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Found 48 with Last Name = 'tosco' and Initial = 'a'
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50081125(CHEMBL3421961)
Affinity DataKi:  2.00E+3nMAssay Description:Noncompetitive inhibition of P300 (unknown origin) using acetyl CoA as substrate after 15 mins by double reciprocal plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50081125(CHEMBL3421961)
Affinity DataKi:  9.40E+3nMAssay Description:Noncompetitive inhibition of P300 (unknown origin) using biotinylated H3 as substrate after 15 mins by double reciprocal plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCREB-binding protein(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50081125(CHEMBL3421961)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of recombinant CBP (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50081162(CHEMBL3421943)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of P300 (unknown origin) using histone H3/[acetyl-3H]-acetyl coenzyme A as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50081170(CHEMBL3421960)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of P300 (unknown origin) using histone H3/[acetyl-3H]-acetyl coenzyme A as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50081160(CHEMBL3421941)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of P300 (unknown origin) using histone H3/[acetyl-3H]-acetyl coenzyme A as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50081159(CHEMBL3421940)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of P300 (unknown origin) using histone H3/[acetyl-3H]-acetyl coenzyme A as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50081125(CHEMBL3421961)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of recombinant P300 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50081168(CHEMBL3421950)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of P300 (unknown origin) using histone H3/[acetyl-3H]-acetyl coenzyme A as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50081166(CHEMBL3421948)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of P300 (unknown origin) using histone H3/[acetyl-3H]-acetyl coenzyme A as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50081161(CHEMBL3421942)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of P300 (unknown origin) using histone H3/[acetyl-3H]-acetyl coenzyme A as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50067040(((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-hept...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of P300 (unknown origin) using histone H3/[acetyl-3H]-acetyl coenzyme A as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50081164(CHEMBL3421945)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of P300 (unknown origin) using histone H3/[acetyl-3H]-acetyl coenzyme A as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50081165(CHEMBL3421947)
Affinity DataIC50:  8.50E+3nMAssay Description:Inhibition of P300 (unknown origin) using histone H3/[acetyl-3H]-acetyl coenzyme A as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50081163(CHEMBL3421944)
Affinity DataIC50:  1.14E+4nMAssay Description:Inhibition of P300 (unknown origin) using histone H3/[acetyl-3H]-acetyl coenzyme A as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50081169(CHEMBL3421957)
Affinity DataIC50:  2.64E+4nMAssay Description:Inhibition of P300 (unknown origin) using histone H3/[acetyl-3H]-acetyl coenzyme A as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50081167(CHEMBL3421949)
Affinity DataIC50:  3.14E+4nMAssay Description:Inhibition of P300 (unknown origin) using histone H3/[acetyl-3H]-acetyl coenzyme A as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50292429(2-Hydroxy-6-pentadecyl-benzoic acid | 2-Pentadecyl...)
Affinity DataIC50:  3.39E+4nMAssay Description:Inhibition of PCAF (unknown origin) using histone H3/[acetyl-3H]-acetyl coenzyme A as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTubulin--tyrosine ligase(Homo sapiens (Human))
Universita Di Salerno

Curated by ChEMBL
LigandPNGBDBM50293292(6alpha,15(S),23-trihydroxy-labd-8(22),13(14),17-tr...)
Affinity DataKd:  2.00E+3nMAssay Description:Binding affinity to TTL by surface plasmon resonanceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTubulin--tyrosine ligase(Homo sapiens (Human))
Universita Di Salerno

Curated by ChEMBL
LigandPNGBDBM50293293(6alpha,8alpha-dihydroxy-23-oxo-labd-13(14),17-dien...)
Affinity DataKd:  810nMAssay Description:Binding affinity to TTL by surface plasmon resonanceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTubulin--tyrosine ligase(Homo sapiens (Human))
Universita Di Salerno

Curated by ChEMBL
LigandPNGBDBM50293294(6alpha,8alpha,15(S)-trihydroxy-23-oxo-labd-13(14),...)
Affinity DataKd:  3.00E+3nMAssay Description:Binding affinity to TTL by surface plasmon resonanceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTubulin--tyrosine ligase(Homo sapiens (Human))
Universita Di Salerno

