Compile Data Set for Download or QSAR
Report error Found 2093 Enz. Inhib. hit(s) with Target = 'Kelch-like ECH-associated protein 1'
LigandPNGBDBM486655(US10947252, Example 89 | US11427601, Example 89)
Affinity DataKd:  0.00500nMAssay Description:The ThermoFluor is a fluorescence based assay (Tf) that estimates ligand binding affinities by measuring the effect of a ligand on protein thermal st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

LigandPNGBDBM486654(US10947252, Example 88 | US11427601, Example 88)
Affinity DataKd:  0.0100nMAssay Description:The ThermoFluor is a fluorescence based assay (Tf) that estimates ligand binding affinities by measuring the effect of a ligand on protein thermal st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

LigandPNGBDBM486580(US10947252, Example 11)
Affinity DataKd:  0.0240nMAssay Description:The ThermoFluor is a fluorescence based assay (Tf) that estimates ligand binding affinities by measuring the effect of a ligand on protein thermal st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

LigandPNGBDBM486569(US10947252, Example 3 | US11427601, Example 3)
Affinity DataKd:  0.0410nMAssay Description:The ThermoFluor is a fluorescence based assay (Tf) that estimates ligand binding affinities by measuring the effect of a ligand on protein thermal st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

LigandPNGBDBM486567(US10947252, Example 1 | US11427601, Example 1)
Affinity DataKd:  0.0420nMAssay Description:The ThermoFluor is a fluorescence based assay (Tf) that estimates ligand binding affinities by measuring the effect of a ligand on protein thermal st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetKelch-like ECH-associated protein 1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50539553(CHEMBL4644995)
Affinity DataKd:  0.0700nMAssay Description:Binding affinity to Keap1 (unknown origin) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
LigandPNGBDBM486582(US10947252, Example 13 | US11427601, Example 13)
Affinity DataKd:  0.0790nMAssay Description:The ThermoFluor is a fluorescence based assay (Tf) that estimates ligand binding affinities by measuring the effect of a ligand on protein thermal st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

LigandPNGBDBM486589(US10947252, Example 22 | US11427601, Example 22)
Affinity DataKd:  0.0810nMAssay Description:The ThermoFluor is a fluorescence based assay (Tf) that estimates ligand binding affinities by measuring the effect of a ligand on protein thermal st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

LigandPNGBDBM486587(US10947252, Example 20 | US11427601, Example 20)
Affinity DataKd:  0.0810nMAssay Description:The ThermoFluor is a fluorescence based assay (Tf) that estimates ligand binding affinities by measuring the effect of a ligand on protein thermal st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

LigandPNGBDBM486575(US10947252, Example 6 | US11427601, Example 6)
Affinity DataKd:  0.0890nMAssay Description:The ThermoFluor is a fluorescence based assay (Tf) that estimates ligand binding affinities by measuring the effect of a ligand on protein thermal st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

TargetKelch-like ECH-associated protein 1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50626728(CHEMBL5414850)
Affinity DataKi: <0.100nMAssay Description:Inhibition of Keap1-Nrf2 protein-protein interaction (unknown origin) preincubated for 30 mins followed by Terbium labeled anti-His antibody addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
LigandPNGBDBM486709(US10947252, Example 152 | US11427601, Example 152)
Affinity DataKd:  0.120nMAssay Description:The ThermoFluor is a fluorescence based assay (Tf) that estimates ligand binding affinities by measuring the effect of a ligand on protein thermal st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

LigandPNGBDBM486576(US10947252, Example 7 | US11427601, Example 7)
Affinity DataKd:  0.127nMAssay Description:The ThermoFluor is a fluorescence based assay (Tf) that estimates ligand binding affinities by measuring the effect of a ligand on protein thermal st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

LigandPNGBDBM669921(US20240132519, Compound A1)
Affinity DataIC50: 0.140nMAssay Description:The inhibitory activity of each compound on the binding between NRF2 and KEAP1 was measured by bioluminescence resonance energy transfer (BRET) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

TargetKelch-like ECH-associated protein 1(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50200467(CHEMBL3899754)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of FITC-9mer Nrf2 peptide interaction with human recombinant Keap1 Kelch domain (321 to 609 residues) expressed in Escherichia coli DE3 ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM576177(WO2022056448, Compound 48)
Affinity DataIC50: 0.150nMAssay Description:In a first step, the Keapl /compound complex was prepared by addition of 100 nL of the compound by ECHO 555, followed by 5 pL aliquots of 2x Keapl. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2022
Entry Details
WIPO WO2022056448

LigandPNGBDBM669915(US20240132519, Compound 48 | Production of 3-(5-ac...)
Affinity DataIC50: 0.150nMAssay Description:The inhibitory activity of each compound on the binding between NRF2 and KEAP1 was measured by bioluminescence resonance energy transfer (BRET) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

