Compile Data Set for Download or QSAR
Report error Found 6859 Enz. Inhib. hit(s) with Target = 'Indoleamine 2,3-dioxygenase 1'
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50520522(CHEMBL4568628)
Affinity DataKd:  0.00450nMAssay Description:Binding affinity to recombinant human IDO1 assessed as kinetic dissociation constant by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50442991(GNF-Pf-3777 | CHEMBL432537 | US10669273, Compound ...)
Affinity DataIC50: 0.0180nMAssay Description:Inhibition of human IDO1 expressed in HEK293 cells assessed as kynurenine release after 5 hrs by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50649664(CHEMBL5618748)
Affinity DataKd:  0.0210nMAssay Description:Binding affinity to recombinant human IDO1 assessed as dissociation rate constant at 0.78 to 25 uM by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50604021(CHEMBL5207194)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of IDO1 in IFNgamma/LPS stimulated human whole blood assessed as unbound concentration using kynurenine/tryptophan as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50538503(CHEMBL4645108)
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of IDO1 in IFNgamma/LPS stimulated human whole blood assessed as unbound concentration using kynurenine/tryptophan as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50567132(CHEMBL4863767)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of IDO1 in human whole blood assessed as unbound concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50618448(CHEMBL5428800)
Affinity DataKd:  0.110nMAssay Description:Binding affinity to human recombinant IDO1 assessed as dissociation constant measured for 60 sec by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50604026(CHEMBL5192384)
Affinity DataKi:  0.110nMAssay Description:Displacement of [3H] labeled-N-(4-Fluorophenyl)-3-(4-(4-(2-hydroxypropan-2-yl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)oxetane-3-carboxamide from huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM309529(3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione |...)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50567128(CHEMBL4855797)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of IDO1 in human whole blood assessed as unbound concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50604023(CHEMBL5192977)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H] labeled-N-(4-Fluorophenyl)-3-(4-(4-(2-hydroxypropan-2-yl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)oxetane-3-carboxamide from huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50604023(CHEMBL5192977)
Affinity DataKd:  0.158nMAssay Description:Displacement of [3H] labeled-N-(4-Fluorophenyl)-3-(4-(4-(2-hydroxypropan-2-yl)-6-(trifluoromethyl)pyridin-3-yl)phenyl)oxetane-3-carboxamide from huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50567131(CHEMBL4848630)
Affinity DataIC50: 0.290nMAssay Description:Inhibition of IDO1 in human whole blood assessed as unbound concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50604026(CHEMBL5192384)
Affinity DataIC50: 0.290nMAssay Description:Inhibition of IDO1 in IFNgamma/LPS stimulated human whole blood assessed as unbound concentration using kynurenine/tryptophan as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50568395(CHEMBL4848098)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of human IDO1 assessed as unbound compound concentration by human whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50568383(CHEMBL4872023)
Affinity DataIC50: 0.450nMAssay Description:Inhibition of human IDO1 assessed as unbound compound concentration by human whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM168435(US9675571, 129)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human IDO1 expressed in HEK293 cells incubated for 20 mins by Ehrlich's reagent based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM168435(US9675571, 129)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human IDO1 in HEK293 cells after 20 hrs by plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM168435(US9675571, 129)
Affinity DataEC50:  0.5nMT: 2°CAssay Description:Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2018
Entry Details
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50285416(CHEMBL4161733)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of IDO1 (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50590772(LINRODOSTAT | Linrodostat | Bms-986205 | BMS 98620...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human IDO1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50285416(CHEMBL4161733)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of IDO1 in human HeLa cells preincubated for 1 hr followed by IFN-gamma stimulation and measured after 20 hrs by Ehrlich colorimetric reag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50285416(CHEMBL4161733)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of IDO1 in IFN-gamma stimulated human HeLa cells in presence of heme measured after 20 hrs by heme-competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50575243(CHEMBL4851825)
Affinity DataIC50: 0.510nMAssay Description:Inhibition of IDO1 in IFN-gamma stimulated human HeLa cells incubated for 48 hrs by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50575244(CHEMBL4851857)
Affinity DataIC50: 0.510nMAssay Description:Inhibition of IDO1 in IFN-gamma stimulated human HeLa cells incubated for 48 hrs by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50575245(CHEMBL4862164)
Affinity DataIC50: 0.510nMAssay Description:Inhibition of IDO1 in IFN-gamma stimulated human HeLa cells incubated for 48 hrs by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM506627(US11046649, Ex. 5)
Affinity DataIC50: 0.520nMAssay Description:Inhibition of IDO1 in human HeLa cells using tryptophan as substrate incubated for 24 hrs by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50575246(CHEMBL4879235)
Affinity DataIC50: 0.590nMAssay Description:Inhibition of IDO1 in IFN-gamma stimulated human HeLa cells incubated for 48 hrs by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50575248(CHEMBL4861457)
Affinity DataIC50: 0.590nMAssay Description:Inhibition of IDO1 in IFN-gamma stimulated human HeLa cells incubated for 48 hrs by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50578624(CHEMBL4856710)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of IDO1 in human HeLa cells using tryptophan as substrate incubated for 24 hrs by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50543295(CHEMBL4642946)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of IDO1 in IFN-gamma stimulated human HeLa cells using L-tryptophan as substrate incubated for 48 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM506733(US11046649, Ex. 111 | 4-(((1R,3s,5S,6r)-6-(1-(5- c...)
