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Report error Found 277 Enz. Inhib. hit(s) with Target = 'Insulin-degrading enzyme'
TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427698(CHEMBL2324206)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human recombinant IDE-mediated fluorescein-Abeta-(1-40)-Lys-biotin degradationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427703(CHEMBL2324220)
Affinity DataKi:  1.70nMAssay Description:Inhibition of human recombinant IDE expressed in CHO cells in presence of [125I]-insulin by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427703(CHEMBL2324220)
Affinity DataKi:  3nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50525490(CHEMBL4437643)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant IDE exosite (unknown origin) expressed in Escherichia coli using insulin as substrate incubated for 4 hrs by AlphaLisa assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM34233(EBSELEN | 2-Phenyl-benzo[d]isoselenazol-3-one(Ebse...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant IDE expressed in Escherichia coli BL21 (DE3) cells using insulin as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50459189(CHEMBL4211248)
Affinity DataKd:  22nMAssay Description:Binding affinity to IDE E111Q mutant (unknown origin) using N-terminal FITC-labeled compound after 2 hrs in absence of light at 298 K by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427703(CHEMBL2324220)
Affinity DataKi:  22nMAssay Description:Inhibition of human recombinant IDE-mediated fluorescein-Abeta-(1-40)-Lys-biotin degradationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Mouse)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50459189(CHEMBL4211248)
Affinity DataIC50: 22nMAssay Description:Inhibition of mouse His-tagged IDE (42 to 1019 residues) using fluorophore/quencher-tagged RPPGFSAFK(Dnp)-OH peptide as substrate preincubated for 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427697(CHEMBL2324207)
Affinity DataKi:  23nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427696(CHEMBL2324201)
Affinity DataKi:  26nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427703(CHEMBL2324220)
Affinity DataKi:  38nMAssay Description:Inhibition of human recombinant IDE-mediated insulin degradationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM34233(EBSELEN | 2-Phenyl-benzo[d]isoselenazol-3-one(Ebse...)
Affinity DataIC50: 42nMAssay Description:Inhibition of human recombinant IDE expressed in Escherichia coli BL21 (DE3) cells using ATTO 655- Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427698(CHEMBL2324206)
Affinity DataKi:  44nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Mouse)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50459187(CHEMBL4211765)
Affinity DataIC50: 44nMAssay Description:Inhibition of mouse His-tagged IDE (42 to 1019 residues) using fluorophore/quencher-tagged RPPGFSAFK(Dnp)-OH peptide as substrate preincubated for 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50525489(CHEMBL4556893)
Affinity DataIC50: 50nMAssay Description:Inhibition of IDE (unknown origin) assessed as cleavage of Mca-RPPGFSAFK(Dnp)-OH by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Mouse)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50525489(CHEMBL4556893)
Affinity DataIC50: 50nMAssay Description:Inhibition of N-terminal His6-tagged mouse recombinant IDE Escherichia coli BL21 (DE3) cells using fluorogenic peptide Mca-RPPGFSAFK(Dnp)-OH as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427700(CHEMBL2324204)
Affinity DataKi:  50nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50525489(CHEMBL4556893)
Affinity DataIC50: 50nMAssay Description:Inhibition of IDE (unknown origin) assessed as cleavage of Mca-RPPGFSAFK(Dnp)-OH by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM209049(US9243038, 26)
Affinity DataIC50: 54nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50514415(CHEMBL4527561)
Affinity DataIC50: 56nMAssay Description:Inhibition of human recombinant IDE pre-incubated for 10 mins before Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp substrate addition and measured after 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50462574(CHEMBL4241044)
Affinity DataIC50: 56nMAssay Description:Inhibition of human IDE using insulin as substrate preincubated for 10 mis followed by substrate addition and measured after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50462574(CHEMBL4241044)
Affinity DataIC50: 56nMAssay Description:Inhibition of human recombinant IDE expressed in Escherichia coli BL21 (DE3) cells using insulin as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM209054(US9243038, 13)
Affinity DataIC50: 60nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM209053(US9243038, 8)
Affinity DataIC50: 60nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50462574(CHEMBL4241044)
Affinity DataIC50: 60nMAssay Description:Inhibition of wild type human IDE catalytic site using insulin as substrate preincubated for 10 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM209051(US9243038, 27)
Affinity DataIC50: 60nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM209032(US9243038, 6b (trans olefin) | US9243038, 6a (cis ...)
Affinity DataIC50: 60nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM314096(US9610322, 6b (trans olefin))
Affinity DataIC50: 60nMAssay Description:In vitro protease assays: Protease assays with IDE and neprilysin were performed using Mca-RPPGFSAFK(Dnp)-OH substrate peptide (R&D Systems, SEQ ID N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
US Patent

TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM209041(US9243038, 15)
Affinity DataIC50: 60nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetInsulin-degrading enzyme(Mouse)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50459188(CHEMBL4206878)
Affinity DataIC50: 60nMAssay Description:Inhibition of mouse His-tagged IDE (42 to 1019 residues) using fluorophore/quencher-tagged RPPGFSAFK(Dnp)-OH peptide as substrate preincubated for 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM209045(US9243038, 20)
Affinity DataIC50: 65nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427696(CHEMBL2324201)
Affinity DataKi:  70nMAssay Description:Inhibition of human recombinant IDE-mediated fluorescein-Abeta-(1-40)-Lys-biotin degradationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427713(CHEMBL2324209)
Affinity DataKi:  73nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Mouse)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50459190(CHEMBL4208119)
Affinity DataIC50: 74nMAssay Description:Inhibition of mouse His-tagged IDE (42 to 1019 residues) using fluorophore/quencher-tagged RPPGFSAFK(Dnp)-OH peptide as substrate preincubated for 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Mouse)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50459181(CHEMBL4207403)
Affinity DataIC50: 77nMAssay Description:Inhibition of mouse His-tagged IDE (42 to 1019 residues) using fluorophore/quencher-tagged RPPGFSAFK(Dnp)-OH peptide as substrate preincubated for 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427715(CHEMBL2324219)
Affinity DataKi:  78nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM209048(US9243038, 28)
Affinity DataIC50: 80nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM209046(US9243038, 21)
Affinity DataIC50: 85nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427699(CHEMBL2324205)
Affinity DataKi:  85nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Mouse)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50459180(CHEMBL4203249)
Affinity DataIC50: 86nMAssay Description:Inhibition of mouse His-tagged IDE (42 to 1019 residues) using fluorophore/quencher-tagged RPPGFSAFK(Dnp)-OH peptide as substrate preincubated for 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427701(CHEMBL2324203)
Affinity DataKi:  87nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Mouse)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM209045(US9243038, 20)
Affinity DataIC50: 90nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetInsulin-degrading enzyme(Mouse)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM209032(US9243038, 6b (trans olefin) | US9243038, 6a (cis ...)
Affinity DataIC50: 90nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)
Affinity DataIC50: 100nMAssay Description:Inhibition of IDE exosite and catalytic site (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM209052(US9243038, 29)
Affinity DataIC50: 100nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50005641(CHEMBL3235416)
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant IDE-mediated amyloid beta (16 to 23) hydrolysis using ATTO 655-Cys-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Trp as substrate p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427702(CHEMBL2324202)
Affinity DataKi:  103nMAssay Description:Inhibition of human recombinant IDE-mediated FRET1 degradationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM50427701(CHEMBL2324203)
Affinity DataKi:  107nMAssay Description:Inhibition of human recombinant IDE-mediated fluorescein-Abeta-(1-40)-Lys-biotin degradationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetInsulin-degrading enzyme(Human)
Mayo Clinic

Curated by ChEMBL
LigandPNGBDBM209024(US9243038, 2a (cis olefin) | US9243038, 2b (trans ...)
Affinity DataIC50: 150nMAssay Description:Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2017
Entry Details
US Patent

TargetInsulin-degrading enzyme(Mouse)
Peking University Shenzhen Graduate School

Curated by ChEMBL
LigandPNGBDBM50459191(CHEMBL4215687)
Affinity DataIC50: 170nMAssay Description:Inhibition of mouse His-tagged IDE (42 to 1019 residues) using fluorophore/quencher-tagged RPPGFSAFK(Dnp)-OH peptide as substrate preincubated for 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
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