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Found 86 with Last Name = 'goffin' and Initial = 'e'
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
H�Pital Kirchberg

Curated by ChEMBL
LigandPNGBDBM50178769((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...)
Affinity DataIC50:  100nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-1 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
H�Pital Kirchberg

Curated by ChEMBL
LigandPNGBDBM50216689(2-cyano-3-(5-(2,5-dichlorophenyl)furan-2-yl)-N-(qu...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-2 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
H�Pital Kirchberg

Curated by ChEMBL
LigandPNGBDBM50179360(CHEMBL3040216)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-1 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
H�Pital Kirchberg

Curated by ChEMBL
LigandPNGBDBM50267646(CHEMBL4102380)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-2 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
H�Pital Kirchberg

Curated by ChEMBL
LigandPNGBDBM50267646(CHEMBL4102380)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-1 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
H�Pital Kirchberg

Curated by ChEMBL
LigandPNGBDBM50179360(CHEMBL3040216)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-2 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
H�Pital Kirchberg

Curated by ChEMBL
LigandPNGBDBM50267628(CHEMBL4074207)
Affinity DataIC50:  1.85E+4nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-2 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
H�Pital Kirchberg

Curated by ChEMBL
LigandPNGBDBM50178769((+/-)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...)
Affinity DataIC50:  2.01E+4nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-2 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
H�Pital Kirchberg

Curated by ChEMBL
LigandPNGBDBM50267662(CHEMBL4059756)
Affinity DataIC50:  2.27E+4nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-2 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
H�Pital Kirchberg

Curated by ChEMBL
LigandPNGBDBM50267628(CHEMBL4074207)
Affinity DataIC50:  3.21E+4nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-1 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
H�Pital Kirchberg

Curated by ChEMBL
LigandPNGBDBM50156760((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
Affinity DataIC50:  4.71E+4nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-2 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
H�Pital Kirchberg

Curated by ChEMBL
LigandPNGBDBM50267654(CHEMBL4104634)
Affinity DataIC50:  4.94E+4nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-2 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
H�Pital Kirchberg

Curated by ChEMBL
LigandPNGBDBM50267627(CHEMBL4090805)
Affinity DataIC50:  5.11E+4nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-2 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
H�Pital Kirchberg

Curated by ChEMBL
LigandPNGBDBM50267662(CHEMBL4059756)
Affinity DataIC50:  5.48E+4nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-1 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
H�Pital Kirchberg

Curated by ChEMBL
LigandPNGBDBM50156760((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
Affinity DataIC50:  8.25E+4nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-1 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
H�Pital Kirchberg

Curated by ChEMBL
LigandPNGBDBM50216689(2-cyano-3-(5-(2,5-dichlorophenyl)furan-2-yl)-N-(qu...)
Affinity DataIC50:  9.81E+4nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-1 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
H�Pital Kirchberg

Curated by ChEMBL
LigandPNGBDBM50267648(CHEMBL4084417)
Affinity DataIC50:  9.98E+4nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-2 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
H�Pital Kirchberg

Curated by ChEMBL
LigandPNGBDBM50267627(CHEMBL4090805)
Affinity DataIC50:  1.09E+5nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-1 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
H�Pital Kirchberg

Curated by ChEMBL
LigandPNGBDBM50267654(CHEMBL4104634)
Affinity DataIC50:  1.10E+5nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-1 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
H�Pital Kirchberg

Curated by ChEMBL
LigandPNGBDBM50267653(CHEMBL4092171)
Affinity DataIC50:  1.10E+5nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-2 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
H�Pital Kirchberg

Curated by ChEMBL
LigandPNGBDBM50267653(CHEMBL4092171)
Affinity DataIC50:  1.21E+5nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-1 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
H�Pital Kirchberg

Curated by ChEMBL
LigandPNGBDBM50267661(CHEMBL608379)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-2 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
H�Pital Kirchberg

Curated by ChEMBL
LigandPNGBDBM50267661(CHEMBL608379)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-1 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
H�Pital Kirchberg

Curated by ChEMBL
LigandPNGBDBM50267646(CHEMBL4102380)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-3 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
H�Pital Kirchberg

Curated by ChEMBL
LigandPNGBDBM50179360(CHEMBL3040216)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-3 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
H�Pital Kirchberg

