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Found 587 with Last Name = 'perez' and Initial = 'di'
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Instituto De Qu£Mica M£Dica (Csic)

Curated by ChEMBL
LigandPNGBDBM50385902(CHEMBL2041596)
Affinity DataKi:  5.91E+3nMAssay Description:Competitive inhibition of human recombinant PDE7A1 using 5 nM to 2 uM cAMP as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Charles University

Curated by ChEMBL
LigandPNGBDBM50508727((+)-Aromoline | CHEMBL508781)
Affinity DataKi:  6.41E+3nMAssay Description:Mixed-type inhibition of human BuChE assessed as enzyme-inhibitor complex using butyrylthiocholine iodide as substrate by Lineweaver-Burk plot analys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Instituto De Qu£Mica M£Dica (Csic)

Curated by ChEMBL
LigandPNGBDBM50385903(CHEMBL2041614)
Affinity DataKi:  7.22E+3nMAssay Description:Competitive inhibition of human recombinant PDE7A1 using 5 nM to 2 uM cAMP as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Charles University

Curated by ChEMBL
LigandPNGBDBM50508727((+)-Aromoline | CHEMBL508781)
Affinity DataKi:  3.97E+4nMAssay Description:Mixed-type inhibition of human BuChE assessed as enzyme-substrate-inhibitor complex using butyrylthiocholine iodide as substrate by Lineweaver-Burk p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Charles University

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of POP (unknown origin) using (Z)-Gly-Pro-p-nitroanilide as substrate preincubated for 5 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50563723(CHEMBL4128865)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of wild-type human CK1delta using PLSRTLpSVASLPGL as substrate incubated for 40 mins in presence of ATP by Kinase-Glo luminescence assayMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Instituto De Quimica Medica-Csic

Curated by ChEMBL
LigandPNGBDBM7262(14-nitro-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant GSK3betaMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Instituto De Quimica Medica-Csic

Curated by ChEMBL
LigandPNGBDBM50347535(CHEMBL1801637)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant GSK3beta using prephosphorylated polypeptide substrate after 30 mins by Glow-type luminescence assay in presence of 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform epsilon(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50364141(CHEMBL1951415)
Affinity DataIC50:  7.70nMAssay Description:Inhibition of full-length human CK1epsilon expressed in Escherichia coli BL21-CodonPlus(DE3)-RIL competent cells using PLSRTLpSVASLPGL as substrate i...More data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas-Csic

Curated by ChEMBL
LigandPNGBDBM50456464(CHEMBL4204350)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant catalytic human GST-tagged LLRK2 (970 to 2527 residues) expressed in baculovirus expression system using LRRKtide as substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sissa-Isas

Curated by ChEMBL
LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  10nMAssay Description:Inhibition of BACE1 using methoxycoumarin-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys-dinitrophenyl as substrate preincubated 1 hr before substrate addit...More data for this Ligand-Target Pair
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50008422(CHEMBL3235552)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant CK-1delta using casein as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50364141(CHEMBL1951415)
Affinity DataIC50:  14nMAssay Description:Inhibition of full-length human CK1delta expressed in Escherichia coli BL21-CodonPlus(DE3)-RIL competent cells using PLSRTLpSVASLPGL as substrate inc...More data for this Ligand-Target Pair
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50008512(CHEMBL3235572)
Affinity DataIC50:  15nMAssay Description:Inhibition of human recombinant CK-1delta using casein as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform epsilon(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50563723(CHEMBL4128865)
Affinity DataIC50:  17nMAssay Description:Inhibition of wild-type human CK1epsilon using PLSRTLpSVASLPGL as substrate incubated for 70 mins in presence of ATP by Kinase-Glo luminescence assayMore data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas-Csic

Curated by ChEMBL
LigandPNGBDBM50456457(CHEMBL4218001)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant catalytic human GST-tagged LLRK2 (970 to 2527 residues) expressed in baculovirus expression system using LRRKtide as substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas-Csic

Curated by ChEMBL
LigandPNGBDBM482157(BDBM50379529 | LRRK2-IN-1 | US11370796, Compound L...)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant catalytic human GST-tagged LLRK2 (970 to 2527 residues) expressed in baculovirus expression system using LRRKtide as substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas-Csic

