Compile Data Set for Download or QSAR
Report error Found 3454 Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase receptor Ret [G810R]'
LigandChemical structure of BindingDB Monomer ID 576988BDBM576988(US11472802, Example 8)
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677846BDBM677846(US20240174674, Compound 11)
Affinity DataIC50: 0.360nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 753584BDBM753584((R)-1-(4-(5-(6-(2-fluoroethoxy)-1H-pyrazolo[3',4':...)
Affinity DataIC50: 0.600nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677936BDBM677936(US20240174674, Compound 276)
Affinity DataIC50: 0.700nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677851BDBM677851(US20240174674, Compound 44)
Affinity DataIC50: 0.800nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677935BDBM677935(US20240174674, Compound 275)
Affinity DataIC50: 0.800nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677938BDBM677938(US20240174674, Compound 278)
Affinity DataIC50: 0.900nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677917BDBM677917(US20240174674, Compound 233)
Affinity DataIC50: 0.960nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 753528BDBM753528(6-(2-fluoroethoxy)-4-(6-(6-((6-methoxypyridin-3-yl...)
Affinity DataIC50: 1nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 577053BDBM577053(US11472802, Example 58)
Affinity DataIC50: 1.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677937BDBM677937(US20240174674, Compound 277)
Affinity DataIC50: 1.20nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677934BDBM677934(US20240174674, Compound 274)
Affinity DataIC50: 1.30nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677850BDBM677850(US20240174674, Compound 42)
Affinity DataIC50: 1.40nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677858BDBM677858(US20240174674, Compound 15)
Affinity DataIC50: 1.5nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677941BDBM677941(US20240174674, Compound 281)
Affinity DataIC50: 1.5nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677852BDBM677852(US20240174674, Compound 46)
Affinity DataIC50: 1.60nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677888BDBM677888(US20240174674, Compound 150 | US20240174674, Compo...)
Affinity DataIC50: 1.60nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 753583BDBM753583((R)-1-(4-(5-(6-(2-fluoroethoxy)-1H-pyrazolo[3',4':...)
Affinity DataIC50: 1.60nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677949BDBM677949(US20240174674, Compound 293)
Affinity DataIC50: 1.60nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677918BDBM677918(US20240174674, Compound 234)
Affinity DataIC50: 1.60nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 753585BDBM753585((4-(5-(6-(2-fluoroethoxy)-1H-pyrazolo[3',4':3,4]py...)
Affinity DataIC50: 1.70nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 577046BDBM577046(7-chloro-3-(5-cyclopropyl- 4-(1H-pyrazol-3- yl)iso...)
Affinity DataIC50: 1.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677919BDBM677919(US20240174674, Compound 235 | US12338253, Compound...)
Affinity DataIC50: 1.70nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677933BDBM677933(US20240174674, Compound 273)
Affinity DataIC50: 1.80nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677948BDBM677948(US20240174674, Compound 292)
Affinity DataIC50: 1.80nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677867BDBM677867(US20240174674, Compound 43)
Affinity DataIC50: 1.90nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677953BDBM677953(US20240174674, Compound 297 | US12338253, Compound...)
Affinity DataIC50: 1.90nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 577061BDBM577061(US11472802, Example 65)
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677878BDBM677878(US20240174674, Compound 89)
Affinity DataIC50: 2nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 576996BDBM576996(US11472802, Example 11)
Affinity DataIC50: 2.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677857BDBM677857(US20240174674, Compound 12)
Affinity DataIC50: 2.10nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677940BDBM677940(US20240174674, Compound 280)
Affinity DataIC50: 2.10nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 597646BDBM597646(US11603374, Example 1)
Affinity DataIC50: 2.10nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 577066BDBM577066(3-(5-cyclopropyl- 4-(1H-pyrazol-3- yl)isoxazol-3- ...)
Affinity DataIC50: 2.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677952BDBM677952(US20240174674, Compound 296)
Affinity DataIC50: 2.10nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677859BDBM677859(US20240174674, Compound 17)
Affinity DataIC50: 2.10nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 753588BDBM753588(2-((4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-di...)
Affinity DataIC50: 2.10nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677951BDBM677951(US20240174674, Compound 295)
Affinity DataIC50: 2.10nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677848BDBM677848(US20240174674, Compound 40)
Affinity DataIC50: 2.20nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677879BDBM677879(US20240174674, Compound 91)
Affinity DataIC50: 2.20nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 753579BDBM753579(6-(2-chloroethoxy)-4-(6-(6-((6-methoxypyridin-3-yl...)
Affinity DataIC50: 2.20nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677939BDBM677939(US20240174674, Compound 279)
Affinity DataIC50: 2.20nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677919BDBM677919(US20240174674, Compound 235 | US12338253, Compound...)
Affinity DataIC50: 2.20nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677845BDBM677845(US20240174674, Compound 4)
Affinity DataIC50: 2.30nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 577050BDBM577050(7-chloro-3-(5- cyclopropyl-4-(1H- imidazol-4- yl)i...)
Affinity DataIC50: 2.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 753566BDBM753566(6-(2,2-difluoroethoxy)-4-(6-(6-((6-methoxypyridin-...)
Affinity DataIC50: 2.30nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 577049BDBM577049(US11472802, Example 55)
Affinity DataIC50: 2.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 753586BDBM753586(6-methoxy-4-(5-(6-((6-methoxypyridin-3-yl)methyl)-...)
Affinity DataIC50: 2.30nMAssay Description:1.3 Preparation of 1× Kinase Buffer4 volume of distilled water was added to 1 volume of enzyme buffer 5×; 5 mM MgCl2; 1 mM DTT.1.4 Screening Methoda)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/17/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 597649BDBM597649(US11603374, Example 4)
Affinity DataIC50: 2.5nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 677862BDBM677862(US20240174674, Compound 33)
Affinity DataIC50: 2.5nMAssay Description:a) 10 nL of compound dilution was transferred to each well of the test plate;b) the compound plate was centrifuged at 1000 g for 1 min;c) the test pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
US Patent

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