Compile Data Set for Download or QSAR
Report error Found 2207 Enz. Inhib. hit(s) with Target = 'Sodium channel protein type 10 subunit alpha'
TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM732865(2-(4,4-difluoroazepan-1-yl)-6,7-difluoro-N-(3-sulf...)
Affinity DataIC50: 0.0710nMAssay Description:Clamped the cell at −80 mV and then depolarized to 10 mV with a square wave lasting 10 ms to get the Nav1.8 current (see FIG. 1 attached). This proce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM732865(2-(4,4-difluoroazepan-1-yl)-6,7-difluoro-N-(3-sulf...)
Affinity DataIC50: 0.0840nMAssay Description:A capillary glass pipette (BF150-86-10, Sutter Instruments) was pulled into a recording electrode with a micropipette puller (P97, Sutter Instruments...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM732866(2-(4,4-difluoroazepan-1-yl)-6,7-difluoro-N-(2-sulf...)
Affinity DataIC50: 0.0950nMAssay Description:A capillary glass pipette (BF150-86-10, Sutter Instruments) was pulled into a recording electrode with a micropipette puller (P97, Sutter Instruments...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM50547894(CHEMBL4760292 | US11377438, Example 172)
Affinity DataIC50: 0.300nMAssay Description:The following buffers were used for the Qube recordings: External buffer for Nav1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2022
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM50547894(CHEMBL4760292 | US11377438, Example 172)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human Nav1.8 expressed in HEK293 cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM686334(US20240246932, Example 22A)
Affinity DataIC50: 0.310nMAssay Description:NaV1.5 current measurements on Qube were obtained as follows: NaV1.5 currents were elicited with a 20 second 3 Hertz pulse train in the control condi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM732864(2-(4,4-difluoroazepan-1-yl)-N-(2-sulfamoylpyridine...)
Affinity DataIC50: 0.340nMAssay Description:A capillary glass pipette (BF150-86-10, Sutter Instruments) was pulled into a recording electrode with a micropipette puller (P97, Sutter Instruments...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM732867(N-(3-carbamoyl-4-fluorophenyl)-2-(4,4-difluoroazep...)
Affinity DataIC50: 0.360nMAssay Description:A capillary glass pipette (BF150-86-10, Sutter Instruments) was pulled into a recording electrode with a micropipette puller (P97, Sutter Instruments...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM50547925(CHEMBL4798938)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human Nav1.8 expressed in HEK cells applied electrical stimulus 10 Hz for 10 seconds measuring relaxation to the resting state followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM732863(N-(2-carbamoylpyridin-4-yl)-2-(4,4-difluoroazepan-...)
Affinity DataIC50: 0.460nMAssay Description:Clamped the cell at −80 mV and then depolarized to 10 mV with a square wave lasting 10 ms to get the Nav1.8 current (see FIG. 1 attached). This proce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM50547896(CHEMBL4777598 | US11377438, Example 184)
Affinity DataIC50: 0.5nMAssay Description:The following buffers were used for the Qube recordings: External buffer for Nav1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2022
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM50547896(CHEMBL4777598 | US11377438, Example 184)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human Nav1.8 expressed in HEK293 cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM686440(US20240246932, Example 79)
Affinity DataIC50: 0.580nMAssay Description:NaV1.5 current measurements on Qube were obtained as follows: NaV1.5 currents were elicited with a 20 second 3 Hertz pulse train in the control condi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM764441(US20250255878, Compound TM1-11)
Affinity DataIC50: 0.690nMAssay Description:The Nav1.8 current is evoked by a 20 ms step voltage pulse to −10 mV from a holding potential of −80 mV at every 10 sec. The maximum amount of peak c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM754079(2-(azepan-1-yl)-5-chloro-4,6-dimethyl-N-(3-sulfamo...)
Affinity DataIC50: 0.700nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM732864(2-(4,4-difluoroazepan-1-yl)-N-(2-sulfamoylpyridine...)
Affinity DataIC50: 0.725nMAssay Description:Clamped the cell at −80 mV and then depolarized to 10 mV with a square wave lasting 10 ms to get the Nav1.8 current (see FIG. 1 attached). This proce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM732863(N-(2-carbamoylpyridin-4-yl)-2-(4,4-difluoroazepan-...)
Affinity DataIC50: 0.784nMAssay Description:A capillary glass pipette (BF150-86-10, Sutter Instruments) was pulled into a recording electrode with a micropipette puller (P97, Sutter Instruments...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM50547926(CHEMBL4753280)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human Nav1.8 expressed in HEK cells applied electrical stimulus 10 Hz for 10 seconds measuring relaxation to the resting state followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM529546(US11203571, Compound 98 | 2,4-dichloro-6-(4-chloro...)
Affinity DataIC50: 0.800nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2022
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM560005(US11377438, Example 53)
Affinity DataIC50: 0.800nMAssay Description:The following buffers were used for the Qube recordings: External buffer for Nav1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2022
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM50547885(CHEMBL4781110 | US11377438, Example 18)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human Nav1.8 expressed in HEK293 cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM50547885(CHEMBL4781110 | US11377438, Example 18)
Affinity DataIC50: 0.900nMAssay Description:The following buffers were used for the Qube recordings: External buffer for Nav1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2022
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM529543(US11203571, Compound 95 | 2,4-dichloro-6-(4-fluoro...)
