Compile Data Set for Download or QSAR
Report error Found 155 Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase receptor Ret [G810S]'
LigandPNGBDBM577053(US11472802, Example 58)
Affinity DataIC50: 0.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM577049(US11472802, Example 55)
Affinity DataIC50: 0.900nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM577050(7-chloro-3-(5- cyclopropyl-4-(1H- imidazol-4- yl)i...)
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM577046(7-chloro-3-(5-cyclopropyl- 4-(1H-pyrazol-3- yl)iso...)
Affinity DataIC50: 1.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM577063(1-(3-(4-amino-7-chloro-1- isopropyl-1H-pyrazolo[4,...)
Affinity DataIC50: 1.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM577061(US11472802, Example 65)
Affinity DataIC50: 1.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM577064(US11472802, Example 68)
Affinity DataIC50: 1.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM576996(US11472802, Example 11)
Affinity DataIC50: 1.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM597662(US11603374, Example 17)
Affinity DataIC50: 1.5nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
US Patent

LigandPNGBDBM577065(US11472802, Example 69)
Affinity DataIC50: 1.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM767012(US20250268897, Compound BLU-667)
Affinity DataIC50: 1.77nMAssay Description:The three drug-resistant mutant RET enzymes were each pre-incubated with different concentrations of test compounds (in the inhibition rate test of t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/8/2025
Entry Details
US Patent

LigandPNGBDBM577047(7-chloro-3-(5-cyclopropyl- 4-(1-methyl-1H-pyrazol-...)
Affinity DataIC50: 1.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM577066(3-(5-cyclopropyl- 4-(1H-pyrazol-3- yl)isoxazol-3- ...)
Affinity DataIC50: 1.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM597647(US11603374, Example 2)
Affinity DataIC50: 1.80nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
US Patent

LigandPNGBDBM577045(US11472802, Example 51)
Affinity DataIC50: 1.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM597672((3-(4-amino-5-(5- cyclopropylisoxazol-3-yl)- 7H-py...)
Affinity DataIC50: 2nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
US Patent

LigandPNGBDBM597674(US11603374, Example 29)
Affinity DataIC50: 2.10nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
US Patent

LigandPNGBDBM577067(3-(5-cyclopropyl- 4-(5-methyl-1H- pyrazol-3-yl) is...)
Affinity DataIC50: 2.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM577062(1-(3-(4-amino-7-chloro-1- isopropyl-1H-pyrazolo[4,...)
Affinity DataIC50: 2.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM576985(US11472802, Example 6)
Affinity DataIC50: 2.45nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM597646(US11603374, Example 1)
Affinity DataIC50: 2.5nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
US Patent

LigandPNGBDBM597648(US11603374, Example 3)
Affinity DataIC50: 2.5nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
US Patent

LigandPNGBDBM577022(3-(5-cyclopropyl-4-(1-methyl- 1H-imidazol-4-yl)iso...)
Affinity DataIC50: 2.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM767014(2-(6-(6-((6-(4-fluoro-1H-pyrazol-1-yl) pyridin-3-y...)
Affinity DataIC50: 2.69nMAssay Description:The three drug-resistant mutant RET enzymes were each pre-incubated with different concentrations of test compounds (in the inhibition rate test of t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/8/2025
Entry Details
US Patent

LigandPNGBDBM577026(7-chloro-3-(5-cyclopropyl-4-(4- methylpyridin-2-yl...)
Affinity DataIC50: 2.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM577025(7-chloro-3-(5-cyclopropyl-4- (pyrazin-2-yl)isoxazo...)
Affinity DataIC50: 2.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM597673(US11603374, Example 28)
Affinity DataIC50: 2.90nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
US Patent

LigandPNGBDBM577015(3-(5-cyclopropyl-4-(4- methylpyridin-2-yl)isoxazol...)
Affinity DataIC50: 3.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM597669(5-(5-cyclopropylisoxazol-3- yl)-7-(1,1,1-trifluoro...)
Affinity DataIC50: 3.10nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
US Patent

LigandPNGBDBM577029(7-chloro-3-(5-cyclopropyl-4-(5- methylpyridin-2-yl...)
Affinity DataIC50: 3.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM597663(7-cyclobutyl-5-(5- cyclopropylisoxazol-3-yl)- 7H-p...)
Affinity DataIC50: 3.5nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
US Patent

LigandPNGBDBM597666(US11603374, Example 21)
Affinity DataIC50: 3.70nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
US Patent

LigandPNGBDBM577048(7-chloro-3-(5-cyclopropyl- 4-(1-ethyl-1H-pyrazol-3...)
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM577007(US11472802, Example 18)
Affinity DataIC50: 4.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM577019(3-(5-cyclopropyl-4-(5- methylpyridin-2-yl)isoxazol...)
Affinity DataIC50: 4.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM577071(US11472802, Example 75)
Affinity DataIC50: 4.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM597675(US11603374, Example 30)
Affinity DataIC50: 4.80nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
US Patent

LigandPNGBDBM577008(US11472802, Example 19)
Affinity DataIC50: 5.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 183 ...)
Affinity DataIC50: 5.66nMAssay Description:The three drug-resistant mutant RET enzymes were each pre-incubated with different concentrations of test compounds (in the inhibition rate test of t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2025
Entry Details
US Patent

LigandPNGBDBM576971(US11472802, Example 1)
Affinity DataIC50: 5.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM577006(US11472802, Example 17)
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM577028(7-chloro-3-(5-cyclopropyl-4-(6- methylpyridin-2-yl...)
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM577060(1-(3-(4-amino-1-isopropyl- 1H-pyrazolo[4,3-c]pyrid...)
Affinity DataIC50: 6.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM577032(US11472802, Example 39)
Affinity DataIC50: 6.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM767008(US20250268897, Compound 21)
Affinity DataIC50: 6.61nMAssay Description:The three drug-resistant mutant RET enzymes were each pre-incubated with different concentrations of test compounds (in the inhibition rate test of t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/8/2025
Entry Details
US Patent

LigandPNGBDBM577013(3-(5-cyclopropyl-4-(pyrazin-2- yl)isoxazol-3-yl)-1...)
Affinity DataIC50: 6.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM577018(3-(5-cyclopropyl-4-(6- methylpyridin-2-yl)isoxazol...)
Affinity DataIC50: 7.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM577042(US11472802, Example 48)
Affinity DataIC50: 7.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM577057(1-(3-(4-amino-1-isopropyl- 1H-pyrazolo[4,3-c]pyrid...)
Affinity DataIC50: 8.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

LigandPNGBDBM597668(2-(4-amino-5-(5- cyclopropylisoxazol-3-yl)- 7H-pyr...)
Affinity DataIC50: 8.20nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
US Patent

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