Compile Data Set for Download or QSAR
Report error Found 229 Enz. Inhib. hit(s) with Target = 'Regulator of G-protein signaling 19'
LigandPNGBDBM33097(MLS000521052 | cid_11957209 | 3-[[7-(1,3-benzothia...)
Affinity DataKi:  10nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM32274(cid_1002249 | SMR000115103 | 2,5-dichloro-3-(4-met...)
Affinity DataEC50:  10nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
LigandPNGBDBM33097(MLS000521052 | cid_11957209 | 3-[[7-(1,3-benzothia...)
Affinity DataEC50:  16nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM32274(cid_1002249 | SMR000115103 | 2,5-dichloro-3-(4-met...)
Affinity DataEC50:  27nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM32274(cid_1002249 | SMR000115103 | 2,5-dichloro-3-(4-met...)
Affinity DataKi:  30nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM47764(cid_5581000 | (4E)-5-methyl-4-[[3-[[(Z)-(3-methyl-...)
Affinity DataKi:  50nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM47764(cid_5581000 | (4E)-5-methyl-4-[[3-[[(Z)-(3-methyl-...)
Affinity DataEC50:  56nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM43363(MLS000550549 | 2,5-dichloro-3-(1-piperidinyl)-6-[2...)
Affinity DataKi:  80nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM43363(MLS000550549 | 2,5-dichloro-3-(1-piperidinyl)-6-[2...)
Affinity DataEC50:  82nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM34524(4,6-dimethyl-2-[2-[3-methyl-4-(3-methylphenyl)-1-p...)
Affinity DataKi:  90nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM46590(4-[[(E)-(2,3-dihydroxy-4-oxo-1-cyclohexa-2,5-dieny...)
Affinity DataKi:  100nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM34524(4,6-dimethyl-2-[2-[3-methyl-4-(3-methylphenyl)-1-p...)
Affinity DataEC50:  100nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM46590(4-[[(E)-(2,3-dihydroxy-4-oxo-1-cyclohexa-2,5-dieny...)
Affinity DataEC50:  109nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM47719(MLS000539990 | 4-chloro-N-(4-chloro-2-methylphenyl...)
Affinity DataKi:  110nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM47719(MLS000539990 | 4-chloro-N-(4-chloro-2-methylphenyl...)
Affinity DataEC50:  115nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM50384774(CHEMBL1917204 | US20230414581, Compound 6)
Affinity DataIC50: 120nMAssay Description:FCPIA Characterization of RGS Inhibitory Activity: CCG-50014 (FIG. 1) was originally identified as a potential inhibitor of RGS8 and RGS16 in a polyp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2015
Entry Details
US Patent

LigandPNGBDBM34336(2-(2-morpholin-4-yl-5-morpholin-4-ylsulfonylphenyl...)
Affinity DataEC50:  120nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
LigandPNGBDBM34435(MLS000051364 | 4-cyano-3-methyl-5-[[1-oxo-2-[[5-(p...)
Affinity DataKi:  140nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM34435(MLS000051364 | 4-cyano-3-methyl-5-[[1-oxo-2-[[5-(p...)
Affinity DataEC50:  155nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM47815(MLS001029846 | cid_121637 | 2-(4-methoxyphenyl)cyc...)
Affinity DataKi:  160nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM34966(N,N-dimethyl-3-(3-oxidanylidene-1,2-benzothiazol-2...)
Affinity DataEC50:  160nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
LigandPNGBDBM47815(MLS001029846 | cid_121637 | 2-(4-methoxyphenyl)cyc...)
Affinity DataEC50:  169nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM34702((4E)-2,3-dihydroxy-4-[[(4-methyl-2-methylimino-1,3...)
Affinity DataKi:  200nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM34702((4E)-2,3-dihydroxy-4-[[(4-methyl-2-methylimino-1,3...)
Affinity DataEC50:  209nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM47770(SMR000273939 | MLS000703574 | cid_1154580 | 4-[5-[...)
Affinity DataKi:  230nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM47770(SMR000273939 | MLS000703574 | cid_1154580 | 4-[5-[...)
Affinity DataEC50:  245nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM46667(2-phenyl-1,2-benzothiazol-3-one (1) | cid_164981 |...)
Affinity DataEC50:  320nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
LigandPNGBDBM33090(cid_5825518 | SMR000151702 | (4E)-4-[[(2-ethylimin...)
Affinity DataKi:  350nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM33090(cid_5825518 | SMR000151702 | (4E)-4-[[(2-ethylimin...)
Affinity DataEC50:  378nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM34849(MLS000729299 | 6-fluoranyl-2-(2-methylphenyl)-1,2-...)
Affinity DataEC50:  460nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
LigandPNGBDBM47776(MLS000684370 | 3-chloro-N-(3-morpholin-4-ylpropyl)...)
Affinity DataKi:  460nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM46646(cid_2327938 | 2-[5-(4-morpholinylsulfonyl)-2-(1-py...)
Affinity DataEC50:  470nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
LigandPNGBDBM47776(MLS000684370 | 3-chloro-N-(3-morpholin-4-ylpropyl)...)
Affinity DataEC50:  488nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM47792(MLS000689390 | cid_4247466 | N-(2-chloro-4-methylp...)
Affinity DataEC50:  510nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
LigandPNGBDBM62216(cid_25227363 | 2-[(4,6-dimethyl-[1,2]thiazolo[5,4-...)
Affinity DataKi:  550nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM62216(cid_25227363 | 2-[(4,6-dimethyl-[1,2]thiazolo[5,4-...)
Affinity DataEC50:  590nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM34340(cid_2327953 | 2-(4-methyl-3-piperidin-1-ylsulfonyl...)
Affinity DataEC50:  610nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
LigandPNGBDBM43363(MLS000550549 | 2,5-dichloro-3-(1-piperidinyl)-6-[2...)
Affinity DataEC50:  670nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
LigandPNGBDBM46590(4-[[(E)-(2,3-dihydroxy-4-oxo-1-cyclohexa-2,5-dieny...)
Affinity DataEC50:  680nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
LigandPNGBDBM34972(SMR000369439 | N''-[(E)-(2,3-dihydroxy-4-oxo-1-cyc...)
Affinity DataKi:  750nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM34972(SMR000369439 | N''-[(E)-(2,3-dihydroxy-4-oxo-1-cyc...)
Affinity DataEC50:  794nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
LigandPNGBDBM47823(N-[2,5-bis(chloranyl)-3,6-bis(oxidanylidene)-4-(pr...)
Affinity DataEC50:  810nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
LigandPNGBDBM33066(cid_1002248 | 2,5-dichloro-3-[2-(dimethylamino)-5-...)
Affinity DataEC50:  840nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
LigandPNGBDBM25469(2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)sulfanyl]-1-o...)
Affinity DataEC50:  880nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
LigandPNGBDBM33097(MLS000521052 | cid_11957209 | 3-[[7-(1,3-benzothia...)
Affinity DataEC50:  980nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
LigandPNGBDBM47791(cid_6619971 | 2-(4,6-dimethyl-3-oxoisothiazolo[5,4...)
Affinity DataEC50:  990nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
LigandPNGBDBM47732(MLS000578271 | cid_2931388 | 9-(2-ethoxyphenyl)-2,...)
Affinity DataEC50:  1.00E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
LigandPNGBDBM47735(3-chloro-N-(3,3-dimethylbutan-2-yl)-6-nitro-1-benz...)
Affinity DataEC50:  1.02E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
LigandPNGBDBM38361(2-(4-pyrrolidin-1-ylsulfonylphenyl)-1,2-benzothiaz...)
Affinity DataEC50:  1.02E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
LigandPNGBDBM47734(cid_2922056 | SMR000172089 | N-[(8-Hydroxy-5-nitro...)
Affinity DataKi:  1.16E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH R21NS057014 HTS to identify small molecule regulators of RGS family protein interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2011
Entry Details
PCBioAssay
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