Affinity DataKi: 2.5nMAssay Description:Inhibition of PRC2 catalytic core EZH2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 1/REST corepressor 3(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Affinity DataKi: 3nMAssay Description:Inhibition of HDAC1/CoREST3 in HEK293 whole cell extract using fluorescent acetylated histone peptide as substrate after 60 mins by fluorescence base...More data for this Ligand-Target Pair
Affinity DataKi: 5.70nMAssay Description:Inhibition of human carbonic anhydrase 12 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 7.5nMAssay Description:Inhibition of human carbonic anhydrase 12 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 8.70nMAssay Description:Inhibition of human carbonic anhydrase 12 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 8.90nMAssay Description:Inhibition of human carbonic anhydrase 12 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Inhibition of human carbonic anhydrase 9 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Inhibition of human carbonic anhydrase 9 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Inhibition of human carbonic anhydrase 9 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Inhibition of human carbonic anhydrase 9 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Inhibition of human carbonic anhydrase 9 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1/REST corepressor 3(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Affinity DataKi: 27nMAssay Description:Inhibition of HDAC1/CoREST3 in HEK293 whole cell extract using fluorescent acetylated histone peptide as substrate after 60 mins by fluorescence base...More data for this Ligand-Target Pair
Affinity DataKi: 35nMAssay Description:Inhibition of human carbonic anhydrase 12 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 38nMAssay Description:Inhibition of human carbonic anhydrase 9 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1/REST corepressor 3(Homo sapiens (Human))
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
Affinity DataKi: 43nMAssay Description:Inhibition of HDAC1/CoREST3 in HEK293 whole cell extract using fluorescent acetylated histone peptide as substrate after 60 mins by fluorescence base...More data for this Ligand-Target Pair
Affinity DataKi: 90nMAssay Description:Inhibition of human carbonic anhydrase 9 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 249nMAssay Description:Inhibition of human carbonic anhydrase 12 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 768nMAssay Description:Inhibition of human carbonic anhydrase 12 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.08E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.58E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 5.03E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 6.18E+3nMAssay Description:Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 7.33E+3nMAssay Description:Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 8.65E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 8.98E+3nMAssay Description:Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 9.44E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human recombinant HDAC3 incubated for 20 mins by HDAC Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human recombinant GST-tagged HDAC1 incubated for 20 mins by HDAC Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human recombinant GST-tagged HDAC2 incubated for 20 mins by HDAC Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant His-tagged HDAC10 incubated for 20 mins by HDAC Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of EZH2 methyltransferase activity (unknown origin) assessed `transfer of [3H]methyl group from SAM to substrate by biochemical assayMore data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Inhibition of BRD4-BD2 domain (unknown origin) assessed as inhibition of tetra-acetylated Histone H4 peptide binding to BRD4 by ALPHA-screen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibition of human recombinant GST-tagged HDAC6 incubated for 20 mins by HDAC Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 45nMAssay Description:Inhibition of His tagged EED (1 to 441) (unknown origin) using biotin-H3K27me3 peptide as substrate by AlphaScreen competition binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant His-tagged HDAC8 incubated for 20 mins by HDAC Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 77nMAssay Description:Inhibition of BRD4-BD1 domain (unknown origin) assessed as inhibition of tetra-acetylated Histone H4 peptide binding to BRD4 by ALPHA-screen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 92nMAssay Description:Inhibition of BRD2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 92nMAssay Description:Inhibition of BRD3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 92nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of EZH2 methyltransferase activity (unknown origin) assessed `transfer of [3H]methyl group from SAM to substrate by biochemical assayMore data for this Ligand-Target Pair
Affinity DataIC50: 247nMAssay Description:Inhibition of PRC2 catalytic core EED (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 370nMAssay Description:Inhibition of SMARCA2 BD (unknown origin)More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University of Freiburg
Curated by ChEMBL
University of Freiburg
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Inhibition of human sirtuin 2 (25 to 389 residues) assessed as inhibition of substrate deacetylation using ZMAL as substrate incubated for 4 hrs by f...More data for this Ligand-Target Pair
Affinity DataIC50: 550nMAssay Description:Inhibition of SMARCA4 BD (unknown origin)More data for this Ligand-Target Pair