Compile Data Set for Download or QSAR
Report error Found 343 Enz. Inhib. hit(s) with Target = 'Protein kinase C gamma type'
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50128285(3-(1-Methyl-1H-indol-3-yl)-4-[1-(1-pyridin-2-ylmet...)
Affinity DataIC50: 0.0830nMAssay Description:Inhibition of recombinant human PKCgamma using myelin basic protein as substrate incubated for 60 mins in presence of 33p-ATP and ATP by microbeta sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50133236(Tetradecanedioic acid ((S)-5-hydroxymethyl-2-isopr...)
Affinity DataKd:  0.160nMAssay Description:Binding affinity for human Protein kinase C gamma with [Ca2+]More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50391386(CHEMBL2148106)
Affinity DataKi:  0.380nMAssay Description:Inhibition of [3H]PDBu binding to PKCgamma C1A domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.542nMAssay Description:Inhibition of human PKCgamma using ERMRPRKRQGSVRRRV as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50327943(Aplysiatoxin | CHEMBL1256416)
Affinity DataKi:  0.630nMAssay Description:Inhibition of [3H]PDBu binding to PKC gamma C1A peptideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50587724(CHEMBL5175742)
Affinity DataKi:  0.650nMAssay Description:Displacement of 3H-PDBu from recombinant human PKCgamma incubated for 25 mins by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50493217(DEMETHOXYDEBROMOAPLYSIATOXIN)
Affinity DataKi:  0.690nMAssay Description:Displacement of [3H]PDBu from PKCgamma C1A domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human PKCg using ERMRPRKRQGSVRRRV as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  1.20nMAssay Description:Binding affinity for Protein kinase C gamma C1b domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  1.20nMAssay Description:Binding affinity for protein kinase C gamma-C1B domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50057514(13-Hydroxymethyl-10-isopropyl-9-methyl-5-octyl-3,9...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]- PDBu from recombinant PKC gamma expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human PKCgamma using ERMRPRKRQGSVRRRV as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  1.5nMAssay Description:Binding affinity for protein kinase C gamma-C1A domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  1.5nMAssay Description:Binding affinity to PKCgamma-C1A domain peptide using [3H]-labeled compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50133236(Tetradecanedioic acid ((S)-5-hydroxymethyl-2-isopr...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human Protein kinase C gamma with [Ca2+]More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  1.5nMAssay Description:Inhibition of [3H]PDBu binding to PKC gamma C1A peptideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKd:  1.5nMAssay Description:Binding affinity for Protein kinase C gamma C1a domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKi:  1.60nMAssay Description:Displacement of 3[H]PDBu from Protein kinase C gamma C1b domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50097750(Butyric acid (1aR,1bS,4aS,7aR,7bR,8R,9R,9aS)-9-but...)
Affinity DataKi:  1.80nMAssay Description:Displacement of 3[H]PDBu from Protein kinase C gamma C1b domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM3033(Indolocarbazole deriv. | 3-{23-methyl-14-oxo-3,13,...)
Affinity DataIC50: 2nMAssay Description:Inhibition of PKCgammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50064089(teleocidin B-4 | telocidinB-4 4-hydroxymethyl-7,10...)
Affinity DataKi:  2nMAssay Description:Inhibition of [3H]- PDBu binding to peptide C, rat brain PKC gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 2.76nMAssay Description:Inhibition of human PKCg using histone H1 as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50057512((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Affinity DataKi:  2.90nMAssay Description:Displacement of 3[H]PDBu from Protein kinase C gamma C1a domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50099066(phorbol 13-acetate 12-myristate | CHEMBL279115)
Affinity DataKi:  4.90nMAssay Description:Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50285239(4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benz...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human Protein kinase C gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50055677(4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benz...)
Affinity DataIC50: 5nMAssay Description:Inhibitory concentration against recombinant human Protein kinase C gamma isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50285241(4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benz...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human Protein kinase C gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50055668(4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benz...)
Affinity DataIC50: 5nMAssay Description:Inhibitory concentration against recombinant human Protein kinase C gamma isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50055672(4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benz...)
Affinity DataIC50: 5nMAssay Description:Inhibitory concentration against recombinant human Protein kinase C gamma isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50285240(4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benz...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human Protein kinase C gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50097750(Butyric acid (1aR,1bS,4aS,7aR,7bR,8R,9R,9aS)-9-but...)
Affinity DataKi:  5.20nMAssay Description:Displacement of 3[H]PDBu from Protein kinase C gamma C1a domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50282632(Ro-32-0557 | 3-((3aR,10aR)-2-Methyl-2,3,3a,4,10,10...)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of Protein kinase C gamma (PKC)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2010
Entry Details Article

TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50391388(CHEMBL2148108)
Affinity DataKi:  5.5nMAssay Description:Inhibition of [3H]PDBu binding to PKCgamma C1A domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50249959([2-(Hydroxymethyl)-4-(methylethylidene)-5-oxo-2-2,...)
Affinity DataKi:  6.20nMAssay Description:Displacement of [3H]PDBu form human PKCgamma in presence of phosphatidylserineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 6.60nMpH: 7.4 T: 2°CAssay Description:The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2007
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM3153(CHEMBL52529 | 2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4...)
Affinity DataIC50: 10nMpH: 7.5 T: 2°CAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2005
Entry Details Article

TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Protein kinase C gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Protein kinase C gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50285250(4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benz...)
Affinity DataIC50: 10nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/24/2005
Entry Details Article

TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Protein kinase C gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM3153(CHEMBL52529 | 2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Protein kinase C gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM3153(CHEMBL52529 | 2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Protein kinase C gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50055685(4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benz...)
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against recombinant human Protein kinase C gamma isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50285242(4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benz...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human Protein kinase C gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM3153(CHEMBL52529 | 2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human Protein kinase C gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM3149(Acyclic Balanol Analog (-)-1 | 2-{[2,6-dihydroxy-4...)
Affinity DataIC50: 10nMAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2005
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM3153(CHEMBL52529 | 2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4...)
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against recombinant human Protein kinase C gamma isozymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM3153(CHEMBL52529 | 2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4...)
Affinity DataIC50: 10nMAssay Description:Inhibition of protein kinase C gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM3183(2-({2,6-dihydroxy-4-[({2-[(4-hydroxybenzene)amido]...)
Affinity DataIC50: 10nMpH: 7.5 T: 2°CAssay Description:PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2005
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Lilly Research Labs

Curated by ChEMBL
LigandPNGBDBM50249958([2-(Hydroxymethyl)-4-(methylethylidene)-5-oxo-2-2,...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]PDBu form human PKCgamma in presence of phosphatidylserineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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