Compile Data Set for Download or QSAR
Report error Found 343 Enz. Inhib. hit(s) with Target = 'Nonstructural protein 3'
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50212337(CHEMBL5267698)
Affinity DataKi:  1.70nMAssay Description:Inhibition of Zika virus NS2B-NS3 protease using PhAc-Leu-LysLys-Arg-AMC as substrate measured for 10 mins by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50508773(CHEMBL4589938)
Affinity DataKd:  5nMAssay Description:Binding affinity to C-terminal His6-tagged linked Zika virus NS2B-NS3 protease domain by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50508771(CHEMBL4555617)
Affinity DataKd:  8nMAssay Description:Binding affinity to C-terminal His6-tagged linked Zika virus NS2B-NS3 protease domain by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50508772(CHEMBL4452943)
Affinity DataKd:  9nMAssay Description:Binding affinity to C-terminal His6-tagged linked Zika virus NS2B-NS3 protease domain by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50508770(CHEMBL4454475)
Affinity DataKd:  9nMAssay Description:Binding affinity to C-terminal His6-tagged linked Zika virus NS2B-NS3 protease domain by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50508769(CHEMBL4483351)
Affinity DataKd:  20nMAssay Description:Binding affinity to C-terminal His6-tagged linked Zika virus NS2B-NS3 protease domain by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50542240(Temoporfin | Mthpc | EF-9 | EF9 | Foscan)
Affinity DataEC50:  22nMAssay Description:Inhibition of Zika virus NS2B-NS3 protease by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50513992(CHEMBL3919119)
Affinity DataKi:  40nMAssay Description:Inhibition of N-terminal His6-tagged Zika virus NS2B (49 to 95 residues) - NS3 (1 to 170 residues) protease domain expressed in Escherichia coli BL21...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50587014(CHEMBL5094815)
Affinity DataKi:  79nMAssay Description:Competitive inhibition of C-terminal His-tagged ZIKV NSB2 (52 to 96 amino acids)-NS3 (1 to 184 amino acids) protease expressed in Escherichia coli BL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50513999(CHEMBL4435769)
Affinity DataIC50: 100nMAssay Description:Inhibition of N-terminal His6-tagged Zika virus NS2B (45 to 96 residues) - NS3 (1 to 177 residues) protease domain expressed in Escherichia coli Bl21...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50513999(CHEMBL4435769)
Affinity DataIC50: 100nMAssay Description:Inhibition of N-terminal His6-tagged Zika virus NS2B (45 to 96 residues) - NS3 (1 to 177 residues) protease domain expressed in Escherichia coli BL21...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM26218((3S,6S,10aS)-N-(diphenylmethyl)-6-[(2S)-2-(methyla...)
Affinity DataIC50: 100nMAssay Description:Inhibition of Zika virus NS2B-NS3 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50587014(CHEMBL5094815)
Affinity DataIC50: 125nMAssay Description:Inhibition of C-terminal His-tagged ZIKV NSB2 (52 to 96 amino acids)-NS3 (1 to 184 amino acids) protease expressed in Escherichia coli BL21(DE3) prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50567473(CHEMBL4872757)
Affinity DataIC50: 130nMAssay Description:Inhibition Zika virus NS3B (47 to 95 residues)/NS3 (1 to 170 residues) protease expressed in Escherichia coli BL21 using 7-amino-4-methylcoumarin as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM13142(Smac AVPI Mimetic 1 | JMC517169 Compound 1 | (2S)-...)
Affinity DataKi:  140nMAssay Description:Inhibition of Zika virus NS2B-NS3 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50508774(CHEMBL4538618)
Affinity DataKd:  168nMAssay Description:Binding affinity to C-terminal His6-tagged linked Zika virus NS2B-NS3 protease domain by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50567516(CHEMBL4865964)
Affinity DataIC50: 200nMAssay Description:Inhibition Zika virus NS3B (47 to 95 residues)/NS3 (1 to 170 residues) protease expressed in Escherichia coli BL21 using 7-amino-4-methylcoumarin as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50567535(CHEMBL4861948)
Affinity DataIC50: 240nMAssay Description:Inhibition Zika virus NS3B (47 to 95 residues)/NS3 (1 to 170 residues) protease expressed in Escherichia coli BL21 using 7-amino-4-methylcoumarin as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50509472(CHEMBL4460508)
Affinity DataKd:  240nMAssay Description:Binding affinity to N-terminal hexa-histidine tagged Zika virus NS2B/NS3 protease expressed in Escherichia coli BL21-Gold (DE3) by microscale thermop...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50513992(CHEMBL3919119)
Affinity DataIC50: 250nMAssay Description:Inhibition of N-terminal His6-tagged Zika virus NS2B (49 to 95 residues) - NS3 (1 to 170 residues) protease domain expressed in Escherichia coli BL21...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50508772(CHEMBL4452943)
Affinity DataIC50: 250nMAssay Description:Inhibition of C-terminal His6-tagged unlinked Zika virus NS2B-NS3 protease domain expressed in Escherichia coli Bl21(DE3) using Bz-Nle-Lys-Lys-Arg-AM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50513899(CHEMBL4542342)
Affinity DataIC50: 280nMAssay Description:Inhibition of Zika virus IbH_30656 NS2B (45 to 96 residues)-NS3 (1 to 177 residues) protease expressed in Escherichia coli BL21/Rosetta (DE3) cells p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50542237(Cudc 427 | Cudc-427 | Gdc-0917)
Affinity DataIC50: 300nMAssay Description:Inhibition of Zika virus NS2B-NS3 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50071920(Birinapant | TL-32711)
Affinity DataEC50:  300nMAssay Description:Inhibition of Zika virus NS2B-NS3 protease by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50567493(CHEMBL4872312)
Affinity DataIC50: 320nMAssay Description:Inhibition Zika virus NS3B (47 to 95 residues)/NS3 (1 to 170 residues) protease expressed in Escherichia coli BL21 using 7-amino-4-methylcoumarin as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50579310(CHEMBL4862793)
Affinity DataIC50: 320nMAssay Description:Inhibition of Zika virus recombinant NS2B (47 to 95 residues)/NS3 (1 to 177 residues) protease expressed in Escherichia coli BL21 using Bz-Nle-Lys-Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50509482(CHEMBL4462325)
Affinity DataIC50: 320nMAssay Description:Inhibition of N-terminal hexa-histidine tagged Zika virus NS2B/NS3 protease expressed in Escherichia coli BL21-Gold (DE3) using fluorogenic AMC-subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50579311(CHEMBL4865004)
Affinity DataIC50: 370nMAssay Description:Inhibition of Zika virus recombinant NS2B (47 to 95 residues)/NS3 (1 to 177 residues) protease expressed in Escherichia coli BL21 using Bz-Nle-Lys-Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50514003(CHEMBL4437334)
Affinity DataIC50: 380nMAssay Description:Inhibition of N-terminal His-tagged Zika virus NS2B (49 to 95 residues) - NS3 (1 to 185 residues) protease domain expressed in Escherichia coli Bl21(...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50567484(CHEMBL4861102)
Affinity DataIC50: 390nMAssay Description:Inhibition Zika virus NS3B (47 to 95 residues)/NS3 (1 to 170 residues) protease expressed in Escherichia coli BL21 using 7-amino-4-methylcoumarin as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50579273(CHEMBL4858884)
Affinity DataIC50: 390nMAssay Description:Inhibition of Zika virus recombinant NS2B (47 to 95 residues)/NS3 (1 to 177 residues) protease expressed in Escherichia coli BL21 using Bz-Nle-Lys-Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50567470(CHEMBL4862353)
Affinity DataIC50: 400nMAssay Description:Inhibition Zika virus NS3B (47 to 95 residues)/NS3 (1 to 170 residues) protease expressed in Escherichia coli BL21 using 7-amino-4-methylcoumarin as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM32580(CS-3)
Affinity DataKi:  430nMAssay Description:Inhibition of Zika virus NS2B-NS3 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50513889(CHEMBL4586476)
