Compile Data Set for Download or QSAR
Report error Found 545 Enz. Inhib. hit(s) with Target = 'Sodium channel protein type 4 subunit alpha'
TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118519(CHEMBL3617050)
Affinity DataIC50: 0.0620nMAssay Description:Inhibition of NaV1.4 channel (unknown origin) expressed in Xenopus laevis oocytes by two-electrode oocyte voltage-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2016
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM190233(US9174999, Table 1, Compound 1)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50595859(CHEMBL5192731)
Affinity DataIC50: 2nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50595862(CHEMBL5189924)
Affinity DataIC50: 2nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium channel protein type 4 subunit alpha(Rat)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM190233(US9174999, Table 1, Compound 1)
Affinity DataIC50: 2.40nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM70937(US9694002, 100 | US9546164, 100)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of full length human Nav1.4 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344821(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM145285(US8952169, 64 | US9771376, Example 64)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of full length human Nav1.4 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Rat)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM50582057(CHEMBL5077579)
Affinity DataEC50:  15nMAssay Description:Modulator activity at rat Nav1.4 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Rat)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM50582058(CHEMBL5093878)
Affinity DataEC50:  15nMAssay Description:Modulator activity at rat Nav1.4 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50595863(CHEMBL5184022)
Affinity DataIC50: 15nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium channel protein type 4 subunit alpha(Rat)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM190239(US9174999, Table 1, Compound 7)
Affinity DataIC50: 15nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM190233(US9174999, Table 1, Compound 1)
Affinity DataIC50: 19nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Rat)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM190241(US9174999, 10)
Affinity DataIC50: 19nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077469(CHEMBL3416888)
Affinity DataIC50: 20nMAssay Description:Inhibition of human NaV1.4 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Rat)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM190238(US9174999, Table 1, Compound 6)
Affinity DataIC50: 22.5nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50450603(CHEMBL4159473)
Affinity DataIC50: 23nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells at holding potential of -125 mV after 10 mins by patchxpress-based electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50450609(CHEMBL4170712)
Affinity DataIC50: 23nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells at holding potential of -125 mV after 10 mins by patchxpress-based electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141067(3-[4-(2,4-Difluoro-phenoxy)-phenyl]-pyrazole-1-car...)
Affinity DataKi:  25nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Rat)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM190234(US9174999, 8)
Affinity DataIC50: 26nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM76858(US9694002, 580 | US9546164, 580)
Affinity DataKd:  28nMAssay Description:Binding affinity to human recombinant Nav1.4 by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50051073(CHEMBL3318132)
Affinity DataIC50: 30nMAssay Description:Inhibition of human NaV1.4 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344821(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)
Affinity DataIC50: 30nMAssay Description:Inhibition of voltage-gated Na channel 1.4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha [I757A](Rat)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM190233(US9174999, Table 1, Compound 1)
Affinity DataIC50: 30nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141062(3-[4-(4-Fluoro-phenoxy)-phenyl]-pyrazole-1-carboxy...)
Affinity DataKi:  31nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141070(3-[4-(4-Nitro-phenoxy)-phenyl]-pyrazole-1-carboxyl...)
Affinity DataKi:  31nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50595856(CHEMBL5205795)
Affinity DataIC50: 32nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50595857(CHEMBL5192925)
Affinity DataIC50: 33nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141072(3-(4-Phenoxy-phenyl)-pyrazole-1-carboxylic acid am...)
Affinity DataKi:  35nMAssay Description:Affinity for inactive human SkM1 sodium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50450602(CHEMBL4167379)
Affinity DataIC50: 37nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells at holding potential of -125 mV after 10 mins by patchxpress-based electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50450610(CHEMBL4160074)
Affinity DataIC50: 39nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells at holding potential of -125 mV after 10 mins by patchxpress-based electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Rat)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM50582059(CHEMBL5082582)
Affinity DataEC50:  46nMAssay Description:Modulator activity at rat Nav1.4 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Rat)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM60830(US9174999, 13)
Affinity DataIC50: 46nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50505257(CHEMBL4471012)
Affinity DataKd:  47nMAssay Description:Binding affinity to human recombinant Nav1.4 by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Rat)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM50242400(CCNCSSKWCRDHSRCC | CHEMBL525818)
Affinity DataKd:  50nMAssay Description:Inhibition of rat Nav1.4 channel expressed in Xenopus oocytes by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50595858(CHEMBL5204844)
Affinity DataIC50: 51nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50450597(CHEMBL4160943)
Affinity DataIC50: 52nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells at holding potential of -125 mV after 10 mins by patchxpress-based electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50450580(CHEMBL4169884)
Affinity DataIC50: 53nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells at holding potential of -125 mV after 10 mins by patchxpress-based electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Rat)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM190237(US9174999, Table 1, Compound 5)
Affinity DataIC50: 55nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetSodium channel protein type 4 subunit alpha(Rat)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM50520482(CHEMBL4562161)
Affinity DataIC50: 69nMAssay Description:Inhibition of rat Nav1.4 expressed in HEK293 cells at -80 mV holding potential by whole cell patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077805(CHEMBL3416931)
Affinity DataIC50: 70nMAssay Description:Inhibition of human NaV1.4 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164184(CHEMBL3798824)
Affinity DataIC50: 70nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2017
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50450583(CHEMBL4174312)
Affinity DataIC50: 72nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells at holding potential of -125 mV after 10 mins by patchxpress-based electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50595861(CHEMBL5204544)
Affinity DataIC50: 75nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50051073(CHEMBL3318132)
Affinity DataIC50: 79nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Rat)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM50505256(CHEMBL4547737)
Affinity DataIC50: 83nMAssay Description:Inhibition of recombinant rat Nav1.4 expressed in CHO cells by whole cell voltage clamp electrophysiology recordingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSodium channel protein type 4 subunit alpha(Rat)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM190240(US9174999, 9)
Affinity DataIC50: 83nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetSodium channel protein type 4 subunit alpha(Rat)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM190243(US9174999, 12)
Affinity DataIC50: 87nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
US Patent

TargetSodium channel protein type 4 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50450590(CHEMBL4163637)
Affinity DataIC50: 89nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells at holding potential of -125 mV after 10 mins by patchxpress-based electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Rat)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM50242400(CCNCSSKWCRDHSRCC | CHEMBL525818)
Affinity DataIC50: 90nMAssay Description:Inhibition of rat Nav1.4 channel expressed in Xenopus oocytes by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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