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Found 110 with Last Name = 'tomaselli' and Initial = 'd'
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))TBA
LigandPNGBDBM172038(US10155002, Compound 44 | US10647700, Compound EPZ...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of PRC2 catalytic core EZH2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 1/REST corepressor 3(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataKi:  3nMAssay Description:Inhibition of HDAC1/CoREST3 in HEK293 whole cell extract using fluorescent acetylated histone peptide as substrate after 60 mins by fluorescence base...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Affinity DataKi:  5.70nMAssay Description:Inhibition of human carbonic anhydrase 12 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50510060(CHEMBL4558305)
Affinity DataKi:  7.5nMAssay Description:Inhibition of human carbonic anhydrase 12 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50510063(CHEMBL4568798)
Affinity DataKi:  8.70nMAssay Description:Inhibition of human carbonic anhydrase 12 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50510058(CHEMBL4439915)
Affinity DataKi:  8.90nMAssay Description:Inhibition of human carbonic anhydrase 12 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50510062(CHEMBL4575531)
Affinity DataKi:  11nMAssay Description:Inhibition of human carbonic anhydrase 9 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Affinity DataKi:  12nMAssay Description:Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50510061(CHEMBL4578890)
Affinity DataKi:  13nMAssay Description:Inhibition of human carbonic anhydrase 9 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50510063(CHEMBL4568798)
Affinity DataKi:  13nMAssay Description:Inhibition of human carbonic anhydrase 9 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50510060(CHEMBL4558305)
Affinity DataKi:  13nMAssay Description:Inhibition of human carbonic anhydrase 9 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Affinity DataKi:  25nMAssay Description:Inhibition of human carbonic anhydrase 9 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1/REST corepressor 3(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL
LigandPNGBDBM50460385(CHEMBL4228572)
Affinity DataKi:  27nMAssay Description:Inhibition of HDAC1/CoREST3 in HEK293 whole cell extract using fluorescent acetylated histone peptide as substrate after 60 mins by fluorescence base...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50510059(CHEMBL4578633)
Affinity DataKi:  35nMAssay Description:Inhibition of human carbonic anhydrase 12 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50510058(CHEMBL4439915)
Affinity DataKi:  38nMAssay Description:Inhibition of human carbonic anhydrase 9 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1/REST corepressor 3(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL
LigandPNGBDBM50460386(CHEMBL4228166)
Affinity DataKi:  43nMAssay Description:Inhibition of HDAC1/CoREST3 in HEK293 whole cell extract using fluorescent acetylated histone peptide as substrate after 60 mins by fluorescence base...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50510059(CHEMBL4578633)
Affinity DataKi:  90nMAssay Description:Inhibition of human carbonic anhydrase 9 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50510061(CHEMBL4578890)
Affinity DataKi:  249nMAssay Description:Inhibition of human carbonic anhydrase 12 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Affinity DataKi:  250nMAssay Description:Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50510062(CHEMBL4575531)
Affinity DataKi:  768nMAssay Description:Inhibition of human carbonic anhydrase 12 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50510062(CHEMBL4575531)
Affinity DataKi:  2.08E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50510063(CHEMBL4568798)
Affinity DataKi:  2.58E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50510060(CHEMBL4558305)
Affinity DataKi:  5.03E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50510061(CHEMBL4578890)
Affinity DataKi:  6.18E+3nMAssay Description:Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50510059(CHEMBL4578633)
Affinity DataKi:  7.33E+3nMAssay Description:Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50510058(CHEMBL4439915)
Affinity DataKi:  8.65E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50510062(CHEMBL4575531)
Affinity DataKi:  8.98E+3nMAssay Description:Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50510061(CHEMBL4578890)
Affinity DataKi:  9.44E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50510063(CHEMBL4568798)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50510058(CHEMBL4439915)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50510060(CHEMBL4558305)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University of Florence

Curated by ChEMBL
LigandPNGBDBM50510059(CHEMBL4578633)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))TBA
LigandPNGBDBM50481803(CHEMBL5269123)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human recombinant HDAC3 incubated for 20 mins by HDAC Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50481803(CHEMBL5269123)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human recombinant GST-tagged HDAC1 incubated for 20 mins by HDAC Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50481803(CHEMBL5269123)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of human recombinant GST-tagged HDAC2 incubated for 20 mins by HDAC Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))TBA
LigandPNGBDBM50481803(CHEMBL5269123)
Affinity DataIC50:  11nMAssay Description:Inhibition of human recombinant His-tagged HDAC10 incubated for 20 mins by HDAC Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))TBA
LigandPNGBDBM50536555(CHEMBL4532174)
Affinity DataIC50:  12nMAssay Description:Inhibition of EZH2 methyltransferase activity (unknown origin) assessed `transfer of [3H]methyl group from SAM to substrate by biochemical assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))TBA
LigandPNGBDBM50365262((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...)
