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TargetIntegrin alpha-4/beta-1(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM17909(4-{[(2S,4S)-1-[2-(3-chloro-4-{[(2-methylphenyl)car...)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of europium labeled human VCAM1/Fc chimera binding to human VLA-4 alpha-4-beta-1 expressed in Chinese hamster 4B4 cells by fluorimetric as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM17909(4-{[(2S,4S)-1-[2-(3-chloro-4-{[(2-methylphenyl)car...)
Affinity DataIC50:  0.510nMAssay Description:Displacement of europium labeled human VCAM1 from human VLA4 expressed in 4B4 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Human)
Daiichi Pharmaceutical

LigandPNGBDBM17909(4-{[(2S,4S)-1-[2-(3-chloro-4-{[(2-methylphenyl)car...)
Affinity DataIC50:  0.510nMpH: 7.5 T: 22°CAssay Description:The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50423675(CHEMBL567396)
Affinity DataIC50:  0.530nMAssay Description:Inhibition of europium labeled human VCAM1/Fc chimera binding to human VLA-4 alpha-4-beta-1 expressed in Chinese hamster 4B4 cells by fluorimetric as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Human)
Daiichi Pharmaceutical

LigandPNGBDBM17910(4-{[(2S,4S)-1-[2-(3-bromo-4-{[(2-methylphenyl)carb...)
Affinity DataIC50:  0.780nMpH: 7.5 T: 22°CAssay Description:The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Human)
Daiichi Pharmaceutical

LigandPNGBDBM17900(4-{[(2S,4S)-1-[2-(4-{[(2-chlorophenyl)carbamoyl]am...)
Affinity DataIC50:  0.870nMpH: 7.5 T: 22°CAssay Description:The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50428682(CHEMBL2332705)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of Europium-labeled human VCAM1 binding to human VLA4 expressed in Chinese hamster 4B4 cells incubated for 60 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Human)
Daiichi Pharmaceutical

LigandPNGBDBM17899(4-{[(2S,4S)-4-fluoro-1-[2-(3-methoxy-4-{[(2-methyl...)
Affinity DataIC50:  1.20nMpH: 7.5 T: 22°CAssay Description:The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50428687(CHEMBL2332700)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of Europium-labeled human VCAM1 binding to human VLA4 expressed in Chinese hamster 4B4 cells incubated for 60 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Human)
Daiichi Pharmaceutical

LigandPNGBDBM17913(4-{[(2S,4S)-1-[2-(3-bromo-4-{[(2-chlorophenyl)carb...)
Affinity DataIC50:  1.30nMpH: 7.5 T: 22°CAssay Description:The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Human)
Daiichi Pharmaceutical

LigandPNGBDBM17912(4-{[(2S,4S)-1-[2-(3-chloro-4-{[(2-chlorophenyl)car...)
Affinity DataIC50:  1.30nMpH: 7.5 T: 22°CAssay Description:The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Human)
Daiichi Pharmaceutical

LigandPNGBDBM17916(4-{[(2S,4S)-1-[2-(3-bromo-4-{[(2-bromophenyl)carba...)
Affinity DataIC50:  1.40nMpH: 7.5 T: 22°CAssay Description:The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50273492(4-[1-[3-Chloro-4-[N'-(5-fluoro-2-methylphenyl)urei...)
Affinity DataIC50:  1.60nMAssay Description:Displacement of europium labeled human VCAM1 from human VLA4 expressed in 4B4 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Human)
Daiichi Pharmaceutical

LigandPNGBDBM17901(4-{[(2S,4S)-1-[2-(4-{[(2-bromophenyl)carbamoyl]ami...)
Affinity DataIC50:  1.60nMpH: 7.5 T: 22°CAssay Description:The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50428680(CHEMBL2332690)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of Europium-labeled human VCAM1 binding to human VLA4 expressed in Chinese hamster 4B4 cells incubated for 60 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Human)
Daiichi Pharmaceutical

