Compile Data Set for Download or QSAR
Report error Found 11748 Enz. Inhib. hit(s) with Target = 'Lysine-specific histone demethylase 1A'
LigandPNGBDBM774892((E)-3-(4- (((1-(3-Cyano- 4-(4-cyano-3- fluoropheny...)
Affinity DataIC50: 0.0200nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM683065(US20240216357, Example 9 | Preparation of 4-(5-(3-...)
Affinity DataIC50: 0.0260nMAssay Description:The effects of compounds on LSD1 enzyme activity are detected by an HTRF technology to evaluate their inhibition levels on LSD1 enzyme activity. Firs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2024
Entry Details
US Patent

LigandPNGBDBM774888(3-(3-chloro-4-((1-(3- cyano-4-(4-cyano-3- fluoroph...)
Affinity DataIC50: 0.0300nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM774878((E)-3-(4- (((1-(3-Cyano- 4-(4-cyano-3- fluoropheny...)
Affinity DataIC50: 0.0400nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM774715(7-(4-(6-(4-aminopiperidin-1-yl)-2-(4-cyano-3-fluor...)
Affinity DataIC50: 0.0500nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM456483(US10723742, Example 213 | US10723742, Example 209 ...)
Affinity DataIC50: 0.0500nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM50551861(CHEMBL4798849)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human recombinant LSD1 using fluorogenic ADHP based substrate preincubated for 30 mins followed by substrate addition measured after 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
LigandPNGBDBM456483(US10723742, Example 213 | US10723742, Example 209 ...)
Affinity DataIC50: 0.0600nMAssay Description:The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2021
Entry Details
US Patent

LigandPNGBDBM456483(US10723742, Example 213 | US10723742, Example 209 ...)
Affinity DataIC50: 0.0600nMAssay Description:The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

LigandPNGBDBM683183(US20240216357, Example 136 | 4-(5-(4- aminopiperid...)
Affinity DataIC50: 0.0600nMAssay Description:The effects of compounds on LSD1 enzyme activity are detected by an HTRF technology to evaluate their inhibition levels on LSD1 enzyme activity. Firs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2024
Entry Details
US Patent

LigandPNGBDBM50551907(CHEMBL4762799)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of human recombinant LSD1 using fluorogenic ADHP based substrate preincubated for 30 mins followed by substrate addition measured after 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
LigandPNGBDBM581928(US11510915, Example 283 | US12435128, Example 283)
Affinity DataIC50: 0.0620nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM581928(US11510915, Example 283 | US12435128, Example 283)
Affinity DataIC50: 0.0620nMAssay Description:The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

LigandPNGBDBM456491(US10723742, Example 221 | US10723742, Example 218 ...)
Affinity DataIC50: 0.0700nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM774897((E)-3-(4-(2-(4-(6-(4-Aminopiperidin-1-yl)-5-cyano-...)
Affinity DataIC50: 0.0700nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM683184(US20240216357, Example 137 | 4-(5-(4- aminopiperid...)
Affinity DataIC50: 0.0700nMAssay Description:The effects of compounds on LSD1 enzyme activity are detected by an HTRF technology to evaluate their inhibition levels on LSD1 enzyme activity. Firs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2024
Entry Details
US Patent

LigandPNGBDBM456491(US10723742, Example 221 | US10723742, Example 218 ...)
Affinity DataIC50: 0.0700nMAssay Description:The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2021
Entry Details
US Patent

LigandPNGBDBM456491(US10723742, Example 221 | US10723742, Example 218 ...)
Affinity DataIC50: 0.0700nMAssay Description:The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

LigandPNGBDBM581933(US11510915, Example 288 | US12435128, Example 288)
Affinity DataIC50: 0.0750nMAssay Description:The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

LigandPNGBDBM581933(US11510915, Example 288 | US12435128, Example 288)
Affinity DataIC50: 0.0750nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM581938(US11510915, Example 293 | US12435128, Example 293)
Affinity DataIC50: 0.0760nMAssay Description:The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

LigandPNGBDBM581938(US11510915, Example 293 | US12435128, Example 293)
Affinity DataIC50: 0.0760nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM683171(US20240216357, Example 124 | 4-(5-(4- aminopiperid...)
Affinity DataIC50: 0.0800nMAssay Description:The effects of compounds on LSD1 enzyme activity are detected by an HTRF technology to evaluate their inhibition levels on LSD1 enzyme activity. Firs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2024
Entry Details
US Patent

