Report error Found 95 Enz. Inhib. hit(s) with Target = 'Threonine--tRNA ligase'
Affinity DataKi: 0.700nMAssay Description:Binding affinity to Yersinia pestis ThrRS by coupled spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Binding affinity to human cytoplasmic ThrRS by coupled spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 1.80nMAssay Description:Binding affinity to human cytoplasmic ThrRS by coupled spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 1.80nMAssay Description:Binding affinity to Yersinia pestis ThrRS by coupled spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 1.80nMAssay Description:Binding affinity to Yersinia pestis ThrRS by coupled spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Binding affinity to Yersinia pestis ThrRS by coupled spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 2.20nMAssay Description:Binding affinity to Yersinia pestis ThrRS by coupled spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 2.70nMAssay Description:Binding affinity to Yersinia pestis ThrRS by coupled spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Binding affinity to human cytoplasmic ThrRS by coupled spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 3.30nMAssay Description:Binding affinity to human cytoplasmic ThrRS by coupled spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 3.90nMAssay Description:Binding affinity to Yersinia pestis ThrRS by coupled spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 4.10nMAssay Description:Binding affinity to human cytoplasmic ThrRS by coupled spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 5.20nMAssay Description:Binding affinity to human cytoplasmic ThrRS by coupled spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKd: 5.30nMAssay Description:Binding affinity to human TARS incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Affinity DataKi: 5.70nMAssay Description:Binding affinity to Yersinia pestis ThrRS by coupled spectrophotometryMore data for this Ligand-Target Pair
TargetThreonine--tRNA ligase, mitochondrial(Homo sapiens)
Johann Wolfgang Goethe University
Curated by ChEMBL
Johann Wolfgang Goethe University
Curated by ChEMBL
Affinity DataKd: 5.90nMAssay Description:Binding affinity to human TARS2 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Affinity DataKi: 8.20nMAssay Description:Binding affinity to Yersinia pestis ThrRS by coupled spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 9.30nMAssay Description:Binding affinity to Yersinia pestis ThrRS by coupled spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 9.80nMAssay Description:Binding affinity to Yersinia pestis ThrRS by coupled spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Binding affinity to human cytoplasmic ThrRS by coupled spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Binding affinity to human cytoplasmic ThrRS by coupled spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibitory activity against cognate Staphylococcus aureus threonyl tRNA synthetaseMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant salmonella enterica threonyl-tRNA synthetase assessed as reduction in enzyme activity incubated for 20 min by Kinase Glo lu...More data for this Ligand-Target Pair
Affinity DataKi: 23nMAssay Description:Binding affinity to Yersinia pestis ThrRS by coupled spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Binding affinity to Yersinia pestis ThrRS by coupled spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 32nMAssay Description:Binding affinity to human cytoplasmic ThrRS by coupled spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKd: 35nMAssay Description:Binding affinity to full length recombinant salmonella enterica threonyl-tRNA synthetase assessed as dissociation constant by isothermal titration ca...More data for this Ligand-Target Pair
Affinity DataKd: 37nMAssay Description:Binding affinity to full length recombinant salmonella enterica threonyl-tRNA synthetase assessed as dissociation constant in presence of tRNA Leucin...More data for this Ligand-Target Pair
Affinity DataKi: 39nMAssay Description:Binding affinity to Yersinia pestis ThrRS by coupled spectrophotometryMore data for this Ligand-Target Pair
Targetthreonine--tRNA ligase(Plasmodium falciparum (isolate 3D7))
Latvian Institute of Organic Synthesis
Curated by ChEMBL
Latvian Institute of Organic Synthesis
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Inhibition of Plasmodium falciparum Threonyl tRNA synthetaseMore data for this Ligand-Target Pair
Affinity DataKd: 44nMAssay Description:Binding affinity to full length recombinant salmonella enterica threonyl-tRNA synthetase assessed as dissociation constant in presence of glycine by ...More data for this Ligand-Target Pair
Affinity DataKd: 49nMAssay Description:Inhibition of human cytosolic ThrRS assessed as dissociation constant by isothermal titration calorimetryMore data for this Ligand-Target Pair
Ligand InfoSimilars
Targetthreonine--tRNA ligase(Plasmodium falciparum (isolate 3D7))
Latvian Institute of Organic Synthesis
Curated by ChEMBL
Latvian Institute of Organic Synthesis
Curated by ChEMBL
Affinity DataIC50: 57nMAssay Description:Inhibition of Plasmodium falciparum Threonyl tRNA synthetaseMore data for this Ligand-Target Pair
Affinity DataKd: 58nMAssay Description:Binding affinity to human TARS incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Affinity DataKi: 70nMAssay Description:Binding affinity to Yersinia pestis ThrRS by coupled spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 72nMAssay Description:Binding affinity to human cytoplasmic ThrRS by coupled spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKd: 75nMAssay Description:Binding affinity to full length recombinant salmonella enterica threonyl-tRNA synthetase assessed as dissociation constant in presence of ATP by isot...More data for this Ligand-Target Pair
Affinity DataKi: 83nMAssay Description:Binding affinity to Yersinia pestis ThrRS by coupled spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 91nMAssay Description:Binding affinity to human cytoplasmic ThrRS by coupled spectrophotometryMore data for this Ligand-Target Pair
Targetthreonine--tRNA ligase(Plasmodium falciparum (isolate 3D7))
Latvian Institute of Organic Synthesis
Curated by ChEMBL
Latvian Institute of Organic Synthesis
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of 6xHis-tag recombinant Plasmodium falciparum threonyl tRNA synthetase expressed in Escherichia using L-threonine and total tRNA by lumin...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 103nMAssay Description:Inhibition of recombinant salmonella enterica threonyl-tRNA synthetase assessed as reduction in enzyme activity incubated for 20 min by Kinase Glo lu...More data for this Ligand-Target Pair
Affinity DataKi: 115nMAssay Description:Binding affinity to Yersinia pestis ThrRS by coupled spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKd: 115nMAssay Description:Inhibition of human cytosolic ThrRS assessed as dissociation constant by isothermal titration calorimetryMore data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataKd: 126nMAssay Description:Inhibition of human cytosolic ThrRS assessed as dissociation constant by isothermal titration calorimetryMore data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataKi: 132nMAssay Description:Binding affinity to Yersinia pestis ThrRS by coupled spectrophotometryMore data for this Ligand-Target Pair
Targetthreonine--tRNA ligase(Plasmodium falciparum (isolate 3D7))
Latvian Institute of Organic Synthesis
Curated by ChEMBL
Latvian Institute of Organic Synthesis
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of Plasmodium falciparum Threonyl tRNA synthetaseMore data for this Ligand-Target Pair
Targetthreonine--tRNA ligase(Plasmodium falciparum (isolate 3D7))
Latvian Institute of Organic Synthesis
Curated by ChEMBL
Latvian Institute of Organic Synthesis
Curated by ChEMBL
Affinity DataKi: 160nMAssay Description:Inhibition of Plasmodium falciparum Threonyl tRNA synthetase expressed in Escherichia coli Rossetta 2 (DE3) assessed as apparent inhibition constant ...More data for this Ligand-Target Pair
Affinity DataKd: 166nMAssay Description:Binding affinity to full length recombinant salmonella enterica threonyl-tRNA synthetase assessed as dissociation constant in presence of tRNA Threon...More data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of recombinant salmonella enterica threonyl-tRNA synthetase assessed as reduction in enzyme activity incubated for 20 min by Kinase Glo lu...More data for this Ligand-Target Pair
Affinity DataIC50: 194nMAssay Description:Inhibition of recombinant salmonella enterica threonyl-tRNA synthetase assessed as reduction in enzyme activity incubated for 20 min by Kinase Glo lu...More data for this Ligand-Target Pair

3D Structure (crystal)

























