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Found 123 with Last Name = 'poinsard' and Initial = 'c'
TargetMetabotropic glutamate receptor 1(RAT)
Medical Research Council Technology

Curated by ChEMBL
LigandPNGBDBM50278288(2-(2-(4-(2,3-dihydro-1H-inden-2-ylamino)pyrido[3,4...)
Affinity DataKi:  3nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Medical Research Council Technology

Curated by ChEMBL
LigandPNGBDBM50278286(CHEMBL511266 | N4-(2,3-dihydro-1H-inden-2-yl)-N6-(...)
Affinity DataKi:  5nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Medical Research Council Technology

Curated by ChEMBL
LigandPNGBDBM50278407(CHEMBL470396 | N-cycloheptyl-6-(2-morpholinoethoxy...)
Affinity DataKi:  6nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Medical Research Council Technology

Curated by ChEMBL
LigandPNGBDBM50278361(CHEMBL471435 | N4-cyclohexyl-N6-(2-morpholinoethyl...)
Affinity DataKi:  10nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Medical Research Council Technology

Curated by ChEMBL
LigandPNGBDBM50278289(CHEMBL469383 | N4-cyclohexyl-N6-(2-methoxyethyl)py...)
Affinity DataKi:  11nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Medical Research Council Technology

Curated by ChEMBL
LigandPNGBDBM50278112(CHEMBL472490 | N4-(2,3-dihydro-1H-inden-2-yl)-N6-m...)
Affinity DataKi:  14nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Medical Research Council Technology

Curated by ChEMBL
LigandPNGBDBM50278358(1-(2-(4-(cyclohexylamino)pyrido[3,4-d]pyrimidin-6-...)
Affinity DataKi:  20nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Medical Research Council Technology

Curated by ChEMBL
LigandPNGBDBM50278232(2-(4-(2,3-dihydro-1H-inden-2-ylamino)pyrido[3,4-d]...)
Affinity DataKi:  21nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Medical Research Council Technology

Curated by ChEMBL
LigandPNGBDBM50278114(CHEMBL513012 | N-cyclohexylquinazolin-4-amine)
Affinity DataKi:  27nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Medical Research Council Technology

Curated by ChEMBL
LigandPNGBDBM50278231(CHEMBL513018 | N4,N6-bis(2,3-dihydro-1H-inden-2-yl...)
Affinity DataKi:  31nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Medical Research Council Technology

Curated by ChEMBL
LigandPNGBDBM50278357(3-(4-(cyclohexylamino)pyrido[3,4-d]pyrimidin-6-ylo...)
Affinity DataKi:  33nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Medical Research Council Technology

Curated by ChEMBL
LigandPNGBDBM50278153(CHEMBL471242 | N-(2,3-dihydro-1H-inden-2-yl)quinaz...)
Affinity DataKi:  34nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Medical Research Council Technology

Curated by ChEMBL
LigandPNGBDBM50278362(CHEMBL512523 | N-cyclohexyl-6-(2-morpholinoethoxy)...)
Affinity DataKi:  42nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Medical Research Council Technology

Curated by ChEMBL
LigandPNGBDBM50278111(CHEMBL472489 | N4-(2,3-dihydro-1H-inden-2-yl)-N4,N...)
Affinity DataKi:  54nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Medical Research Council Technology

Curated by ChEMBL
LigandPNGBDBM50278291(CHEMBL471666 | N-cyclohexyl-6-(2-methoxyethoxy)pyr...)
Affinity DataKi:  101nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Medical Research Council Technology

Curated by ChEMBL
LigandPNGBDBM50278287(CHEMBL469381 | N4-(2,3-dihydro-1H-inden-2-yl)-N6-(...)
Affinity DataKi:  102nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Medical Research Council Technology

Curated by ChEMBL
LigandPNGBDBM50278113(CHEMBL513761 | N-(2,3-dihydro-1H-inden-2-yl)-6-met...)
Affinity DataKi:  115nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Medical Research Council Technology

Curated by ChEMBL
LigandPNGBDBM50278229(2-(6-(2,3-dihydro-1H-inden-2-ylamino)pyrido[3,4-d]...)
Affinity DataKi:  125nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Medical Research Council Technology

