Compile Data Set for Download or QSAR
Report error Found 413 Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 7'
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human ERK5 using myelin basic protein as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50652900(CHEMBL4746525)
Affinity DataIC50: 2nMAssay Description:Inhibition of GST-tagged ERK5 catalytic domain (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50641884(CHEMBL5555328)
Affinity DataIC50: 5nMAssay Description:Inhibition of ERK5 in human SN12C cells assessed as luciferase activity by Bright-Glo luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50605526(CHEMBL5188920)
Affinity DataIC50: 5nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50605525(CHEMBL5175191)
Affinity DataIC50: 5nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50605527(CHEMBL5186248)
Affinity DataIC50: 6nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50641882(CHEMBL5573086)
Affinity DataIC50: 6nMAssay Description:Inhibition of ERK5 in human SN12C cells assessed as luciferase activity by Bright-Glo luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50605535(CHEMBL5198962)
Affinity DataIC50: 7nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50605523(CHEMBL5197199)
Affinity DataIC50: 7nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50508013(CHEMBL4541479)
Affinity DataIC50: 8nMAssay Description:Inhibition of ERK5 (unknown origin) incubated for 1 hr by KiNativ profiling analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50508013(CHEMBL4541479)
Affinity DataIC50: 8nMAssay Description:Inhibition of ERK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50605522(CHEMBL5172952)
Affinity DataIC50: 8nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50508013(CHEMBL4541479)
Affinity DataIC50: 8nMAssay Description:Inhibition of ERK5 in human HeLa cells by KiNativ profiling methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50641886(CHEMBL5569331)
Affinity DataIC50: 9nMAssay Description:Inhibition of ERK5 in human SN12C cells assessed as luciferase activity by Bright-Glo luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50641885(CHEMBL5574029)
Affinity DataIC50: 9nMAssay Description:Inhibition of ERK5 in human SN12C cells assessed as luciferase activity by Bright-Glo luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50641887(CHEMBL5571189)
Affinity DataIC50: 9nMAssay Description:Inhibition of ERK5 in human SN12C cells assessed as luciferase activity by Bright-Glo luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50641883(CHEMBL5566766)
Affinity DataIC50: 10nMAssay Description:Inhibition of ERK5 in human SN12C cells assessed as luciferase activity by Bright-Glo luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50337130(2-((2-methoxy-4-(piperazin-1-yl)phenyl)amino)-5,11...)
Affinity DataIC50: 10nMAssay Description:Inhibition of ERK5 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50559468(CHEMBL4757477)
Affinity DataIC50: 11nMAssay Description:Inhibition of ERK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50434070(CHEMBL2381340)
Affinity DataIC50: 13nMAssay Description:Inhibition of ERK5 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50605520(CHEMBL5202924)
Affinity DataIC50: 13nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50605519(CHEMBL5175007)
Affinity DataIC50: 13nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50605528(CHEMBL5175760)
Affinity DataIC50: 14nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50605521(CHEMBL5173346)
Affinity DataIC50: 14nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50605536(CHEMBL5208879)
Affinity DataIC50: 16nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50508008(CHEMBL4438379)
Affinity DataIC50: 17nMAssay Description:Inhibition of His-tagged MAP2K5 activated N-terminal GST-tagged recombinant human ERK5 (1 to 398 residues) expressed in Escherichia coli using biotin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50605533(CHEMBL5180089)
Affinity DataIC50: 19nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50337127(US9266890, IV-1 | 2-(2-methoxy-4-(4-methylpiperazi...)
Affinity DataKd:  19nMAssay Description:In vitro Erk5 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
US Patent

TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50605523(CHEMBL5197199)
Affinity DataIC50: 20nMAssay Description:Inhibition of ERK5 phosphorylation in human HeLa cells incubated for 1 hr by Western blot densitometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50508013(CHEMBL4541479)
Affinity DataIC50: 20nMAssay Description:Inhibition of His-tagged MAP2K5 activated N-terminal GST-tagged recombinant human ERK5 (1 to 398 residues) expressed in Escherichia coli using biotin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50605534(CHEMBL5208123)
Affinity DataIC50: 22nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50605524(CHEMBL5193573)
Affinity DataIC50: 25nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50629292(CHEMBL5422839)
Affinity DataIC50: 27nMAssay Description:Inhibition of ERK5 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50605527(CHEMBL5186248)
Affinity DataIC50: 31nMAssay Description:Inhibition of ERK5 phosphorylation in human HeLa cells incubated for 1 hr by Western blot densitometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50507989(CHEMBL4445670)
Affinity DataIC50: 35nMAssay Description:Inhibition of His-tagged MAP2K5 activated N-terminal GST-tagged recombinant human ERK5 (1 to 398 residues) expressed in Escherichia coli using biotin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50507989(CHEMBL4445670)
Affinity DataIC50: 35nMAssay Description:Activation of ERK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50507989(CHEMBL4445670)
Affinity DataIC50: 35nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged ERK5 (1 to 398 residues) expressed in Escherichia coli using biotinylated peptide Ahx-PPGDYSTTP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50605518(CHEMBL5179461)
Affinity DataIC50: 37nMAssay Description:Inhibition of ERK5 (unknown origin) using K-5FAM-LVEPLTPSGEAPNQ-COOH as substrate incubated for 2 hrs in presence of ATP by IMAP-FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM24654(pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...)
Affinity DataKd:  42nMAssay Description:Binding constant for ERK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50363196(CHEMBL1944698)
Affinity DataKd:  43nMAssay Description:Binding affinity to ERK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50363196(CHEMBL1944698)
Affinity DataIC50: 43nMAssay Description:Inhibition of ERK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50605521(CHEMBL5173346)
Affinity DataIC50: 43nMAssay Description:Inhibition of ERK5 phosphorylation in human HeLa cells incubated for 1 hr by Western blot densitometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataKd:  48nMAssay Description:Binding constant for ERK5 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM209448(US9266890, IV-8)
Affinity DataKd:  50nMAssay Description:In vitro Erk5 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
US Patent

TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50507990(CHEMBL4469661)
Affinity DataIC50: 51nMAssay Description:Inhibition of His-tagged MAP2K5 activated N-terminal GST-tagged recombinant human ERK5 (1 to 398 residues) expressed in Escherichia coli using biotin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50337134(US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...)
Affinity DataIC50: 52nMAssay Description:Inhibition of ERK5 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50508009(CHEMBL4550589)
Affinity DataIC50: 54nMAssay Description:Inhibition of His-tagged MAP2K5 activated N-terminal GST-tagged recombinant human ERK5 (1 to 398 residues) expressed in Escherichia coli using biotin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50337128(US9266890, IV-7 | 2-((4-(4-hydroxypiperidin-1-yl)-...)
Affinity DataKd:  57nMAssay Description:In vitro Erk5 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
US Patent

TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50605528(CHEMBL5175760)
Affinity DataIC50: 58nMAssay Description:Inhibition of ERK5 phosphorylation in human HeLa cells incubated for 1 hr by Western blot densitometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 7(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50434072(CHEMBL2381342)
Affinity DataIC50: 59nMAssay Description:Inhibition of GST-tagged ERK5 (unknown origin) expressed in baculovirus expression system incubated for 90 mins in presence of ATP by PKLight ATP Det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
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