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Report error Found 573 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase ZAP-70'
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM103511(US8546370, 17)
Affinity DataIC50: 1nMAssay Description:Homogenous time-resolved fluorescence assay using Syk enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2014
Entry Details
US Patent

TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of N-terminal GST-fused human recombinant full length ZAP70 (1 to 619 residues) expressed in baculovirus-infected Sf21 cells using FAM-22 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human ZAP70 using poly[Glu:Tyr] (4:1) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of ZAP70 (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM103519(US8546370, 164)
Affinity DataIC50: 2nMAssay Description:Homogenous time-resolved fluorescence assay using Syk enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2014
Entry Details
US Patent

TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM103512(US8546370, 83)
Affinity DataIC50: 3nMAssay Description:Homogenous time-resolved fluorescence assay using Syk enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2014
Entry Details
US Patent

TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human ZAP70 using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50628376(CHEMBL5416354)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of ZAP-70 (unknown origin) using ULight-TK peptide as substrate incubated for 120 mins in presence of ATP by Lance Ultra Kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50628378(CHEMBL5415461)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of ZAP-70 (unknown origin) using ULight-TK peptide as substrate incubated for 120 mins in presence of ATP by Lance Ultra Kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50075735(CHEMBL3415583)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of GST-fused Zap70 (unknown origin) expressed in insect SF9 cells using biotin-EQEDEPEGDYFEWLE-CONH2 as substrate preincubated for 10 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50075735(CHEMBL3415583)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of LCK activated GST-fused ZAP70 (unknown origin) expressed in fall armyworm sf9 cells preincubated for 10 mins followed by biotin-EQEDEPE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2018
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of human ZAP70 using poly[Glu:Tyr] (4:1) as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM103524(US8546370, 304)
Affinity DataIC50: 8nMAssay Description:Homogenous time-resolved fluorescence assay using Syk enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2014
Entry Details
US Patent

TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM103522(US8546370, 190)
Affinity DataIC50: 8nMAssay Description:Homogenous time-resolved fluorescence assay using Syk enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2014
Entry Details
US Patent

TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50083639({4-[6-((S)-3-Ethyl-piperazin-1-yl)-pyridin-3-yl]-p...)
Affinity DataIC50: 8nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa phosphorylation of polyGly-Tyr.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of ZAP70 using biotinylated substrate preincubated for 15 mins before substrate addition measured after 30 mins by fluorescence microplate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50628379(CHEMBL5404631)
Affinity DataIC50: 8.90nMAssay Description:Inhibition of ZAP-70 (unknown origin) using ULight-TK peptide as substrate incubated for 120 mins in presence of ATP by Lance Ultra Kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM103512(US8546370, 83)
Affinity DataIC50: 9nMAssay Description:Homogenous time-resolved fluorescence assay using Syk enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2014
Entry Details
US Patent

TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50628374(CHEMBL5417597)
Affinity DataIC50: 9.40nMAssay Description:Inhibition of ZAP-70 (unknown origin) using ULight-TK peptide as substrate incubated for 120 mins in presence of ATP by Lance Ultra Kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50442760(CHEMBL2443044)
Affinity DataIC50: 10nMAssay Description:Inhibition of ZAP70 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50442759(CHEMBL2443138)
Affinity DataIC50: 10nMAssay Description:Inhibition of ZAP70 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50300382(4-(4-(5-chloro-4-(2-(propylsulfonyl)phenylamino)py...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human GST-fused ZAP-70 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50442758(CHEMBL2443139)
Affinity DataIC50: 10nMAssay Description:Inhibition of ZAP70 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50442757(CHEMBL2443026)
Affinity DataIC50: 10nMAssay Description:Inhibition of ZAP70 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of ZAP70 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50300401(2-(5-bromo-2-(2,3-dihydro-1H-inden-4-ylamino)pyrim...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human GST-fused ZAP-70 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50628377(CHEMBL5397244)
Affinity DataIC50: 10nMAssay Description:Inhibition of ZAP-70 (unknown origin) using ULight-TK peptide as substrate incubated for 120 mins in presence of ATP by Lance Ultra Kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50083638({4-[6-((S)-3-Methyl-piperazin-1-yl)-pyridin-3-yl]-...)
Affinity DataIC50: 11nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa phosphorylation of polyGly-Tyr.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 12.4nMAssay Description:Inhibition of human ZAP70 using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50548351(CHEMBL4786316)
Affinity DataKd:  14nMAssay Description:Binding affinity to ZAP70 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50013165(CHEMBL3262616)
Affinity DataIC50: 14nMAssay Description:Inhibition of ZAP70 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50628372(CHEMBL5414412)
Affinity DataIC50: 15nMAssay Description:Inhibition of ZAP-70 (unknown origin) using ULight-TK peptide as substrate incubated for 120 mins in presence of ATP by Lance Ultra Kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  16nMAssay Description:Binding affinity to ZAP70More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  16nMAssay Description:Binding constant for ZAP70 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50013170(CHEMBL3262622)
Affinity DataIC50: 18nMAssay Description:Inhibition of ZAP70 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM60665(US9145414, R406 | US9212178, R406 | BDBM50249542 |...)
Affinity DataKd:  21nMAssay Description:Binding constant for ZAP70 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM103521(US8546370, 183)
Affinity DataIC50: 24nMAssay Description:Homogenous time-resolved fluorescence assay using Syk enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2014
Entry Details
US Patent

TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50083649({4-[6-(3-Methyl-piperazin-1-yl)-pyridin-3-yl]-pyri...)
Affinity DataIC50: 26nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa phosphorylation of polyGly-Tyr.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50503098(CHEMBL4582324)
Affinity DataEC50:  28nMAssay Description:Effect on ZAP70 phosphorylation in human Jurkat cells pre-incubated for 30 mins followed by anti-CD3/CD28 stimulation measured after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50069336(NQLPpYNELNLGRREEpYDVLD | NELNLGRREE | CHEMBL439120)
Affinity DataIC50: 30nMAssay Description:Inhibition of binding to human ZAP-70 SH2 domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50069336(NQLPpYNELNLGRREEpYDVLD | NELNLGRREE | CHEMBL439120)
Affinity DataIC50: 30nMAssay Description:Antagonistic activity against SH2 domain of Zeta-chain (TCR) associated protein kinase, ZAP-70More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50083640([4-(6-[1,4]Diazepan-1-yl-pyridin-3-yl)-pyrimidin-2...)
Affinity DataIC50: 31nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa phosphorylation of polyGly-Tyr.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM103530(US8546370, 643)
Affinity DataIC50: 31nMAssay Description:Homogenous time-resolved fluorescence assay using Syk enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2014
Entry Details
US Patent

TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50628375(CHEMBL5434338)
Affinity DataIC50: 31nMAssay Description:Inhibition of ZAP-70 (unknown origin) using ULight-TK peptide as substrate incubated for 120 mins in presence of ATP by Lance Ultra Kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50013162(CHEMBL3262357)
Affinity DataIC50: 33nMAssay Description:Inhibition of ZAP70 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50300383(4-(4-(5-chloro-4-(2-(propylsulfonyl)phenylamino)py...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human GST-fused ZAP-70 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50274757(5-((1S,2R)-2-Aminocyclohexylamino)-7-(3,5-dimethox...)
Affinity DataIC50: 41nMAssay Description:Inhibition of human ZAP70 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50503102(CHEMBL4445994)
Affinity DataEC50:  41nMAssay Description:Effect on ZAP70 phosphorylation in human Jurkat cells pre-incubated for 30 mins followed by anti-CD3/CD28 stimulation measured after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM50503095(CHEMBL4577049)
Affinity DataEC50:  42nMAssay Description:Effect on ZAP70 phosphorylation in human Jurkat cells pre-incubated for 30 mins followed by anti-CD3/CD28 stimulation measured after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Irm

US Patent
LigandPNGBDBM60665(US9145414, R406 | US9212178, R406 | BDBM50249542 |...)
Affinity DataIC50: 42nMAssay Description:Inhibition of ZAP70 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
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