Curated by ChEMBL
LigandPNGBDBM50267648(CHEMBL4084417)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of N-terminal His-tagged recombinant human SIRT-1 expressed in Escherichia coli using Fluor-de-Lys-SIRT1 as substrate after 15 mins by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50032241(CHEMBL2441067)
Affinity DataKd:  350nMAssay Description:Binding affinity to GluA2-LBD-L483Y-N754S complex (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50032243(CHEMBL411612)
Affinity DataKd:  5.60E+3nMAssay Description:Binding affinity to GluA2-LBD-L483Y-N754S complex (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50032245(CHEMBL99732)
Affinity DataKd:  1.20E+6nMAssay Description:Binding affinity to GluA2-LBD-L483Y-N754S complex (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50032248(CHEMBL103741)
Affinity DataKd:  9.80E+3nMAssay Description:Binding affinity to GluA2-LBD-L483Y-N754S complex (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50251223(CHEMBL4091590)
Affinity DataEC50:  1.00E+4nMAssay Description:Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expressed in HEK293 cells assessed as potentiation of glutamate-evoked calc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50251225(CHEMBL4073898)
Affinity DataEC50:  1.56E+4nMAssay Description:Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expressed in HEK293 cells assessed as potentiation of glutamate-evoked calc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50251226(CHEMBL4071167)
Affinity DataEC50:  1.56E+4nMAssay Description:Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expressed in HEK293 cells assessed as potentiation of glutamate-evoked calc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50251227(CHEMBL4084231)
Affinity DataEC50:  3.19E+3nMAssay Description:Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expressed in HEK293 cells assessed as potentiation of glutamate-evoked calc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50251228(CHEMBL4100668)
Affinity DataEC50:  710nMAssay Description:Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expressed in HEK293 cells assessed as potentiation of glutamate-evoked calc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50251230(CHEMBL4062069)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expressed in HEK293 cells assessed as potentiation of glutamate-evoked calc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50251231(CHEMBL4083809)
Affinity DataEC50:  950nMAssay Description:Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expressed in HEK293 cells assessed as potentiation of glutamate-evoked calc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50251224(CHEMBL4073431)
Affinity DataEC50:  1.87E+4nMAssay Description:Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expressed in HEK293 cells assessed as potentiation of glutamate-evoked calc...More data for this Ligand-Target Pair
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50251234(CHEMBL4081714)
Affinity DataEC50:  1.82E+3nMAssay Description:Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expressed in HEK293 cells assessed as potentiation of glutamate-evoked calc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50251233(CHEMBL4092527)
Affinity DataEC50:  7.62E+3nMAssay Description:Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expressed in HEK293 cells assessed as potentiation of glutamate-evoked calc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50032241(CHEMBL2441067)
Affinity DataEC50:  810nMAssay Description:Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expressed in HEK293 cells assessed as potentiation of glutamate-evoked calc...More data for this Ligand-Target Pair
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50251239(CHEMBL581906)
Affinity DataEC50:  2.04E+4nMAssay Description:Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expressed in HEK293 cells assessed as potentiation of glutamate-evoked calc...More data for this Ligand-Target Pair
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50251229(CHEMBL4089172)
Affinity DataEC50:  5.90E+3nMAssay Description:Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expressed in HEK293 cells assessed as potentiation of glutamate-evoked calc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50251232(CHEMBL4070694)
Affinity DataEC50:  390nMAssay Description:Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expressed in HEK293 cells assessed as potentiation of glutamate-evoked calc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50251235(CHEMBL4066717)
Affinity DataEC50:  454nMAssay Description:Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expressed in HEK293 cells assessed as potentiation of glutamate-evoked calc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50251237(CHEMBL4062524)
Affinity DataEC50:  46nMAssay Description:Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expressed in HEK293 cells assessed as potentiation of glutamate-evoked calc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50251238(CHEMBL4060993)
Affinity DataEC50:  371nMAssay Description:Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expressed in HEK293 cells assessed as potentiation of glutamate-evoked calc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50032248(CHEMBL103741)
Affinity DataEC50:  5.06E+4nMAssay Description:Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expressed in HEK293 cells assessed as potentiation of glutamate-evoked calc...More data for this Ligand-Target Pair
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50251236(CHEMBL4091984)
Affinity DataEC50:  2nMAssay Description:Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expressed in HEK293 cells assessed as potentiation of glutamate-evoked calc...More data for this Ligand-Target Pair
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50457614(CHEMBL4202524)
Affinity DataEC50:  14nMAssay Description:Positive allosteric modulation of GluA2Q flop isoform (unknown origin) expressed in HEK293 cells assessed as increase in L-glutamate induced calcium ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
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