Compile Data Set for Download or QSAR
Report error Found 1494 Enz. Inhib. hit(s) with Target = 'Protein kinase C beta type'
TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50128285(3-(1-Methyl-1H-indol-3-yl)-4-[1-(1-pyridin-2-ylmet...)
Affinity DataIC50: 0.00600nMAssay Description:Inhibition of recombinant human PKCbetaII using myelin basic protein as substrate incubated for 60 mins in presence of 33p-ATP and ATP by microbeta s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM286349(US9518060, Example K7 | US11220518, Ex. No. K7 | U...)
Affinity DataKi:  0.165nMAssay Description:A typical assay was carried out on a 96-well, clear microtiter plate in a Molecular Devices spectrophotometer for 20 minutes at 30° C. in 0.1 mL of a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2022
Entry Details
US Patent

TargetProtein kinase C beta type Isoform 2(Human)
Pfizer

US Patent
LigandPNGBDBM286349(US9518060, Example K7 | US11220518, Ex. No. K7 | U...)
Affinity DataKi:  0.165nMAssay Description:Protein Kinase C beta 2 (PKCpII) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2023
Entry Details
US Patent

TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50391386(CHEMBL2148106)
Affinity DataKi:  0.170nMAssay Description:Inhibition of [3H]PDBu binding to PKCbeta C1A domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProtein kinase C beta type Isoform 2(Human)
Pfizer

US Patent
LigandPNGBDBM286350(US9518060, Example K8 | US11220518, Ex. No. K8 | U...)
Affinity DataKi:  0.181nMAssay Description:Protein Kinase C beta 2 (PKCpII) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2023
Entry Details
US Patent

TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM286350(US9518060, Example K8 | US11220518, Ex. No. K8 | U...)
Affinity DataKi:  0.181nMAssay Description:A typical assay was carried out on a 96-well, clear microtiter plate in a Molecular Devices spectrophotometer for 20 minutes at 30° C. in 0.1 mL of a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2022
Entry Details
US Patent

TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50133236(Tetradecanedioic acid ((S)-5-hydroxymethyl-2-isopr...)
Affinity DataKd:  0.190nMAssay Description:Binding affinity for human PKC beta-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50393214(CHEMBL2151411)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of PKCbeta-1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50092014(Butyric acid (1aS,1bS,4aS,7aS,8R,9S,9aR)-9-butyryl...)
Affinity DataKd:  0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2013
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM102423(Bryostatin | Bryostatin 7)
Affinity DataKd:  0.320nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2013
Entry Details Article
PubMed
TargetProtein kinase C beta type Isoform 2(Human)
Pfizer

US Patent
LigandPNGBDBM286348(US9518060, Example K6 | US11220518, Ex. No. K6 | U...)
Affinity DataKi:  0.376nMAssay Description:Protein Kinase C beta 2 (PKCpII) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2023
Entry Details
US Patent

TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM286348(US9518060, Example K6 | US11220518, Ex. No. K6 | U...)
Affinity DataKi:  0.376nMAssay Description:A typical assay was carried out on a 96-well, clear microtiter plate in a Molecular Devices spectrophotometer for 20 minutes at 30° C. in 0.1 mL of a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2022
Entry Details
US Patent

TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50057514(13-Hydroxymethyl-10-isopropyl-9-methyl-5-octyl-3,9...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]- PDBu from recombinant PKC beta expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50258529(CHEMBL449158 | bryostatin 1)
Affinity DataKd:  0.420nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2013
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50327943(Aplysiatoxin | CHEMBL1256416)
Affinity DataKi:  0.450nMAssay Description:Inhibition of [3H]PDBu binding to PKC beta C1A peptideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50235282(CHEMBL4077967)
Affinity DataKi:  0.5nMAssay Description:Reversible competitive inhibition of PKCbeta1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2019
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50393218(CHEMBL1996510)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of PKCbeta-1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM33971(Sotrastaurin | AEB071 | med.21724, Compound 190)
Affinity DataIC50: 0.640nMAssay Description:Inhibition of PKCbeta1 (unknown origin) by IMAP kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProtein kinase C beta type Isoform 2(Human)
Pfizer

US Patent
LigandPNGBDBM286347(US9518060, Example K5 | US11220518, Ex. No. K5 | U...)
Affinity DataKi:  0.683nMAssay Description:Protein Kinase C beta 2 (PKCpII) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2023
Entry Details
US Patent

TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM286347(US9518060, Example K5 | US11220518, Ex. No. K5 | U...)
Affinity DataKi:  0.683nMAssay Description:A typical assay was carried out on a 96-well, clear microtiter plate in a Molecular Devices spectrophotometer for 20 minutes at 30° C. in 0.1 mL of a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2022
Entry Details
US Patent

TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50235283(CHEMBL4102228)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of PKCbeta1 (unknown origin) after 60 mins in presence of [gamma33P]ATP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2019
Entry Details Article
PubMed
TargetProtein kinase C beta type Isoform 2(Human)
Pfizer

US Patent
LigandPNGBDBM286345(US9518060, Example K3 | US11220518, Ex. No. K3 | U...)
Affinity DataKi:  0.912nMAssay Description:Protein Kinase C beta 2 (PKCpII) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2023
Entry Details
US Patent

TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM286345(US9518060, Example K3 | US11220518, Ex. No. K3 | U...)
Affinity DataKi:  0.912nMAssay Description:A typical assay was carried out on a 96-well, clear microtiter plate in a Molecular Devices spectrophotometer for 20 minutes at 30° C. in 0.1 mL of a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2022
Entry Details
US Patent

TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM286246(5-{[(8S)-6,8-dimethyl-6,9-diazaspiro[4.5]dec-9-yl]...)
Affinity DataKi:  1.01nMAssay Description:A typical assay was carried out on a 96-well, clear microtiter plate in a Molecular Devices spectrophotometer for 20 minutes at 30° C. in 0.1 mL of a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2022
Entry Details
US Patent

TargetProtein kinase C beta type Isoform 2(Human)
Pfizer

US Patent
LigandPNGBDBM286246(5-{[(8S)-6,8-dimethyl-6,9-diazaspiro[4.5]dec-9-yl]...)
Affinity DataKi:  1.01nMAssay Description:Protein Kinase C beta 2 (PKCpII) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2023
Entry Details
US Patent

TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM533472(US11220518, Ex. No. K1 | US11780853, Example K1)
Affinity DataKi:  1.12nMAssay Description:A typical assay was carried out on a 96-well, clear microtiter plate in a Molecular Devices spectrophotometer for 20 minutes at 30° C. in 0.1 mL of a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2022
Entry Details
US Patent

TargetProtein kinase C beta type Isoform 2(Human)
Pfizer

US Patent
LigandPNGBDBM533472(US11220518, Ex. No. K1 | US11780853, Example K1)
Affinity DataKi:  1.12nMAssay Description:Protein Kinase C beta 2 (PKCpII) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2023
Entry Details
US Patent

TargetProtein kinase C beta type Isoform 2(Human)
Pfizer

US Patent
LigandPNGBDBM533459(US11220518, Ex. No. J6 | US11780853, Example J6)
Affinity DataKi:  1.17nMAssay Description:Protein Kinase C beta 2 (PKCpII) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2023
Entry Details
US Patent

TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM533459(US11220518, Ex. No. J6 | US11780853, Example J6)
Affinity DataKi:  1.17nMAssay Description:A typical assay was carried out on a 96-well, clear microtiter plate in a Molecular Devices spectrophotometer for 20 minutes at 30° C. in 0.1 mL of a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2022
Entry Details
US Patent

TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50393228(CHEMBL2153750)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of PKCbeta-1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  1.30nMAssay Description:Binding affinity for protein kinase C Beta-C1B domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  1.30nMAssay Description:Inhibition of [3H]PDBu binding to PKC beta C1A peptideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  1.30nMAssay Description:Binding affinity for Protein kinase C beta C1a domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to PKCbeta-C1A domain peptide using [3H]-labeled compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  1.30nMAssay Description:Displacement of [3H]PDBu from protein kinase C beta C1b domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  1.30nMAssay Description:Binding affinity for protein kinase C Beta-C1A domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  1.30nMAssay Description:Binding affinity for Protein kinase C beta C1b domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50486405(CHEMBL2236794)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of PKCbeta2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human PKCb2 using Histone H1 as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50235288(CHEMBL4072879)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of PKCbeta1 (unknown origin) after 60 mins in presence of [gamma33P]ATP by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2019
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human PKCb2 using Histone H1 as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50393219(CHEMBL2151415)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of PKCbeta-1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50133236(Tetradecanedioic acid ((S)-5-hydroxymethyl-2-isopr...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human PKC beta-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50486405(CHEMBL2236794)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of PKCbeta2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50493217(DEMETHOXYDEBROMOAPLYSIATOXIN)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]PDBu from PKCbeta C1A domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM2683(2-[1-(3-dimethylaminopropyl)-indol-3-yl]-3-(indol-...)
Affinity DataIC50: 1.60nMpH: 7.4 T: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2009
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM286270(US9518060, Example E2 | US11220518, Ex. No. E2 | U...)
Affinity DataKi:  1.64nMAssay Description:A typical assay was carried out on a 96-well, clear microtiter plate in a Molecular Devices spectrophotometer for 20 minutes at 30° C. in 0.1 mL of a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2022
Entry Details
US Patent

TargetProtein kinase C beta type Isoform 2(Human)
Pfizer

US Patent
LigandPNGBDBM286270(US9518060, Example E2 | US11220518, Ex. No. E2 | U...)
Affinity DataKi:  1.64nMAssay Description:Protein Kinase C beta 2 (PKCpII) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2023
Entry Details
US Patent

TargetProtein kinase C beta type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM153901(US8999981, A146)
Affinity DataKi:  1.70nM ΔG°:  -50.9kJ/molepH: 7.4 T: 2°CAssay Description:Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2015
Entry Details
US Patent

TargetProtein kinase C beta type Isoform 2(Human)
Pfizer

US Patent
LigandPNGBDBM286377(US9518060, Example L4 | US11220518, Ex. No. L4 | U...)
Affinity DataKi:  1.71nMAssay Description:Protein Kinase C beta 2 (PKCpII) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2023
Entry Details
US Patent

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