Compile Data Set for Download or QSAR
Report error Found 944 Enz. Inhib. hit(s) with Target = 'Macrophage migration inhibitory factor'
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  1.90nMAssay Description:Binding affinity to human MIF incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM648297(US11884682, Compound 31 | 1-(3-methoxy-4-(((5-(thi...)
Affinity DataIC50: 6.92nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

LigandPNGBDBM648295(US11884682, Compound 29 | 3'-methoxy-4'-((5-(thiop...)
Affinity DataIC50: 7.24nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

LigandPNGBDBM50327348(3-(3-hydroxybenzyl)-6-methylbenzo[d]oxazol-2(3H)-o...)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of human recombinant MIF tautomeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
LigandPNGBDBM648298(US11884682, Compound 32 | 2-((3-metboxy-4-((5-(thi...)
Affinity DataIC50: 9.55nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

LigandPNGBDBM50327346(3-(3-hydroxybenzyl)-5-methylbenzo[d]oxazol-2(3H)-o...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant MIF tautomeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
LigandPNGBDBM648281(US11884682, Compound 17 | 4-(2-hydroxyethoxy)-2-me...)
Affinity DataIC50: 10.5nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

LigandPNGBDBM648291(US11884682, Compound 26 | 4-(3-(2H-tetrazol-5-yl)p...)
Affinity DataIC50: 11.2nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

LigandPNGBDBM648286(US11884682, Compound 22 | 4-((2H-tetrazol-5-yl)met...)
Affinity DataIC50: 12.3nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

LigandPNGBDBM648296(US11884682, Compound 30 | (3-methoxy-4-((5-(thioph...)
Affinity DataIC50: 12.6nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

LigandPNGBDBM50206092(CHEMBL3917143 | US10336721, Example 32 | US1096819...)
Affinity DataKi:  14nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli assessed as borate-enol complex formation using 4-hydroxypheny...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50206092(CHEMBL3917143 | US10336721, Example 32 | US1096819...)
Affinity DataKi:  14nMAssay Description:Inhibition of recombinant human MIF tautomerase activity using 4-hydroxyphenyl pyruvic acid (HPP) as substrate pre-incubated for 30 mins and followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50553887(CHEMBL4779696)
Affinity DataKd:  16nMAssay Description:Binding affinity to C-terminal His-tagged recombinant human MIF expressed in Escherichia coli BL21 (DE3) at 200 nM by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandPNGBDBM648293(US11884682, Compound 27 | Cis-4-(3-methoxy-4-((5-(...)
Affinity DataIC50: 18.6nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

LigandPNGBDBM648260(US11884682, Compound 5 | 2,4-dimethoxy-N-(5-(thiop...)
Affinity DataIC50: 18.6nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

LigandPNGBDBM648289(US11884682, Compound 25 | 4-(3-cyanopropyl)-2-meth...)
Affinity DataIC50: 20.9nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

LigandPNGBDBM648267(US11884682, Compound 9 | 2,4-dimethoxy-N-(5-(thiop...)
Affinity DataIC50: 22.9nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

LigandPNGBDBM50206092(CHEMBL3917143 | US10336721, Example 32 | US1096819...)
Affinity DataKi:  23nMAssay Description:Data obtained for the Example compounds, obtained using the methods described in Example B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM50206092(CHEMBL3917143 | US10336721, Example 32 | US1096819...)
Affinity DataKi:  23nMAssay Description:Inhibition of the tautomerase activity of MIF was measured using 4-hydroxyphenyl pyruvic acid (HPP) as substrate, largely following previously report...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM648282(US11884682, Compound 18 | 4-(2-(benzyloxy)ethoxy)-...)
Affinity DataIC50: 23.4nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

LigandPNGBDBM50206091(CHEMBL3918231 | US10336721, Example 25 | US1096819...)
Affinity DataKi:  24nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli assessed as borate-enol complex formation using 4-hydroxypheny...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2018
Entry Details Article
PubMed
LigandPNGBDBM648285(US11884682, Compound 21 | 2-(3-methoxy-4-((5-(thio...)
Affinity DataIC50: 25.7nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

LigandPNGBDBM648283(US11884682, Compound 19 | 2-(3-methoxy-4-((5-(thio...)
Affinity DataIC50: 28.8nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

LigandPNGBDBM648287(US11884682, Compound 23 | 2-methoxy-4-((2-((5-meth...)
Affinity DataIC50: 31.6nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

LigandPNGBDBM50206083(CHEMBL3927658 | US10968198, Example 43)
Affinity DataKi:  34nMAssay Description:Data obtained for the Example compounds, obtained using the methods described in Example B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent

LigandPNGBDBM403784(US10336721, Example 43)
Affinity DataKi:  34nMAssay Description:Inhibition of the tautomerase activity of MIF was measured using 4-hydroxyphenyl pyruvic acid (HPP) as substrate, largely following previously report...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent

LigandPNGBDBM648303(US11884682, Compound 37 | 2-methoxy-4-morpholino-N...)
Affinity DataIC50: 36.3nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

