Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with Target = 'Glycine--tRNA ligase'
TargetGlycine--tRNA ligase(Homo sapiens)TBA
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  37nMAssay Description:Binding affinity to human GARS incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetGlycine--tRNA ligase(Silk moth)
Medical College of Ohio

LigandPNGBDBM18138(5-O-[N-(L-glycyl)sulfamoyl]adenosine | 2-amino-1-[...)
Affinity DataKi:  50nM ΔG°:  -41.7kJ/mole IC50: 2.00E+3nM Kd:  270nMpH: 7.5 T: 2°CAssay Description:Aminoacyl-tRNA synthetase assays were measuring the incorporation of [14C] amino acid into tRNA.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2007
Entry Details Article
PubMed
TargetGlycine--tRNA ligase(Silk moth)
Medical College of Ohio

LigandPNGBDBM18135(adenylylmethylenediphosphonate | CHEMBL133463 | ({...)
Affinity DataKi:  800nM ΔG°:  -34.8kJ/mole IC50: 1.00E+4nMpH: 7.5 T: 2°CAssay Description:Aminoacyl-tRNA synthetase assays were measuring the incorporation of [14C] amino acid into tRNA.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2007
Entry Details Article
PubMed
TargetGlycine--tRNA ligase(Homo sapiens)TBA
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GARS (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetGlycine--tRNA ligase(Silk moth)
Medical College of Ohio

LigandPNGBDBM2(CHEMBL14249 | ({[({[(2R,3S,4R,5R)-5-(6-amino-9H-pu...)
Affinity DataKi:  1.30E+4nM ΔG°:  -27.9kJ/mole IC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:Aminoacyl-tRNA synthetase assays were measuring the incorporation of [14C] amino acid into tRNA.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2007
Entry Details Article
PubMed
TargetGlycine--tRNA ligase(Homo sapiens)TBA
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  1.76E+4nMAssay Description:Binding affinity to human GARS incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetGlycine--tRNA ligase(Silk moth)
Medical College of Ohio

LigandPNGBDBM18134(AMP.P[NH]P | 5-Adenylyl imidodiphosphate | ({[({[(...)
Affinity DataKi:  2.00E+4nM ΔG°:  -26.8kJ/mole IC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:Aminoacyl-tRNA synthetase assays were measuring the incorporation of [14C] amino acid into tRNA.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2007
Entry Details Article
PubMed
TargetGlycine--tRNA ligase(Silk moth)
Medical College of Ohio

LigandPNGBDBM18136(alpha, beta-methyleneadenosine 5 -diphosphate | ci...)
Affinity DataKi:  6.00E+4nM ΔG°:  -24.1kJ/mole IC50: 6.00E+5nMpH: 7.5 T: 2°CAssay Description:Aminoacyl-tRNA synthetase assays were measuring the incorporation of [14C] amino acid into tRNA.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2007
Entry Details Article
PubMed
TargetGlycine--tRNA ligase(Silk moth)
Medical College of Ohio

LigandPNGBDBM18137(adenosine 5 -monophosphate | CHEMBL752 | [(2R,3S,4...)
Affinity DataKi:  8.00E+4nM ΔG°:  -23.4kJ/mole IC50: 8.00E+5nMpH: 7.5 T: 2°CAssay Description:Aminoacyl-tRNA synthetase assays were measuring the incorporation of [14C] amino acid into tRNA.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2007
Entry Details Article
PubMed