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Found 168 with Last Name = 'tjoeng' and Initial = 'fs'
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50064015(7-Propyl-azepan-(2Z)-ylideneamine; hydrochloride |...)
Affinity DataKi:  90nMAssay Description:Inhibitory activity against L-arginine binding to Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Searle Research & Development

Curated by ChEMBL
LigandPNGBDBM50031555((S)-3-[3-(4-Carbamimidoyl-phenylcarbamoyl)-propion...)
Affinity DataIC50:  50nMAssay Description:Inhibition of collagen-induced canine platelet aggregation in vitro (blood is pooled from more than 2 dogs).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Searle Research & Development

Curated by ChEMBL
LigandPNGBDBM50031545((S)-3-Benzo[1,3]dioxol-5-yl-3-[3-(4-carbamimidoyl-...)
Affinity DataIC50:  52nMAssay Description:Inhibition of collagen-induced canine platelet aggregation in vitro (blood is pooled from more than 2 dogs).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
G. D. Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50062142(4,6-Dimethyl-piperidin-(2Z)-ylideneamine | CHEMBL2...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Searle Research & Development

Curated by ChEMBL
LigandPNGBDBM50031565((S)-3-[3-(4-Carbamimidoyl-phenylcarbamoyl)-propion...)
Affinity DataIC50:  67nMAssay Description:Inhibition of collagen-induced canine platelet aggregation in vitro (blood is pooled from more than 2 dogs).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062142(4,6-Dimethyl-piperidin-(2Z)-ylideneamine | CHEMBL2...)
Affinity DataIC50:  80nMAssay Description:Inhibition of human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062133(4-Methyl-piperidin-(2E)-ylideneamine | 4-Methyl-pi...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Searle Research & Development

Curated by ChEMBL
LigandPNGBDBM50031553(3-[3-(4-Carbamimidoyl-phenylcarbamoyl)-propionylam...)
Affinity DataIC50:  101nMAssay Description:Inhibition of collagen-induced canine platelet aggregation in vitro (blood is pooled from more than 2 dogs).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Searle Research & Development

Curated by ChEMBL
LigandPNGBDBM50031559(3-Benzo[1,3]dioxol-5-yl-3-[3-(4-carbamimidoyl-phen...)
Affinity DataIC50:  104nMAssay Description:Inhibition of collagen-induced canine platelet aggregation in vitro (blood is pooled from more than 2 dogs).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Searle Research & Development

Curated by ChEMBL
LigandPNGBDBM50031561(3-[3-(4-Carbamimidoyl-phenylcarbamoyl)-propionylam...)
Affinity DataIC50:  108nMAssay Description:Inhibition of collagen-induced canine platelet aggregation in vitro (blood is pooled from more than 2 dogs).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Searle Research & Development

Curated by ChEMBL
LigandPNGBDBM50031544(3-[3-(4-Carbamimidoyl-phenylcarbamoyl)-propionylam...)
Affinity DataIC50:  115nMAssay Description:Inhibition of collagen-induced canine platelet aggregation in vitro (blood is pooled from more than 2 dogs).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Searle Research & Development

Curated by ChEMBL
LigandPNGBDBM50031547(3-[3-(4-Carbamimidoyl-phenylcarbamoyl)-propionylam...)
Affinity DataIC50:  122nMAssay Description:Inhibition of collagen-induced canine platelet aggregation in vitro (blood is pooled from more than 2 dogs).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Searle Research & Development

Curated by ChEMBL
LigandPNGBDBM50031556((Aminobenzamidino)succinyl analogue | (S)-3-[3-(4-...)
Affinity DataIC50:  133nMAssay Description:Inhibition of collagen-induced canine platelet aggregation in vitro (blood is pooled from more than 2 dogs).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Searle Research & Development

Curated by ChEMBL
LigandPNGBDBM50031556((Aminobenzamidino)succinyl analogue | (S)-3-[3-(4-...)
Affinity DataIC50:  133nMAssay Description:Inhibition of collagen-induced canine platelet aggregation in vitro (blood is pooled from more than 2 dogs).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Searle Research & Development

