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Report error Found 212 Enz. Inhib. hit(s) with Target = 'NADPH oxidase 4'
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50576853(CHEMBL4859206)
Affinity DataIC50: 11nMAssay Description:Inhibition of human NADPH oxidase 4 by quantitative sandwich enzyme immunoassay techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50576853(CHEMBL4859206)
Affinity DataIC50: 11nMAssay Description:Inhibition of human NADPH oxidase 4 by quantitative sandwich enzyme immunoassay techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50576851(CHEMBL1876217)
Affinity DataIC50: 16nMAssay Description:Inhibition of human NADPH oxidase 4 by quantitative sandwich enzyme immunoassay techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50576851(CHEMBL1876217)
Affinity DataIC50: 16nMAssay Description:Inhibition of human NADPH oxidase 4 by quantitative sandwich enzyme immunoassay techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50576852(CHEMBL4849098)
Affinity DataIC50: 22nMAssay Description:Inhibition of human NADPH oxidase 4 by quantitative sandwich enzyme immunoassay techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50576852(CHEMBL4849098)
Affinity DataIC50: 22nMAssay Description:Inhibition of human NADPH oxidase 4 by quantitative sandwich enzyme immunoassay techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50330742(2-(2-Chlorophenyl)-5-[(1-methyl-1H-pyrazol-3-yl)me...)
Affinity DataKi:  47nMAssay Description:Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50330740(2-(2-chlorophenyl)-4-((4-(3-methoxyphenyl)piperazi...)
Affinity DataKi:  65nMAssay Description:Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50359519(CHEMBL1927157)
Affinity DataKi:  67nMAssay Description:Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 71nMAssay Description:Inhibition of human NADPH oxidase 4 by quantitative sandwich enzyme immunoassay techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50359523(CHEMBL1927147)
Affinity DataKi:  72nMAssay Description:Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50359528(CHEMBL1927149)
Affinity DataKi:  76nMAssay Description:Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50330744(4-((2-chlorobenzyloxy)methyl)-2-(2-chlorophenyl)-5...)
Affinity DataKi:  82nMAssay Description:Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50359525(CHEMBL1927146)
Affinity DataKi:  87nMAssay Description:Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50206334(Diphenylene iodonium chloride | dibenziodolium chl...)
Affinity DataIC50: 90nMAssay Description:Inhibition of human NOX4 expressed in HEK293T cells assessed as inhibition of teracycline-induced hydrogen peroxide production pretreated for 18 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM713684(2,4,6-trimethyl-N-[2-(2- methylphenyl)ethyl]benzen...)
Affinity DataIC50: 90nMAssay Description:Reactive oxygen produced in whole cells or in membrane preparation of Nox1, Nox3, Nox4, Nox5 and xanthine oxidase and glucose oxidase were determined...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
US Patent

TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50359520(CHEMBL1927158)
Affinity DataKi:  93nMAssay Description:Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50359518(CHEMBL1927156)
Affinity DataKi:  94nMAssay Description:Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50330743(4-(benzyloxymethyl)-2-(2-chlorophenyl)-5-(pyrazin-...)
Affinity DataKi:  95nMAssay Description:Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50359529(CHEMBL1927150)
Affinity DataKi:  101nMAssay Description:Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50359524(CHEMBL1927145)
Affinity DataKi:  103nMAssay Description:Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50359530(CHEMBL1927151)
Affinity DataKi:  103nMAssay Description:Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50628591(Setanaxib | GKT-137831 | GKT-831 | SETANAXIB)
Affinity DataKi:  110nMAssay Description:Binding affinity to human NOX4 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50359534(CHEMBL1927155)
Affinity DataKi:  111nMAssay Description:Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50359531(CHEMBL1927152)
Affinity DataKi:  111nMAssay Description:Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50359532(CHEMBL1927153)
Affinity DataKi:  112nMAssay Description:Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50330738(2-(2-chloro-4-fluorophenyl)-5-(2-(pyridin-2-yl)eth...)
Affinity DataKi:  114nMAssay Description:Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50330745(2-(2-chlorophenyl)-4-((4-fluorophenoxy)methyl)-5-m...)
Affinity DataKi:  114nMAssay Description:Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50359533(CHEMBL1927154)
Affinity DataKi:  116nMAssay Description:Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50330746(2-(2-chlorophenyl)-4-(2-fluorophenyl)-5-methyl-1H-...)
Affinity DataKi:  128nMAssay Description:Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50359521(CHEMBL1927159)
Affinity DataKi:  131nMAssay Description:Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50359526(CHEMBL1926690)
Affinity DataKi:  142nMAssay Description:Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50359527(CHEMBL1927148)
Affinity DataKi:  144nMAssay Description:Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50330739(2-(2-chlorophenyl)-4-((methyl(phenyl)amino)methyl)...)
Affinity DataKi:  151nMAssay Description:Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50330737(4-((4-fluorophenoxy)methyl)-5-(2-methoxyethyl)-2-(...)
Affinity DataKi:  153nMAssay Description:Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50359522(CHEMBL1927160)
Affinity DataKi:  156nMAssay Description:Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50330718(2-(2-chlorophenyl)-4-methyl-5-(3-phenylprop-2-ynyl...)
Affinity DataKi:  158nMAssay Description:Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50330722(2-(2-chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)...)
Affinity DataKi:  165nMAssay Description:Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50330736(4-((benzyl(methyl)amino)methyl)-2-(2-chloro-4-fluo...)
Affinity DataKi:  165nMAssay Description:Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50326495(2,3,8,9-tetrahydroxy-5-(2-hydroxy-5-nitrobenzyl)ph...)
Affinity DataIC50: 170nMAssay Description:Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50330741(2-(2-chlorophenyl)-4-((methyl(phenyl)amino)methyl)...)
Affinity DataKi:  172nMAssay Description:Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50330734(4-Methyl-2-(2-methylphenyl)-5-(pyridine-2-ylmethyl...)
Affinity DataKi:  173nMAssay Description:Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50330709(2-(2-chloro-4-fluorophenyl)-4,5-dimethyl-1H-pyrazo...)
Affinity DataKi:  213nMAssay Description:Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50330704(2-(2-chlorophenyl)-4,5-dimethyl-1H-pyrazolo[4,3-c]...)
Affinity DataKi:  215nMAssay Description:Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50330719(N-(2-(2-chlorophenyl)-4-methyl-3,6-dioxo-2,3-dihyd...)
Affinity DataKi:  218nMAssay Description:Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50330729(2-(2,5-dichlorobenzyl)-4-methyl-5-(pyridin-2-ylmet...)
Affinity DataKi:  218nMAssay Description:Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50330733(2-(2-chloro-4-fluorophenyl)-4-methyl-5-(pyridin-2-...)
Affinity DataKi:  235nMAssay Description:Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50330716(2-(2-chlorophenyl)-5-(2-(dimethylamino)ethyl)-4-me...)
Affinity DataKi:  235nMAssay Description:Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50330723(2-(2-chlorophenyl)-4-methyl-5-((6-morpholinopyridi...)
Affinity DataKi:  236nMAssay Description:Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetNADPH oxidase 4(Human)
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50330703(1-acetyl-2-(2-chlorophenyl)-4-methyl-5-(pyridin-3-...)
Affinity DataKi:  240nMAssay Description:Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
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