Report error Found 5399 Enz. Inhib. hit(s) with Target = 'Son of sevenless homolog 1'
Affinity DataKi: <0.0100nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.0100nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: <0.0100nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.0100nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.0100nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.0100nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: <0.0100nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: <0.0100nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.0100nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.0200nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.0500nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.0700nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.0800nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.0900nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.110nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.110nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataKi: 0.110nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.120nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.170nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.230nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.240nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.240nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.25nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.25nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.25nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.25nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.25nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.270nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.280nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.290nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.290nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.310nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.310nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.320nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.330nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.330nMAssay Description:Binding affinity to SOS1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 0.330nMAssay Description:Binding affinity to SOS1 (unknown origin) assessed as inhibition constant by HTRF methodMore data for this Ligand-Target Pair
Affinity DataKi: 0.330nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKi: 0.350nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.360nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.360nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
Affinity DataKd: 0.366nMAssay Description:The purpose of this assay was to characterize the inhibitory activity of compounds on SOS1 nucleotide exchange of KRAS. Data was reported as IC50 val...More data for this Ligand-Target Pair
Affinity DataKi: 0.370nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.390nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.390nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