Affinity DataIC50: 0.630nMAssay Description:HeLa cells were obtained from the American Type Culture Collection (ATCC) and maintained in DMEM media containing 10% FBS. Cells (7,000/well) were se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50568397(CHEMBL4869600)
Affinity DataIC50: 0.630nMAssay Description:Inhibition of human IDO1 assessed as unbound compound concentration by human whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50575247(CHEMBL4867998)
Affinity DataIC50: 0.640nMAssay Description:Inhibition of IDO1 in IFN-gamma stimulated human HeLa cells incubated for 48 hrs by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM506769(N-(5-cyanopyridin-2-yl)-2- ((1R,3s,5S,6r)-3-((6- f...)
Affinity DataIC50: 0.660nMAssay Description:HeLa cells were obtained from the American Type Culture Collection (ATCC) and maintained in DMEM media containing 10% FBS. Cells (7,000/well) were se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50578623(CHEMBL4858888)
Affinity DataIC50: 0.690nMAssay Description:Inhibition of IDO1 in human HeLa cells using tryptophan as substrate incubated for 24 hrs by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM506768(N-(5-cyanopyrazin-2-yl)-2- ((1R,3s,5S,6r)-3-((6- f...)
Affinity DataIC50: 0.690nMAssay Description:HeLa cells were obtained from the American Type Culture Collection (ATCC) and maintained in DMEM media containing 10% FBS. Cells (7,000/well) were se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50573448(CHEMBL4862659)
Affinity DataIC50: 0.693nMAssay Description:Inhibition of IDO1 in IFN-gamma induced human HeLa cells measured after 48 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM317549(US9624188, 30 | 3-(3-(3-(2,4- difluorophenyl)ureid...)
Affinity DataIC50: 0.700nMAssay Description:Human IDO1/HEK293 cells were seeded at 10,000 cells per 50 uL per well with RPMI/phenol red free media contains 10% FBS in a 384-well black wall clea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50567134(CHEMBL4848366)
Affinity DataIC50: 0.730nMAssay Description:Inhibition of IDO1 in human whole blood assessed as unbound concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM506767(2-((1R,3s,5S,6r)-3-((6- fluoroquinolin-4-yl)oxy)- ...)
Affinity DataIC50: 0.780nMAssay Description:HeLa cells were obtained from the American Type Culture Collection (ATCC) and maintained in DMEM media containing 10% FBS. Cells (7,000/well) were se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM506721(US11046649, Ex. 99 | N-(4-fluorophenyl)-2- ((1R,3s...)
Affinity DataIC50: 0.780nMAssay Description:HeLa cells were obtained from the American Type Culture Collection (ATCC) and maintained in DMEM media containing 10% FBS. Cells (7,000/well) were se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50604025(CHEMBL5173861)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of IDO1 in IFNgamma/LPS stimulated human whole blood assessed as unbound concentration using kynurenine/tryptophan as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50552941(CHEMBL4764710)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as reduction in kynurenine production using L-Tryptophan as substrate incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM506758(4-(((1R,3s,5S,6r)-6-(1-(5- chloro-1H-benzo[d]- imi...)
Affinity DataIC50: 0.810nMAssay Description:HeLa cells were obtained from the American Type Culture Collection (ATCC) and maintained in DMEM media containing 10% FBS. Cells (7,000/well) were se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM506730(US11046649, Ex. 108 | N-(4-chlorophenyl)-2- cyclop...)
Affinity DataIC50: 0.820nMAssay Description:HeLa cells were obtained from the American Type Culture Collection (ATCC) and maintained in DMEM media containing 10% FBS. Cells (7,000/well) were se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50568391(CHEMBL4855740)
Affinity DataIC50: 0.840nMAssay Description:Inhibition of human IDO1 assessed as unbound compound concentration by human whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM506634(US11046649, Ex. 12)
Affinity DataIC50: 0.850nMAssay Description:HeLa cells were obtained from the American Type Culture Collection (ATCC) and maintained in DMEM media containing 10% FBS. Cells (7,000/well) were se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50567130(CHEMBL4858599)
Affinity DataIC50: 0.860nMAssay Description:Inhibition of IDO1 in human whole blood assessed as unbound concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM506736(US11046649, Ex. 114 | N-(4-chlorophenyl)-2- ((1R,3...)
Affinity DataIC50: 0.870nMAssay Description:HeLa cells were obtained from the American Type Culture Collection (ATCC) and maintained in DMEM media containing 10% FBS. Cells (7,000/well) were se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

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