Affinity DataIC50:  33nMAssay Description:Inhibition of BRD4-BD2 domain (unknown origin) assessed as inhibition of tetra-acetylated Histone H4 peptide binding to BRD4 by ALPHA-screen assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))TBA
LigandPNGBDBM50481803(CHEMBL5269123)
Affinity DataIC50:  36nMAssay Description:Inhibition of human recombinant GST-tagged HDAC6 incubated for 20 mins by HDAC Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolycomb protein EED(Homo sapiens (Human))TBA
LigandPNGBDBM225230(EED226 | US11013745, Compound EED226)
Affinity DataIC50:  45nMAssay Description:Inhibition of His tagged EED (1 to 441) (unknown origin) using biotin-H3K27me3 peptide as substrate by AlphaScreen competition binding assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))TBA
LigandPNGBDBM50481803(CHEMBL5269123)
Affinity DataIC50:  60nMAssay Description:Inhibition of human recombinant His-tagged HDAC8 incubated for 20 mins by HDAC Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))TBA
LigandPNGBDBM50365262((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...)
Affinity DataIC50:  77nMAssay Description:Inhibition of BRD4-BD1 domain (unknown origin) assessed as inhibition of tetra-acetylated Histone H4 peptide binding to BRD4 by ALPHA-screen assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))TBA
LigandPNGBDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataIC50:  92nMAssay Description:Inhibition of BRD2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBromodomain-containing protein 3(Homo sapiens (Human))TBA
LigandPNGBDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataIC50:  92nMAssay Description:Inhibition of BRD3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))TBA
LigandPNGBDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataIC50:  92nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))TBA
LigandPNGBDBM50562609(CHEMBL4787413)
Affinity DataIC50:  120nMAssay Description:Inhibition of EZH2 methyltransferase activity (unknown origin) assessed `transfer of [3H]methyl group from SAM to substrate by biochemical assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolycomb protein EED(Homo sapiens (Human))TBA
LigandPNGBDBM50562612(CHEMBL4749741)
Affinity DataIC50:  247nMAssay Description:Inhibition of PRC2 catalytic core EED (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProbable global transcription activator SNF2L2(Homo sapiens (Human))TBA
LigandPNGBDBM394406(2-(6-amino-5-(piperazin- | US10308614, Example 7)
Affinity DataIC50:  370nMAssay Description:Inhibition of SMARCA2 BD (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University of Freiburg

Curated by ChEMBL
LigandPNGBDBM50148781(CHEMBL3770903)
Affinity DataIC50:  400nMAssay Description:Inhibition of human sirtuin 2 (25 to 389 residues) assessed as inhibition of substrate deacetylation using ZMAL as substrate incubated for 4 hrs by f...More data for this Ligand-Target Pair
TargetTranscription activator BRG1(Homo sapiens (Human))TBA
LigandPNGBDBM394406(2-(6-amino-5-(piperazin- | US10308614, Example 7)
Affinity DataIC50:  550nMAssay Description:Inhibition of SMARCA4 BD (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
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