Compile Data Set for Download or QSAR
Report error Found 977 Enz. Inhib. hit(s) with Target = 'Nucleotide-binding oligomerization domain-containing protein 2'
LigandPNGBDBM50564984(CHEMBL4781373)
Affinity DataIC50: 1nMAssay Description:Inhibition of human NOD2 expressed in HEK293 cells coexpressing NFkappaB-SEAP reporter measured after 7 to 9 hrs by HEKBIue reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM50568933(CHEMBL4847211)
Affinity DataIC50: 3nMAssay Description:Inhibition of human NOD2 expressed in HEK-blue cells coexpressing NFkappaB-SEAP reporter assessed as reduction in L18-MDP-induced NF-kappaB activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM50516677(CHEMBL4514780)
Affinity DataIC50: 4nMAssay Description:Inhibition of human NOD2 expressed in HEK293 cells assessed as reduction in MDP-induced IL8 production measured after 22 hrs by HTRF fluorescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
LigandPNGBDBM50568927(CHEMBL4853179)
Affinity DataIC50: 4nMAssay Description:Inhibition of human NOD2 expressed in HEK-blue cells coexpressing NFkappaB-SEAP reporter assessed as reduction in L18-MDP-induced NF-kappaB activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM50594560(CHEMBL5180843)
Affinity DataEC50:  4.5nMAssay Description:Agonist activity at human human NOD2 expressed in HEK-Blue NOD2 reporter cells by colorimetry based SEAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM50568934(CHEMBL4864576)
Affinity DataIC50: 5nMAssay Description:Inhibition of human NOD2 expressed in HEK-blue cells coexpressing NFkappaB-SEAP reporter assessed as reduction in L18-MDP-induced NF-kappaB activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM50568929(CHEMBL4870434)
Affinity DataIC50: 5nMAssay Description:Inhibition of human NOD2 expressed in HEK-blue cells coexpressing NFkappaB-SEAP reporter assessed as reduction in L18-MDP-induced NF-kappaB activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM50568932(CHEMBL4858463)
Affinity DataIC50: 9nMAssay Description:Inhibition of human NOD2 expressed in HEK-blue cells coexpressing NFkappaB-SEAP reporter assessed as reduction in L18-MDP-induced NF-kappaB activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM50568931(CHEMBL4859716)
Affinity DataIC50: 13nMAssay Description:Inhibition of human NOD2 expressed in HEK-blue cells coexpressing NFkappaB-SEAP reporter assessed as reduction in L18-MDP-induced NF-kappaB activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM50516677(CHEMBL4514780)
Affinity DataIC50: 13nMAssay Description:Inhibition of NOD2 in human monocytes assessed as reduction in MDP-induced TNFalpha production preincubated for 30 mins followed by MDP-stimulation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
LigandPNGBDBM4067(2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-meth...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human NOD2 expressed in HEK-blue cells coexpressing NFkappaB-SEAP reporter assessed as reduction in L18-MDP-induced NF-kappaB activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM4077(2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-ethy...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human NOD2 expressed in HEK-blue cells coexpressing NFkappaB-SEAP reporter assessed as reduction in L18-MDP-induced NF-kappaB activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM50564997(CHEMBL4799077)
Affinity DataIC50: 16nMAssay Description:Inhibition of human NOD2 expressed in HEK293 cells coexpressing NFkappaB-SEAP reporter measured after 7 to 9 hrs by HEKBIue reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM50568937(CHEMBL4861488)
Affinity DataIC50: 20nMAssay Description:Inhibition of human NOD2 expressed in HEK-blue cells coexpressing NFkappaB-SEAP reporter assessed as reduction in L18-MDP-induced NF-kappaB activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM50568936(CHEMBL4864600)
Affinity DataIC50: 22nMAssay Description:Inhibition of human NOD2 expressed in HEK-blue cells coexpressing NFkappaB-SEAP reporter assessed as reduction in L18-MDP-induced NF-kappaB activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM50564987(CHEMBL4789724)
Affinity DataIC50: 26nMAssay Description:Inhibition of human NOD2 expressed in HEK293 cells coexpressing NFkappaB-SEAP reporter measured after 7 to 9 hrs by HEKBIue reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM62288(cid_44229055 | MLS-0412185.0001 | 4-(3,4-dihydro-1...)
