Compile Data Set for Download or QSAR
Report error Found 607 Enz. Inhib. hit(s) with Target = 'Transcriptional enhancer factor TEF-1'
LigandPNGBDBM50626276(CHEMBL5198469)
Affinity DataIC50: 1nMAssay Description:Inhibition of N-terminal His-tagged TEAD1 (unknown origin) (209 to 426 residues) expressed in Escherichia coli BL21 by chromatography analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM699325(2-chloro-N-methyl-N-((1-(4- (trifluoromethoxy)phen...)
Affinity DataIC50: 2.90nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

LigandPNGBDBM50630292(US12110276, Compound 49 | CHEMBL5408536)
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged TEAD1 (unknown origin) preincubated for 0.5 to 4 hrs followed by biotinylated lipid pocket probe addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50629174(CHEMBL5422959)
Affinity DataIC50: 3nMAssay Description:Displacement of biotinylated lipid pocket probes from His-tagged TEAD1 (unknown origin) preincubated for 4 hrs followed by lipid pocket probe additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM50630290(CHEMBL5438256)
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged TEAD1 (unknown origin) preincubated for 0.5 to 4 hrs followed by biotinylated lipid pocket probe addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50629172(CHEMBL5401444)
Affinity DataIC50: 3nMAssay Description:Displacement of biotinylated lipid pocket probes from His-tagged TEAD1 (unknown origin) preincubated for 4 hrs followed by lipid pocket probe additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM50630292(US12110276, Compound 49 | CHEMBL5408536)
Affinity DataIC50: 3.05nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

LigandPNGBDBM699311(2-chloro-N-((1-(4- (trifluoromethoxy)phenyl)-1H-in...)
Affinity DataIC50: 3.30nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

LigandPNGBDBM699405((Z)-3-chloro-N-[[4-(hydroxymethyl)-1- [4- (trifluo...)
Affinity DataIC50: 3.30nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

LigandPNGBDBM50630291(US12110276, Compound 48 | CHEMBL5411200)
Affinity DataIC50: 3.5nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

LigandPNGBDBM50630293(US12110276, Compound 86 | CHEMBL5403826)
Affinity DataIC50: 3.60nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

LigandPNGBDBM50630293(US12110276, Compound 86 | CHEMBL5403826)
Affinity DataIC50: 4nMAssay Description:Inhibition of His-tagged TEAD1 (unknown origin) preincubated for 0.5 to 4 hrs followed by biotinylated lipid pocket probe addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50630291(US12110276, Compound 48 | CHEMBL5411200)
Affinity DataIC50: 4nMAssay Description:Inhibition of His-tagged TEAD1 (unknown origin) preincubated for 0.5 to 4 hrs followed by biotinylated lipid pocket probe addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50629173(CHEMBL5415215)
Affinity DataIC50: 4nMAssay Description:Displacement of biotinylated lipid pocket probes from His-tagged TEAD1 (unknown origin) preincubated for 4 hrs followed by lipid pocket probe additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM50629170(CHEMBL5419829)
Affinity DataIC50: 4nMAssay Description:Displacement of biotinylated lipid pocket probes from His-tagged TEAD1 (unknown origin) preincubated for 4 hrs followed by lipid pocket probe additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM699310(N-((1-(4-(trifluoromethoxy)phenyl)- 1H-indazol-3-y...)
Affinity DataIC50: 5.30nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

LigandPNGBDBM50629171(CHEMBL5416415)
Affinity DataIC50: 6nMAssay Description:Displacement of biotinylated lipid pocket probes from His-tagged TEAD1 (unknown origin) preincubated for 4 hrs followed by lipid pocket probe additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM699375((E)-4,4-difluoro-N-[[4- (hydroxymethyl)-1-[4- (tri...)
Affinity DataIC50: 6.10nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

LigandPNGBDBM699434(4-hydroxy-N-[[4-(hydroxymethyl)-1- [4- (trifluorom...)
Affinity DataIC50: 6.5nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

LigandPNGBDBM699324(N-methyl-N-((1-(4- (trifluoromethoxy)phenyl)-1H-in...)
Affinity DataIC50: 6.80nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

LigandPNGBDBM699343((E)-3-chloro-N-[[4-(hydroxymethyl)-1- [4- (trifluo...)
Affinity DataIC50: 6.90nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

LigandPNGBDBM699312(N-((1-(4-(pentafluoro-lambda6- sulfaneyl)phenyl)-1...)
Affinity DataIC50: 7nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

LigandPNGBDBM50629175(CHEMBL5400400)
Affinity DataIC50: 7nMAssay Description:Displacement of biotinylated lipid pocket probes from His-tagged TEAD1 (unknown origin) preincubated for 4 hrs followed by lipid pocket probe additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM699494(N-((1-(4-(trifluoromethoxy)phenyl)- 1H-pyrazolo[3,...)
Affinity DataIC50: 7.20nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

LigandPNGBDBM50630295(US12110276, Compound 127 | CHEMBL5428867)
Affinity DataIC50: 7.90nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

LigandPNGBDBM50630295(US12110276, Compound 127 | CHEMBL5428867)
Affinity DataIC50: 8nMAssay Description:Inhibition of His-tagged TEAD1 (unknown origin) preincubated for 0.5 to 4 hrs followed by biotinylated lipid pocket probe addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM699342(N-[[4-(2-hydroxyethylamino)-1-[4- (trifluoromethox...)
Affinity DataIC50: 9.20nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

LigandPNGBDBM50630294(US12110276, Compound 112 | CHEMBL5432828)
Affinity DataIC50: 9.30nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

LigandPNGBDBM699408((E)-3-chloro-1-[3-[4-(hydroxymethyl)- 1-[4- (trifl...)
Affinity DataIC50: 10nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

LigandPNGBDBM626350(2-[[[4-cyano-7-(4-isopropyl-2- thienyl)-2,3-dihyd...)
Affinity DataIC50: 10nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

LigandPNGBDBM699319(N-((1-(4-(pentafluoro-lambda6- sulfaneyl)phenyl)-1...)
Affinity DataIC50: 10nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

LigandPNGBDBM50630294(US12110276, Compound 112 | CHEMBL5432828)
Affinity DataIC50: 10nMAssay Description:Inhibition of His-tagged TEAD1 (unknown origin) preincubated for 0.5 to 4 hrs followed by biotinylated lipid pocket probe addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM626350(2-[[[4-cyano-7-(4-isopropyl-2- thienyl)-2,3-dihyd...)
Affinity DataIC50: 10nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

LigandPNGBDBM699402((E)-4-hydroxy-1-[3-[4-methyl-1-[4- (trifluorometho...)
Affinity DataIC50: 10nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

LigandPNGBDBM626331(US11787775, Compound 16-C)
Affinity DataEC50:  10nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

LigandPNGBDBM699395(cyclobuten-1-yl-[3-[4- (hydroxymethyl)-1-[4- (trif...)
Affinity DataIC50: 11nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

LigandPNGBDBM50639695(CHEMBL5433922)
Affinity DataIC50: 11nMAssay Description:Inhibition of N-terminal His-tagged human TEAD1 expressed in Escherichia coli BL21 (DE3) (209 to 424 residues) by affinity chromatography analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM699469(Cyclobut-1-en-1-yl(3-(1-(4- (trifluoromethoxy)phen...)
Affinity DataIC50: 11nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

LigandPNGBDBM699438((E)-4,4,4-trifluoro-N-[[4- (hydroxymethyl)-1-[4- (...)
Affinity DataIC50: 12nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

LigandPNGBDBM699326(2-fluoro-1-[3-[4-(hydroxymethyl)-1-[4- (trifluorom...)
Affinity DataIC50: 12nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

LigandPNGBDBM699338(N-[[4-(hydroxymethyl)-1-[4- (trifluoromethoxy)phen...)
Affinity DataIC50: 13nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

LigandPNGBDBM699349(N-[[4-[3-(hydroxymethyl)azetidin-1- yl]-1-[4- (tri...)
Affinity DataIC50: 13nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

LigandPNGBDBM699420(1-[3-[4-[(1R)-1,2-dihydroxyethyl]-1- [4- (trifluor...)
Affinity DataIC50: 14nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

LigandPNGBDBM699440(N-[[4-(1H-pyrazol-4-yl)-1-[4- (trifluoromethoxy)ph...)
Affinity DataIC50: 14nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

LigandPNGBDBM699358(N-[[4-(3-cyanoazetidin-1-yl)-1-[4- (trifluorometho...)
Affinity DataIC50: 14nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

LigandPNGBDBM699400((E)-4-hydroxy-1-[3-[4- (hydroxymethyl)-1-[4- (trif...)
Affinity DataIC50: 15nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

LigandPNGBDBM50497300(CHEMBL3335461)
Affinity DataKd:  15nMAssay Description:Inhibition of YAP/ GST-TEAD1 interaction in human Bel-7404 cells by GST pull-down assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
LigandPNGBDBM50271260(CHEMBL4130196)
Affinity DataKd:  15nMAssay Description:Binding affinity to human GST-tagged TEAD1 (194 to 411) expressed in Escherichia coli BL21(DE3) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2020
Entry Details Article
PubMed
LigandPNGBDBM699412(N-[[4-(3-hydroxyazetidin-1-yl)-1-[4- (trifluoromet...)
Affinity DataIC50: 15.5nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

LigandPNGBDBM699424(N-[[4-(3-methoxyazetidin-1-yl)-1-[4- (trifluoromet...)
Affinity DataIC50: 16nMAssay Description:His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid pocket probe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2025
Entry Details
US Patent

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