Curated by ChEMBL
LigandPNGBDBM482157(BDBM50379529 | LRRK2-IN-1 | US11370796, Compound L...)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant catalytic human GST-tagged LLRK2 G2019S mutant (970 to 2527 residues) expressed in baculovirus expression system using LRRK...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas-Csic

Curated by ChEMBL
LigandPNGBDBM50456451(CHEMBL4204860)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant catalytic human GST-tagged LLRK2 (970 to 2527 residues) expressed in baculovirus expression system using LRRKtide as substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50008401(CHEMBL3235538)
Affinity DataIC50:  23nMAssay Description:Inhibition of human recombinant CK-1delta using casein as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas-Csic

Curated by ChEMBL
LigandPNGBDBM50456457(CHEMBL4218001)
Affinity DataIC50:  30nMAssay Description:Inhibition of recombinant catalytic human GST-tagged LLRK2 G2019S mutant (970 to 2527 residues) expressed in baculovirus expression system using LRRK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50008500(CHEMBL3235560)
Affinity DataIC50:  33nMAssay Description:Inhibition of human recombinant CK-1delta using casein as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Charles University

Curated by ChEMBL
LigandPNGBDBM50199522((+)-huperzine A | (+-)-HA | (-)-1-Amino-13-ethylid...)
Affinity DataIC50:  33nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate measured for 1 min by Ellman's methodMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Sissa-Isas

Curated by ChEMBL
LigandPNGBDBM50145903(CHEMBL3763728)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant BACE1 using M-2420 as substrate preincubated for 1 hr followed by substrate addition incubated for 15 mins by FRET as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50008496(CHEMBL3235556)
Affinity DataIC50:  42nMAssay Description:Inhibition of human recombinant CK-1delta using casein as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Instituto De Quimica Medica-Csic

Curated by ChEMBL
LigandPNGBDBM50347531(CHEMBL1801633)
Affinity DataIC50:  47nMAssay Description:Inhibition of human recombinant GSK3beta using prephosphorylated polypeptide substrate after 30 mins by Glow-type luminescence assay in presence of 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50008503(CHEMBL3235563)
Affinity DataIC50:  47nMAssay Description:Inhibition of human recombinant CK-1delta using casein as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas-Csic

Curated by ChEMBL
LigandPNGBDBM50456464(CHEMBL4204350)
Affinity DataIC50:  50nMAssay Description:Inhibition of recombinant catalytic human GST-tagged LLRK2 G2019S mutant (970 to 2527 residues) expressed in baculovirus expression system using LRRK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50008504(CHEMBL3235564)
Affinity DataIC50:  56nMAssay Description:Inhibition of human recombinant CK-1delta using casein as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50008411(CHEMBL3235545)
Affinity DataIC50:  65nMAssay Description:Inhibition of human recombinant CK-1delta using casein as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50008406(CHEMBL3235542)
Affinity DataIC50:  68nMAssay Description:Inhibition of human recombinant CK-1delta using casein as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50008509(CHEMBL3235569)
Affinity DataIC50:  79nMAssay Description:Inhibition of human recombinant CK-1delta using casein as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase/Protein DBF4 homolog A(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas-Csic

Curated by ChEMBL
LigandPNGBDBM50562391(CHEMBL4747601)
Affinity DataIC50:  80nMAssay Description:Inhibition of recombinant human CDC7/Dbf4 expressed in baculovirus infected Sf9 insect cells assessed as inhibition of fluorescein labelled substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50008399(CHEMBL3235535)
Affinity DataIC50:  83nMAssay Description:Inhibition of human recombinant CK-1delta using casein as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas (Csic)

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  83nMAssay Description:Inhibition of human recombinant PDE4D3 assessed after 60 mins by IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50008499(CHEMBL3235559)
Affinity DataIC50:  87nMAssay Description:Inhibition of human recombinant CK-1delta using casein as substrate after 60 mins by Kinase-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Instituto De Qu£Mica M£Dica (Csic)

Curated by ChEMBL
LigandPNGBDBM350906(3-Phenyl-2-(2-naphthylmethylthio)-4-oxo-3,4-dihydr...)
Affinity DataIC50:  90nMAssay Description:Measurement of PDE7 inhibition was carried out using a commercial phosphodiesterase activity measurement kit.Some of the compounds of the present inv...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Instituto De Qu£Mica M£Dica (Csic)