Affinity DataIC50: 30nMAssay Description:Inhibition of NOD2 (unknown origin) expressed in HEK293T cells coexpressing NF-kappaB driven luciferase reporter gene by HTS primary assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
LigandPNGBDBM50582642(CHEMBL5070781)
Affinity DataEC50:  30nMAssay Description:Agonist activity at NOD2 in HEK-Blue hNOD2 cells assessed as increase in NFkappaB transactivation-mediated SEAP activity measured after 18 hrs by spe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM62288(cid_44229055 | MLS-0412185.0001 | 4-(3,4-dihydro-1...)
Affinity DataIC50: 30nMAssay Description:Inhibition of NOD-2 mediated NFkappaB activation in HEK293T cells assessed as inhibition of MDP-induced luciferase activity after 14 hrs by reporter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50594558(CHEMBL5187281)
Affinity DataEC50:  35nMAssay Description:Agonist activity at human human NOD2 expressed in HEK-Blue NOD2 reporter cells by colorimetry based SEAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM54356([2-[2,5-dimethyl-1-(oxolan-2-ylmethyl)pyrrol-3-yl]...)
Affinity DataIC50: 36nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay
LigandPNGBDBM3096(6-(2,6-dichlorophenyl)-2-({4-[2-(diethylamino)etho...)
Affinity DataIC50: 37nMAssay Description:Inhibition of human NOD2 expressed in HEK-blue cells coexpressing NFkappaB-SEAP reporter assessed as reduction in L18-MDP-induced NF-kappaB activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM50582634(CHEMBL5077049)
Affinity DataEC50:  39nMAssay Description:Agonist activity at NOD2 in HEK-Blue hNOD2 cells assessed as increase in NFkappaB transactivation-mediated SEAP activity measured after 18 hrs by spe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50582640(CHEMBL5079672)
Affinity DataEC50:  40nMAssay Description:Agonist activity at NOD2 in HEK-Blue hNOD2 cells assessed as increase in NFkappaB transactivation-mediated SEAP activity measured after 18 hrs by spe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50594561(CHEMBL5203244)
Affinity DataEC50:  44nMAssay Description:Agonist activity at human human NOD2 expressed in HEK-Blue NOD2 reporter cells by colorimetry based SEAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM50582640(CHEMBL5079672)
Affinity DataEC50:  45nMAssay Description:Agonist activity at human human NOD2 expressed in HEK-Blue NOD2 reporter cells by colorimetry based SEAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM50564979(CHEMBL4795976)
Affinity DataIC50: 46nMAssay Description:Inhibition of human NOD2 expressed in HEK293 cells coexpressing NFkappaB-SEAP reporter measured after 7 to 9 hrs by HEKBIue reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM50164885(CHEBI:59414 | muramyldipeptide)
Affinity DataEC50:  46nMAssay Description:Agonist activity at NOD2 receptor (unknown origin) expressed in HEK-Blue cells assessed as NF-kappaB transcriptional activity after 18 hrs by secrete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2017
Entry Details Article
PubMed
LigandPNGBDBM50564988(CHEMBL4793153)
Affinity DataIC50: 46nMAssay Description:Inhibition of human NOD2 expressed in HEK293 cells coexpressing NFkappaB-SEAP reporter measured after 7 to 9 hrs by HEKBIue reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM50245040(CHEMBL4090558)
Affinity DataEC50:  46nMAssay Description:Agonist activity at human NOD2 expressed in HEK-Blue cells assessed as induction of NF-kB transcriptional activity after 18 hrs by SEAP reporter gene...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed
LigandPNGBDBM50594550(CHEMBL5207301)
Affinity DataEC50:  47nMAssay Description:Agonist activity at human human NOD2 expressed in HEK-Blue NOD2 reporter cells by colorimetry based SEAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM50582630(CHEMBL5086803)
Affinity DataEC50:  49nMAssay Description:Agonist activity at NOD2 in HEK-Blue hNOD2 cells assessed as increase in NFkappaB transactivation-mediated SEAP activity measured after 18 hrs by spe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50245039(CHEMBL4069541)
Affinity DataEC50:  49nMAssay Description:Agonist activity at NOD2 in HEK-Blue hNOD2 cells assessed as increase in NFkappaB transactivation-mediated SEAP activity measured after 18 hrs by spe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50564978(CHEMBL4776631)
Affinity DataIC50: 53nMAssay Description:Inhibition of human NOD2 expressed in HEK293 cells coexpressing NFkappaB-SEAP reporter measured after 7 to 9 hrs by HEKBIue reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM50594551(CHEMBL5193116)
Affinity DataEC50:  61nMAssay Description:Agonist activity at human human NOD2 expressed in HEK-Blue NOD2 reporter cells by colorimetry based SEAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM50582641(CHEMBL5085864)
Affinity DataEC50:  62nMAssay Description:Agonist activity at NOD2 in HEK-Blue hNOD2 cells assessed as increase in NFkappaB transactivation-mediated SEAP activity measured after 18 hrs by spe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50582644(CHEMBL5077437)
Affinity DataEC50:  63nMAssay Description:Agonist activity at NOD2 in HEK-Blue hNOD2 cells assessed as increase in NFkappaB transactivation-mediated SEAP activity measured after 18 hrs by spe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50582633(CHEMBL5075343)
Affinity DataEC50:  66nMAssay Description:Agonist activity at NOD2 in HEK-Blue hNOD2 cells assessed as increase in NFkappaB transactivation-mediated SEAP activity measured after 18 hrs by spe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50582629(CHEMBL5090188)
Affinity DataEC50:  71nMAssay Description:Agonist activity at NOD2 in HEK-Blue hNOD2 cells assessed as increase in NFkappaB transactivation-mediated SEAP activity measured after 18 hrs by spe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50594548(CHEMBL5192766)
Affinity DataEC50:  82nMAssay Description:Agonist activity at human human NOD2 expressed in HEK-Blue NOD2 reporter cells by colorimetry based SEAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM50245040(CHEMBL4090558)
Affinity DataEC50:  89nMAssay Description:Agonist activity at NOD2 in HEK-Blue hNOD2 cells assessed as increase in NFkappaB transactivation-mediated SEAP activity measured after 18 hrs by spe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50164885(CHEBI:59414 | muramyldipeptide)
Affinity DataEC50:  92nMAssay Description:Agonist activity at human NOD2 expressed in HEK-Blue cells assessed as induction of NF-kB transcriptional activity after 18 hrs by SEAP reporter gene...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed
LigandPNGBDBM50568942(CHEMBL4874031)
Affinity DataIC50: 94nMAssay Description:Inhibition of human NOD2 expressed in HEK-blue cells coexpressing NFkappaB-SEAP reporter assessed as reduction in L18-MDP-induced NF-kappaB activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM50245040(CHEMBL4090558)
Affinity DataEC50:  99nMAssay Description:Agonist activity at NOD2 in HEK-Blue hNOD2 cells assessed as increase in NFkappaB activation incubated for 18 hrs by SEAP-based spectrophotometry ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandPNGBDBM54367(SMR000415593 | MLS000778899 | cid_16460826 | 2-[(4...)
Affinity DataIC50: 103nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay
LigandPNGBDBM50588617(CHEMBL5178827)
Affinity DataEC50:  114nMAssay Description:Agonist activity at NOD2 in HEK-Blue hNOD2 cells assessed as increase in NFkappaB activation incubated for 18 hrs by SEAP-based spectrophotometry ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
LigandPNGBDBM50564977(CHEMBL4781705)
Affinity DataIC50: 121nMAssay Description:Inhibition of human NOD2 expressed in HEK293 cells coexpressing NFkappaB-SEAP reporter measured after 7 to 9 hrs by HEKBIue reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM50245097(CHEMBL4060406)
Affinity DataEC50:  121nMAssay Description:Agonist activity at human NOD2 expressed in HEK-Blue cells assessed as induction of NF-kB transcriptional activity after 18 hrs by SEAP reporter gene...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2019
Entry Details Article
PubMed
LigandPNGBDBM50564986(CHEMBL4788375)
Affinity DataIC50: 129nMAssay Description:Inhibition of human NOD2 expressed in HEK293 cells coexpressing NFkappaB-SEAP reporter measured after 7 to 9 hrs by HEKBIue reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
LigandPNGBDBM50594559(CHEMBL5184036)
Affinity DataEC50:  130nMAssay Description:Agonist activity at human human NOD2 expressed in HEK-Blue NOD2 reporter cells by colorimetry based SEAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
Displayed 1 to 50 (of 977 total ) | Next | Last >>
Jump to: