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Found 27 with Last Name = 'chen' and Initial = 'hl'
TargetDNA topoisomerase 1(Homo sapiens (Human))
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50008923((S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel by electrophoresisMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Tamkang University

Curated by ChEMBL
LigandPNGBDBM50009004((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibitory activity against 15-lipoxygenase was determined obtained from soya beanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50326196((E)-6-Hydroxy-9-methoxy-11H-indeno[1,2-c]quinolin-...)
Affinity DataIC50:  3.76E+3nMAssay Description:Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel by electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50099692(CHEMBL51314 | N-(9,10-Dioxo-9,10-dihydro-phenanthr...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of Lck (unknown origin) phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50326192((E)-9-methoxy-6-(piperazin-1-yl)-11H-indeno[1,2-c]...)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel by electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50326187((E)-9-Methoxy-11H-indeno[1,2-c]quinolin-11-oneO-2-...)
Affinity DataIC50:  7.20E+3nMAssay Description:Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel by electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50326181((E)-6-Hydroxy-9-methoxy-11H-indeno[1,2-c]quinolin-...)
Affinity DataIC50:  7.40E+3nMAssay Description:Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel by electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50326186((E)-9-Methoxy-11H-indeno[1,2-c]quinolin-11-one O-2...)
Affinity DataIC50:  8.20E+3nMAssay Description:Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel by electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50326191((E)-9-methoxy-6-(piperazin-1-yl)-11H-indeno[1,2-c]...)
Affinity DataIC50:  8.50E+3nMAssay Description:Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel by electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
National Yang-Ming University

Curated by ChEMBL
LigandPNGBDBM50260179(CHEMBL4090305)
Affinity DataIC50:  1.12E+4nMAssay Description:Displacement of [3H]R-1881 from Androgen receptor of LNCaP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50326194((E)-9-methoxy-6-(piperazin-1-yl)-11H-indeno[1,2-c]...)
Affinity DataIC50:  1.15E+4nMAssay Description:Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel by electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50326193((E)-9-methoxy-6-(piperazin-1-yl)-11H-indeno[1,2-c]...)
Affinity DataIC50:  1.28E+4nMAssay Description:Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel by electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50326195((E)-9-methoxy-6-(piperazin-1-yl)-11H-indeno[1,2-c]...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel by electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50326184((E)-9-Methoxy-11H-indeno[1,2-c]quinolin-11-one O-2...)
Affinity DataIC50:  1.65E+4nMAssay Description:Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel by electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM22984((8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-me...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel by electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
National Yang-Ming University

Curated by ChEMBL
LigandPNGBDBM50260177(CHEMBL3409195)
Affinity DataIC50:  2.17E+4nMAssay Description:Displacement of [3H]R-1881 from Androgen receptor of PC3-AR cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
National Yang-Ming University

Curated by ChEMBL
LigandPNGBDBM50260178(CHEMBL3409192)
Affinity DataIC50:  2.35E+4nMAssay Description:Displacement of [3H]R-1881 from Androgen receptor of PC3-AR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Tamkang University

Curated by ChEMBL
LigandPNGBDBM50137349(1-Cyano-4-ethoxy-2-oxo-2H-3-oxa-benzo[a]azulene-10...)
Affinity DataIC50:  2.42E+4nMAssay Description:Inhibitory activity against 15-lipoxygenase was determined obtained from soya beanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 13(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50099692(CHEMBL51314 | N-(9,10-Dioxo-9,10-dihydro-phenanthr...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of protein tyrosine phosphatase N13 (unknown origin) phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50099692(CHEMBL51314 | N-(9,10-Dioxo-9,10-dihydro-phenanthr...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of protein tyrosine phosphatase N1 (unknown origin) phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
National Yang-Ming University

Curated by ChEMBL
LigandPNGBDBM50260176(CHEMBL4062993)
Affinity DataIC50:  3.62E+4nMAssay Description:Displacement of [3H]R-1881 from Androgen receptor of LNCaP cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50326185((E)-9-Methoxy-11H-indeno[1,2-c]quinolin-11-oneO-3-...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel by electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50326188(9-Methoxy-11H-indeno[1,2-c]quinolin-11-one | CHEMB...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel by electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50326190((E)-6-Hydroxy-9-methoxy-11H-indeno[1,2-c]quinolin-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel by electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50326189((E)-6-Hydroxy-9-methoxy-11H-indeno[1,2-c]quinolin-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel by electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50326182((E)-6-Hydroxy-9-methoxy-11H-indeno[1,2-c]quinolin-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel by electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50326183((E)-9-Methoxy-11H-indeno[1,2-c]quinolin-11-oneO-2-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human topoisomerase 1 assessed as decrease in pBR322 mobility on agarose gel by electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed