...)
Affinity DataIC50: 300nMAssay Description:The half maximal inhibitory concentration (IC50) with respect to HIPK2 inhibition was determined for the compounds of the invention by using Z′...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2024
Entry Details
US Patent

TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM658675(Sodium 5-bromobenzo[h]isoquinoline-8- carboxylate ...)
Affinity DataIC50: 300nMAssay Description:The half maximal inhibitory concentration (IC50) with respect to HIPK2 inhibition was determined for the compounds of the invention by using Z′...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2024
Entry Details
US Patent

TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM658691(Sodium 5-(cyclopropylamino)benzo[h]isoquinoline- 8...)
Affinity DataIC50: 300nMAssay Description:The half maximal inhibitory concentration (IC50) with respect to HIPK2 inhibition was determined for the compounds of the invention by using Z′...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2024
Entry Details
US Patent

TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM658696(Sodium (R)-5-(sec- butylamino)benzo[h]isoquinoline...)
Affinity DataIC50: 300nMAssay Description:The half maximal inhibitory concentration (IC50) with respect to HIPK2 inhibition was determined for the compounds of the invention by using Z′...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2024
Entry Details
US Patent

TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM658703(Sodium 1-amino-5-bromobenzo[h]isoquinoline-8- carb...)
Affinity DataIC50: 300nMAssay Description:The half maximal inhibitory concentration (IC50) with respect to HIPK2 inhibition was determined for the compounds of the invention by using Z′...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2024
Entry Details
US Patent

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