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Found 247 with Last Name = 'houck' and Initial = 'j'
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50175282(CHEMBL3809146)
Affinity DataKi:  40nMAssay Description:Inhibition of human SphK1 expressed in baculovirus infected in Sf9 cells using D-erythro-sphingosine as substrate and [gamma-32P]ATP by scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50343835((S)-1-(4-(4-(3-(2-Cyclohexylethyl)phenyl)oxazol-2-...)
Affinity DataKi:  47nMAssay Description:Inhibition of human recombinant SPHK1 expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50175281(CHEMBL3809554)
Affinity DataKi:  70nMAssay Description:Inhibition of human SphK1 expressed in baculovirus infected in Sf9 cells using D-erythro-sphingosine as substrate and [gamma-32P]ATP by scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50343831((S)-1-(4-(7-(Cyclohexylmethoxy)heptyl)benzoyl)pyrr...)
Affinity DataKi:  75nMAssay Description:Inhibition of human recombinant SPHK1 expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50343827(CHEMBL1774569 | N-(1-Carbamimidoylcyclopropyl)-11-...)
Affinity DataKi:  95nMAssay Description:Inhibition of human recombinant SPHK1 expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50343832((S)-1-(4-(9-cyclohexylnonyl)benzoyl)pyrrolidine-2-...)
Affinity DataKi:  99nMAssay Description:Inhibition of human recombinant SPHK1 expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50175280(CHEMBL3809162)
Affinity DataKi:  100nMAssay Description:Inhibition of human SphK1 expressed in baculovirus infected in Sf9 cells using D-erythro-sphingosine as substrate and [gamma-32P]ATP by scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM174126(US9688668, 1a)
Affinity DataKi:  100nMAssay Description:SLR080811, prepared as the HCl salt, was tested first at recombinant SphK1 and SphK2 using a broken cell assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50343836((S)-1-(4-(4-(3-(2-Cyclohexylethyl)phenyl)thiazol-2...)
Affinity DataKi:  110nMAssay Description:Inhibition of human recombinant SPHK1 expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50343821(1-Carbamimidoyl-N-(10-(cyclohexylmethoxy)decyl)cyc...)
Affinity DataKi:  110nMAssay Description:Inhibition of human recombinant SPHK1 expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50343833((S)-1-(11-(Cyclohexylmethoxy)undecanoyl)pyrrolidin...)
Affinity DataKi:  130nMAssay Description:Inhibition of human recombinant SPHK1 expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50343829((S)-1-(4-Dodecylbenzoyl)pyrrolidine-2-carboximidam...)
Affinity DataKi:  130nMAssay Description:Inhibition of human recombinant SPHK1 expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50343823(CHEMBL1774565 | N-(1-Carbamimidoylcyclopropyl)-4-(...)
Affinity DataKi:  130nMAssay Description:Inhibition of human recombinant SPHK1 expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50343824(CHEMBL1774566 | N-(1-Carbamimidoylcyclopropyl)-4-(...)
Affinity DataKi:  170nMAssay Description:Inhibition of human recombinant SPHK1 expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50175287(CHEMBL3810270)
Affinity DataKi:  200nMAssay Description:Inhibition of human SphK1 expressed in baculovirus infected in Sf9 cells using D-erythro-sphingosine as substrate and [gamma-32P]ATP by scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50343818(1-Carbamimidoyl-N-(4-(7-(cyclohexylmethoxy)heptyl)...)
Affinity DataKi:  240nMAssay Description:Inhibition of human recombinant SPHK1 expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50175276(CHEMBL3809326)
Affinity DataKi:  260nMAssay Description:Inhibition of human SphK1 expressed in baculovirus infected in Sf9 cells using D-erythro-sphingosine as substrate and [gamma-32P]ATP by scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50175277(CHEMBL3809675)
Affinity DataKi:  320nMAssay Description:Inhibition of human SphK1 expressed in baculovirus infected in Sf9 cells using D-erythro-sphingosine as substrate and [gamma-32P]ATP by scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50343817(1-Carbamimidoyl-N-(4-(6-(cyclohexylmethoxy)hexyl)p...)
Affinity DataKi:  390nMAssay Description:Inhibition of human recombinant SPHK1 expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50175285(CHEMBL3809605)
Affinity DataKi:  400nMAssay Description:Inhibition of human SphK1 expressed in baculovirus infected in Sf9 cells using D-erythro-sphingosine as substrate and [gamma-32P]ATP by scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50175275(CHEMBL3809598)
Affinity DataKi:  440nMAssay Description:Inhibition of human SphK1 expressed in baculovirus infected in Sf9 cells using D-erythro-sphingosine as substrate and [gamma-32P]ATP by scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50343822(1-carbamimidoyl-N-(10-(cyclopentylmethoxy)decyl)cy...)
Affinity DataKi:  450nMAssay Description:Inhibition of human recombinant SPHK1 expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50343815(1-Carbamimidoyl-N-(4-(9-phenylnonyl)phenyl)cyclopr...)
Affinity DataKi:  500nMAssay Description:Inhibition of human recombinant SPHK1 expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50343819(1-Carbamimidoyl-N-(4-(8-(cyclohexylmethoxy)octyl)p...)
Affinity DataKi:  800nMAssay Description:Inhibition of human recombinant SPHK1 expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50175283(CHEMBL3809544)
Affinity DataKi:  980nMAssay Description:Inhibition of human SphK1 expressed in baculovirus infected in Sf9 cells using D-erythro-sphingosine as substrate and [gamma-32P]ATP by scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM174064(US9688668, 28)
Affinity DataKi: <1.00E+3nMAssay Description:SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM174065(US9688668, 29)
Affinity DataKi: <1.00E+3nMAssay Description:SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM174066(US9688668, 30)
Affinity DataKi: <1.00E+3nMAssay Description:SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM174067(US9688668, 31)
Affinity DataKi: <1.00E+3nMAssay Description:SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM174068(US9688668, 32)
Affinity DataKi: <1.00E+3nMAssay Description:SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM174114(US9688668, 64)
Affinity DataKi: <1.00E+3nMAssay Description:SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM174044(US9688668, 13)
Affinity DataKi: <1.00E+3nMAssay Description:SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM174046(US9688668, 14)
Affinity DataKi: <1.00E+3nMAssay Description:SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM174047(US9688668, 15)
Affinity DataKi: <1.00E+3nMAssay Description:SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM174049(US9688668, 16)
Affinity DataKi: <1.00E+3nMAssay Description:SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM174050(US9688668, 17)
Affinity DataKi: <1.00E+3nMAssay Description:SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM174053(US9688668, 20)
Affinity DataKi: <1.00E+3nMAssay Description:SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM174054(US9688668, 21)
Affinity DataKi: <1.00E+3nMAssay Description:SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM174055(US9688668, 22)
Affinity DataKi: <1.00E+3nMAssay Description:SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM174056(US9688668, 23)
Affinity DataKi: <1.00E+3nMAssay Description:SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM174059(US9688668, 24)
Affinity DataKi: <1.00E+3nMAssay Description:SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM174060(US9688668, 25)
Affinity DataKi: <1.00E+3nMAssay Description:SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM174061(US9688668, 26)
Affinity DataKi: <1.00E+3nMAssay Description:SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM174063(US9688668, 27)
Affinity DataKi: <1.00E+3nMAssay Description:SphK activity was measured by a scintillation proximity assay as previously described [1], the disclosure of which is incorporated herein. Briefly, r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine kinase 2(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50175286(CHEMBL3809791)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of human SphK2 expressed in baculovirus infected in Sf9 cells using D-erythro-sphingosine as substrate and [gamma-32P]ATP by scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 2(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50443388(CHEMBL3086782 | US9688668, SLR080811)
Affinity DataKi:  1.30E+3nMAssay Description:SLR080811, prepared as the HCl salt, was tested first at recombinant SphK1 and SphK2 using a broken cell assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50343825(4-(7-Butoxyheptyl)-N-(1-carbamimidoylcyclopropyl)b...)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of human recombinant SPHK1 expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50343816(1-carbamimidoyl-N-(4-(8-phenyloctyl)phenyl)cyclopr...)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of human recombinant SPHK1 expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50299323((S)-2-amino-4-hydroxy-N-(4-octylphenyl)butanamide ...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of human recombinant SPHK1 expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
University Of Virginia

Curated by ChEMBL
LigandPNGBDBM50299323((S)-2-amino-4-hydroxy-N-(4-octylphenyl)butanamide ...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of SPHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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