Compile Data Set for Download or QSAR
Report error Found 174 Enz. Inhib. hit(s) with Target = 'SRSF protein kinase 2'
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human SRPK2 using GRSRSRSRSR as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM50512854(CHEMBL4468747 | US11066363, Compound 37)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human SRPK2 using GRSRSRSRSR as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM50500357(CHEMBL3746522 | US11066363, Compound 31)
Affinity DataIC50: 6.60nMAssay Description:SRPK1 Inhibitory Activities of the Compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent

TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM50500359(CHEMBL3747611 | US11066363, Compound 13)
Affinity DataIC50: 7.46nMAssay Description:SRPK1 Inhibitory Activities of the Compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent

TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM50500351(CHEMBL3746960 | US11066363, Compound 19)
Affinity DataIC50: 8.57nMAssay Description:SRPK1 Inhibitory Activities of the Compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent

TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM50500356(CHEMBL3747406 | US11066363, Compound 7)
Affinity DataIC50: 12.4nMAssay Description:SRPK1 Inhibitory Activities of the Compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent

TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM504520(9-ethyl-6,6-dimethyl-11-oxo-8- (pyrimidin-5-yl)-6,...)
Affinity DataIC50: 12.5nMAssay Description:SRPK1 Inhibitory Activities of the Compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent

TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM504519((9-ethyl-6,6-dimethyl-11-oxo-8- (pyridin-4-yl)-6,1...)
Affinity DataIC50: 13.2nMAssay Description:SRPK1 Inhibitory Activities of the Compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent

TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM50500353(CHEMBL3746395 | US11066363, Compound 10)
Affinity DataIC50: 14.5nMAssay Description:SRPK1 Inhibitory Activities of the Compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent

TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM50355496(CHEMBL1908397)
Affinity DataKd:  15nMAssay Description:Binding constant for SRPK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM50500355(CHEMBL3747108 | US11066363, Compound 36)
Affinity DataIC50: 23.6nMAssay Description:SRPK1 Inhibitory Activities of the Compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent

TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM50362781(CHEMBL1738797 | US9126931, 366 | Alectinib | 12565...)
Affinity DataIC50: 28.2nMAssay Description:SRPK1 Inhibitory Activities of the Compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent

TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | Vargatef | US10981896, Co...)
Affinity DataKd:  36nMAssay Description:Binding constant for SRPK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  51nMAssay Description:Binding affinity to SRPK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  51nMAssay Description:Binding constant for SRPK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  67nMAssay Description:Binding constant for full-length SRPK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  67nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  67nMAssay Description:Binding constant for SRPK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM50617302(CHEMBL5085558)
Affinity DataIC50: 80nMAssay Description:Inhibition of human SRPK2 using GRSRSRSRSR as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM50512854(CHEMBL4468747 | US11066363, Compound 37)
Affinity DataIC50: 98nMAssay Description:Inhibition of SRPK2 (unknown origin) incubated for 1 hr in presence of ATP by fluorescent plate reader methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataKd:  100nMAssay Description:Binding constant for SRPK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM50617306(CHEMBL5435975)
Affinity DataIC50: 147nMAssay Description:Inhibition of human SRPK2 using GRSRSRSRSR as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM50617308(CHEMBL5397100)
Affinity DataIC50: 147nMAssay Description:Inhibition of human SRPK2 using GRSRSRSRSR as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM50617302(CHEMBL5085558)
Affinity DataEC50:  149nMAssay Description:Inhibition of N-terminal nLuc-fused SRPK2 (unknown origin) transfected in lysed HEK293T cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 185nMAssay Description:Inhibition of human SRPK2 using GRSRSRSRSR as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  190nMAssay Description:Binding constant for SRPK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  190nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  190nMAssay Description:Binding affinity to SRPK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  190nMAssay Description:Binding constant for full-length SRPK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  200nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  200nMAssay Description:Binding constant for SRPK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  200nMAssay Description:Binding constant for full-length SRPK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM50564378(CHEMBL4787157)
Affinity DataIC50: 203nMAssay Description:Inhibition of SRPK2 (unknown origin) incubated for 10 mins in presence of ATP by Kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM50617313(CHEMBL5405335)
Affinity DataIC50: 210nMAssay Description:Inhibition of human SRPK2 using GRSRSRSRSR as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 227nMAssay Description:Inhibition of human SRPK2 using GRSRSRSRSR as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM221074(US9695160, 12 | SPHINX31 | US9796707, Compound 12)
Affinity DataIC50: 256nMAssay Description:Inhibition of human SRPK2 using GRSRSRSRSR as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM50617299(CHEMBL5439515)
Affinity DataIC50: 260nMAssay Description:Inhibition of human SRPK2 using GRSRSRSRSR as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataKd:  290nMAssay Description:Binding constant for full-length SRPK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataKd:  290nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataKd:  290nMAssay Description:Binding constant for SRPK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM50617311(CHEMBL5416930)
Affinity DataIC50: 300nMAssay Description:Inhibition of human SRPK2 using GRSRSRSRSR as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  330nMAssay Description:Binding affinity to SRPK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM31094(PKC-412 | cid_24202429)
Affinity DataKd:  330nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  330nMAssay Description:Binding constant for SRPK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  330nMAssay Description:Binding constant for full-length SRPK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM50617312(CHEMBL5437009)
Affinity DataIC50: 340nMAssay Description:Inhibition of human SRPK2 using GRSRSRSRSR as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM50617310(CHEMBL5409896)
Affinity DataIC50: 460nMAssay Description:Inhibition of human SRPK2 using GRSRSRSRSR as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM50242737((R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimet...)
Affinity DataKd:  500nMAssay Description:Binding constant for SRPK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM50617297(CHEMBL5407046)
Affinity DataIC50: 510nMAssay Description:Inhibition of human SRPK2 using GRSRSRSRSR as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSRSF protein kinase 2(Human)TBA
LigandPNGBDBM50617307(CHEMBL5409387)
Affinity DataIC50: 626nMAssay Description:Inhibition of human SRPK2 using GRSRSRSRSR as substrate in presence of [gamma-33p]-ATP by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
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