Affinity DataIC50: 0.900nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2022
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM732862(US20250115578, KH09 | US20250115578, Example 09)
Affinity DataIC50: 0.918nMAssay Description:Clamped the cell at −80 mV and then depolarized to 10 mV with a square wave lasting 10 ms to get the Nav1.8 current (see FIG. 1 attached). This proce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM181203(US9139529, 46 | US9783501, Compound 46)
Affinity DataIC50: 1nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2019
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM161329(US9163042, 1a | US9051270, 114 | US10087143, Compo...)
Affinity DataIC50: 1nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM50547890(CHEMBL4745699 | US11377438, Example 46)
Affinity DataIC50: 1nMAssay Description:Inhibition of human Nav1.8 expressed in HEK293 cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM161329(US9163042, 1a | US9051270, 114 | US10087143, Compo...)
Affinity DataIC50: 1nMAssay Description:1) Pre-spotted compounds (in neat DMSO) into compound plates. Vehicle control (neat DMSO), the positive control (20 mM DMSO stock tetracaine, 125 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM50330935(N-(m-Tolyl)-6-(4-ethoxyphenyl)-pyrazine-2-carboxam...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant NaV1.8 expressed in HEK293 cells by conventional voltage clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM529537(US11203571, Compound 89 | 2-(4-fluoro-2-methoxyphe...)
Affinity DataIC50: 1nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2022
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Rat)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM161329(US9163042, 1a | US9051270, 114 | US10087143, Compo...)
Affinity DataIC50: 1nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2016
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM529544(US11203571, Compound 96 | 2,4-dichloro-6-(4-fluoro...)
Affinity DataIC50: 1nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2022
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Rat)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM181203(US9139529, 46 | US9783501, Compound 46)
Affinity DataIC50: 1nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2016
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM161329(US9163042, 1a | US9051270, 114 | US10087143, Compo...)
Affinity DataIC50: 1nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2021
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Rat)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM161329(US9163042, 1a | US9051270, 114 | US10087143, Compo...)
Affinity DataIC50: 1nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2016
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM50547890(CHEMBL4745699 | US11377438, Example 46)
Affinity DataIC50: 1nMAssay Description:The following buffers were used for the Qube recordings: External buffer for Nav1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2022
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM732862(US20250115578, KH09 | US20250115578, Example 09)
Affinity DataIC50: 1nMAssay Description:A capillary glass pipette (BF150-86-10, Sutter Instruments) was pulled into a recording electrode with a micropipette puller (P97, Sutter Instruments...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/22/2025
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM529525(US11203571, Compound 77 | 4,5-dichloro-2-(4-fluoro...)
Affinity DataIC50: 1nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2022
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM161329(US9163042, 1a | US9051270, 114 | US10087143, Compo...)
Affinity DataIC50: 1nMAssay Description:Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM686404(US20240246932, Example 61A)
Affinity DataIC50: 1.02nMAssay Description:NaV1.5 current measurements on Qube were obtained as follows: NaV1.5 currents were elicited with a 20 second 3 Hertz pulse train in the control condi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM686437(US20240246932, Example 77B | US20240246932, Exampl...)
Affinity DataIC50: 1.06nMAssay Description:NaV1.5 current measurements on Qube were obtained as follows: NaV1.5 currents were elicited with a 20 second 3 Hertz pulse train in the control condi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM686263(US20240246932, Example 1A)
Affinity DataIC50: 1.09nMAssay Description:NaV1.5 current measurements on Qube were obtained as follows: NaV1.5 currents were elicited with a 20 second 3 Hertz pulse train in the control condi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM686408(US20240246932, Example 63A)
Affinity DataIC50: 1.12nMAssay Description:NaV1.5 current measurements on Qube were obtained as follows: NaV1.5 currents were elicited with a 20 second 3 Hertz pulse train in the control condi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM686359(US20240246932, Example 35)
Affinity DataIC50: 1.13nMAssay Description:NaV1.5 current measurements on Qube were obtained as follows: NaV1.5 currents were elicited with a 20 second 3 Hertz pulse train in the control condi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM686310(US20240246932, Example 10A)
Affinity DataIC50: 1.18nMAssay Description:NaV1.5 current measurements on Qube were obtained as follows: NaV1.5 currents were elicited with a 20 second 3 Hertz pulse train in the control condi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM560161(US11377438, Example 201)
Affinity DataIC50: 1.30nMAssay Description:The following buffers were used for the Qube recordings: External buffer for Nav1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2022
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM50547929(CHEMBL4744908)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human Nav1.8 expressed in HEK cells applied electrical stimulus 10 Hz for 10 seconds measuring relaxation to the resting state followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM686396(US20240246932, Example 56B)
Affinity DataIC50: 1.31nMAssay Description:NaV1.5 current measurements on Qube were obtained as follows: NaV1.5 currents were elicited with a 20 second 3 Hertz pulse train in the control condi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM764448(3-((2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-...)
Affinity DataIC50: 1.34nMAssay Description:The Nav1.8 current is evoked by a 20 ms step voltage pulse to −10 mV from a holding potential of −80 mV at every 10 sec. The maximum amount of peak c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Chengdu Kanghong Pharmaceutical Co.

US Patent
LigandPNGBDBM686390(US20240246932, Example 53B)
Affinity DataIC50: 1.38nMAssay Description:NaV1.5 current measurements on Qube were obtained as follows: NaV1.5 currents were elicited with a 20 second 3 Hertz pulse train in the control condi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
US Patent

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