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Found 78 with Last Name = 'curtis' and Initial = 'jk'
LigandPNGBDBM104963(CHEMBL507361 | US11147816, PD0325901 | US11701360,...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of MEK1-mediated ERK2 T202/Y204 phosphorylation using biotinylated MBP as substrate preincubated for 30 mins measured after 100 mins by cR...More data for this Ligand-Target Pair
LigandPNGBDBM50391802((3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of MEK1-mediated ERK2 T202/Y204 phosphorylation using biotinylated MBP as substrate preincubated for 30 mins measured after 100 mins by cR...More data for this Ligand-Target Pair
LigandPNGBDBM50391804(CHEMBL2146893)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of MEK1-mediated ERK2 T202/Y204 phosphorylation using biotinylated MBP as substrate preincubated for 30 mins measured after 100 mins by cR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50391805(CHEMBL2146894)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of MEK1-mediated ERK2 T202/Y204 phosphorylation using biotinylated MBP as substrate preincubated for 30 mins measured after 100 mins by cR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50391811(CHEMBL2146895)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of MEK1-mediated ERK2 T202/Y204 phosphorylation using biotinylated MBP as substrate preincubated for 30 mins measured after 100 mins by cR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50391800(CHEMBL2146898)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of MEK1-mediated ERK2 T202/Y204 phosphorylation using biotinylated MBP as substrate preincubated for 30 mins measured after 100 mins by cR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50391803(CHEMBL2146888)
Affinity DataIC50:  6.60nMAssay Description:Inhibition of MEK1-mediated ERK2 T202/Y204 phosphorylation using biotinylated MBP as substrate preincubated for 30 mins measured after 100 mins by cR...More data for this Ligand-Target Pair
LigandPNGBDBM50391801(CHEMBL2146892)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of MEK1-mediated ERK2 T202/Y204 phosphorylation using biotinylated MBP as substrate preincubated for 30 mins measured after 100 mins by cR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50391808(CHEMBL2146896)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of MEK1-mediated ERK2 T202/Y204 phosphorylation using biotinylated MBP as substrate preincubated for 30 mins measured after 100 mins by cR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50391806(CHEMBL2146899)
Affinity DataIC50:  16nMAssay Description:Inhibition of MEK1-mediated ERK2 T202/Y204 phosphorylation using biotinylated MBP as substrate preincubated for 30 mins measured after 100 mins by cR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50391812(CHEMBL2146885)
Affinity DataIC50:  19.5nMAssay Description:Inhibition of MEK1-mediated ERK2 T202/Y204 phosphorylation using biotinylated MBP as substrate preincubated for 30 mins measured after 100 mins by cR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486034(CHEMBL2204501)
Affinity DataIC50:  21nMAssay Description:Displacement of biotinylated geldanamycin from human His-tagged Hsp90 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486035(CHEMBL2204498)
Affinity DataIC50:  21nMAssay Description:Displacement of biotinylated geldanamycin from human His-tagged Hsp90 by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486032(CHEMBL2204497)
Affinity DataIC50:  24nMAssay Description:Displacement of biotinylated geldanamycin from human His-tagged Hsp90 by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486033(CHEMBL2204502)
Affinity DataIC50:  24nMAssay Description:Displacement of biotinylated geldanamycin from human His-tagged Hsp90 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486041(CHEMBL2204500)
Affinity DataIC50:  25nMAssay Description:Displacement of biotinylated geldanamycin from human His-tagged Hsp90 by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486036(CHEMBL2204496)
Affinity DataIC50:  25nMAssay Description:Displacement of biotinylated geldanamycin from human His-tagged Hsp90 by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50391797(CHEMBL2146890)
Affinity DataIC50:  27nMAssay Description:Inhibition of MEK1-mediated ERK2 T202/Y204 phosphorylation using biotinylated MBP as substrate preincubated for 30 mins measured after 100 mins by cR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486042(CHEMBL2204499)
Affinity DataIC50:  27nMAssay Description:Displacement of biotinylated geldanamycin from human His-tagged Hsp90 by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486043(CHEMBL2204504)
Affinity DataIC50:  28nMAssay Description:Displacement of biotinylated geldanamycin from human His-tagged Hsp90 by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486037(CHEMBL2204503)
Affinity DataIC50:  38nMAssay Description:Displacement of biotinylated geldanamycin from human His-tagged Hsp90 by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486038(CHEMBL2204525)
Affinity DataIC50:  40nMAssay Description:Displacement of biotinylated geldanamycin from human His-tagged Hsp90 by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486045(CHEMBL2204520)
Affinity DataIC50:  42nMAssay Description:Inhibition of Hsp90 in human A549 cells assessed as Raf1 degradation after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50391809(CHEMBL2146887)
Affinity DataIC50:  44nMAssay Description:Inhibition of MEK1-mediated ERK2 T202/Y204 phosphorylation using biotinylated MBP as substrate preincubated for 30 mins measured after 100 mins by cR...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486043(CHEMBL2204504)
Affinity DataIC50:  44nMAssay Description:Inhibition of Hsp90 in human NCI-N87 cells assessed as Her2 degradation after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486037(CHEMBL2204503)
Affinity DataIC50:  52nMAssay Description:Inhibition of Hsp90 in human NCI-N87 cells assessed as Her2 degradation after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486052(CHEMBL2204518)
Affinity DataIC50:  53nMAssay Description:Displacement of biotinylated geldanamycin from human His-tagged Hsp90 by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486033(CHEMBL2204502)
Affinity DataIC50:  56nMAssay Description:Inhibition of Hsp90 in human NCI-N87 cells assessed as Her2 degradation after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486046(CHEMBL2204519)
Affinity DataIC50:  59nMAssay Description:Inhibition of Hsp90 in human A549 cells assessed as Raf1 degradation after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486045(CHEMBL2204520)
Affinity DataIC50:  80nMAssay Description:Displacement of biotinylated geldanamycin from human His-tagged Hsp90 by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486058(CHEMBL2204517)
Affinity DataIC50:  81nMAssay Description:Displacement of biotinylated geldanamycin from human His-tagged Hsp90 by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50391807(CHEMBL2146889)
Affinity DataIC50:  82nMAssay Description:Inhibition of MEK1-mediated ERK2 T202/Y204 phosphorylation using biotinylated MBP as substrate preincubated for 30 mins measured after 100 mins by cR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486036(CHEMBL2204496)
Affinity DataIC50:  82nMAssay Description:Inhibition of Hsp90 in human NCI-N87 cells assessed as Her2 degradation after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486056(CHEMBL2204506)
Affinity DataIC50:  86nMAssay Description:Displacement of biotinylated geldanamycin from human His-tagged Hsp90 by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486039(CHEMBL2204522)
Affinity DataIC50:  89nMAssay Description:Displacement of biotinylated geldanamycin from human His-tagged Hsp90 by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486040(CHEMBL2204523)
Affinity DataIC50:  104nMAssay Description:Displacement of biotinylated geldanamycin from human His-tagged Hsp90 by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486061(CHEMBL2204521)
Affinity DataIC50:  105nMAssay Description:Inhibition of Hsp90 in human A549 cells assessed as Raf1 degradation after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486060(CHEMBL2204511)
Affinity DataIC50:  108nMAssay Description:Displacement of biotinylated geldanamycin from human His-tagged Hsp90 by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486056(CHEMBL2204506)
Affinity DataIC50:  117nMAssay Description:Inhibition of Hsp90 in human NCI-N87 cells assessed as Her2 degradation after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486057(CHEMBL2204505)
Affinity DataIC50:  120nMAssay Description:Displacement of biotinylated geldanamycin from human His-tagged Hsp90 by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486049(CHEMBL2204510)
Affinity DataIC50:  126nMAssay Description:Displacement of biotinylated geldanamycin from human His-tagged Hsp90 by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486047(CHEMBL2204514)
Affinity DataIC50:  128nMAssay Description:Displacement of biotinylated geldanamycin from human His-tagged Hsp90 by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486035(CHEMBL2204498)
Affinity DataIC50:  130nMAssay Description:Inhibition of Hsp90 in human NCI-N87 cells assessed as Her2 degradation after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486046(CHEMBL2204519)
Affinity DataIC50:  160nMAssay Description:Displacement of biotinylated geldanamycin from human His-tagged Hsp90 by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486038(CHEMBL2204525)
Affinity DataIC50:  182nMAssay Description:Inhibition of Hsp90 in human NCI-N87 cells assessed as Her2 degradation after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486059(CHEMBL2204512)
Affinity DataIC50:  200nMAssay Description:Displacement of biotinylated geldanamycin from human His-tagged Hsp90 by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50391798(CHEMBL2146891)
Affinity DataIC50:  220nMAssay Description:Inhibition of MEK1-mediated ERK2 T202/Y204 phosphorylation using biotinylated MBP as substrate preincubated for 30 mins measured after 100 mins by cR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486041(CHEMBL2204500)
Affinity DataIC50:  245nMAssay Description:Inhibition of Hsp90 in human NCI-N87 cells assessed as Her2 degradation after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486034(CHEMBL2204501)
Affinity DataIC50:  252nMAssay Description:Inhibition of Hsp90 in human NCI-N87 cells assessed as Her2 degradation after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50486061(CHEMBL2204521)
Affinity DataIC50:  260nMAssay Description:Displacement of biotinylated geldanamycin from human His-tagged Hsp90 by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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