LigandPNGBDBM50206062(CHEMBL3890541 | US10968198, Example 44)
Affinity DataKi:  37nMAssay Description:Inhibition of recombinant human MIF tautomerase activity using 4-hydroxyphenyl pyruvic acid (HPP) as substrate pre-incubated for 30 mins and followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM50206062(CHEMBL3890541 | US10968198, Example 44)
Affinity DataKi:  37nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli assessed as borate-enol complex formation using 4-hydroxypheny...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2018
Entry Details Article
PubMed
LigandPNGBDBM50095997(3',4',7-trihydroxyisoflavone | CHEMBL13486)
Affinity DataKi:  38nMAssay Description:Inhibition of human recombinant MIF tautomeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50095997(3',4',7-trihydroxyisoflavone | CHEMBL13486)
Affinity DataKi:  38nMAssay Description:Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50095997(3',4',7-trihydroxyisoflavone | CHEMBL13486)
Affinity DataIC50: 38nMAssay Description:Inhibition of human MIF tautomerase activity expressed in Escherichia coli BL21 (DE3) using 4-hydroxyphenyl pyruvic acid as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50313986(3-(3,4-dihydroxyphenyl)-4H-chromen-4-one | CHEMBL1...)
Affinity DataIC50: 38nMAssay Description:Inhibition of MIFMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Plasmodium falciparum (isolate 3D7))
Yale University

Curated by ChEMBL
LigandPNGBDBM50399046(CHEMBL2178862)
Affinity DataKi:  38nMAssay Description:Inhibition of recombinant Plasmodium falciparum MIF expressed in Escherichia coli BL21 (DE3) assessed as ketonization of enol form of 4-HPP substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50095997(3',4',7-trihydroxyisoflavone | CHEMBL13486)
Affinity DataIC50: 38nMAssay Description:Inhibition of recombinant human His-tagged MIF tautomerization expressed in Escherichia coli BL21 (DE3) using D-dopachrome as substrate after 10 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM648294(US11884682, Compound 28 | Trans-4-(3-methoxy-4-((5...)
Affinity DataIC50: 38nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

LigandPNGBDBM50206083(CHEMBL3927658 | US10968198, Example 43)
Affinity DataKi:  39nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli assessed as decrease in formation of borate complex of enol pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2020
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Plasmodium falciparum (isolate 3D7))
Yale University

Curated by ChEMBL
LigandPNGBDBM50399047(CHEMBL2178856)
Affinity DataKi:  39nMAssay Description:Inhibition of recombinant Plasmodium falciparum MIF expressed in Escherichia coli BL21 (DE3) assessed as ketonization of enol form of 4-HPP substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50206083(CHEMBL3927658 | US10968198, Example 43)
Affinity DataKi:  39nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli assessed as borate-enol complex formation using 4-hydroxypheny...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2018
Entry Details Article
PubMed
LigandPNGBDBM490115(US10968198, Example 42)
Affinity DataKi:  43nMAssay Description:Data obtained for the Example compounds, obtained using the methods described in Example B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent

LigandPNGBDBM403783(US10336721, Example 42)
Affinity DataKi:  43nMAssay Description:Inhibition of the tautomerase activity of MIF was measured using 4-hydroxyphenyl pyruvic acid (HPP) as substrate, largely following previously report...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent

TargetMacrophage migration inhibitory factor(Plasmodium falciparum (isolate 3D7))
Yale University

Curated by ChEMBL
LigandPNGBDBM50399054(CHEMBL2178851)
Affinity DataKi:  43nMAssay Description:Inhibition of recombinant Plasmodium falciparum MIF expressed in Escherichia coli BL21 (DE3) assessed as ketonization of enol form of 4-HPP substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50206062(CHEMBL3890541 | US10968198, Example 44)
Affinity DataKi:  45nMAssay Description:Data obtained for the Example compounds, obtained using the methods described in Example B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent

LigandPNGBDBM403785(US10336721, Example 44)
Affinity DataKi:  45nMAssay Description:Inhibition of the tautomerase activity of MIF was measured using 4-hydroxyphenyl pyruvic acid (HPP) as substrate, largely following previously report...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent

LigandPNGBDBM648300(US11884682, Compound 34 | 2-methoxy-4-morpholino-N...)
Affinity DataIC50: 46.8nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

LigandPNGBDBM50206084(CHEMBL3899123)
Affinity DataKi:  48nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli assessed as borate-enol complex formation using 4-hydroxypheny...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2018
Entry Details Article
PubMed
LigandPNGBDBM50206084(CHEMBL3899123)
Affinity DataKi:  48nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli assessed as decrease in formation of borate complex of enol pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2020
Entry Details Article
PubMed
LigandPNGBDBM648288(US11884682, Compound 24 | 2-methoxy-4-((1-((5-meth...)
Affinity DataIC50: 49nMAssay Description:Assays were performed in small-volume clear-bottom black 96 or 384-well polystyrene plates (Greiner Bio-One). First, 2 μL of the enzyme solution...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
US Patent

LigandPNGBDBM50326574(6-phenylpyridazin-3-yl thiophene-2-carboxylate | C...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human MIF tautomerase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
LigandPNGBDBM50326574(6-phenylpyridazin-3-yl thiophene-2-carboxylate | C...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human MIF tautomerase activity in presence of Triton X-100 as detergentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2013
Entry Details Article
PubMed
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