Compile Data Set for Download or QSAR
Report error Found 33 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2 [V617F]'
TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 50332294BDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 3.69nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 50332294BDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 3.78nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 50332294BDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 4.05nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 50332294BDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 4.05nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 50332294BDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 4.06nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 50332294BDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 4.55nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 433329BDBM433329(US10561657, Example 7)
Affinity DataIC50: 20nMAssay Description:A testing platform for kinase activity of JAK2 (wild type and V617F mutant type) was established based on Homogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 433324BDBM433324(US10561657, Example 1)
Affinity DataIC50: 20nMAssay Description:A testing platform for kinase activity of JAK2 (wild type and V617F mutant type) was established based on Homogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 433323BDBM433323(US10561657, Ruxolitinib | US10617692, Ruxolitinib ...)
Affinity DataIC50: 20nMAssay Description:A testing platform for kinase activity of JAK2 (wild type and V617F mutant type) was established based on Homogeneous Time-Resolved Fluorescence (HTR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 608216BDBM608216(US11691971, Example 8)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 608210BDBM608210(US11691971, Example 2)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 608213BDBM608213(US11691971, Example 5)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 608209BDBM608209(US11691971, Example 1)
Affinity DataIC50: 300nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 608212BDBM608212(US11691971, Example 4)
Affinity DataIC50: 300nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 608222BDBM608222(US11691971, Example 14)
Affinity DataIC50: 300nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 608211BDBM608211(US11691971, Example 3)
Affinity DataIC50: 300nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 608220BDBM608220(US11691971, Example 12)
Affinity DataIC50: 750nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 608226BDBM608226(US11691971, Example 18)
Affinity DataIC50: 750nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 608224BDBM608224(US11691971, Example 16)
Affinity DataIC50: 750nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 608223BDBM608223(US11691971, Example 15)
Affinity DataIC50: 750nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 608225BDBM608225(US11691971, Example 17)
Affinity DataIC50: 5.50E+3nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 608219BDBM608219(US11691971, Example 11)
Affinity DataIC50: 5.50E+3nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 608232BDBM608232(US11691971, Example 24)
Affinity DataIC50: 5.50E+3nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 608221BDBM608221(US11691971, Example 13)
Affinity DataIC50: 5.50E+3nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 608228BDBM608228(US11691971, Example 20)
Affinity DataIC50: 5.50E+3nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 608217BDBM608217(US11691971, Example 9)
Affinity DataIC50: 5.50E+3nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 608227BDBM608227(US11691971, Example 19)
Affinity DataIC50: 5.50E+3nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 608218BDBM608218(US11691971, Example 10)
Affinity DataIC50: 5.50E+3nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 608214BDBM608214(US11691971, Example 6)
Affinity DataIC50: 1.00E+4nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 608230BDBM608230(US11691971, Example 22)
Affinity DataIC50: 1.00E+4nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 608215BDBM608215(US11691971, Example 7)
Affinity DataIC50: 1.00E+4nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 608231BDBM608231(US11691971, Example 23)
Affinity DataIC50: 1.00E+4nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [V617F](Human)
Shenzhen Targetrx

US Patent
LigandChemical structure of BindingDB Monomer ID 608229BDBM608229(US11691971, Example 21)
Affinity DataIC50: 1.00E+4nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent