Compile Data Set for Download or QSAR
Report error Found 179 Enz. Inhib. hit(s) with Target = 'Lon protease homolog, mitochondrial'
TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50571496BDBM50571496(CHEMBL4876525)
Affinity DataIC50: 17nMAssay Description:Inhibition of LONP1 (unknown origin) using QXL520-YRGITCSGRQK(5-FAM)-NH2 peptide as substrate incubated for 50 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50571500BDBM50571500(CHEMBL4856865)
Affinity DataIC50: 18nMAssay Description:Inhibition of LONP1 (unknown origin) using QXL520-YRGITCSGRQK(5-FAM)-NH2 peptide as substrate incubated for 50 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50571499BDBM50571499(CHEMBL4864108)
Affinity DataIC50: 34nMAssay Description:Inhibition of LONP1 (unknown origin) using QXL520-YRGITCSGRQK(5-FAM)-NH2 peptide as substrate incubated for 50 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50571493BDBM50571493(CHEMBL4877126)
Affinity DataIC50: 38nMAssay Description:Inhibition of LONP1 (unknown origin) using QXL520-YRGITCSGRQK(5-FAM)-NH2 peptide as substrate incubated for 50 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 781937BDBM781937(US20250320234, Compound 43)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/5/2026
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 781936BDBM781936(US20250320234, Compound 42)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/5/2026
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 722813BDBM722813(US20250059213, Compound 35 | US20250320234, Compou...)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/5/2026
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 781930BDBM781930(US20250320234, Compound 36)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/5/2026
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 781945BDBM781945(US20250320234, Compound 56)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/5/2026
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 781944BDBM781944(US20250320234, Compound 55)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/5/2026
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 781943BDBM781943(US20250320234, Compound 54)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/5/2026
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 781941BDBM781941(US20250320234, Compound 52)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/5/2026
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 781940BDBM781940(US20250320234, Compound 51)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/5/2026
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 781938BDBM781938(US20250320234, Compound 44)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/5/2026
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 781919BDBM781919(US20250320234, Compound 25)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/5/2026
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 781918BDBM781918(US20250320234, Compound 24)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/5/2026
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 781917BDBM781917(US20250320234, Compound 23)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/5/2026
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 781915BDBM781915(US20250320234, Compound 21)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/5/2026
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 781914BDBM781914(US20250320234, Compound 20)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/5/2026
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 781929BDBM781929(US20250320234, Compound 35)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/5/2026
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 781928BDBM781928(US20250320234, Compound 34)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/5/2026
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 722800BDBM722800(US20250059213, Compound 13 | US20250320234, Compou...)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/5/2026
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 781926BDBM781926(US20250320234, Compound 32)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/5/2026
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 781925BDBM781925(US20250320234, Compound 31)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/5/2026
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 781946BDBM781946(US20250320234, Compound 57)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/5/2026
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 722809BDBM722809(US20250059213, Compound 29 | US20250320234, Compou...)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 722810BDBM722810(US20250059213, Compound 31)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 722807BDBM722807(US20250059213, Compound 23)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 722808BDBM722808(US20250059213, Compound 27)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 722805BDBM722805(US20250059213, Compound 21)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 722803BDBM722803(US20250059213, Compound 19)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 722804BDBM722804(US20250059213, Compound 20)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 722818BDBM722818(US20250059213, Compound 41)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 722815BDBM722815(US20250059213, Compound 38 | US20250320234, Compou...)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 722816BDBM722816(US20250059213, Compound 39)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 722813BDBM722813(US20250059213, Compound 35 | US20250320234, Compou...)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 722814BDBM722814(US20250059213, Compound 37)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 722811BDBM722811(US20250059213, Compound 32)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 722812BDBM722812(US20250059213, Compound 33)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 722793BDBM722793(US20250059213, Compound 6)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 722794BDBM722794(US20250059213, Compound 7)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 722791BDBM722791(US20250059213, Compound 4)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 722792BDBM722792(US20250059213, Compound 5)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 722789BDBM722789(US20250059213, Compound 2)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 722790BDBM722790(US20250059213, Compound 3)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 722735BDBM722735(US20250059213, Compound 1)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 720787BDBM720787(US20250051367, Compound 10)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 722802BDBM722802(US20250059213, Compound 17)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 720782BDBM720782(US20250051367, Compound 5)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetLon protease homolog, mitochondrial(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 722800BDBM722800(US20250059213, Compound 13 | US20250320234, Compou...)
Affinity DataIC50: 50nMAssay Description:In this Example, LONP1 (NM_004793.4) activity was measured by a FRET-based assay for protease activity using a fluorogenic peptide DabcylYRGIT(2Abu)S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

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