Compile Data Set for Download or QSAR
Report error Found 6053 Enz. Inhib. hit(s) with Target = 'RAC-alpha serine/threonine-protein kinase'
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50629264(CHEMBL5426560)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50629268(CHEMBL5421280)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50629260(CHEMBL5407182)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50629267(CHEMBL5406146)
Affinity DataIC50: 0.0230nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50629258(CHEMBL5414576)
Affinity DataIC50: 0.0350nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50629277(CHEMBL5398425)
Affinity DataIC50: 0.0360nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50278693((+/-)-N-(1-amino-3-phenylpropan-2-yl)-4-bromo-5-(1...)
Affinity DataKi:  0.0400nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50278098(N-((S)-1-amino-3-(2-(trifluoromethyl)phenyl)propan...)
Affinity DataKi:  0.0500nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50629266(CHEMBL5437264)
Affinity DataIC50: 0.0530nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50629263(CHEMBL5428430)
Affinity DataIC50: 0.0540nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50278837(N-((S)-1-amino-3-(4-fluorophenyl)propan-2-yl)-4-br...)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50170284(GSK2141795 | GSK2141795C | Uprosertib)
Affinity DataIC50: 0.0660nMAssay Description:Inhibition of AKT1 (unknown origin) using Sox-AKT-tide as substrate by continuous real time fluorescence detection based [gamma33P]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50502477(ASB183 | ASB-183 | Afuresertib | GSK-2110183C | GS...)
Affinity DataKi:  0.0800nMAssay Description:Inhibition of Akt1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50502477(ASB183 | ASB-183 | Afuresertib | GSK-2110183C | GS...)
Affinity DataKi:  0.0800nMAssay Description:Inhibition of AKT1 (unknown origin) using Ac-KKGGRARTSSFAEPG-amide as substrate preincubated for 1 hr followed by substrate and gamma33P-ATP addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50502477(ASB183 | ASB-183 | Afuresertib | GSK-2110183C | GS...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of AKT1 (unknown origin) using Sox-AKT-tide as substrate by continuous real time fluorescence detection based [gamma33P]ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50629272(CHEMBL5400934)
Affinity DataIC50: 0.0830nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50629262(CHEMBL5408482)
Affinity DataIC50: 0.0910nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50278099(N-((S)-1-amino-3-(3-(trifluoromethyl)phenyl)propan...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50278099(N-((S)-1-amino-3-(3-(trifluoromethyl)phenyl)propan...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM182489(US9145392, 190)
Affinity DataIC50: 0.100nMpH: 7.5Assay Description:A TTP Mosquito liquid handling instrument is used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50629271(CHEMBL5438374)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50629280(CHEMBL5399312)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM182480(US9145392, 181)
Affinity DataIC50: 0.150nMpH: 7.5Assay Description:A TTP Mosquito liquid handling instrument is used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM15131(5-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...)
Affinity DataKi:  0.160nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM15131(5-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of AktMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
LigandPNGBDBM15131(5-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...)
Affinity DataIC50: 0.160nMpH: 7.5 T: 2°CAssay Description:The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2007
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM15131(5-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...)
Affinity DataKi:  0.160nMAssay Description:Binding affinity to AKT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM15131(5-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...)
Affinity DataKi:  0.160nM ΔG°:  -55.3kJ/molepH: 7.5 T: 2°CAssay Description:The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2007
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50298443(5-(5-((S)-2-amino-3-(1H-indol-3-yl)propoxy)pyridin...)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of AktMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
LigandPNGBDBM16531((3Z)-5-(5-{[(2S)-2-amino-3-(1H-indol-3-yl)propyl]o...)
Affinity DataIC50: 0.170nMpH: 7.5 T: 2°CAssay Description:The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2007
Entry Details Article
PubMed
LigandPNGBDBM16531((3Z)-5-(5-{[(2S)-2-amino-3-(1H-indol-3-yl)propyl]o...)
Affinity DataIC50: 0.170nMAssay Description:The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2007
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM431867(US10550114, Compound 1a)
Affinity DataIC50: 0.200nMAssay Description:iFLiK and HTRF studies were carried out as described in Z. Fang, J. R. Simard, D. Plenker, H. D. Nguyen, T. Phan, P. Wolle, S. Baumeister, D. Rauh, A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM431867(US10550114, Compound 1a)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of 6xHis-tagged full-length wild-type AKT1 (unknown origin) expressed in baculovirus infected Sf9 insect cells by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM108431(US8609688, 9)
Affinity DataKd:  0.200nMAssay Description:Binding analysis. Protein-ligand binding was identified with the thermal shift assay which is based on the ligand-induced stabilization of the protei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2015
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM108432(US8609688, 10)
Affinity DataKd:  0.200nMAssay Description:Binding analysis. Protein-ligand binding was identified with the thermal shift assay which is based on the ligand-induced stabilization of the protei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2015
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM108433(US8609688, 11)
Affinity DataKd:  0.200nMAssay Description:Binding analysis. Protein-ligand binding was identified with the thermal shift assay which is based on the ligand-induced stabilization of the protei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2015
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM108434(US8609688, 12)
Affinity DataKd:  0.200nMAssay Description:Binding analysis. Protein-ligand binding was identified with the thermal shift assay which is based on the ligand-induced stabilization of the protei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2015
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50316184(4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-6-((S)-3-amino...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of AKTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM108433(US8609688, 11)
Affinity DataKd:  0.200nMpH: 7.5 T: 2°CAssay Description:Protein-ligand binding was identified with the thermal shift assay which is based on the ligand-induced stabilization of the protein tertiary structu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM108432(US8609688, 10)
Affinity DataKd:  0.200nMpH: 7.5 T: 2°CAssay Description:Protein-ligand binding was identified with the thermal shift assay which is based on the ligand-induced stabilization of the protein tertiary structu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM108431(US8609688, 9)
Affinity DataKd:  0.200nMpH: 7.5 T: 2°CAssay Description:Protein-ligand binding was identified with the thermal shift assay which is based on the ligand-induced stabilization of the protein tertiary structu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50316183(4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-6-((R)-2-amino...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of AKTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM108434(US8609688, 12)
Affinity DataKd:  0.200nMpH: 7.5 T: 2°CAssay Description:Protein-ligand binding was identified with the thermal shift assay which is based on the ligand-induced stabilization of the protein tertiary structu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50629274(CHEMBL5411877)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM430070(US10538528, Compound 28)
Affinity DataIC50: 0.300nMAssay Description:S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2020
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50629275(CHEMBL5405650)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM430063(US10538528, Compound 10)
Affinity DataIC50: 0.300nMAssay Description:S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2020
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM430062(US10538528, Compound 9)
Affinity DataIC50: 0.300nMAssay Description:S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2020
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM430064(US10538528, Compound 12)
Affinity DataIC50: 0.300nMAssay Description:S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2020
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM430030(US10538528, Compound 11)
Affinity DataIC50: 0.300nMAssay Description:S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2020
Entry Details
US Patent

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