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LigandPNGBDBM50544523(CHEMBL4647674)
Affinity DataIC50:  4.10nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50544513(CHEMBL4649088)
Affinity DataIC50:  6.60nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50544531(CHEMBL4648953)
Affinity DataIC50:  7.70nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50544501(CHEMBL4647444)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50544506(CHEMBL4647464)
Affinity DataIC50:  15nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50544503(CHEMBL4644158)
Affinity DataIC50:  37nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50592161(CHEMBL5198220)
Affinity DataIC50:  60nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of menthol-induced calcium currents at -60 mV measured fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50544500(CHEMBL4649195)
Affinity DataIC50:  90nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50592164(CHEMBL5208212)
Affinity DataIC50:  100nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of menthol-induced calcium currents at -60 mV measured fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50592165(CHEMBL5198707)
Affinity DataIC50:  110nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of menthol-induced calcium currents at -60 mV measured fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50592161(CHEMBL5198220)
Affinity DataIC50:  110nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50405790(CHEMBL5284121)
Affinity DataIC50:  150nMAssay Description:Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50405760(CHEMBL5284133)
Affinity DataIC50:  200nMAssay Description:Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50544531(CHEMBL4648953)
Affinity DataIC50:  200nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50592165(CHEMBL5198707)
Affinity DataIC50:  210nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Universiti Kebangsaan Malaysia

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  210nMAssay Description:Inhibition of ovine COX1 using arachidonic acid substrate assessed as PGE2 production ELISA method after 2 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50592163(CHEMBL5169807)
Affinity DataIC50:  250nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCarboxypeptidase A1(Bovine)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50365328(CHEMBL1955927)
Affinity DataIC50:  250nMAssay Description:Inhibition of bovine pancreas carboxypeptidase A using N-(4-methoxyphenylazoformyl)-phenylalanine as substrate after 5 mins by colorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50592159(CHEMBL5193429)
Affinity DataIC50:  280nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50592160(CHEMBL5182352)
Affinity DataIC50:  290nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50592162(CHEMBL5205458)
Affinity DataIC50:  320nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Universiti Kebangsaan Malaysia

Curated by ChEMBL
LigandPNGBDBM50021461(CHEMBL3289927)
Affinity DataIC50:  370nMAssay Description:Inhibition of ovine COX1 using arachidonic acid substrate assessed as PGE2 production ELISA method after 2 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50544513(CHEMBL4649088)
Affinity DataIC50:  400nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50061980(CHEMBL3394323)
Affinity DataIC50:  410nMAssay Description:Inhibition of mPGES-1 in interleukin-1beta-stimulated human A549 cells microsomal membranes assessed as reduction in PGE2 formation incubated for 15 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Sheep)
Universiti Kebangsaan Malaysia

Curated by ChEMBL
LigandPNGBDBM50021468(CHEMBL3289934)
Affinity DataIC50:  420nMAssay Description:Inhibition of ovine COX1 using arachidonic acid substrate assessed as PGE2 production ELISA method after 2 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Sheep)
Universiti Kebangsaan Malaysia

Curated by ChEMBL
LigandPNGBDBM50021447(CHEMBL3289926)
Affinity DataIC50:  460nMAssay Description:Inhibition of ovine COX1 using arachidonic acid substrate assessed as PGE2 production ELISA method after 2 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50592164(CHEMBL5208212)
Affinity DataIC50:  490nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50544523(CHEMBL4647674)
Affinity DataIC50:  500nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Sheep)
Universiti Kebangsaan Malaysia

Curated by ChEMBL
LigandPNGBDBM50045848(CHEMBL3309948)
Affinity DataIC50:  670nMAssay Description:Inhibition of ovine COX1 using arachidonic acid substrate assessed as PGE2 production ELISA method after 2 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Sheep)
Universiti Kebangsaan Malaysia

Curated by ChEMBL
LigandPNGBDBM50045847(CHEMBL3309947)
Affinity DataIC50:  720nMAssay Description:Inhibition of ovine COX1 using arachidonic acid substrate assessed as PGE2 production ELISA method after 2 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50544521(CHEMBL4634053)
Affinity DataIC50:  800nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50592157(CHEMBL5193818)
Affinity DataIC50:  850nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50544503(CHEMBL4644158)
Affinity DataIC50:  900nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50544501(CHEMBL4647444)
Affinity DataIC50:  900nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Sheep)
Universiti Kebangsaan Malaysia

Curated by ChEMBL
LigandPNGBDBM50021418(CHEMBL3289925)
Affinity DataIC50:  990nMAssay Description:Inhibition of ovine COX1 using arachidonic acid substrate assessed as PGE2 production ELISA method after 2 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50544506(CHEMBL4647464)
Affinity DataIC50:  1.10E+3nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Sheep)
Universiti Kebangsaan Malaysia

Curated by ChEMBL
LigandPNGBDBM50021467(CHEMBL3289933)
Affinity DataIC50:  1.12E+3nMAssay Description:Inhibition of ovine COX1 using arachidonic acid substrate assessed as PGE2 production ELISA method after 2 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50592155(CHEMBL5203685)
Affinity DataIC50:  1.20E+3nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Universiti Kebangsaan Malaysia

Curated by ChEMBL
LigandPNGBDBM50045849(CHEMBL3309949)
Affinity DataIC50:  1.22E+3nMAssay Description:Inhibition of ovine COX1 using arachidonic acid substrate assessed as PGE2 production ELISA method after 2 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50544515(CHEMBL4645828)
Affinity DataIC50:  1.30E+3nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50061981(CHEMBL3394322)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of mPGES-1 in interleukin-1beta-stimulated human A549 cells microsomal membranes assessed as reduction in PGE2 formation incubated for 15 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50544516(CHEMBL4643039)
Affinity DataIC50:  1.50E+3nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50544502(CHEMBL4634045)
Affinity DataIC50:  1.60E+3nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50544512(CHEMBL229543)
Affinity DataIC50:  1.60E+3nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50544517(CHEMBL4641209)
Affinity DataIC50:  1.70E+3nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50405791(CHEMBL5285589)
Affinity DataIC50:  1.70E+3nMAssay Description:Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50592153(CHEMBL5176697)
Affinity DataIC50:  1.70E+3nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Universiti Kebangsaan Malaysia

Curated by ChEMBL
LigandPNGBDBM50021417(CHEMBL3289924)
Affinity DataIC50:  1.77E+3nMAssay Description:Inhibition of ovine COX1 using arachidonic acid substrate assessed as PGE2 production ELISA method after 2 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50592156(CHEMBL5206192)
Affinity DataIC50:  2.10E+3nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50592154(CHEMBL5173566)
Affinity DataIC50:  2.20E+3nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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