Compile Data Set for Download or QSAR
Report error Found 6264 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase ATR'
LigandPNGBDBM350086(US10208027, Compound II-2 | 3-[3-[4-[dideuterio-(t...)
Affinity DataKi:  0.00800nMAssay Description:Inhibition of ATR (unknown origin) by Morrison equation based analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50585017(CERALASERTIB | Ceralasertib | Atr kinase inhibitor...)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of ATR (unknown origin) by Morrison equation based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50043407(CHEMBL3355476)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human ATR using ATP substrate measured after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
LigandPNGBDBM50513177(CHEMBL4444602)
Affinity DataKi:  0.140nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM350085(US10208027, Compound II-1 | US10208027, Compound I...)
Affinity DataKi:  0.148nMAssay Description:Compounds can be screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays are carried out in a mixt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2021
Entry Details
US Patent

LigandPNGBDBM350085(US10208027, Compound II-1 | US10208027, Compound I...)
Affinity DataKi:  0.148nMAssay Description:Compounds can be screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays are carried out in a mixt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

LigandPNGBDBM412060(US10392391, Compound I-G-32 | 2-amino-6-fluoro-N-[...)
Affinity DataKi: <0.150nMAssay Description:Binding affinity to ATR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM412060(US10392391, Compound I-G-32 | 2-amino-6-fluoro-N-[...)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of ATR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM350085(US10208027, Compound II-1 | US10208027, Compound I...)
Affinity DataKi:  0.165nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM350086(US10208027, Compound II-2 | 3-[3-[4-[dideuterio-(t...)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of ATR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM350085(US10208027, Compound II-1 | US10208027, Compound I...)
Affinity DataKi:  0.200nMAssay Description:Compounds can be screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays are carried out in a mixt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2021
Entry Details
US Patent

LigandPNGBDBM412060(US10392391, Compound I-G-32 | 2-amino-6-fluoro-N-[...)
Affinity DataKi: <0.200nMAssay Description:Binding affinity to ATR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
LigandPNGBDBM50043409(CHEMBL3355474)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human ATR using ATP substrate measured after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
LigandPNGBDBM350085(US10208027, Compound II-1 | US10208027, Compound I...)
Affinity DataKi:  0.200nMAssay Description:Compounds can be screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays are carried out in a mixt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

LigandPNGBDBM420857(US10479784, Compound IIA-10 | US10961232, Compound...)
Affinity DataKi:  0.210nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM420852(US10479784, Compound IIA-5 | US10961232, Compound ...)
Affinity DataKi:  0.270nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM50043385(CHEMBL3355072)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of ATR (unknown origin) using Avi-tagged protein substrate by alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
LigandPNGBDBM724380(US20250066350, Example RP3500)
Affinity DataIC50: 0.330nMAssay Description:Inhibition of ATR in gemcitabine-stimulated human LoVo cells assessed as decrease in CHK1 phosphorylation at Ser345 residueMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50043387(CHEMBL3355074)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of ATR (unknown origin) using Avi-tagged protein substrate by alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
LigandPNGBDBM50043408(CHEMBL3355475 | US20250051362, Comparative Compoun...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human ATR using ATP substrate measured after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
LigandPNGBDBM714736(US20250026742, Example 35-1)
Affinity DataIC50: 0.410nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

LigandPNGBDBM50043384(CHEMBL3355071)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of ATR (unknown origin) using Avi-tagged protein substrate by alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
LigandPNGBDBM50043411(CHEMBL3355480)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human ATR using ATP substrate measured after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
LigandPNGBDBM50043382(CHEMBL3355069)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of ATR (unknown origin) using Avi-tagged protein substrate by alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
LigandPNGBDBM97372(US20130089624, 1)
Affinity DataKi:  0.503nM ΔG°:  -53.1kJ/mole IC50: 200nMpH: 7.5 T: 2°CAssay Description:Assays were carried out in a mixture of 50 mM Tris/HCl (pH 7.5), 10 mM MgCl2 and 1 mM DTT. Final substrate concentrations were 10 μM [γ-33P]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2013
Entry Details
US Patent

TargetSerine/threonine-protein kinase ATR [14-953](Human)
Shanghai De Novo Pharmatech

US Patent
LigandPNGBDBM647614(US20240025899, Compound 3 | (R)-N,N-dimethyl-4-(3-...)
Affinity DataIC50: 0.510nMAssay Description:In this experiment, the phosphorylation level of substrate protein P53 (Eurofins, 14-952) was detected by HTRF technology to measure the activity of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM50513173(CHEMBL4566104)
Affinity DataKi:  0.530nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM714737(5-(5-amino-6-(5-(4-((1-methylpiperidin-4-yl)amino)...)
Affinity DataIC50: 0.570nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

LigandPNGBDBM268079(2-[(3R)-3-methylmorpholin-4-yl]-4-(1-methyl-1H-pyr...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of ATR in gemcitabine-stimulated human LoVo cells assessed as decrease in CHK1 phosphorylation at Ser345 residueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetSerine/threonine-protein kinase ATR [14-953](Human)
Shanghai De Novo Pharmatech

US Patent
LigandPNGBDBM647613(US20240025899, Compound 2 | (R)-3-methyl-4-(1-(met...)
Affinity DataIC50: 0.690nMAssay Description:In this experiment, the phosphorylation level of substrate protein P53 (Eurofins, 14-952) was detected by HTRF technology to measure the activity of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

LigandPNGBDBM714724(1-(4-(5-(3-amino-6-(4-(cyclopropylsulfonyl)phenyl)...)
Affinity DataIC50: 0.700nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

LigandPNGBDBM714739(US20250026742, Example 38-1)
Affinity DataIC50: 0.75nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

LigandPNGBDBM50513176(CHEMBL4448538)
Affinity DataKi:  0.75nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM714728(1-(4-(5-(3-amino)-6-(1,1-dioxo-2,3-dihydrobenzo[b]...)
Affinity DataIC50: 0.75nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

LigandPNGBDBM714738(5-(5-amino-6-(5-(4-((methylamino)methyl)phenyl)-1,...)
Affinity DataIC50: 0.770nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

LigandPNGBDBM730138(US12264155, Compound 24)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of ATR in human HeLa S3 cells assessed as decrease in CHK1 phosphorylation at Ser345 residue pretreated for 20 mins followed by gemcitabin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM714712(1-(4-(5-(3-amino-6-(4-(isopropylsulfonyl)phenyl)py...)
Affinity DataIC50: 0.820nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

LigandPNGBDBM714705(1-(4-(5-(3-amino-6-(4-isopropylsulfonyl)phenyl)pyr...)
Affinity DataIC50: 0.830nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

LigandPNGBDBM714734(US20250026742, Example 33-1)
Affinity DataIC50: 0.830nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

LigandPNGBDBM724380(US20250066350, Example RP3500)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of ATR in human HeLa S3 cells assessed as decrease in CHK1 phosphorylation at Ser345 residue pretreated for 20 mins followed by gemcitabin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM714735(5-(5-amino-6-(5-(4-((methylamino)methyl)phenyl)iso...)
Affinity DataIC50: 0.920nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

LigandPNGBDBM714718(1-(4-(5-(3-amino-6-(4-(isopropylsulfonyl)phenyl)py...)
Affinity DataIC50: 0.930nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

LigandPNGBDBM714664(1-(4-(5-(3-amino-6-(4-(isopropylsulfonyl)phenyl)py...)
Affinity DataIC50: 0.970nMAssay Description:Prepare various buffer systems required for the experiment:1. Prepare ATR reaction buffer containing 25 mM HEPES (Gibco, Cat #15630-080), 5 mM DTT (S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

LigandPNGBDBM350085(US10208027, Compound II-1 | US10208027, Compound I...)
Affinity DataKi: <1nMAssay Description:Compounds can be screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays are carried out in a mixt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2021
Entry Details
US Patent

LigandPNGBDBM50513181(CHEMBL4440048)
Affinity DataKi:  1nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM350085(US10208027, Compound II-1 | US10208027, Compound I...)
Affinity DataKi: <1nMAssay Description:Compounds can be screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays are carried out in a mixt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2021
Entry Details
US Patent

LigandPNGBDBM420609(US10479784, Compound IA-116 | US10961232, Compound...)
Affinity DataKi:  1nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM50513178(CHEMBL4434665)
Affinity DataKi:  1nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM50043386(CHEMBL3355073)
Affinity DataIC50: 1nMAssay Description:Inhibition of ATR (unknown origin) using Avi-tagged protein substrate by alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
LigandPNGBDBM50043383(CHEMBL3355070)
Affinity DataIC50: 1nMAssay Description:Inhibition of ATR (unknown origin) using Avi-tagged protein substrate by alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
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