LigandPNGBDBM456476(US10723742, Example 202 | US11510915, Example 202 ...)
Affinity DataIC50: 0.0900nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM774849(2-(4-(((1-(3- Cyano-4- (4-cyano-3- fluorophenyl)-5...)
Affinity DataIC50: 0.0900nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM774850((E)-3-(5- ((1-(3-Cyano- 4-(4-cyano-3- fluorophenyl...)
Affinity DataIC50: 0.0900nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM774848((E)-3-(5- (((1-(3-Cyano- 4-(4-cyano-3- fluoropheny...)
Affinity DataIC50: 0.0900nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM456476(US10723742, Example 202 | US11510915, Example 202 ...)
Affinity DataIC50: 0.0900nMAssay Description:The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2021
Entry Details
US Patent

LigandPNGBDBM456476(US10723742, Example 202 | US11510915, Example 202 ...)
Affinity DataIC50: 0.0900nMAssay Description:The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

LigandPNGBDBM581930(US11510915, Example 285 | US12435128, Example 285)
Affinity DataIC50: 0.0910nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM581930(US11510915, Example 285 | US12435128, Example 285)
Affinity DataIC50: 0.0910nMAssay Description:The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

LigandPNGBDBM581931(US11510915, Example 286 | US12435128, Example 286)
Affinity DataIC50: 0.0930nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM581931(US11510915, Example 286 | US12435128, Example 286)
Affinity DataIC50: 0.0930nMAssay Description:The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

LigandPNGBDBM50551904(CHEMBL4785635)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human recombinant LSD1 using fluorogenic ADHP based substrate preincubated for 30 mins followed by substrate addition measured after 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
LigandPNGBDBM774814((E)-3-(4-(((1-(3- Cyano-4-(4- cyano-3- fluoropheny...)
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM683266(US20240216357, Example 223 | Preparation of 4-(2-(...)
Affinity DataIC50: 0.100nMAssay Description:The effects of compounds on LSD1 enzyme activity are detected by an HTRF technology to evaluate their inhibition levels on LSD1 enzyme activity. Firs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2024
Entry Details
US Patent

LigandPNGBDBM456492(US10723742, Example 219 | US11510915, Example 219 ...)
Affinity DataIC50: 0.100nMAssay Description:The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2021
Entry Details
US Patent

LigandPNGBDBM456492(US10723742, Example 219 | US11510915, Example 219 ...)
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM456487(US10723742, Example 217 | US10723742, Example 214 ...)
Affinity DataIC50: 0.100nMAssay Description:The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2021
Entry Details
US Patent

LigandPNGBDBM50540648(CHEMBL4639944)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of recombinant human LSD1 expressed in Escherichia coli using biotinylated H3K4me as substrate by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
LigandPNGBDBM456490(US10723742, Example 217 | US12435128, Example 217)
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM456487(US10723742, Example 217 | US10723742, Example 214 ...)
Affinity DataIC50: 0.100nMAssay Description:The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

LigandPNGBDBM581932(US11510915, Example 287 | US12435128, Example 287)
Affinity DataIC50: 0.100nMAssay Description:The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

LigandPNGBDBM774744(N1-(4-(6-(4-aminopiperidin-1-yl)-5-cyano-4-(4-cyan...)
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM683314(US20240216357, Example 276 | Preparation of (2-(4-...)
Affinity DataIC50: 0.100nMAssay Description:The effects of compounds on LSD1 enzyme activity are detected by an HTRF technology to evaluate their inhibition levels on LSD1 enzyme activity. Firs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2024
Entry Details
US Patent

LigandPNGBDBM581932(US11510915, Example 287 | US12435128, Example 287)
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM683185(US20240216357, Example 138 | 2-fluoro-4-(8- (3-hyd...)
Affinity DataIC50: 0.100nMAssay Description:The effects of compounds on LSD1 enzyme activity are detected by an HTRF technology to evaluate their inhibition levels on LSD1 enzyme activity. Firs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2024
Entry Details
US Patent

LigandPNGBDBM456492(US10723742, Example 219 | US11510915, Example 219 ...)
Affinity DataIC50: 0.100nMAssay Description:The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

LigandPNGBDBM456471(US10723742, Example 197 | US11510915, Example 197 ...)
Affinity DataIC50: 0.110nMAssay Description:The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2021
Entry Details
US Patent

LigandPNGBDBM774846((E)-3-(4- (((1-(3-Cyano- 4-(4-cyano-3- fluoropheny...)
Affinity DataIC50: 0.110nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

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