TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Instituto De Qu£Mica M£Dica (Csic)
Curated by ChEMBL
Instituto De Qu£Mica M£Dica (Csic)
Curated by ChEMBL
Affinity DataKi: 5.91E+3nMAssay Description:Competitive inhibition of human recombinant PDE7A1 using 5 nM to 2 uM cAMP as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 6.41E+3nMAssay Description:Mixed-type inhibition of human BuChE assessed as enzyme-inhibitor complex using butyrylthiocholine iodide as substrate by Lineweaver-Burk plot analys...More data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Instituto De Qu£Mica M£Dica (Csic)
Curated by ChEMBL
Instituto De Qu£Mica M£Dica (Csic)
Curated by ChEMBL
Affinity DataKi: 7.22E+3nMAssay Description:Competitive inhibition of human recombinant PDE7A1 using 5 nM to 2 uM cAMP as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 3.97E+4nMAssay Description:Mixed-type inhibition of human BuChE assessed as enzyme-substrate-inhibitor complex using butyrylthiocholine iodide as substrate by Lineweaver-Burk p...More data for this Ligand-Target Pair
Affinity DataIC50: 2.80nMAssay Description:Inhibition of POP (unknown origin) using (Z)-Gly-Pro-p-nitroanilide as substrate preincubated for 5 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.90nMAssay Description:Inhibition of wild-type human CK1delta using PLSRTLpSVASLPGL as substrate incubated for 40 mins in presence of ATP by Kinase-Glo luminescence assayMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Instituto De Quimica Medica-Csic
Curated by ChEMBL
Instituto De Quimica Medica-Csic
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant GSK3betaMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Instituto De Quimica Medica-Csic
Curated by ChEMBL
Instituto De Quimica Medica-Csic
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant GSK3beta using prephosphorylated polypeptide substrate after 30 mins by Glow-type luminescence assay in presence of 1...More data for this Ligand-Target Pair
Affinity DataIC50: 7.70nMAssay Description:Inhibition of full-length human CK1epsilon expressed in Escherichia coli BL21-CodonPlus(DE3)-RIL competent cells using PLSRTLpSVASLPGL as substrate i...More data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas-Csic
Curated by ChEMBL
Centro De Investigaciones Biol�Gicas-Csic
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant catalytic human GST-tagged LLRK2 (970 to 2527 residues) expressed in baculovirus expression system using LRRKtide as substr...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of BACE1 using methoxycoumarin-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys-dinitrophenyl as substrate preincubated 1 hr before substrate addit...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant CK-1delta using casein as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of full-length human CK1delta expressed in Escherichia coli BL21-CodonPlus(DE3)-RIL competent cells using PLSRTLpSVASLPGL as substrate inc...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant CK-1delta using casein as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of wild-type human CK1epsilon using PLSRTLpSVASLPGL as substrate incubated for 70 mins in presence of ATP by Kinase-Glo luminescence assayMore data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas-Csic
Curated by ChEMBL
Centro De Investigaciones Biol�Gicas-Csic
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant catalytic human GST-tagged LLRK2 (970 to 2527 residues) expressed in baculovirus expression system using LRRKtide as substr...More data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas-Csic
Curated by ChEMBL
Centro De Investigaciones Biol�Gicas-Csic
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant catalytic human GST-tagged LLRK2 (970 to 2527 residues) expressed in baculovirus expression system using LRRKtide as substr...More data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas-Csic
Curated by ChEMBL
Centro De Investigaciones Biol�Gicas-Csic
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant catalytic human GST-tagged LLRK2 G2019S mutant (970 to 2527 residues) expressed in baculovirus expression system using LRRK...More data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas-Csic
Curated by ChEMBL
Centro De Investigaciones Biol�Gicas-Csic
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant catalytic human GST-tagged LLRK2 (970 to 2527 residues) expressed in baculovirus expression system using LRRKtide as substr...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of human recombinant CK-1delta using casein as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas-Csic
Curated by ChEMBL
Centro De Investigaciones Biol�Gicas-Csic
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant catalytic human GST-tagged LLRK2 G2019S mutant (970 to 2527 residues) expressed in baculovirus expression system using LRRK...More data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Inhibition of human recombinant CK-1delta using casein as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant BACE1 using M-2420 as substrate preincubated for 1 hr followed by substrate addition incubated for 15 mins by FRET as...More data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Inhibition of human recombinant CK-1delta using casein as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Instituto De Quimica Medica-Csic
Curated by ChEMBL
Instituto De Quimica Medica-Csic
Curated by ChEMBL
Affinity DataIC50: 47nMAssay Description:Inhibition of human recombinant GSK3beta using prephosphorylated polypeptide substrate after 30 mins by Glow-type luminescence assay in presence of 1...More data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inhibition of human recombinant CK-1delta using casein as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas-Csic
Curated by ChEMBL
Centro De Investigaciones Biol�Gicas-Csic
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant catalytic human GST-tagged LLRK2 G2019S mutant (970 to 2527 residues) expressed in baculovirus expression system using LRRK...More data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Inhibition of human recombinant CK-1delta using casein as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 65nMAssay Description:Inhibition of human recombinant CK-1delta using casein as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 68nMAssay Description:Inhibition of human recombinant CK-1delta using casein as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 79nMAssay Description:Inhibition of human recombinant CK-1delta using casein as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
TargetCell division cycle 7-related protein kinase/Protein DBF4 homolog A(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas-Csic
Curated by ChEMBL
Centro De Investigaciones Biol�Gicas Margarita Salas-Csic
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of recombinant human CDC7/Dbf4 expressed in baculovirus infected Sf9 insect cells assessed as inhibition of fluorescein labelled substrate...More data for this Ligand-Target Pair
Affinity DataIC50: 83nMAssay Description:Inhibition of human recombinant CK-1delta using casein as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas (Csic)
Curated by ChEMBL
Centro De Investigaciones Biol�Gicas (Csic)
Curated by ChEMBL
Affinity DataIC50: 83nMAssay Description:Inhibition of human recombinant PDE4D3 assessed after 60 mins by IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 87nMAssay Description:Inhibition of human recombinant CK-1delta using casein as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Instituto De Qu£Mica M£Dica (Csic)
Curated by ChEMBL
Instituto De Qu£Mica M£Dica (Csic)
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Measurement of PDE7 inhibition was carried out using a commercial phosphodiesterase activity measurement kit.Some of the compounds of the present inv...More data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Instituto De Qu£Mica M£Dica (Csic)
Curated by ChEMBL
Instituto De Qu£Mica M£Dica (Csic)
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of human recombinant PDE7A1-mediated [3H]cAMP hydrolysis after 20 mins by scintillation proximity assayMore data for this Ligand-Target Pair
TargetCell division cycle 7-related protein kinase/Protein DBF4 homolog A(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas-Csic
Curated by ChEMBL
Centro De Investigaciones Biol�Gicas Margarita Salas-Csic
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of recombinant human CDC7/Dbf4 expressed in baculovirus infected Sf9 insect cells assessed as inhibition of fluorescein labelled substrate...More data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Instituto De Qu£Mica M£Dica (Csic)
Curated by ChEMBL
Instituto De Qu£Mica M£Dica (Csic)
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of human recombinant PDE7A1 assessed as inhibition of hydrolysis of [3H]cAMP after 20 mins by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas (Csic)
Curated by ChEMBL
Centro De Investigaciones Biol�Gicas (Csic)
Curated by ChEMBL
Affinity DataIC50: 98nMAssay Description:Inhibition of human recombinant PDE4B2 assessed after 60 mins by IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Instituto De Qu£Mica M£Dica (Csic)
Curated by ChEMBL
Instituto De Qu£Mica M£Dica (Csic)
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Measurement of PDE7 inhibition was carried out using a commercial phosphodiesterase activity measurement kit.Some of the compounds of the present inv...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Instituto De Quimica Medica-Csic
Curated by ChEMBL
Instituto De Quimica Medica-Csic
Curated by ChEMBL
Affinity DataIC50: 104nMAssay Description:Inhibition of human recombinant GSK3betaMore data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas-Csic
Curated by ChEMBL
Centro De Investigaciones Biol�Gicas-Csic
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant catalytic human GST-tagged LLRK2 (970 to 2527 residues) expressed in baculovirus expression system using LRRKtide as substr...More data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Instituto De Qu£Mica M£Dica (Csic)
Curated by ChEMBL
Instituto De Qu£Mica M£Dica (Csic)
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Measurement of PDE7 inhibition was carried out using a commercial phosphodiesterase activity measurement kit.Some of the compounds of the present inv...More data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas-Csic
Curated by ChEMBL
Centro De Investigaciones Biol�Gicas-Csic
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of recombinant catalytic human GST-tagged LLRK2 G2019S mutant (970 to 2527 residues) expressed in baculovirus expression system using LRRK...More data for this Ligand-Target Pair
TargetCell division cycle 7-related protein kinase/Protein DBF4 homolog A(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas-Csic
Curated by ChEMBL
Centro De Investigaciones Biol�Gicas Margarita Salas-Csic
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of recombinant human CDC7/Dbf4 expressed in baculovirus infected Sf9 insect cells assessed as inhibition of fluorescein labelled substrate...More data for this Ligand-Target Pair
TargetCell division cycle 7-related protein kinase/Protein DBF4 homolog A(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas-Csic
Curated by ChEMBL
Centro De Investigaciones Biol�Gicas Margarita Salas-Csic
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of recombinant human CDC7/Dbf4 expressed in baculovirus infected Sf9 insect cells assessed as inhibition of fluorescein labelled substrate...More data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas-Csic
Curated by ChEMBL
Centro De Investigaciones Biol�Gicas-Csic
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of recombinant catalytic human GST-tagged LLRK2 (970 to 2527 residues) expressed in baculovirus expression system using LRRKtide as substr...More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of human recombinant BACE1 using M-2420 as substrate preincubated for 1 hr followed by substrate addition incubated for 15 mins by FRET as...More data for this Ligand-Target Pair