Compile Data Set for Download or QSAR
Report error Found 241 Enz. Inhib. hit(s) with Target = 'Mas-related G-protein coupled receptor member X2'
TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50594463(CHEMBL5184300)
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at human MRGPRX2 expressed in HEK293 cells co-expressing mouse Galpha15 assessed as inhibition of Cortistatin-14 induced Ca2+ mob...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770760(4-((S)-1-((R)-1-([1,3]dioxolo[4',5':4,5]benzo[1,2-...)
Affinity DataIC50: 3.70nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770735((S)-2-((S)-4,4-difluoro-3-(5-oxo-4,5-dihydropyrazi...)
Affinity DataIC50: 5.90nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770711((S)-2-((R)-3-(5-((R)-1-amino-2,2,2-trifluoroethyl)...)
Affinity DataIC50: 6nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770745(4-((R)-1-((S)-1-((2,2-difluoro-[1,3]dioxolo[4',5':...)
Affinity DataIC50: 6.60nMAssay Description:LAD-2 cells were maintained at 37oC with 5% CO2 and grown in complete StemPro-34 media supplemented with 1% L-Glutamate, 1% penicillin/streptomycin, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770737((S)-N-(2,2-difluoro-[1,3]dioxolo[4',5':4,5]benzo[1...)
Affinity DataIC50: 7.40nMAssay Description:LAD-2 cells were maintained at 37oC with 5% CO2 and grown in complete StemPro-34 media supplemented with 1% L-Glutamate, 1% penicillin/streptomycin, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770745(4-((R)-1-((S)-1-((2,2-difluoro-[1,3]dioxolo[4',5':...)
Affinity DataIC50: 7.80nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770723((S)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridi...)
Affinity DataIC50: 8.60nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770746((S)-2-(4,4-difluoropiperidin-1-yl)-N-(6,7-dihydro-...)
Affinity DataIC50: 9.40nMAssay Description:LAD-2 cells were maintained at 37oC with 5% CO2 and grown in complete StemPro-34 media supplemented with 1% L-Glutamate, 1% penicillin/streptomycin, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770746((S)-2-(4,4-difluoropiperidin-1-yl)-N-(6,7-dihydro-...)
Affinity DataIC50: 10nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770737((S)-N-(2,2-difluoro-[1,3]dioxolo[4',5':4,5]benzo[1...)
Affinity DataIC50: 11nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770760(4-((S)-1-((R)-1-([1,3]dioxolo[4',5':4,5]benzo[1,2-...)
Affinity DataIC50: 12nMAssay Description:LAD-2 cells were maintained at 37oC with 5% CO2 and grown in complete StemPro-34 media supplemented with 1% L-Glutamate, 1% penicillin/streptomycin, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770728((S)-2-((R)-4,4-difluoro-3-(5-oxo-4,5-dihydropyrazi...)
Affinity DataIC50: 14nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770748(4-((R)-1-((S)-1-((6,7-dihydro-5H-indeno[5,6-d]thia...)
Affinity DataIC50: 15nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770726((S)-2-((R)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridi...)
Affinity DataIC50: 15nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770779(4-((S)-1-((S)-1-((6,7-dihydro-[1,4]dioxino[2',3':4...)
Affinity DataIC50: 17nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770727((S)-N-([1,3]dioxolo[4',5':4,5]benzo[1,2-d]thiazol-...)
Affinity DataIC50: 17nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770716((S)-2-((S)-3-(5-((R)-1-amino-2,2-difluoroethyl)-6-...)
Affinity DataIC50: 17nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770722((S)-2-((R)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridi...)
Affinity DataIC50: 18nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770776(4-((R)-1-((S)-1-((2,2-difluoro-[1,3]dioxolo[4',5':...)
Affinity DataIC50: 18nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770715((S)-2-((S)-3-(5-((S)-1-amino-2,2-difluoroethyl)-6-...)
Affinity DataIC50: 18nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770723((S)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridi...)
Affinity DataIC50: 20nMAssay Description:LAD-2 cells were maintained at 37oC with 5% CO2 and grown in complete StemPro-34 media supplemented with 1% L-Glutamate, 1% penicillin/streptomycin, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770739((S)-N-(2,2-difluoro-[1,3]dioxolo[4',5':4,5]benzo[1...)
Affinity DataIC50: 22nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770735((S)-2-((S)-4,4-difluoro-3-(5-oxo-4,5-dihydropyrazi...)
Affinity DataIC50: 23nMAssay Description:LAD-2 cells were maintained at 37oC with 5% CO2 and grown in complete StemPro-34 media supplemented with 1% L-Glutamate, 1% penicillin/streptomycin, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770710((S)-2-((S)-3-(5-((R)-1-amino-2,2,2-trifluoroethyl)...)
Affinity DataIC50: 24nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770774(4-((S)-1-((R)-1-((6,7-dihydro-5H-indeno[5,6-d]thia...)
Affinity DataIC50: 26nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770726((S)-2-((R)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridi...)
Affinity DataIC50: 27nMAssay Description:LAD-2 cells were maintained at 37oC with 5% CO2 and grown in complete StemPro-34 media supplemented with 1% L-Glutamate, 1% penicillin/streptomycin, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770720((S)-2-((S)-4,4-difluoro-3-(5-oxo-4,5-dihydropyrazi...)
Affinity DataIC50: 29nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770748(4-((R)-1-((S)-1-((6,7-dihydro-5H-indeno[5,6-d]thia...)
Affinity DataIC50: 29nMAssay Description:LAD-2 cells were maintained at 37oC with 5% CO2 and grown in complete StemPro-34 media supplemented with 1% L-Glutamate, 1% penicillin/streptomycin, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770744(4-((S)-1-((S)-1-((2,2-difluoro-[1,3]dioxolo[4',5':...)
Affinity DataIC50: 30nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770768((S)-2-((R)-4,4-difluoro-3-(5-(hydroxymethyl)-6-oxo...)
Affinity DataIC50: 30nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770779(4-((S)-1-((S)-1-((6,7-dihydro-[1,4]dioxino[2',3':4...)
Affinity DataIC50: 30nMAssay Description:LAD-2 cells were maintained at 37oC with 5% CO2 and grown in complete StemPro-34 media supplemented with 1% L-Glutamate, 1% penicillin/streptomycin, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770783((S)-2-((R)-4,4-difluoro-3-(1H-1,2,4-triazol-5-yl)p...)
Affinity DataIC50: 31nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM726378(US12247015, Example 16)
Affinity DataKd:  31.6nMAssay Description:Equilibrium dissociation constants, Kd, for many of the compounds described in the Examples section (“test compounds”) are determined in the presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/15/2025
Entry Details
US Patent

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770752(2-(aminomethyl)-4-((R)-1-((S)-1-((2,2-difluoro-[1,...)
Affinity DataIC50: 32nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770732(4-((3S,4S)-1-((S)-1-((2,2-difluoro-[1,3]dioxolo[4'...)
Affinity DataIC50: 32nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM702970(US20240366606, Compound 9-(ZINC49534341))
Affinity DataKi:  32nMAssay Description:HEK293 cells were cultured in DMEM with 4.5 g L-1 glucose, L-glutamine, and sodium pyruvate (Mediatech) containing 10% (v/v) FBS (Axenia BioLogix) an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
US Patent

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770758(4-((S)-1-((R)-1-((2,2-difluoro-[1,3]dioxolo[4',5':...)
Affinity DataIC50: 34nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770776(4-((R)-1-((S)-1-((2,2-difluoro-[1,3]dioxolo[4',5':...)
Affinity DataIC50: 35nMAssay Description:LAD-2 cells were maintained at 37oC with 5% CO2 and grown in complete StemPro-34 media supplemented with 1% L-Glutamate, 1% penicillin/streptomycin, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM726377(US12247015, Example 12)
Affinity DataKd:  35.5nMAssay Description:Equilibrium dissociation constants, Kd, for many of the compounds described in the Examples section (“test compounds”) are determined in the presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
7/15/2025
Entry Details
US Patent

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770770((S)-2-((S)-4,4-difluoro-3-(6-(hydroxymethyl)-5-oxo...)
Affinity DataIC50: 36nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770764((S)-2-((R)-3-(5-(aminomethyl)-6-oxo-1,6-dihydropyr...)
Affinity DataIC50: 36nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM702976(US20240366606, Compound C9-6)
Affinity DataKi:  38nMAssay Description:HEK293 cells were cultured in DMEM with 4.5 g L-1 glucose, L-glutamine, and sodium pyruvate (Mediatech) containing 10% (v/v) FBS (Axenia BioLogix) an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
US Patent

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770766((S)-2-((R)-4,4-difluoro-3-(5-((methylamino)methyl)...)
Affinity DataIC50: 41nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770758(4-((S)-1-((R)-1-((2,2-difluoro-[1,3]dioxolo[4',5':...)
Affinity DataIC50: 46nMAssay Description:LAD-2 cells were maintained at 37oC with 5% CO2 and grown in complete StemPro-34 media supplemented with 1% L-Glutamate, 1% penicillin/streptomycin, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM702979(US20240366606, Compound C9-9)
Affinity DataKi:  47nMAssay Description:HEK293 cells were cultured in DMEM with 4.5 g L-1 glucose, L-glutamine, and sodium pyruvate (Mediatech) containing 10% (v/v) FBS (Axenia BioLogix) an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
US Patent

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770786((S)-2-((R)-4,4-difluoro-3-(5-(hydroxymethyl)-6-oxo...)
Affinity DataIC50: 49nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770697((S)-N-(2,2-difluoro-[1,3]dioxolo[4',5':4,5]benzo[1...)
Affinity DataIC50: 49nMAssay Description:FlpIn TRex-MRGPRX2-HEK293 cells (herein TRex-MRPGRX2-HEK) stably transfected to express human MRGPRX2 were maintained at 37oC with 5% CO2 and grown i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770727((S)-N-([1,3]dioxolo[4',5':4,5]benzo[1,2-d]thiazol-...)
Affinity DataIC50: 49nMAssay Description:LAD-2 cells were maintained at 37oC with 5% CO2 and grown in complete StemPro-34 media supplemented with 1% L-Glutamate, 1% penicillin/streptomycin, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

TargetMas-related G-protein coupled receptor member X2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM770728((S)-2-((R)-4,4-difluoro-3-(5-oxo-4,5-dihydropyrazi...)
Affinity DataIC50: 52nMAssay Description:LAD-2 cells were maintained at 37oC with 5% CO2 and grown in complete StemPro-34 media supplemented with 1% L-Glutamate, 1% penicillin/streptomycin, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/25/2025
Entry Details
WIPO WO2025064535

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