Compile Data Set for Download or QSAR
Report error Found 611 Enz. Inhib. hit(s) with Target = 'Interferon-induced, double-stranded RNA-activated protein kinase'
LigandChemical structure of BindingDB Monomer ID 787917BDBM787917(3-amino-6-(4- (2-(3,5- difluorophenyl)- 2- hydroxy...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787919BDBM787919(3-amino-6-(4- (2-(3,5- difluorophenyl)- 2- hydroxy...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787920BDBM787920(3-amino-6-(4- (2-(3,5- difluorophenyl)- 2- hydroxy...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787922BDBM787922(3-amino-N- cyclopropyl-6- (4-(2-(3,5- difluorophen...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787908BDBM787908(2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxy...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787912BDBM787912(3-amino-6-(4- (2-(3,5- difluorophenyl)- 2- hydroxy...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787913BDBM787913(3-amino-6-(4- (2-(3,5- difluorophenyl)- 2- hydroxy...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787914BDBM787914(3-amino-N- cyclopropyl-6- (4-(2-(3,5- difluorophen...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787915BDBM787915(3-amino-N- cyclopropyl-6- (4-(2-(3,5- difluorophen...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787900BDBM787900(2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxy...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787901BDBM787901(2-amino-N- cyclopropyl-5- (4-(2-(3,5- difluorophen...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787902BDBM787902(2-amino-N- cyclopropyl-5- (4-(2-(3,5- difluorophen...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787903BDBM787903(2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxy...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787905BDBM787905(2-amino-5-(2- chloro-4-(2- (3,5- difluorophenyl)- ...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787892BDBM787892(2-amino-5-(2- ethyl-4-(2- hydroxy-2-(3- (trifluoro...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787897BDBM787897(2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxy...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787899BDBM787899(2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxy...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787820BDBM787820(2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxy...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787822BDBM787822(2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxy...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787823BDBM787823(2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxy...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787824BDBM787824(2-amino-N- cyclopropyl-5- (4-(2-(3,5- difluorophen...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787637BDBM787637(2-amino-5-(4- (2-hydroxy-2- phenylacetamido)- 2- m...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787818BDBM787818(2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxy...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787947BDBM787947(2-amino-N- isopropyl-5-(2- methyl-4-(2-(6- methylp...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787621BDBM787621(2-amino-5-(4- (2-hydroxy-2- phenylacetamido)- 2- m...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787924BDBM787924(3-amino-6-(4- (3-(3,5- difluorophenyl)- 2- hydroxy...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787926BDBM787926(3-amino-6-(2- ethyl-4-(2- hydroxy-2-(m- tolyl)acet...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787931BDBM787931(3-amino-6-(2- chloro-4-(2- (3,5- difluorophenyl)- ...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787852BDBM787852(isopropyl 2- amino-5-(4-(2- (3,5- difluorophenyl)-...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787854BDBM787854(2-amino-N- (azetidin-3-yl)- 5-(4-(2-(3,5- difluoro...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787856BDBM787856(2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxy...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787857BDBM787857(2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxy...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787858BDBM787858(2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxy...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787844BDBM787844(2-amino-5-(2- chloro-4-(2- (3,5- difluorophenyl)- ...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787846BDBM787846(2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxy...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787848BDBM787848(2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxy...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787850BDBM787850(2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxy...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787836BDBM787836(2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxy...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787838BDBM787838(2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxy...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787967BDBM787967(2-amino-5-(4-(2-(3- ethylphenyl) acetamido)-2- met...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787840BDBM787840(N-(1- acetylazetidin- 3-yl)-2-amino- 5-(4-(2-(3,5-...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787969BDBM787969(2-amino-N- isopropyl-5-(2- methyl-4-(2- (naphthale...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787842BDBM787842(2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxy...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787828BDBM787828(2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxy...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787830BDBM787830(2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxy...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787834BDBM787834(2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxy...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787884BDBM787884(2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxy...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787885BDBM787885(2-amino-5-(4- (2-(3,5- difluorophenyl)- 2- hydroxy...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787886BDBM787886(2-amino-N- cyclopropyl-5- (4-(2-(3,5- difluorophen...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 787888BDBM787888(2-amino-5-(2- ethyl-4-(2-(3- ethylphenyl)-2- hydro...)
Affinity DataIC50: 13nMAssay Description:In vitro Inhibition of PERK Enzyme Activity (isolated) Recombinant human EIF2AK2 (PKR) catalytic domain (amino acids 252-551), EIF2AK3 (PERK) catalyt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

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