Curated by ChEMBL
LigandPNGBDBM50278228(CHEMBL447113 | N6-(2,3-dihydro-1H-inden-2-yl)-N4-m...)
Affinity DataKi:  160nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Medical Research Council Technology

Curated by ChEMBL
LigandPNGBDBM50278290(2-(4-(cyclohexylamino)pyrido[3,4-d]pyrimidin-6-ylo...)
Affinity DataKi:  177nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Medical Research Council Technology

Curated by ChEMBL
LigandPNGBDBM50278853(CHEMBL496897 | N4-(2,3-dihydro-1H-inden-2-yl)-N6,N...)
Affinity DataKi:  185nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Medical Research Council Technology

Curated by ChEMBL
LigandPNGBDBM50278850(CHEMBL497918 | N4-cyclohexyl-N6,N6-dimethylpyrido[...)
Affinity DataKi:  199nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Medical Research Council Technology

Curated by ChEMBL
LigandPNGBDBM50278360(CHEMBL471434 | N6-(3-aminopropyl)-N4-cyclohexylpyr...)
Affinity DataKi:  200nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Medical Research Council Technology

Curated by ChEMBL
LigandPNGBDBM50278110(CHEMBL511838 | N4-(2,3-dihydro-1H-inden-2-yl)-N4,N...)
Affinity DataKi:  300nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Medical Research Council Technology

Curated by ChEMBL
LigandPNGBDBM50278116(4-(cyclohexyloxy)quinazoline | CHEMBL471866)
Affinity DataKi:  694nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Medical Research Council Technology

Curated by ChEMBL
LigandPNGBDBM50278852(CHEMBL525546 | N6,N6-dimethyl-N4-(pentan-2-yl)pyri...)
Affinity DataKi:  858nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Medical Research Council Technology

Curated by ChEMBL
LigandPNGBDBM50278851((S)-N6,N6-dimethyl-N4-(1-phenylethyl)pyrido[3,4-d]...)
Affinity DataKi:  1.40E+3nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Medical Research Council Technology

Curated by ChEMBL
LigandPNGBDBM50278227(CHEMBL470205 | N-(2,3-dihydro-1H-inden-2-yl)isoqui...)
Affinity DataKi:  1.65E+3nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Medical Research Council Technology

Curated by ChEMBL
LigandPNGBDBM50278359(CHEMBL509066 | N6-(2-aminoethyl)-N4-cyclohexylpyri...)
Affinity DataKi:  2.20E+3nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Medical Research Council Technology

Curated by ChEMBL
LigandPNGBDBM50278230(2,2'-(pyrido[3,4-d]pyrimidine-4,6-diylbis(azanediy...)
Affinity DataKi:  6.15E+3nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Medical Research Council Technology

Curated by ChEMBL
LigandPNGBDBM50278115(CHEMBL449616 | N-cyclohexylquinolin-4-amine)
Affinity DataKi:  6.16E+3nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50359779(CHEMBL1928271)
Affinity DataIC50:  0.260nMAssay Description:Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50359773(CHEMBL1928265)
Affinity DataIC50:  0.310nMAssay Description:Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50359767(CHEMBL1928259)
Affinity DataIC50:  0.690nMAssay Description:Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50359795(CHEMBL1928258)
Affinity DataIC50:  0.690nMAssay Description:Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50359774(CHEMBL1928266)
Affinity DataIC50:  0.740nMAssay Description:Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50359768(CHEMBL1928260)
Affinity DataIC50:  0.75nMAssay Description:Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50359777(CHEMBL1928269)
Affinity DataIC50:  0.780nMAssay Description:Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50359778(CHEMBL1928270)
Affinity DataIC50:  0.860nMAssay Description:Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50359790(CHEMBL1928253)
Affinity DataIC50:  1nMAssay Description:Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50359789(CHEMBL1928252)
Affinity DataIC50:  1nMAssay Description:Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50359771(CHEMBL1928263)
Affinity DataIC50:  1nMAssay Description:Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246483(3-ethyl-5-(5-(4-ethylpiperazin-1-ylsulfonyl)-2-pro...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50359770(CHEMBL1928262)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50359780(CHEMBL1928272)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50359787(CHEMBL1928250)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50359769(CHEMBL1928261)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50359791(CHEMBL1928254)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50359786(CHEMBL1928249)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50359788(CHEMBL1928251)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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