Compile Data Set for Download or QSAR
Report error Found 4681 Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase 1'
LigandPNGBDBM158752(US9034866, 227)
Affinity DataKi:  0.0400nMpH: 7.2Assay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2015
Entry Details
US Patent

LigandPNGBDBM431887(3-(3-(((1R,4R,5S)-4-hydroxy-2-methyl-3-oxo-2- azab...)
Affinity DataKi:  0.0500nMAssay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent

LigandPNGBDBM312808(US9605005, Example 97 | 1-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataKi:  0.0500nMAssay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent

LigandPNGBDBM312809(US9605005, Example 98 | 1-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataKi:  0.0500nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM431888(1-(3-(((1R,4R,5S)-4-hydroxy-2-methyl-3-oxo-2- azab...)
Affinity DataKi:  0.0500nMAssay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent

LigandPNGBDBM431890(5-amino-2-(3-(((1R,4R,5S)-4-hydroxy-2-methyl-3- ox...)
Affinity DataKi:  0.0500nMAssay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent

LigandPNGBDBM158801(US9034866, 276)
Affinity DataKi:  0.0550nMpH: 7.2Assay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2015
Entry Details
US Patent

LigandPNGBDBM50457820(CHEMBL4216289)
Affinity DataKi:  0.0700nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50457816(CHEMBL4215425)
Affinity DataKi:  0.0700nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM312763(US9605005, Example 52 | 1-[4-[2-[(3R)-3-hydroxy-1-...)
Affinity DataKi:  0.0800nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM312788(US9605005, Example 77 | 1-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataKi:  0.0950nMAssay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent

LigandPNGBDBM158931(US9034866, 406)
Affinity DataKi: <0.100nMpH: 7.2Assay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2015
Entry Details
US Patent

LigandPNGBDBM159077(US9034866, 552)
Affinity DataKi:  0.100nMpH: 7.2Assay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2015
Entry Details
US Patent

LigandPNGBDBM158883(US9034866, 358)
Affinity DataKi:  0.100nMpH: 7.2Assay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2015
Entry Details
US Patent

LigandPNGBDBM158884(US9034866, 359)
Affinity DataKi:  0.100nMpH: 7.2Assay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2015
Entry Details
US Patent

LigandPNGBDBM159087(US9034866, 562)
Affinity DataKi:  0.100nMpH: 7.2Assay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 12(Human)
The University of Texas System

US Patent
LigandPNGBDBM289495(US10093664, Example 67 | 1-(4-(6-amino-5-(tri- flu...)
Affinity DataKd:  0.110nMAssay Description:The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 12(Human)
The University of Texas System

US Patent
LigandPNGBDBM590003((S)-1-(4-(6-amino-5- (trifluoromethyl)pyridin-3-yl...)
Affinity DataKd:  0.120nMAssay Description:A fusion protein of full length of human DLK (amino acids 1-859) and the DNA binding domain of NFkB was expressed in transiently transfected HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

LigandPNGBDBM158798(US9034866, 273)
Affinity DataKi:  0.120nMpH: 7.2Assay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2015
Entry Details
US Patent

LigandPNGBDBM158775(US9034866, 250)
Affinity DataKi:  0.120nMpH: 7.2Assay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2015
Entry Details
US Patent

LigandPNGBDBM312785(US9605005, Example 74 | 1-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataKi:  0.130nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM312905(US9605005, Example 195 | 5-amino-2-[3-[2-[(3R)-3-h...)
Affinity DataKi:  0.130nMAssay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent

LigandPNGBDBM636782(US20230382863, Compound I-2)
Affinity DataKd:  0.144nMAssay Description:Table 11: The experiments were performed on Biacore S200 (Cytiva). Biotinylated, unphosphorylated MEK1 was diluted to 0.1 uM by SPR buffer C (20 mM T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
US Patent

LigandPNGBDBM158808(US9034866, 283)
Affinity DataKi:  0.160nMpH: 7.2Assay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2015
Entry Details
US Patent

LigandPNGBDBM50502744(CHEMBL4524153)
Affinity DataKi:  0.160nMAssay Description:Inhibition of NIK (unknown origin) using ATP as substrate by transcreener ADP assay based fluorescence correlation spectroscopic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 12(Human)
The University of Texas System

US Patent
LigandPNGBDBM365304(US9868720, No. 425 | (2-Methoxy-4-methyl- phenyl)-...)
Affinity DataKi:  0.170nMAssay Description:DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details
US Patent

LigandPNGBDBM312765(US9605005, Example 54 | 5-fluoro-1-[4-[2-[(3R)-3-h...)
Affinity DataKi:  0.170nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM312764(US9605005, Example 53 | 1-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataKi:  0.170nMAssay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent

LigandPNGBDBM312788(US9605005, Example 77 | 1-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataKi:  0.180nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM158886(US9034866, 361)
Affinity DataKi:  0.200nMpH: 7.2Assay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2015
Entry Details
US Patent

LigandPNGBDBM158904(US9034866, 379)
Affinity DataKi:  0.200nMpH: 7.2Assay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2015
Entry Details
US Patent

LigandPNGBDBM158532(US9034866, 7)
Affinity DataKi:  0.200nMpH: 7.2Assay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2015
Entry Details
US Patent

LigandPNGBDBM312764(US9605005, Example 53 | 1-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of NIK (unknown origin) catalyzed ATP hydrolysis assessed as inhibition constant by fluorescence polarization methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM158565(US9034866, 40)
Affinity DataKi:  0.200nMpH: 7.2Assay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2015
Entry Details
US Patent

LigandPNGBDBM158794(US9034866, 269)
Affinity DataKi:  0.200nMpH: 7.2Assay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 12(Human)
The University of Texas System

US Patent
LigandPNGBDBM50059194(CHEMBL3393337)
Affinity DataKi:  0.200nMAssay Description:Inhibition of DLK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2016
Entry Details Article
PubMed
LigandPNGBDBM159164(US9034866, 641)
Affinity DataKi:  0.200nMpH: 7.2Assay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 12(Human)
The University of Texas System

US Patent
LigandPNGBDBM589995((R)-1-(4-(6-amino-5-(trifluoromethyl)pyridin-3-yl)...)
Affinity DataKd:  0.210nMAssay Description:A fusion protein of full length of human DLK (amino acids 1-859) and the DNA binding domain of NFkB was expressed in transiently transfected HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 13(Human)
Department of Health And Human Services

US Patent
LigandPNGBDBM716313(US20250032489, Compound 216)
Affinity DataKd:  0.220nMAssay Description:One hundred nanograms of glutathione S-transferase (GST)-tagged human LZK pure protein (Carna Biosciences, #09-114) was incubated with 100 ng of GST-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

LigandPNGBDBM312711(US9605005, Example 1 | 1-[3-[2-[(3R)-3-hydroxy-1- ...)
Affinity DataKi:  0.230nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM312764(US9605005, Example 53 | 1-[3-[2-[(3R)-3-hydroxy-1-...)
Affinity DataKi:  0.230nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50457815(CHEMBL4211840)
Affinity DataKi:  0.230nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50457815(CHEMBL4211840)
Affinity DataKi:  0.230nMAssay Description:Inhibition of NIK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
LigandPNGBDBM158788(US9034866, 263)
Affinity DataKi:  0.240nMpH: 7.2Assay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 12(Human)
The University of Texas System

US Patent
LigandPNGBDBM589991(US11560366, Example 3b)
Affinity DataKd:  0.240nMAssay Description:A fusion protein of full length of human DLK (amino acids 1-859) and the DNA binding domain of NFkB was expressed in transiently transfected HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

LigandPNGBDBM312723(US9605005, Example 13 | 5-fluoro-1-[3-[2-[(3R)-3-h...)
Affinity DataKi:  0.270nMAssay Description:Inhibition of NIK (unknown origin) expressed in baculovirus infected insect cells assessed as reduction in hydrolysis of ATP to ADP after 1 to 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 12(Human)
The University of Texas System

US Patent
LigandPNGBDBM590004((S)-1-(4-(6-amino-5- (trifluoromethoxy)pyridin-3-y...)
Affinity DataKd:  0.290nMAssay Description:A fusion protein of full length of human DLK (amino acids 1-859) and the DNA binding domain of NFkB was expressed in transiently transfected HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

LigandPNGBDBM159182(US9034866, 659)
Affinity DataKi:  0.290nMpH: 7.2Assay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 12(Human)
The University of Texas System

US Patent
LigandPNGBDBM589992((S)-1-(4-(6-amino-5-(trifluoromethyl)pyridin-3-yl)...)
Affinity DataKd:  0.290nMAssay Description:A fusion protein of full length of human DLK (amino acids 1-859) and the DNA binding domain of NFkB was expressed in transiently transfected HEK293 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

LigandPNGBDBM159183(US9034866, 660)
Affinity DataKi:  0.290nMpH: 7.2Assay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5'-triphosphate (ATP) was monitored u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2015
Entry Details
US Patent

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