Curated by ChEMBL
LigandPNGBDBM50293295(6alpha,8alpha,15(S)-trihydroxy-23-carbossimethylla...)
Affinity DataKd:  6.20E+3nMAssay Description:Binding affinity to TTL by surface plasmon resonanceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTubulin--tyrosine ligase(Homo sapiens (Human))
Universita Di Salerno

Curated by ChEMBL
LigandPNGBDBM50293296(6alpha,8alpha-dihydroxy-23-carbossi-labd-13(14),17...)
Affinity DataKd:  7nMAssay Description:Binding affinity to TTL by surface plasmon resonanceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTubulin--tyrosine ligase(Homo sapiens (Human))
Universita Di Salerno

Curated by ChEMBL
LigandPNGBDBM50293297(6alpha,8alpha,15(S)-trihydroxy-23-carbossi-labd-13...)
Affinity DataKd:  3.00E+3nMAssay Description:Binding affinity to TTL by surface plasmon resonanceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTubulin--tyrosine ligase(Homo sapiens (Human))
Universita Di Salerno

Curated by ChEMBL
LigandPNGBDBM50293298(6alpha,8alpha,23-trihydroxy-labd-13(14),17-dien-16...)
Affinity DataKd:  72nMAssay Description:Binding affinity to TTL by surface plasmon resonanceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTubulin--tyrosine ligase(Homo sapiens (Human))
Universita Di Salerno

Curated by ChEMBL
LigandPNGBDBM50293299(6alpha,8alpha,15(S),23-tetrahydroxy-labd-13(14),17...)
Affinity DataKd:  4.70E+3nMAssay Description:Binding affinity to TTL by surface plasmon resonanceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTubulin--tyrosine ligase(Homo sapiens (Human))
Universita Di Salerno

Curated by ChEMBL
LigandPNGBDBM50293300(8alpha-hydroxy,23alpha-O-ethyl-23,6alpha-epoxy-lab...)
Affinity DataKd:  73nMAssay Description:Binding affinity to TTL by surface plasmon resonanceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTubulin--tyrosine ligase(Homo sapiens (Human))
Universita Di Salerno

Curated by ChEMBL
LigandPNGBDBM50293301(8alpha,15(S)-dihydroxy,23alpha-O-ethyl-23,6alpha-e...)
Affinity DataKd:  960nMAssay Description:Binding affinity to TTL by surface plasmon resonanceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTubulin--tyrosine ligase(Homo sapiens (Human))
Universita Di Salerno

Curated by ChEMBL
LigandPNGBDBM50293302(8alpha,15(S),23alpha-trihydroxy-23,6alpha-epoxy-la...)
Affinity DataKd:  2.10E+5nMAssay Description:Binding affinity to TTL by surface plasmon resonanceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTubulin--tyrosine ligase(Homo sapiens (Human))
Universita Di Salerno

Curated by ChEMBL
LigandPNGBDBM50293291(6alpha,15(S)-dihydroxy-23-oxo-labd-8(22),13(14),17...)
Affinity DataKd:  3.30E+3nMAssay Description:Binding affinity to TTL by surface plasmon resonanceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTubulin--tyrosine ligase(Homo sapiens (Human))
Universita Di Salerno

Curated by ChEMBL
LigandPNGBDBM50293290(6alpha,8alpha,23-trihydroxy-labd-13(14),15,17-trie...)
Affinity DataKd:  110nMAssay Description:Binding affinity to TTL by surface plasmon resonanceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTubulin--tyrosine ligase(Homo sapiens (Human))
Universita Di Salerno

Curated by ChEMBL
LigandPNGBDBM50293289(6alpha,8alpha-dihydroxy-23-carbossi-labd-13(14),15...)
Affinity DataKd:  93nMAssay Description:Binding affinity to TTL by surface plasmon resonanceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTubulin--tyrosine ligase(Homo sapiens (Human))
Universita Di Salerno

Curated by ChEMBL
LigandPNGBDBM50293288(6alpha,8alpha-dihydroxy-23-oxo-13(14),15,17-trien-...)
Affinity DataKd:  200nMAssay Description:Binding affinity to TTL by surface plasmon resonanceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTubulin--tyrosine ligase(Homo sapiens (Human))
Universita Di Salerno

Curated by ChEMBL
LigandPNGBDBM50293287(8alpha-hydroxylabd-13(14),15,17-trien-6alpha,23-16...)
Affinity DataKd:  150nMAssay Description:Binding affinity to TTL by surface plasmon resonanceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTubulin--tyrosine ligase(Homo sapiens (Human))
Universita Di Salerno

Curated by ChEMBL
LigandPNGBDBM50293286(8alpha-23-dihydroxy-23,6alpha-epoxy-labd-13(14),15...)
Affinity DataKd:  480nMAssay Description:Binding affinity to TTL by surface plasmon resonanceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTubulin--tyrosine ligase(Homo sapiens (Human))
Universita Di Salerno

Curated by ChEMBL
LigandPNGBDBM50293285(23,6alpha-epoxy-labd-8,13(14),17-trien-16(R),19-ol...)
Affinity DataKd:  8.70E+3nMAssay Description:Binding affinity to TTL by surface plasmon resonanceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50081172(CHEMBL3421930)
Affinity DataKd:  110nMAssay Description:Binding affinity to human recombinant P300 catalytic domain by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50081171(CHEMBL3421905)
Affinity DataKd:  2.40E+3nMAssay Description:Binding affinity to human recombinant P300 catalytic domain by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50024797(CHEBI:60283 | CHEMBL1163500 | N6-Isopentenyladenos...)
Affinity DataKd:  2.02E+6nMAssay Description:Binding affinity to FPPS (unknown origin) expressed in Escherichia coli BL21(DEscherichia ) assessed as binding constant of proton H2/H8 of purine ri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50024797(CHEBI:60283 | CHEMBL1163500 | N6-Isopentenyladenos...)
Affinity DataKd:  2.21E+6nMAssay Description:Binding affinity to FPPS (unknown origin) expressed in Escherichia coli BL21(DEscherichia ) assessed as binding constant of proton H12 of isopentenyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50024797(CHEBI:60283 | CHEMBL1163500 | N6-Isopentenyladenos...)
Affinity DataKd:  5.50E+5nMAssay Description:Binding affinity to FPPS (unknown origin) expressed in Escherichia coli BL21(DEscherichia ) assessed as binding constant of proton H11 of isopentenyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50024797(CHEBI:60283 | CHEMBL1163500 | N6-Isopentenyladenos...)
Affinity DataKd:  1.21E+6nMAssay Description:Binding affinity to FPPS (unknown origin) expressed in Escherichia coli BL21(DEscherichia ) assessed as binding constant of proton H14-H15 of isopent...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM84877(Clusianone, 10)
Affinity DataKd:  810nMT: 2°CAssay Description:The p300 activity assays were performed by a colorimetric kit (JM-K322-100, MBL) using active recombinant p300/HAT as positive control and acetyl-CoA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM84875(Guttiferone E, 4)
Affinity DataKd:  390nMT: 2°CAssay Description:The p300 activity assays were performed by a colorimetric kit (JM-K322-100, MBL) using active recombinant p300/HAT as positive control and acetyl-CoA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM84874(Guttiferone A, 3)
Affinity DataKd:  100nMT: 2°CAssay Description:The p300 activity assays were performed by a colorimetric kit (JM-K322-100, MBL) using active recombinant p300/HAT as positive control and acetyl-CoA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 1 [11-371](Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50206427(7,7'-carbonylbis(azanediyl)bis(4-hydroxynaphthalen...)
Affinity DataKd:  810nMAssay Description:Binding affinity to human recombinant GST-PRMT1 expressed Escherichia coli BL21 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50241990(CHEMBL502489 | Camboginol | Garcinol | Garcinol, 1)
Affinity DataKd:  400nMT: 2°CAssay Description:The p300 activity assays were performed by a colorimetric kit (JM-K322-100, MBL) using active recombinant p300/HAT as positive control and acetyl-CoA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM84873(Nemorosone, 2)
Affinity DataKd:  250nMT: 2°CAssay Description:The p300 activity assays were performed by a colorimetric kit (JM-K322-100, MBL) using active recombinant p300/HAT as positive control and acetyl-CoA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed