Compile Data Set for Download or QSAR
Report error Found 698 Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 7'
TargetMetabotropic glutamate receptor 7(Mouse)
Cerevance

Curated by ChEMBL
LigandPNGBDBM50614232(CHEMBL5266235)
Affinity DataEC50:  2nMAssay Description:Agonist activity at mouse mGluR7 expressed in CHO cells expressing CRE-Luc reporter gene assessed as reduction in forskolin-stimulated cAMP productio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Cerevance

Curated by ChEMBL
LigandPNGBDBM50614234(CHEMBL5285249)
Affinity DataEC50:  6nMAssay Description:Agonist activity at human mGluR7 expressed in CHO cells expressing CRE-Luc reporter gene assessed as reduction in forskolin-stimulated cAMP productio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Cerevance

Curated by ChEMBL
LigandPNGBDBM50614232(CHEMBL5266235)
Affinity DataEC50:  7nMAssay Description:Agonist activity at human mGluR7 expressed in CHO cells expressing CRE-Luc reporter gene assessed as reduction in forskolin-stimulated cAMP productio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50305863(3-(3-methoxyphenyl)-5-methyl-6-phenylisoxazolo[4,5...)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50305859(CHEMBL595840 | cid_4250909 | 5-methyl-3,6-diphenyl...)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50305864(3-(2-methoxyphenyl)-5-methyl-6-phenylisoxazolo[4,5...)
Affinity DataIC50: 21nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50196289(6-(4-methoxyphenyl)-5-methyl-3-phenylisoxazolo[4,5...)
Affinity DataIC50: 22nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50196291(6-(benzo[d][1,3]dioxol-5-yl)-5-methyl-3-phenylisox...)
Affinity DataIC50: 26nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50305877(6-(4-methoxyphenyl)-5-methyl-3-(pyridin-4-yl)isoxa...)
Affinity DataIC50: 26nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Cerevance

Curated by ChEMBL
LigandPNGBDBM50614233(CHEMBL5280256)
Affinity DataEC50:  28nMAssay Description:Agonist activity at human mGluR7 expressed in CHO cells expressing CRE-Luc reporter gene assessed as reduction in forskolin-stimulated cAMP productio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50305862(3-(4-methoxyphenyl)-5-methyl-6-phenylisoxazolo[4,5...)
Affinity DataIC50: 29nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50305873(6-(3-(dimethylamino)phenyl)-5-methyl-3-phenylisoxa...)
Affinity DataIC50: 31nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Cerevance

Curated by ChEMBL
LigandPNGBDBM50614231(CHEMBL5288955)
Affinity DataEC50:  38nMAssay Description:Agonist activity at human mGluR7 expressed in CHO cells expressing CRE-Luc reporter gene assessed as reduction in forskolin-stimulated cAMP productio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50610106(CHEMBL5271313)
Affinity DataEC50:  43nMAssay Description:Positive allosteric modulation of rat mGluR7More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50305868(5-methyl-3-phenyl-6-p-tolylisoxazolo[4,5-c]pyridin...)
Affinity DataIC50: 51nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Cerevance

Curated by ChEMBL
LigandPNGBDBM50614235(CHEMBL5286456)
Affinity DataEC50:  55nMAssay Description:Agonist activity at human mGluR7 expressed in CHO cells expressing CRE-Luc reporter gene assessed as reduction in forskolin-stimulated cAMP productio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50610103(CHEMBL5281472)
Affinity DataEC50:  56nMAssay Description:Positive allosteric modulation of rat mGluR7More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Cerevance

Curated by ChEMBL
LigandPNGBDBM58360(MLS001173561 | N,N'-dibenzhydrylethane-1,2-diamine...)
Affinity DataEC50:  64nMAssay Description:Agonist activity at human mGluR7b expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50305869(6-(4-fluorophenyl)-5-methyl-3-phenylisoxazolo[4,5-...)
Affinity DataIC50: 72nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50639733(CHEMBL5561878)
Affinity DataIC50: 80nMAssay Description:Inhibition of [3H] -LY341495 binding to rat mGlu7 expressed in CHO cell membrane incubated for 30 mins in presence of LY341495 by liquid scintillatio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50305874(5-methyl-3-phenyl-6-(3-(trifluoromethyl)phenyl)iso...)
Affinity DataIC50: 96nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Cerevance

Curated by ChEMBL
LigandPNGBDBM50552347(CHEMBL4798021)
Affinity DataEC50:  98nMAssay Description:Positive allosteric modulation of human mGluR7 in presence of EC20 concentration of L-AP4 by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50305865(5-methyl-6-phenyl-3-(pyridin-4-yl)isoxazolo[4,5-c]...)
Affinity DataIC50: 101nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Cerevance

Curated by ChEMBL
LigandPNGBDBM50552346(CHEMBL4777502)
Affinity DataEC50:  106nMAssay Description:Positive allosteric modulation of human mGluR7 in presence of EC20 concentration of L-AP4 by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-...)
Affinity DataKi:  110nMAssay Description:Binding affinity towards metabotropic glutamate receptor 7 of rat expressed in CHO cells was determined by using [3H]MGS-0008More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 7(Human)
Cerevance

Curated by ChEMBL
LigandPNGBDBM50614239(CHEMBL5272418)
Affinity DataEC50:  110nMAssay Description:Agonist activity at human mGluR7b expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Cerevance

Curated by ChEMBL
LigandPNGBDBM50614236(CHEMBL5291195)
Affinity DataEC50:  113nMAssay Description:Agonist activity at human mGluR7 expressed in CHO cells expressing CRE-Luc reporter gene assessed as reduction in forskolin-stimulated cAMP productio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Cerevance

Curated by ChEMBL
LigandPNGBDBM50552348(CHEMBL4764083)
Affinity DataEC50:  114nMAssay Description:Positive allosteric modulation of human mGluR7 in presence of EC20 concentration of L-AP4 by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50610109(CHEMBL5273386)
Affinity DataEC50:  120nMAssay Description:Positive allosteric modulation of rat mGluR7More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50610102(CHEMBL5286074)
Affinity DataEC50:  130nMAssay Description:Positive allosteric modulation of rat mGluR7More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50305870(6-(4-(dimethylamino)phenyl)-5-methyl-3-phenylisoxa...)
Affinity DataIC50: 140nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50283487(CHEMBL4162576)
Affinity DataEC50:  146nMAssay Description:Positive allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galphai5 assessed as increase in glutamate-induced calcium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2020
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Cerevance

Curated by ChEMBL
LigandPNGBDBM50283487(CHEMBL4162576)
Affinity DataEC50:  148nMAssay Description:Positive allosteric modulation of mGluR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50305872(5-methyl-3-phenyl-6-(4-propylphenyl)isoxazolo[4,5-...)
Affinity DataIC50: 150nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50610104(CHEMBL5282643)
Affinity DataEC50:  150nMAssay Description:Positive allosteric modulation of rat mGluR7More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Cerevance

Curated by ChEMBL
LigandPNGBDBM50614238(CHEMBL5281755)
Affinity DataEC50:  156nMAssay Description:Agonist activity at human mGluR7 expressed in CHO cells expressing CRE-Luc reporter gene assessed as reduction in forskolin-stimulated cAMP productio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Cerevance

Curated by ChEMBL
LigandPNGBDBM50552330(CHEMBL4745982)
Affinity DataEC50:  180nMAssay Description:Positive allosteric modulation of human mGluR7 in presence of EC20 concentration of L-AP4 by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-...)
Affinity DataIC50: 190nMAssay Description:Inhibition of [3H] -LY341495 binding to rat mGlu7 expressed in CHO cell membrane incubated for 30 mins by liquid scintillation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMetabotropic glutamate receptor 7(Human)
Cerevance

Curated by ChEMBL
LigandPNGBDBM50552342(CHEMBL4787053)
Affinity DataEC50:  201nMAssay Description:Positive allosteric modulation of human mGluR7 in presence of EC20 concentration of L-AP4 by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50305875(6-(3-fluoro-4-methoxyphenyl)-5-methyl-3-phenylisox...)
Affinity DataIC50: 210nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50305866(5-methyl-6-phenyl-3-(pyridin-3-yl)isoxazolo[4,5-c]...)
Affinity DataIC50: 240nMAssay Description:Antagonist activity at rat mGluR7 expressed in CHO cells assessed as inhibition of LAP-induced intracellular calcium mobilization by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50610105(CHEMBL5290711)
Affinity DataEC50:  260nMAssay Description:Positive allosteric modulation of rat mGluR7More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50610100(CHEMBL5288109)
Affinity DataEC50:  260nMAssay Description:Positive allosteric modulation of rat mGluR7More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50589650(CHEMBL5202961)
Affinity DataIC50: 263nMAssay Description:Negative allosteric modulation of rat mGlu7 in HEK cells expressing Galpha15 assessed as inhibition of L-AP4-induced response measured by calcium mob...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50589650(CHEMBL5202961)
Affinity DataIC50: 263nMAssay Description:Negative allosteric modulation of rat mGlu7 in HEK cells expressing Galpha15 assessed as inhibition of L-AP4-induced response measured by calcium mob...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Cerevance

Curated by ChEMBL
LigandPNGBDBM50552354(CHEMBL4799902)
Affinity DataEC50:  302nMAssay Description:Positive allosteric modulation of human mGluR7 in presence of EC20 concentration of L-AP4 by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50610101(CHEMBL5269255)
Affinity DataEC50:  310nMAssay Description:Positive allosteric modulation of rat mGluR7More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50610108(CHEMBL5285820)
Affinity DataEC50:  340nMAssay Description:Positive allosteric modulation of rat mGluR7More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50531687(CHEMBL4445682)
Affinity DataIC50: 347nMAssay Description:Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells harboring Ga15 assessed as reduction in L-AP4-induced calcium flux preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Rat)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50531687(CHEMBL4445682)
Affinity DataIC50: 347nMAssay Description:Negative allosteric modulation of rat mGlu7 in HEK cells expressing Galpha15 assessed as inhibition of L-AP4-induced response measured by calcium mob...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
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