LigandPNGBDBM17915(4-{[(2S,4S)-1-[2-(4-{[(2-bromophenyl)carbamoyl]ami...)
Affinity DataIC50:  1.70nMpH: 7.5 T: 22°CAssay Description:The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50428679(CHEMBL2332691)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of Europium-labeled human VCAM1 binding to human VLA4 expressed in Chinese hamster 4B4 cells incubated for 60 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50428689(CHEMBL2332698)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of Europium-labeled human VCAM1 binding to human VLA4 expressed in Chinese hamster 4B4 cells incubated for 60 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50428678(CHEMBL2332692)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of Europium-labeled human VCAM1 binding to human VLA4 expressed in Chinese hamster 4B4 cells incubated for 60 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50273911(4-[1-[3-Chloro-6-fluoro-4-[N'-(2-methylphenyl)urei...)
Affinity DataIC50:  1.80nMAssay Description:Displacement of europium labeled human VCAM1 from human VLA4 expressed in 4B4 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50428681(CHEMBL2332706)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of Europium-labeled human VCAM1 binding to human VLA4 expressed in Chinese hamster 4B4 cells incubated for 60 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50423681(CHEMBL583324)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of europium labeled human VCAM1/Fc chimera binding to human VLA-4 alpha-4-beta-1 expressed in Chinese hamster 4B4 cells by fluorimetric as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50273912(4-[1-[5-chloro-4-[N'-(2-methylphenyl)ureido]-2-met...)
Affinity DataIC50:  1.90nMAssay Description:Displacement of europium labeled human VCAM1 from human VLA4 expressed in 4B4 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50448871(CHEMBL3125101)
Affinity DataIC50:  2nMAssay Description:Inhibition of Mycobacterium tuberculosis full length biotinylated InhA (270 amino acids) using DDCoA as substrate assessed as NADH oxidation by fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50448867(CHEMBL3125235)
Affinity DataIC50:  2nMAssay Description:Inhibition of Mycobacterium tuberculosis full length biotinylated InhA (270 amino acids) using DDCoA as substrate assessed as NADH oxidation by fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50273910(4-[1-[2,5-Dichloro-4-[N'-(2-methylphenyl)ureido]ph...)
Affinity DataIC50:  2.20nMAssay Description:Displacement of europium labeled human VCAM1 from human VLA4 expressed in 4B4 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50428688(CHEMBL2332699)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of Europium-labeled human VCAM1 binding to human VLA4 expressed in Chinese hamster 4B4 cells incubated for 60 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Human)
Daiichi Pharmaceutical

LigandPNGBDBM17905(4-{[(2S,4S)-4-fluoro-1-[2-(3-methyl-4-{[(2-methylp...)
Affinity DataIC50:  2.30nMpH: 7.5 T: 22°CAssay Description:The 4B4 cells expressing VLA-4 were distributed into each well of a 96-well culture plate for 2 days. Compound and Eu-labeled Human VCAM-1/Fc Chimera...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50423847(CHEMBL1940750)
Affinity DataIC50:  2.30nMAssay Description:Displacement of Eu-labeled VCAM-1 from human VLA alpha4 beta1 expressed in CHO-K1 cells after 60 mins by time-resolved fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50423857(CHEMBL1940761)
Affinity DataIC50:  2.5nMAssay Description:Displacement of Eu-labeled VCAM-1 from human VLA alpha4 beta1 expressed in CHO-K1 cells after 60 mins by time-resolved fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50423680(CHEMBL568265)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of europium labeled human VCAM1/Fc chimera binding to human VLA-4 alpha-4-beta-1 expressed in Chinese hamster 4B4 cells by fluorimetric as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50423863(CHEMBL1940902)
Affinity DataIC50:  2.60nMAssay Description:Displacement of Eu-labeled VCAM-1 from human VLA alpha4 beta1 expressed in CHO-K1 cells after 60 mins by time-resolved fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50423678(CHEMBL583429)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of europium labeled human VCAM1/Fc chimera binding to human VLA-4 alpha-4-beta-1 expressed in Chinese hamster 4B4 cells by fluorimetric as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50423679(CHEMBL566091)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of europium labeled human VCAM1/Fc chimera binding to human VLA-4 alpha-4-beta-1 expressed in Chinese hamster 4B4 cells by fluorimetric as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50255892(CHEMBL481501 | trans-4-(((2S,4S)-4-fluoro-1-(2-(2-...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of europium labeled human VCAM1/Fc chimera binding to human VLA-4 alpha-4-beta-1 expressed in Chinese hamster 4B4 cells by fluorimetric as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50423661(CHEMBL584081)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of europium labeled human VCAM1/Fc chimera binding to human VLA-4 alpha-4-beta-1 expressed in Chinese hamster 4B4 cells by fluorimetric as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50423661(CHEMBL584081)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of Europium-labeled human VCAM1 binding to human VLA4 expressed in Chinese hamster 4B4 cells incubated for 60 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50273387(4-[1-[3-Chloro-4-[N'-(4-fluoro-2-methylphenyl)-ure...)
Affinity DataIC50:  2.80nMAssay Description:Displacement of europium labeled human VCAM1 from human VLA4 expressed in 4B4 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50255892(CHEMBL481501 | trans-4-(((2S,4S)-4-fluoro-1-(2-(2-...)
Affinity DataIC50:  2.80nMAssay Description:Displacement of europium labeled human VCAM1 from human VLA4 expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50428675(CHEMBL2332695)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of Europium-labeled human VCAM1 binding to human VLA4 expressed in Chinese hamster 4B4 cells incubated for 60 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50273879(4-[1-[3-Chloro-4-[N'-(2-chlorophenyl)ureido]-6-flu...)
Affinity DataIC50:  2.90nMAssay Description:Displacement of europium labeled human VCAM1 from human VLA4 expressed in 4B4 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50423677(CHEMBL585371)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of europium labeled human VCAM1/Fc chimera binding to human VLA-4 alpha-4-beta-1 expressed in Chinese hamster 4B4 cells by fluorimetric as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50448875(CHEMBL3125266)
Affinity DataIC50:  3nMAssay Description:Inhibition of Mycobacterium tuberculosis full length biotinylated InhA (270 amino acids) using DDCoA as substrate assessed as NADH oxidation by fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50423676(CHEMBL571944)
Affinity DataIC50:  3nMAssay Description:Inhibition of europium labeled human VCAM1/Fc chimera binding to human VLA-4 alpha-4-beta-1 expressed in Chinese hamster 4B4 cells by fluorimetric as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50448868(CHEMBL3125104)
Affinity DataIC50:  3nMAssay Description:Inhibition of Mycobacterium tuberculosis full length biotinylated InhA (270 amino acids) using DDCoA as substrate assessed as NADH oxidation by fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50448888(CHEMBL3125253)
Affinity DataIC50:  3nMAssay Description:Inhibition of Mycobacterium tuberculosis full length biotinylated InhA (270 amino acids) using DDCoA as substrate assessed as NADH oxidation by fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50448880(CHEMBL3125261)
Affinity DataIC50:  3nMAssay Description:Inhibition of Mycobacterium tuberculosis full length biotinylated InhA (270 amino acids) using DDCoA as substrate assessed as NADH oxidation by fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50273959(4-[1-[4-[N'-(2-chlorophenyl)ureido]-2,5-dichloroph...)
Affinity DataIC50:  3.40nMAssay Description:Displacement of europium labeled human VCAM1 from human VLA4 expressed in 4B4 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50273960(4-[1-[5-Chloro-4-[N'-(2-chlorophenyl)ureido]-3-met...)
Affinity DataIC50:  3.5nMAssay Description:Displacement of europium labeled human VCAM1 from human VLA4 expressed in 4B4 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50428677(CHEMBL2332693)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of Europium-labeled human VCAM1 binding to human VLA4 expressed in Chinese hamster 4B4 cells incubated for 60 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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