Curated by ChEMBL
LigandPNGBDBM50277784(CHEMBL484928 | N,N,2-trimethyl-5-nitrobenzenesulfo...)
Affinity DataIC50:  90nMAssay Description:Inhibition of human recombinant PDE7A1-mediated [3H]cAMP hydrolysis after 20 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase/Protein DBF4 homolog A(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas-Csic

Curated by ChEMBL
LigandPNGBDBM50562397(CHEMBL4083753)
Affinity DataIC50:  90nMAssay Description:Inhibition of recombinant human CDC7/Dbf4 expressed in baculovirus infected Sf9 insect cells assessed as inhibition of fluorescein labelled substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Instituto De Qu£Mica M£Dica (Csic)

Curated by ChEMBL
LigandPNGBDBM50277784(CHEMBL484928 | N,N,2-trimethyl-5-nitrobenzenesulfo...)
Affinity DataIC50:  90nMAssay Description:Inhibition of human recombinant PDE7A1 assessed as inhibition of hydrolysis of [3H]cAMP after 20 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas (Csic)

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  98nMAssay Description:Inhibition of human recombinant PDE4B2 assessed after 60 mins by IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Instituto De Qu£Mica M£Dica (Csic)

Curated by ChEMBL
LigandPNGBDBM350888(3-Phenyl-2-neopentylthio-4-oxo-3,4-dihydroquinazol...)
Affinity DataIC50:  100nMAssay Description:Measurement of PDE7 inhibition was carried out using a commercial phosphodiesterase activity measurement kit.Some of the compounds of the present inv...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Instituto De Quimica Medica-Csic

Curated by ChEMBL
LigandPNGBDBM50229962(1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | ...)
Affinity DataIC50:  104nMAssay Description:Inhibition of human recombinant GSK3betaMore data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas-Csic

Curated by ChEMBL
LigandPNGBDBM50456447(CHEMBL4218856)
Affinity DataIC50:  110nMAssay Description:Inhibition of recombinant catalytic human GST-tagged LLRK2 (970 to 2527 residues) expressed in baculovirus expression system using LRRKtide as substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Instituto De Qu£Mica M£Dica (Csic)

Curated by ChEMBL
LigandPNGBDBM350903(3-(2-Methylphenyl)-2-(3-pyridylmethylthio)-4-oxo-3...)
Affinity DataIC50:  120nMAssay Description:Measurement of PDE7 inhibition was carried out using a commercial phosphodiesterase activity measurement kit.Some of the compounds of the present inv...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas-Csic

Curated by ChEMBL
LigandPNGBDBM50456451(CHEMBL4204860)
Affinity DataIC50:  120nMAssay Description:Inhibition of recombinant catalytic human GST-tagged LLRK2 G2019S mutant (970 to 2527 residues) expressed in baculovirus expression system using LRRK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase/Protein DBF4 homolog A(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas-Csic

Curated by ChEMBL
LigandPNGBDBM50562388(CHEMBL4094018)
Affinity DataIC50:  130nMAssay Description:Inhibition of recombinant human CDC7/Dbf4 expressed in baculovirus infected Sf9 insect cells assessed as inhibition of fluorescein labelled substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase/Protein DBF4 homolog A(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas-Csic

Curated by ChEMBL
LigandPNGBDBM50562380(CHEMBL4798875)
Affinity DataIC50:  130nMAssay Description:Inhibition of recombinant human CDC7/Dbf4 expressed in baculovirus infected Sf9 insect cells assessed as inhibition of fluorescein labelled substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas-Csic

Curated by ChEMBL
LigandPNGBDBM50456465(CHEMBL4211027)
Affinity DataIC50:  130nMAssay Description:Inhibition of recombinant catalytic human GST-tagged LLRK2 (970 to 2527 residues) expressed in baculovirus expression system using LRRKtide as substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sissa-Isas

Curated by ChEMBL
LigandPNGBDBM50145908(CHEMBL3763318)
Affinity DataIC50:  140nMAssay Description:Inhibition of human recombinant BACE1 using M-2420 as substrate preincubated for 1 hr followed by substrate addition incubated for 15 mins by FRET as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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