LigandPNGBDBM486636(US10947252, Example 69 | US11427601, Example 69)
Affinity DataKd:  0.160nMAssay Description:The ThermoFluor is a fluorescence based assay (Tf) that estimates ligand binding affinities by measuring the effect of a ligand on protein thermal st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

LigandPNGBDBM486568(US10947252, Example 2 | US11427601, Example 2)
Affinity DataKd:  0.162nMAssay Description:The ThermoFluor is a fluorescence based assay (Tf) that estimates ligand binding affinities by measuring the effect of a ligand on protein thermal st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

LigandPNGBDBM669915(US20240132519, Compound 48 | Production of 3-(5-ac...)
Affinity DataIC50: 0.170nMAssay Description:The inhibitory activity of each compound on the binding between NRF2 and KEAP1 was measured by bioluminescence resonance energy transfer (BRET) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

LigandPNGBDBM669923(US20240132519, Compound B1)
Affinity DataIC50: 0.170nMAssay Description:The inhibitory activity of each compound on the binding between NRF2 and KEAP1 was measured by bioluminescence resonance energy transfer (BRET) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

LigandPNGBDBM669894(US20240132519, Compound 3 | Production of 3-(4-ace...)
Affinity DataIC50: 0.170nMAssay Description:The inhibitory activity of each compound on the binding between NRF2 and KEAP1 was measured by bioluminescence resonance energy transfer (BRET) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

LigandPNGBDBM486593(US10947252, Example 26 | US11427601, Example 26)
Affinity DataKd:  0.174nMAssay Description:The ThermoFluor is a fluorescence based assay (Tf) that estimates ligand binding affinities by measuring the effect of a ligand on protein thermal st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

LigandPNGBDBM486577(US10947252, Example 8 | US11427601, Example 8)
Affinity DataKd:  0.188nMAssay Description:The ThermoFluor is a fluorescence based assay (Tf) that estimates ligand binding affinities by measuring the effect of a ligand on protein thermal st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

LigandPNGBDBM669917(US20240132519, Compound 50 | Production of 3-(5-ac...)
Affinity DataIC50: 0.190nMAssay Description:The inhibitory activity of each compound on the binding between NRF2 and KEAP1 was measured by bioluminescence resonance energy transfer (BRET) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

LigandPNGBDBM576172(WO2022056448, Compound 43)
Affinity DataIC50: 0.200nMAssay Description:In a first step, the Keapl /compound complex was prepared by addition of 100 nL of the compound by ECHO 555, followed by 5 pL aliquots of 2x Keapl. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2022
Entry Details
WIPO WO2022056448

LigandPNGBDBM576170(WO2022056448, Compound 41)
Affinity DataIC50: 0.200nMAssay Description:In a first step, the Keapl /compound complex was prepared by addition of 100 nL of the compound by ECHO 555, followed by 5 pL aliquots of 2x Keapl. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2022
Entry Details
WIPO WO2022056448

LigandPNGBDBM669907(US20240132519, Compound 16 | Production of 3-(5-ac...)
Affinity DataIC50: 0.200nMAssay Description:The inhibitory activity of each compound on the binding between NRF2 and KEAP1 was measured by bioluminescence resonance energy transfer (BRET) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

LigandPNGBDBM669902(US20240132519, Compound 11 | Production of 3-(5-ac...)
Affinity DataIC50: 0.230nMAssay Description:The inhibitory activity of each compound on the binding between NRF2 and KEAP1 was measured by bioluminescence resonance energy transfer (BRET) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

LigandPNGBDBM669896(US20240132519, Compound 5 | Production of 3-(5-ace...)
Affinity DataIC50: 0.230nMAssay Description:The inhibitory activity of each compound on the binding between NRF2 and KEAP1 was measured by bioluminescence resonance energy transfer (BRET) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

LigandPNGBDBM486570(US10947252, Example 4 | US11427601, Example 4)
Affinity DataKd:  0.240nMAssay Description:The ThermoFluor is a fluorescence based assay (Tf) that estimates ligand binding affinities by measuring the effect of a ligand on protein thermal st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

LigandPNGBDBM669892(US20240132519, Compound 1 | Production of 3-(5-ace...)
Affinity DataIC50: 0.240nMAssay Description:The inhibitory activity of each compound on the binding between NRF2 and KEAP1 was measured by bioluminescence resonance energy transfer (BRET) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

LigandPNGBDBM576179(WO2022056448, Compound 50)
Affinity DataIC50: 0.25nMAssay Description:In a first step, the Keapl /compound complex was prepared by addition of 100 nL of the compound by ECHO 555, followed by 5 pL aliquots of 2x Keapl. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2022
Entry Details
WIPO WO2022056448

LigandPNGBDBM669893(US20240132519, Compound 2 | Production of 3-(5-ace...)
Affinity DataIC50: 0.25nMAssay Description:The inhibitory activity of each compound on the binding between NRF2 and KEAP1 was measured by bioluminescence resonance energy transfer (BRET) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

LigandPNGBDBM50544959(CHEMBL4635873 | US12122742, Compound II-a-2)
Affinity DataIC50: 0.260nMAssay Description:Fluorescence polarization assay was performed on a Wallac Victor 3V multi-label counter/plate reader (PerkinElmer, Shelton, CT) using 484 nm excitati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
US Patent

LigandPNGBDBM486591(US10947252, Example 24 | US11427601, Example 24)
Affinity DataKd:  0.264nMAssay Description:The ThermoFluor is a fluorescence based assay (Tf) that estimates ligand binding affinities by measuring the effect of a ligand on protein thermal st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

LigandPNGBDBM669919(US20240132519, Compound 52 | Production of 3-(5-ac...)
Affinity DataIC50: 0.270nMAssay Description:The inhibitory activity of each compound on the binding between NRF2 and KEAP1 was measured by bioluminescence resonance energy transfer (BRET) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

LigandPNGBDBM669897(US20240132519, Compound 6 | Production of 3-(5-ace...)
Affinity DataIC50: 0.270nMAssay Description:The inhibitory activity of each compound on the binding between NRF2 and KEAP1 was measured by bioluminescence resonance energy transfer (BRET) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

LigandPNGBDBM486588(US10947252, Example 21 | US11427601, Example 21)
Affinity DataKd:  0.273nMAssay Description:The ThermoFluor is a fluorescence based assay (Tf) that estimates ligand binding affinities by measuring the effect of a ligand on protein thermal st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

LigandPNGBDBM486590(US10947252, Example 23 | US11427601, Example 23)
Affinity DataKd:  0.278nMAssay Description:The ThermoFluor is a fluorescence based assay (Tf) that estimates ligand binding affinities by measuring the effect of a ligand on protein thermal st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

LigandPNGBDBM669903(US20240132519, Compound 12 | Production of 3-(5-ac...)
Affinity DataIC50: 0.280nMAssay Description:The inhibitory activity of each compound on the binding between NRF2 and KEAP1 was measured by bioluminescence resonance energy transfer (BRET) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

LigandPNGBDBM669900(US20240132519, Compound 9 | Production of 3-(5-ace...)
Affinity DataIC50: 0.300nMAssay Description:The inhibitory activity of each compound on the binding between NRF2 and KEAP1 was measured by bioluminescence resonance energy transfer (BRET) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

LigandPNGBDBM669901(US20240132519, Compound 10 | Production of 3-(4-ac...)
Affinity DataIC50: 0.300nMAssay Description:The inhibitory activity of each compound on the binding between NRF2 and KEAP1 was measured by bioluminescence resonance energy transfer (BRET) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

LigandPNGBDBM669916(US20240132519, Compound 49 | Production of 3-(5-ac...)
Affinity DataIC50: 0.310nMAssay Description:The inhibitory activity of each compound on the binding between NRF2 and KEAP1 was measured by bioluminescence resonance energy transfer (BRET) assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
US Patent

LigandPNGBDBM486631(US10947252, Example 67 | US11427601, Example 67)
Affinity DataKd:  0.340nMAssay Description:The ThermoFluor is a fluorescence based assay (Tf) that estimates ligand binding affinities by measuring the effect of a ligand on protein thermal st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

LigandPNGBDBM576175(WO2022056448, Compound 46)
Affinity DataIC50: 0.350nMAssay Description:In a first step, the Keapl /compound complex was prepared by addition of 100 nL of the compound by ECHO 555, followed by 5 pL aliquots of 2x Keapl. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2022
Entry Details
WIPO WO2022056448

LigandPNGBDBM576156(WO2022056448, Compound 27)
Affinity DataIC50: 0.350nMAssay Description:In a first step, the Keapl /compound complex was prepared by addition of 100 nL of the compound by ECHO 555, followed by 5 pL aliquots of 2x Keapl. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2022
Entry Details
WIPO WO2022056448

LigandPNGBDBM576162(WO2022056448, Compound 33)
Affinity DataIC50: 0.350nMAssay Description:In a first step, the Keapl /compound complex was prepared by addition of 100 nL of the compound by ECHO 555, followed by 5 pL aliquots of 2x Keapl. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2022
Entry Details
WIPO WO2022056448

LigandPNGBDBM576167(WO2022056448, Compound 38)
Affinity DataIC50: 0.350nMAssay Description:In a first step, the Keapl /compound complex was prepared by addition of 100 nL of the compound by ECHO 555, followed by 5 pL aliquots of 2x Keapl. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2022
Entry Details
WIPO WO2022056448

LigandPNGBDBM576155(WO2022056448, Compound 26)
Affinity DataIC50: 0.350nMAssay Description:In a first step, the Keapl /compound complex was prepared by addition of 100 nL of the compound by ECHO 555, followed by 5 pL aliquots of 2x Keapl. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2022
Entry Details
WIPO WO2022056448

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