Curated by ChEMBL
LigandPNGBDBM50031563(3-[3-(4-Carbamimidoyl-phenylcarbamoyl)-propionylam...)
Affinity DataIC50:  158nMAssay Description:Inhibition of collagen-induced canine platelet aggregation in vitro (blood is pooled from more than 2 dogs).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50064015(7-Propyl-azepan-(2Z)-ylideneamine; hydrochloride |...)
Affinity DataIC50:  160nMAssay Description:Inhibitory activity evaluated for soluble cell extract of human Inducible nitric oxide synthase and partially purified by DEAE-sepharose chromatograp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Searle Research & Development

Curated by ChEMBL
LigandPNGBDBM50031550(3-[3-(4-Carbamimidoyl-phenylcarbamoyl)-propionylam...)
Affinity DataIC50:  170nMAssay Description:Inhibition of collagen-induced canine platelet aggregation in vitro (blood is pooled from more than 2 dogs).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50064018(7-Allyl-azepan-(2Z)-ylideneamine; hydrochloride | ...)
Affinity DataIC50:  190nMAssay Description:Inhibitory activity evaluated for soluble cell extract of human Inducible nitric oxide synthase and partially purified by DEAE-sepharose chromatograp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
G. D. Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50062133(4-Methyl-piperidin-(2E)-ylideneamine | 4-Methyl-pi...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062132(6-Propyl-piperidin-(2Z)-ylideneamine | CHEMBL6760)
Affinity DataIC50:  200nMAssay Description:Inhibition of human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Searle Research & Development

Curated by ChEMBL
LigandPNGBDBM50031557(3-[3-(4-Carbamimidoyl-phenylcarbamoyl)-propionylam...)
Affinity DataIC50:  224nMAssay Description:Inhibition of collagen-induced canine platelet aggregation in vitro (blood is pooled from more than 2 dogs).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Searle Research & Development

Curated by ChEMBL
LigandPNGBDBM50031554(3-[3-(4-Carbamimidoyl-phenylcarbamoyl)-propionylam...)
Affinity DataIC50:  256nMAssay Description:Inhibition of collagen-induced canine platelet aggregation in vitro (blood is pooled from more than 2 dogs).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Searle Research & Development

Curated by ChEMBL
LigandPNGBDBM50031552(3-[3-(4-Carbamimidoyl-phenylcarbamoyl)-propionylam...)
Affinity DataIC50:  294nMAssay Description:Inhibition of collagen-induced canine platelet aggregation in vitro (blood is pooled from more than 2 dogs).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
G. D. Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50062142(4,6-Dimethyl-piperidin-(2Z)-ylideneamine | CHEMBL2...)
Affinity DataIC50:  300nMAssay Description:inhibition of human endothelial constitutive Endothelial nitric oxide synthase (heNOS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Searle Research & Development

Curated by ChEMBL
LigandPNGBDBM50031539(3-[3-(4-Carbamimidoyl-phenylcarbamoyl)-propionylam...)
Affinity DataIC50:  302nMAssay Description:Inhibition of collagen-induced canine platelet aggregation in vitro (blood is pooled from more than 2 dogs).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Searle Research & Development

Curated by ChEMBL
LigandPNGBDBM50031540(3-[3-(4-Carbamimidoyl-phenylcarbamoyl)-propionylam...)
Affinity DataIC50:  321nMAssay Description:Inhibition of collagen-induced canine platelet aggregation in vitro (blood is pooled from more than 2 dogs).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
G. D. Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50062137(6-Methyl-piperidin-(2Z)-ylideneamine | CHEMBL26567...)
Affinity DataIC50:  400nMAssay Description:Inhibition of human Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
G. D. Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50064015(7-Propyl-azepan-(2Z)-ylideneamine; hydrochloride |...)
Affinity DataIC50:  460nMAssay Description:Inhibitory activity evaluated from soluble cell extract of human Neuronal nitric oxide synthase and partially purified by DEAE-sepharose chromatograp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Searle Research & Development

Curated by ChEMBL
LigandPNGBDBM50031558(3-[3-(4-Carbamimidoyl-phenylcarbamoyl)-propionylam...)
Affinity DataIC50:  491nMAssay Description:Inhibition of collagen-induced canine platelet aggregation in vitro (blood is pooled from more than 2 dogs).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
G. D. Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50049252(2-Amino-5-(N-nitro-guanidino)-pentanoic acid | CHE...)
Affinity DataIC50:  500nMAssay Description:Inhibitory activity against human Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
G. D. Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50049252(2-Amino-5-(N-nitro-guanidino)-pentanoic acid | CHE...)
Affinity DataIC50:  500nMAssay Description:Inhibitory activity against human Endothelial nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50064011(7-Butyl-azepan-(2Z)-ylideneamine; hydrochloride | ...)
Affinity DataIC50:  500nMAssay Description:Inhibitory activity evaluated for soluble cell extract of human Inducible nitric oxide synthase and partially purified by DEAE-sepharose chromatograp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
G. D. Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50062131(6-Trifluoromethyl-piperidin-(2Z)-ylideneamine | CH...)
Affinity DataIC50:  500nMAssay Description:Inhibition of human Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062131(6-Trifluoromethyl-piperidin-(2Z)-ylideneamine | CH...)
Affinity DataIC50:  500nMAssay Description:Inhibition of human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062137(6-Methyl-piperidin-(2Z)-ylideneamine | CHEMBL26567...)
Affinity DataIC50:  500nMAssay Description:Inhibition of human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
G. D. Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50062132(6-Propyl-piperidin-(2Z)-ylideneamine | CHEMBL6760)
Affinity DataIC50:  500nMAssay Description:Inhibition of human Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
G. D. Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50225106((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...)
Affinity DataIC50:  500nMAssay Description:Tested for inhibition of mouse inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Searle Research & Development

Curated by ChEMBL
LigandPNGBDBM50031566(3-[3-(4-Carbamimidoyl-phenylcarbamoyl)-propionylam...)
Affinity DataIC50:  580nMAssay Description:Inhibition of collagen-induced canine platelet aggregation in vitro (blood is pooled from more than 2 dogs).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
G. D. Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50064015(7-Propyl-azepan-(2Z)-ylideneamine; hydrochloride |...)
Affinity DataIC50:  600nMAssay Description:The ability of compound to inhibit mouse Inducible nitric oxide synthase in LPS stimulated mouse RAW cells was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
G. D. Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50064018(7-Allyl-azepan-(2Z)-ylideneamine; hydrochloride | ...)
Affinity DataIC50:  600nMAssay Description:The ability of compound to inhibit mouse Inducible nitric oxide synthase in LPS stimulated mouse RAW cells was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
G. D. Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50062137(6-Methyl-piperidin-(2Z)-ylideneamine | CHEMBL26567...)
Affinity DataIC50:  600nMAssay Description:inhibition of human endothelial constitutive Endothelial nitric oxide synthase (heNOS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
G. D. Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50062145(3-Methyl-piperidin-(2Z)-ylideneamine | CHEMBL26716...)
Affinity DataIC50:  700nMAssay Description:Inhibition of human Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
G. D. Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50064011(7-Butyl-azepan-(2Z)-ylideneamine; hydrochloride | ...)
Affinity DataIC50:  850nMAssay Description:Inhibitory activity evaluated from soluble cell extract of human nNeuronal nitric oxide synthase and partially purified by DEAE-sepharose chromatogra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
G. D. Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50064018(7-Allyl-azepan-(2Z)-ylideneamine; hydrochloride | ...)
Affinity DataIC50:  870nMAssay Description:Inhibitory activity evaluated from soluble cell extract of human Neuronal nitric oxide synthase and partially purified by DEAE-sepharose chromatograp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
G. D. Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50062136(6-Benzyl-piperidin-(2Z)-ylideneamine | CHEMBL6875)
Affinity DataIC50:  900nMAssay Description:Inhibition of human Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Searle Research & Development

Curated by ChEMBL
LigandPNGBDBM50031551(3-[5-(4-Carbamimidoyl-phenyl)-pent-4-enoylamino]-p...)
Affinity DataIC50:  904nMAssay Description:Inhibition of collagen-induced canine platelet aggregation in vitro (blood is pooled from more than 2 dogs).More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50049255(CHEMBL269058 | PIPERIDIN-2-IMINE | Piperidin-(2E)-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity against human inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Searle Research & Development

Curated by ChEMBL
LigandPNGBDBM50031564(3-[3-(4-Carbamimidoyl-phenylcarbamoyl)-propionylam...)
Affinity DataIC50:  1.09E+3nMAssay Description:Inhibition of collagen-induced canine platelet aggregation in vitro (blood is pooled from more than 2 dogs).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
G. D. Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50049255(CHEMBL269058 | PIPERIDIN-2-IMINE | Piperidin-(2E)-...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50049255(CHEMBL269058 | PIPERIDIN-2-IMINE | Piperidin-(2E)-...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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