Compile Data Set for Download or QSAR
Report error Found 385 Enz. Inhib. hit(s) with Target = 'Probable G-protein coupled receptor 139'
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50566740(CHEMBL4776509)
Affinity DataEC50:  9nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263478((s)-2-(6,8-dimethyl-4-oxobenzo[d][1,2,3]triazin-3(...)
Affinity DataKi:  10nMAssay Description:Membranes were removed from −80° C., thawed and diluted in cold radioligand assay buffer (20 mM HEPES pH 7.4/5 mM MgCl2/1 mM CaCl2/Roche protea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263453((s)-2-(6-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263478((s)-2-(6,8-dimethyl-4-oxobenzo[d][1,2,3]triazin-3(...)
Affinity DataKi:  10nM ΔG°:  -42.4kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263499((s)-n-(1-(2-fluoro-4-(trifluoromethyl)phenyl)ethyl...)
Affinity DataKi:  11nM ΔG°:  -42.2kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263499((s)-n-(1-(2-fluoro-4-(trifluoromethyl)phenyl)ethyl...)
Affinity DataKi:  11nMAssay Description:Membranes were removed from −80° C., thawed and diluted in cold radioligand assay buffer (20 mM HEPES pH 7.4/5 mM MgCl2/1 mM CaCl2/Roche protea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263445((s)-2-(6-fluoro-4-oxobenzo[d][1,2,3]triazin-3(4h)-...)
Affinity DataEC50:  11nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM743224(Preparation of (S)-2-(6-methyl-4-oxopyrrolo[1,2-d]...)
Affinity DataEC50:  13nMAssay Description:Determination of the Agonistic Activity of the Compounds of the Present Disclosure on GPR139More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM743236(Preparation of (S)—N-1-(4-bromophenyl)ethyl-2-(6-m...)
Affinity DataEC50:  15nMAssay Description:Determination of the Agonistic Activity of the Compounds of the Present Disclosure on GPR139More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263482((s)-2-(8-fluoro-6-methyl-4-oxobenzo[d][1,2,3]triaz...)
Affinity DataEC50:  15nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263440((s)-2-(4-oxobenzo[d][1,2,3]triazin-3(4h)-yl)-n-(1-...)
Affinity DataEC50:  15nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50132143(CHEMBL3633720)
Affinity DataEC50:  16nMAssay Description:Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263498((s)-n-(1-(4-(difluoromethoxy)phenyl)ethyl)-2-(4-ox...)
Affinity DataEC50:  18nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM743221(Preparation of (S)—N-(1-(4-fluorophenyl)ethyl-2-(6...)
Affinity DataEC50:  19nMAssay Description:Determination of the Agonistic Activity of the Compounds of the Present Disclosure on GPR139More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263497((s)-n-(1-(2-fluoro-4-(trifluoromethyl)phenyl)ethyl...)
Affinity DataEC50:  19nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM743230(Preparation of (S)-2-(6,8-dimethyl-4-oxopyrrolo[1,...)
Affinity DataEC50:  19nMAssay Description:Determination of the Agonistic Activity of the Compounds of the Present Disclosure on GPR139More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263471((s)-2-(7-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Affinity DataEC50:  19nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM743222(Preparation of (S)-2-(6-methyl-4-oxopyrrolo[1,2-d]...)
Affinity DataEC50:  21nMAssay Description:Determination of the Agonistic Activity of the Compounds of the Present Disclosure on GPR139More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263501((s)-n-(1-(4-(difluoromethoxy)phenyl)ethyl)-2-(5-me...)
Affinity DataEC50:  21nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263505(n-(4-chlorophenethyl)-2-(4-oxobenzo[d][1,2,3]triaz...)
Affinity DataEC50:  21nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263368((s)-2-(4-oxobenzo[d][1,2,3]triazin-3(4h)-yl)-n-(1-...)
Affinity DataEC50:  22nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263490((s)-2-(5-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Affinity DataEC50:  22nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263391((s)-n-(1-(4-chlorophenyl)ethyl)-2-(4-oxobenzo[d][1...)
Affinity DataEC50:  22nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM743243(Preparation of (S)-2 (6-methyl-4-oxopyrrolo[1,2-d]...)
Affinity DataEC50:  22nMAssay Description:Determination of the Agonistic Activity of the Compounds of the Present Disclosure on GPR139More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM743233(Preparation of (S)—N-(1-(naphthalen-1-ethyl)-2-(4-...)
Affinity DataEC50:  23nMAssay Description:Determination of the Agonistic Activity of the Compounds of the Present Disclosure on GPR139More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM743226(Preparation of (S)—N-1-(4-chlorophenyl)ethyl-2-(6-...)
Affinity DataEC50:  23nMAssay Description:Determination of the Agonistic Activity of the Compounds of the Present Disclosure on GPR139More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM743223(Preparation of (S)—N-(1-(4-methoxyphenyl)ethyl-2-(...)
Affinity DataEC50:  24nMAssay Description:Determination of the Agonistic Activity of the Compounds of the Present Disclosure on GPR139More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50131904(CHEMBL3633888)
Affinity DataEC50:  24nMAssay Description:Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50132137(CHEMBL3633878)
Affinity DataEC50:  24nMAssay Description:Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263369((s)-2-(5-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Affinity DataEC50:  24nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263485((s)-n-(1-(2-fluoro-4-methylphenyl)ethyl)-2-(4-oxob...)
Affinity DataEC50:  24nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263433((s)-2-(4-oxobenzo[d][1,2,3]triazin-3(4h)-yl)-n-(1-...)
Affinity DataEC50:  24nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50566745(CHEMBL4869182)
Affinity DataEC50:  24nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM743218(Preparation of (S)-2-(4-oxopyrrolo[1,2-d][1,2,4]tr...)
Affinity DataEC50:  25nMAssay Description:Determination of the Agonistic Activity of the Compounds of the Present Disclosure on GPR139More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263493((s)-2-(5-methoxy-4-oxobenzo[d][1,2,3]triazin-3 (4h...)
Affinity DataKi:  26nMAssay Description:Membranes were removed from −80° C., thawed and diluted in cold radioligand assay buffer (20 mM HEPES pH 7.4/5 mM MgCl2/1 mM CaCl2/Roche protea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263461((s)-2-(6,8-dichloro-4-oxobenzo[d][1,2,3]triazin-3(...)
Affinity DataKi:  26nMAssay Description:Membranes were removed from −80° C., thawed and diluted in cold radioligand assay buffer (20 mM HEPES pH 7.4/5 mM MgCl2/1 mM CaCl2/Roche protea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263461((s)-2-(6,8-dichloro-4-oxobenzo[d][1,2,3]triazin-3(...)
Affinity DataKi:  26nM ΔG°:  -40.2kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263493((s)-2-(5-methoxy-4-oxobenzo[d][1,2,3]triazin-3 (4h...)
Affinity DataKi:  26nM ΔG°:  -40.2kJ/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM743241(Preparation of (S)—N-(1-(4-fluorophenyl)-2-methylp...)
Affinity DataEC50:  26nMAssay Description:Determination of the Agonistic Activity of the Compounds of the Present Disclosure on GPR139More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263420((s)-n-(1-(2,4-dimethylphenyl)ethyl)-2-(4-oxobenzo[...)
Affinity DataEC50:  27nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM743215(Preparation of (S)-2-(4-oxopyrrolo[1,2-d][1,2,4]tr...)
Affinity DataEC50:  28nMAssay Description:Determination of the Agonistic Activity of the Compounds of the Present Disclosure on GPR139More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263502((s)-n-(1-(2-fluoro-4-(trifluoromethoxy)phenyl)ethy...)
Affinity DataEC50:  29nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263507(n-(4-methylphenethyl)-2-(4-oxobenzo[d][1,2,3]triaz...)
Affinity DataEC50:  30nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM743219(Preparation of (S)—N-1-(4-chlorophenyl)ethyl-2-(4-...)
Affinity DataEC50:  30nMAssay Description:Determination of the Agonistic Activity of the Compounds of the Present Disclosure on GPR139More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263465((s)-2-(8-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Affinity DataEC50:  30nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50566743(CHEMBL4847108)
Affinity DataEC50:  30nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263370((s)-2-(4-oxobenzo[d][1,2,3]triazin-3(4h)-yl)-n-(1-...)
Affinity DataEC50:  30nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50131902(CHEMBL3633890)
Affinity DataEC50:  32nMAssay Description:Agonist activity at human GPR139 receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263454((s)-2-(6-chloro-4-oxobenzo[d][1,2,3]triazin-3 (4h)...)
Affinity DataEC50:  32nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 139(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM263490((s)-2-(5-methoxy-4-oxobenzo[d][1,2,3]triazin-3(4h)...)
Affinity DataKi:  33nMAssay Description:Membranes were removed from −80° C., thawed and diluted in cold radioligand assay buffer (20 mM HEPES pH 7.4/5 mM MgCl2/1 mM CaCl2/Roche protea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

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