Compile Data Set for Download or QSAR
Report error Found 167 Enz. Inhib. hit(s) with Target = 'Leukocyte tyrosine kinase receptor'
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM144315(US8969336, 577 | US8969336, 547 | Gilteritinib | U...)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of LTK (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50512318(CHEMBL4546504)
Affinity DataIC50: 0.567nMAssay Description:Inhibition of recombinant human GST-tagged LTK cytoplasmic domain (450 to 864 residues) expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataKd:  0.950nMAssay Description:Binding constant for LTK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM27817(2-{[2-({1-[2-(dimethylamino)acetyl]-5-methoxy-2,3-...)
Affinity DataKd:  1.10nMAssay Description:Binding constant for LTK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human N-terminal GST-fused LTK catalytic domain (498 to 796 residues) expressed in baculovirus expression system using Srctide as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50448785(CHEMBL3128069)
Affinity DataIC50: 2nMAssay Description:Inhibition of LTK (unknown origin) using Km levels of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50396243(CHEMBL2172308 | US10370379, Compound TSR-011)
Affinity DataKd:  2.5nMAssay Description:Binding affinity to human LTK by Ambit titration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of LTK (unknown origin) by TR-FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50653010(CHEMBL5712062)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of GST-tagged recombinant LTK (450 to 864 residues) (unknown origin) expressed in Insect cellMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human TYK1/LTK using EAIYAAPFAKKK as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of LTK (unknown origin) incubated for 1 hr by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2017
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50520589(CHEMBL4473365)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant GST-tagged human LTK cytoplasmic domain (440 to 864 residues) expressed in baculovirus expression system by Z-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50554817(CHEMBL4764610)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human LTKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50396263(CHEMBL2172315)
Affinity DataKd:  8.20nMAssay Description:Binding affinity to human LTK by Ambit titration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataKd:  12nMAssay Description:Binding constant for LTK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human LTK using EAIYAAPFAKKK as substrate in presence of [gamma33P]-ATP by HotSpot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 19nMAssay Description:Inhibition of human TYK1 using EAIYAAPFAKKK as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 29.2nMAssay Description:Inhibition of human TYK1 using EAIYAAPFAKKK as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  37nMAssay Description:Binding constant for LTK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  37nMAssay Description:Binding constant for LTK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50187716(CHEMBL3735648)
Affinity DataIC50: 43nMAssay Description:Inhibition of recombinant LTK (unknown origin) using poly(Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2017
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50240779(CHEMBL4067871)
Affinity DataIC50: 45nMAssay Description:Inhibition of recombinant LTK (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2019
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50273571(Hesperadin | TCMDC-135395 | N-(2-oxo-3-(phenyl(4-(...)
Affinity DataKd:  52nMAssay Description:Binding affinity to human LTKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 61nMAssay Description:Inhibition of human N-terminal GST-fused LTK catalytic domain (498 to 796 residues) expressed in baculovirus expression system using Srctide as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM662623(US20240109865, Example 46.)
Affinity DataIC50: 65nMAssay Description:Inhibition of human LTK by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50240782(CHEMBL4075917)
Affinity DataIC50: 69nMAssay Description:Inhibition of recombinant LTK (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2019
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50355504(CHEMBL1908393)
Affinity DataKd:  110nMAssay Description:Binding constant for LTK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50240780(CHEMBL4062877)
Affinity DataIC50: 123nMAssay Description:Inhibition of recombinant LTK (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2019
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | Vargatef | US10981896, Co...)
Affinity DataKd:  150nMAssay Description:Binding constant for LTK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  160nMAssay Description:Binding constant for LTK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  160nMAssay Description:Binding constant for LTK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50505542(CHEMBL4576489)
Affinity DataKd:  193nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged LTK (unknown origin) (498 to 796 residues) expressed in baculovirus infect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50505541(CHEMBL4465866)
Affinity DataKd:  193nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged LTK (unknown origin) (498 to 796 residues) expressed in baculovirus infect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM185674(Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...)
Affinity DataIC50: 260nMAssay Description:Inhibition of human wild type TYK1 using PolyEY as substrate preincubated for 2 hrs followed by ATP addition and measured every 2 mins for 2.5 hrs by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50240781(CHEMBL4105329)
Affinity DataIC50: 300nMAssay Description:Inhibition of recombinant LTK (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2019
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50235830(CHEMBL2006765)
Affinity DataIC50: 360nMAssay Description:Inhibition of LTK (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2019
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataKd:  440nMAssay Description:Binding constant for LTK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  490nMAssay Description:Binding affinity to LTKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  490nMAssay Description:Binding constant for LTK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataKd:  550nMAssay Description:Binding constant for LTK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM21(VANDETANIB | N-(4-bromo-2-fluorophenyl)-6-methoxy-...)
Affinity DataKd:  550nMAssay Description:Binding constant for LTK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataKd:  550nMAssay Description:Binding constant for LTK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM21(VANDETANIB | N-(4-bromo-2-fluorophenyl)-6-methoxy-...)
Affinity DataKd:  550nMAssay Description:Binding constant for LTK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM60665(US9145414, R406 | US9212178, R406 | BDBM50249542 |...)
Affinity DataKd:  800nMAssay Description:Binding constant for LTK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataKd:  890nMAssay Description:Binding constant for LTK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataKd:  890nMAssay Description:Binding constant for LTK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50355496(CHEMBL1908397)
Affinity DataKd:  920nMAssay Description:Binding constant for LTK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM174948(US9096593, P-2049)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of LTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity to LTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetLeukocyte tyrosine kinase receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50311017(N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of LTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
Displayed 1 to 50 (of 167 total ) | Next | Last >>
Jump to: