Compile Data Set for Download or QSAR
Report error Found 469 Enz. Inhib. hit(s) with Target = 'Myosin light chain kinase, smooth muscle'
TargetMyosin light chain kinase, smooth muscle(Chicken)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM6760(CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of Smooth muscle myosin light chain kinase of chicken gizzardMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  0.317nMAssay Description:Binding affinity to human MYLK incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMyosin light chain kinase, smooth muscle(Chicken)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataKd:  2nMAssay Description:Binding constant for MLCK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of human MLCK using KKLNRTLSFAEPG as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 10nMAssay Description:The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Chicken)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50058332(methyl 10,23-di(ethylsulfanylmethyl)-16-hydroxy-15...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Smooth muscle myosin light chain kinase of chicken gizzardMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Chicken)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 10nMAssay Description:In vitro for inhibitory activity against myosin light-chain kinase from chicken gizzard (M-kinase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Chicken)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 10nMpH: 7.2 T: 2°CAssay Description:The activity of MLCK is measured by its ability to transfer 32P from [gamma-32P]ATP to myosin light-chain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM27817(2-{[2-({1-[2-(dimethylamino)acetyl]-5-methoxy-2,3-...)
Affinity DataKd:  11nMAssay Description:Binding constant for MYLK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  12nMAssay Description:Binding affinity to MLCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  13nMAssay Description:Binding affinity to MYLKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  13nMAssay Description:Binding constant for MYLK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Chicken)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKd:  15nMAssay Description:Binding constant for MLCK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  15nMAssay Description:Binding constant for MYLK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  15nMAssay Description:Binding constant for MYLK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  15nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM199250(US9221808, 1bo-HCl | US9221808, 1bo-Mes | US922180...)
Affinity DataIC50: 16nMAssay Description:Inhibition of MLCK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM2580(methyl (15R,16S,18S)-16-hydroxy-15-methyl-3-oxo-28...)
Affinity DataKi:  17nMAssay Description:Inhibition of human myosin light chain kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Chicken)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM3040(23-(3-aminopropyl)-3-methyl-3,13,23-triazahexacycl...)
Affinity DataIC50: 18nMpH: 7.2 T: 2°CAssay Description:The activity of MLCK is measured by its ability to transfer 32P from [gamma-32P]ATP to myosin light-chain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM3040(23-(3-aminopropyl)-3-methyl-3,13,23-triazahexacycl...)
Affinity DataIC50: 18nMAssay Description:The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM6760(CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...)
Affinity DataKi:  20nMAssay Description:Inhibition of MLCK by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM6760(CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...)
Affinity DataIC50: 22nMAssay Description:Inhibition of Myosin light chain kinase 1 (MLCK1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Chicken)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  23nMAssay Description:Binding constant for MLCK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  23nMAssay Description:Binding affinity to MLCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50118955(Compound K-252a(epi) | CHEMBL94678)
Affinity DataIC50: 25nMAssay Description:Inhibition of Myosin light chain kinase 1 (MLCK1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Chicken)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM3035(3-{7,19-dihydroxy-23-methyl-14-oxo-3,13,23-triazah...)
Affinity DataIC50: 30nMpH: 7.2 T: 2°CAssay Description:The activity of MLCK is measured by its ability to transfer 32P from [gamma-32P]ATP to myosin light-chain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM3035(3-{7,19-dihydroxy-23-methyl-14-oxo-3,13,23-triazah...)
Affinity DataIC50: 30nMAssay Description:The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Chicken)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM3038(23-[3-(dimethylamino)propyl]-7,19-dihydroxy-3,13,2...)
Affinity DataIC50: 31nMpH: 7.2 T: 2°CAssay Description:The activity of MLCK is measured by its ability to transfer 32P from [gamma-32P]ATP to myosin light-chain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50284317(3-(9-methoxy-13-methyl-5,7-dioxo-6,7,12,13-tetrahy...)
Affinity DataIC50: 32nMAssay Description:The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Chicken)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM3047(4-{19-methoxy-23-methyl-12,14-dioxo-3,13,23-triaza...)
Affinity DataIC50: 32nMpH: 7.2 T: 2°CAssay Description:The activity of MLCK is measured by its ability to transfer 32P from [gamma-32P]ATP to myosin light-chain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Chicken)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50074653(R-K-K-Y-(Ach)-Y-R-R-K-NH2 | CHEMBL385812)
Affinity DataIC50: 40nMAssay Description:Inhibitory activity against MLCK (smooth muscle myosin light chain kinase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2012
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Chicken)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  42nMAssay Description:Binding constant for MLCK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 43.2nMAssay Description:Inhibition of human MLCK using KKLNRTLSFAEPG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM3045(3-{19-methoxy-23-methyl-12,14-dioxo-3,13,23-triaza...)
Affinity DataIC50: 49nMAssay Description:The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Chicken)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM3044(3-{7-methoxy-23-methyl-12,14-dioxo-3,13,23-triazah...)
Affinity DataIC50: 49nMpH: 7.2 T: 2°CAssay Description:The activity of MLCK is measured by its ability to transfer 32P from [gamma-32P]ATP to myosin light-chain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Chicken)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50074638(R-K-K-Y-K-Y-R-R-K-NH2 | CHEMBL443574)
Affinity DataIC50: 50nMAssay Description:Inhibitory activity against MLCK (smooth muscle myosin light chain kinase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2012
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 51.3nMAssay Description:Inhibition of human MLCK using KKLNRTLSFAEPG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Chicken)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM3043(3-{23-methyl-12,14-dioxo-3,13,23-triazahexacyclo[1...)
Affinity DataIC50: 55nMpH: 7.2 T: 2°CAssay Description:The activity of MLCK is measured by its ability to transfer 32P from [gamma-32P]ATP to myosin light-chain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM3043(3-{23-methyl-12,14-dioxo-3,13,23-triazahexacyclo[1...)
Affinity DataIC50: 55nMAssay Description:The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Chicken)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50280875(3-(5-oxo-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrr...)
Affinity DataIC50: 82nMAssay Description:In vitro for inhibitory activity against myosin light-chain kinase from chicken gizzard (M-kinase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataKd:  97nMAssay Description:Binding constant for MYLK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Chicken)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50074648(R-K-K-Y-(Ach)-(Ach)-R-R-K-NH2 | CHEMBL268790)
Affinity DataIC50: 110nMAssay Description:Inhibitory activity against MLCK (smooth muscle myosin light chain kinase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2012
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Chicken)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM3049(23-[3-(dimethylamino)-2-hydroxypropyl]-7-methoxy-3...)
Affinity DataIC50: 120nMpH: 7.2 T: 2°CAssay Description:The activity of MLCK is measured by its ability to transfer 32P from [gamma-32P]ATP to myosin light-chain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50284318(13-(3-dimethylamino-2-hydroxypropyl)-3-methoxy-12-...)
Affinity DataIC50: 120nMAssay Description:The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Chicken)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50074635(R-K-K-Y-K-P-R-R-K-NH2 | CHEMBL425624)
Affinity DataIC50: 120nMAssay Description:Inhibitory activity against MLCK (smooth muscle myosin light chain kinase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2012
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM3048(23-[3-(dimethylamino)-2-hydroxypropyl]-3-methyl-3,...)
Affinity DataIC50: 120nMAssay Description:The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Chicken)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM3048(23-[3-(dimethylamino)-2-hydroxypropyl]-3-methyl-3,...)
Affinity DataIC50: 120nMpH: 7.2 T: 2°CAssay Description:The activity of MLCK is measured by its ability to transfer 32P from [gamma-32P]ATP to myosin light-chain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2005
Entry Details Article

TargetMyosin light chain kinase, smooth muscle(Chicken)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  140nMAssay Description:Binding constant for MLCK kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Chicken)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50074644(R-K-K-Y-K-F-R-R-K-NH2 | CHEMBL409544)
Affinity DataIC50: 150nMAssay Description:Inhibitory activity against MLCK (smooth muscle myosin light chain kinase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2012
Entry Details Article
PubMed
TargetMyosin light chain kinase, smooth muscle(Chicken)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50074657(R-K-K-Y-K-S-R-R-K-NH2 | CHEMBL267348)
Affinity DataIC50: 150nMAssay Description:Inhibitory activity against MLCK (smooth muscle myosin light chain kinase)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2012
Entry Details Article
PubMed
Displayed 1 to 50 (of 469 total ) | Next | Last >>
Jump to: