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Report error Found 153 Enz. Inhib. hit(s) with Target = 'Muscle, skeletal receptor tyrosine-protein kinase'
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human MUSK using myelin basic protein as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  3.10nMAssay Description:Binding constant for MUSK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  3.10nMAssay Description:Binding constant for MUSK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  3.10nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2011
Entry Details
PCBioAssay
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of MUSK (unknown origin) incubated for 1 hr by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2017
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of human N-terminal GST-fused MUSK catalytic domain (527 to 869(end) residues) expressed in baculovirus expression system using CSKtide as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataKd:  10nMAssay Description:Binding constant for MUSK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataKd:  10nMAssay Description:Binding constant for MUSK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM21079(1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluora...)
Affinity DataKd:  10nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2011
Entry Details
PCBioAssay
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50628739(CHEMBL5423601)
Affinity DataIC50: 13nMAssay Description:Inhibition of Musk (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50355504(CHEMBL1908393)
Affinity DataKd:  13nMAssay Description:Binding constant for MUSK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50550246(Pf-06273340 | PF06273340)
Affinity DataIC50: 53nMAssay Description:Inhibition of MUSK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 54.4nMAssay Description:Inhibition of human MUSK using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  86nMAssay Description:Binding constant for MUSK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  86nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2011
Entry Details
PCBioAssay
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  86nMAssay Description:Binding constant for MUSK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  100nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2011
Entry Details
PCBioAssay
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM60665(US9145414, R406 | US9212178, R406 | BDBM50249542 |...)
Affinity DataKd:  100nMAssay Description:Binding constant for MUSK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human N-terminal GST-fused MUSK catalytic domain (527 to 869(end) residues) expressed in baculovirus expression system using CSKtide as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  100nMAssay Description:Binding constant for MUSK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  100nMAssay Description:Binding constant for MUSK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50565310(CHEMBL4792981)
Affinity DataKd:  110nMAssay Description:Binding affinity to wild-type human partial length MUSK (M553 to V869 residues) expressed in bacterial expression system by Kinomescan method relativ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataKd:  130nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2011
Entry Details
PCBioAssay
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataKd:  130nMAssay Description:Binding constant for MUSK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataKd:  130nMAssay Description:Binding constant for MUSK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataKd:  130nMAssay Description:Binding affinity to MUSKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50355496(CHEMBL1908397)
Affinity DataKd:  200nMAssay Description:Binding constant for MUSK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)
Affinity DataIC50: 224nMAssay Description:Inhibition of human MuSkMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataKd:  230nMAssay Description:Binding constant for MUSK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50637925(CHEMBL5559304)
Affinity DataIC50: 257nMAssay Description:Inhibition of MUSK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataKd:  260nMAssay Description:Binding constant for MUSK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 290nMAssay Description:Inhibition of human MUSK using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKd:  300nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2011
Entry Details
PCBioAssay
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKd:  300nMAssay Description:Binding constant for MUSK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKd:  300nMAssay Description:Binding constant for MUSK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM465748(US10793575, Example 23 | 2-(3-{2-amino-6-[1-(oxeta...)
Affinity DataIC50: 306nMAssay Description:Inhibition of human MUSK expressed in baculovirus expression system by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  490nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2011
Entry Details
PCBioAssay
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  490nMAssay Description:Binding constant for MUSK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  490nMAssay Description:Binding constant for MUSK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  490nMAssay Description:Binding affinity to MUSKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50528539(CHEMBL4553037)
Affinity DataKd:  530nMAssay Description:Binding affinity to wild type human partial length MUSK (553 to 869 residues) expressed in bacterial expression system preincubated for 1 hr measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50528539(CHEMBL4553037)
Affinity DataKd:  530nMAssay Description:Binding affinity to wild type human partial length MUSK (553 to 869 residues) expressed in bacterial expression system preincubated for 1 hr measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | Vargatef | US10981896, Co...)
Affinity DataKd:  590nMAssay Description:Binding constant for MUSK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50081537(CHEMBL3422092)
Affinity DataIC50: 690nMAssay Description:Inhibition of human MuSK by millipore radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2016
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataKd:  800nMAssay Description:Binding constant for MUSK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataKd:  830nMAssay Description:Binding constant for MUSK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataKd:  830nMAssay Description:Binding constant for MUSK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataKd:  830nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2011
Entry Details
PCBioAssay
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50311017(N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of MUSK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandPNGBDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity to MUSKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
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