Affinity DataKi:  430nMAssay Description:Inhibition of Zika virus unlinked NS2B-NS3 protease preincubated for 5 mins followed by benzoyl-nKRR-AMC addition and measured every 60 secs for 12 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50508772(CHEMBL4452943)
Affinity DataKi:  440nMAssay Description:Non-competitive inhibition of C-terminal His6-tagged linked Zika virus NS2B-NS3 protease domain expressed in Escherichia coli Bl21(DE3) using Bz-Nle-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50579316(CHEMBL4852919)
Affinity DataIC50: 450nMAssay Description:Inhibition of Zika virus recombinant NS2B (47 to 95 residues)/NS3 (1 to 177 residues) protease expressed in Escherichia coli BL21 using Bz-Nle-Lys-Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50513897(CHEMBL4541542)
Affinity DataKi:  470nMAssay Description:Inhibition of Zika virus unlinked NS2B-NS3 protease preincubated for 5 mins followed by benzoyl-nKRR-AMC addition and measured every 60 secs for 12 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50509476(CHEMBL4560058)
Affinity DataKd:  490nMAssay Description:Binding affinity to N-terminal hexa-histidine tagged Zika virus NS2B/NS3 protease expressed in Escherichia coli BL21-Gold (DE3) by microscale thermop...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50509464(CHEMBL4453301)
Affinity DataIC50: 510nMAssay Description:Inhibition of N-terminal hexa-histidine tagged Zika virus NS2B/NS3 protease expressed in Escherichia coli BL21-Gold (DE3) using fluorogenic AMC-subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50567477(CHEMBL4852716)
Affinity DataIC50: 510nMAssay Description:Inhibition Zika virus NS3B (47 to 95 residues)/NS3 (1 to 170 residues) protease expressed in Escherichia coli BL21 using 7-amino-4-methylcoumarin as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50567474(CHEMBL4867031)
Affinity DataIC50: 520nMAssay Description:Inhibition Zika virus NS3B (47 to 95 residues)/NS3 (1 to 170 residues) protease expressed in Escherichia coli BL21 using 7-amino-4-methylcoumarin as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50528558(CHEMBL4448497)
Affinity DataIC50: 520nMAssay Description:Inhibition of N-terminal unlinked Zika virus NS2B (45 to 96 residues) - NS3 (1 to 177 residues) protease domain expressed in Escherichia coli Bl21(DE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50509465(CHEMBL4515653)
Affinity DataIC50: 580nMAssay Description:Inhibition of N-terminal hexa-histidine tagged Zika virus NS2B/NS3 protease expressed in Escherichia coli BL21-Gold (DE3) using fluorogenic AMC-subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50567550(CHEMBL4849574)
Affinity DataIC50: 590nMAssay Description:Inhibition Zika virus NS3B (47 to 95 residues)/NS3 (1 to 170 residues) protease expressed in Escherichia coli BL21 using 7-amino-4-methylcoumarin as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50513896(CHEMBL4436979)
Affinity DataKi:  600nMAssay Description:Inhibition of Zika virus unlinked NS2B-NS3 protease preincubated for 5 mins followed by benzoyl-nKRR-AMC addition and measured every 60 secs for 12 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50579317(CHEMBL4868723)
Affinity DataIC50: 600nMAssay Description:Inhibition of Zika virus recombinant NS2B (47 to 95 residues)/NS3 (1 to 177 residues) protease expressed in Escherichia coli BL21 using Bz-Nle-Lys-Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50542241(E127 | ERYTHROSINE | US20230364057, Compound 253)
Affinity DataEC50:  600nMAssay Description:Inhibition of Zika virus NS2B-NS3 protease by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50567480(CHEMBL4862454)
Affinity DataIC50: 620nMAssay Description:Inhibition Zika virus NS3B (47 to 95 residues)/NS3 (1 to 170 residues) protease expressed in Escherichia coli BL21 using 7-amino-4-methylcoumarin as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50508772(CHEMBL4452943)
Affinity DataIC50: 620nMAssay Description:Inhibition of C-terminal His6-tagged linked Zika virus NS2B-NS3 protease domain expressed in Escherichia coli Bl21(DE3) using Bz-Nle-Lys-Lys-Arg-AMC ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Australian National University Canberra

Curated by ChEMBL
LigandPNGBDBM50579275(CHEMBL4870701)
Affinity DataIC50: 630nMAssay Description:Inhibition of Zika virus recombinant NS2B (47 to 95 residues)/NS3 (1 to 177 residues) protease expressed in Escherichia coli BL21 using Bz-Nle-Lys-Ly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
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