Report error Found 209 Enz. Inhib. hit(s) with Target = 'Lethal(3)malignant brain tumor-like protein 3'
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKd: 0.0360nMAssay Description:Binding affinity to GFP-tagged full length L3MBTL3 (unknown origin) assessed as dissociation constant at 1 uM (Rvb = 0.037549815 um2/s)More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKd: 0.0430nMAssay Description:Binding affinity to GFP-tagged full length L3MBTL3 (unknown origin) assessed as dissociation constant at 0.01 uM (Rvb = 0.037549815 um2/s)More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKd: 0.0500nMAssay Description:Binding affinity to GFP-tagged full length L3MBTL3 (unknown origin) assessed as dissociation constant at 0.1 uM (Rvb = 0.037549815 um2/s)More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKd: 0.0500nMAssay Description:Binding affinity to GFP-tagged full length L3MBTL3 (unknown origin) assessed as dissociation constant at 0.5 uM (Rvb = 0.037549815 um2/s)More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKd: 0.0510nMAssay Description:Binding affinity to GFP-tagged full length L3MBTL3 (unknown origin) assessed as dissociation constant at 1 uM (Rvb = 0.037549815 um2/s)More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKd: 0.124nMAssay Description:Binding affinity to GFP-3MBT tagged L3MBTL3 (unknown origin) assessed as dissociation constant at 1 uM (Rvb = 0.1272 um2/s)More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKd: 0.146nMAssay Description:Binding affinity to GFP-3MBT tagged L3MBTL3 (unknown origin) assessed as dissociation constant at 0.01 uM (Rvb = 0.1272 um2/s)More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKd: 0.156nMAssay Description:Binding affinity to GFP-3MBT tagged L3MBTL3 (unknown origin) assessed as dissociation constant at 0.05 uM (Rvb = 0.1272 um2/s)More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKd: 0.284nMAssay Description:Binding affinity to GFP-3MBT tagged L3MBTL3 (unknown origin) assessed as dissociation constant at 1 uM (Rvb = 0.1272 um2/s)More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKd: 0.297nMAssay Description:Binding affinity to GFP-3MBT tagged L3MBTL3 (unknown origin) assessed as dissociation constant at 0.5 uM (Rvb = 0.1272 um2/s)More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKd: 0.311nMAssay Description:Binding affinity to GFP-3MBT tagged L3MBTL3 (unknown origin) assessed as dissociation constant at 0.1 uM (Rvb = 0.1272 um2/s)More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of His-tagged L3MBTL3 (unknown origin) using H4K20Me2 as substrate incubated for 30 mins at room temperature followed by incubation under ...More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of His-tagged L3MBTL3 (unknown origin) using H4K20Me2 as substrate incubated for 30 mins at room temperature followed by incubation under ...More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 39nMAssay Description:Inhibition of L3MBTL3 (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of L3MBTL3 (unknown origin) using H4K20me2 peptide by Alpha-Screen methylated histone peptide competition assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Inhibition of L3MBTL3 (unknown origin) using H4K20me2 as substrate after 30 mins by LNCE-TR-FRET assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of His-tagged L3MBTL3 (unknown origin) using H4K20Me2 as substrate incubated for 30 mins at room temperature followed by incubation under ...More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of L3MBTL3 (unknown origin) using H4K20me2 as substrate after 30 mins by LNCE-TR-FRET assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of L3MBTL3 (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 49nMAssay Description:Inhibition of L3MBTL3 (unknown origin) using H4K20me2 as substrate after 30 mins by LNCE-TR-FRET assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of GFP-3MBT tagged L3MBTL3 (unknown origin) expressed in HEK293 cells assessed as reduction in recovery of fluorescence intensity measured...More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of L3MBTL3 (unknown origin) using H4K20me2 as substrate after 30 mins by LNCE-TR-FRET assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 51nMAssay Description:Inhibition of L3MBTL3 (unknown origin) using H4K20me2 as substrate after 30 mins by LNCE-TR-FRET assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 53nMAssay Description:Inhibition of L3MBTL3 (unknown origin) using H4K20me2 as substrate after 30 mins by LNCE-TR-FRET assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 58nMAssay Description:Inhibition of L3MBTL3 (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 59nMAssay Description:Inhibition of His-tagged L3MBTL3 (unknown origin) using H4K20Me2 as substrate incubated for 30 mins at room temperature followed by incubation under ...More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 61nMAssay Description:Inhibition of L3MBTL3 (unknown origin) using H4K20me2 as substrate after 30 mins by LNCE-TR-FRET assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 61nMAssay Description:Inhibition of L3MBTL3 (unknown origin) using H4K20me2 as substrate after 30 mins by LNCE-TR-FRET assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 62nMAssay Description:Inhibition of His-tagged L3MBTL3 (unknown origin) using H4K20Me2 as substrate incubated for 30 mins at room temperature followed by incubation under ...More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 64nMAssay Description:Inhibition of L3MBTL3 (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 66nMAssay Description:Inhibition of L3MBTL3 (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 68nMAssay Description:Inhibition of L3MBTL3 (unknown origin) using H4K20me2 as substrate after 30 mins by LNCE-TR-FRET assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of His-tagged L3MBTL3 (unknown origin) using H4K20Me2 as substrate incubated for 30 mins at room temperature followed by incubation under ...More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 71nMAssay Description:Inhibition of L3MBTL3 (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 72nMAssay Description:Inhibition of L3MBTL3 (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 74nMAssay Description:Inhibition of L3MBTL3 (unknown origin) using H4K20me2 as substrate after 30 mins by LNCE-TR-FRET assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 74nMAssay Description:Inhibition of L3MBTL3 (unknown origin) using H4K20me2 as substrate after 30 mins by LNCE-TR-FRET assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of His-tagged L3MBTL3 (unknown origin) using H4K20Me2 as substrate incubated for 30 mins at room temperature followed by incubation under ...More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 81nMAssay Description:Inhibition of L3MBTL3 (unknown origin) using H4K20me2 as substrate after 30 mins by LNCE-TR-FRET assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 88nMAssay Description:Inhibition of L3MBTL3 (unknown origin) using H4K20me2 as substrate after 30 mins by LNCE-TR-FRET assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 92nMAssay Description:Inhibition of L3MBTL3 (unknown origin) using H4K20me2 as substrate after 30 mins by LNCE-TR-FRET assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 92nMAssay Description:Inhibition of L3MBTL3 (unknown origin) using H4K20me2 as substrate after 30 mins by LNCE-TR-FRET assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 96nMAssay Description:Inhibition of L3MBTL3 (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 96nMAssay Description:Inhibition of L3MBTL3 (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 97nMAssay Description:Inhibition of L3MBTL3 (unknown origin) using H4K20me2 as substrate after 30 mins by LNCE-TR-FRET assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 99nMAssay Description:Inhibition of L3MBTL3 (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of His-tagged L3MBTL3 (unknown origin) using H4K20Me2 as substrate incubated for 30 mins at room temperature followed by incubation under ...More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of L3MBTL3 (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of L3MBTL3 (unknown origin) using H4K20me2 as substrate after 30 mins by LNCE-TR-FRET assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
University of North Carolina Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of L3MBTL3 (unknown origin) using H4K20me2 as substrate after 30 mins by LNCE-TR-FRET assayMore data for this Ligand-Target Pair


3D Structure (crystal)






















