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Found 185 with Last Name = 'castonguay' and Initial = 'l'
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105372((S)-2-{[(S)-1-(3,5-Dichloro-benzenesulfonyl)-2-met...)
Affinity DataIC50:  0.0700nMAssay Description:Inhibition of Mn2+ activated state of very late antigen 4 (VLA-4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50373120(CHEMBL260977 | MK-0364)
Affinity DataIC50:  0.0940nMAssay Description:Displacement of [3H]SR-141716 from human wild type CB1R expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144790((S)-2-{[(S)-1-(3,5-Dichloro-benzenesulfonyl)-azeti...)
Affinity DataIC50:  0.270nMAssay Description:Inhibition of Mn2+ activated state of very late antigen 4 (VLA-4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105372((S)-2-{[(S)-1-(3,5-Dichloro-benzenesulfonyl)-2-met...)
Affinity DataIC50:  0.270nMAssay Description:Inhibition of [Ca2+]/Mg2+ unactivated state of very late antigen 4 (VLA-4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144790((S)-2-{[(S)-1-(3,5-Dichloro-benzenesulfonyl)-azeti...)
Affinity DataIC50:  0.310nMAssay Description:Inhibition of [Ca2+]/Mg2+ unactivated state of very late antigen 4 (VLA-4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM21279(1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N...)
Affinity DataIC50:  0.320nMAssay Description:Displacement of [3H]SR-141716 from human wild type CB1R expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144791((S)-3-[2-(2,6-Dichloro-phenyl)-benzooxazol-5-yl]-2...)
Affinity DataIC50:  0.340nMAssay Description:Inhibition of Mn2+ activated state of very late antigen 4 (VLA-4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50200833(CHEMBL373626 | N-((2S,3S)-4-(4-chlorophenyl)-3-phe...)
Affinity DataIC50:  0.540nMAssay Description:Displacement of [3H]CP55490 from human recombinant cannabinoid CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144786((S)-2-{[(S)-1-(3,5-Dichloro-benzenesulfonyl)-azeti...)
Affinity DataIC50:  0.540nMAssay Description:Inhibition of Mn2+ activated state of very late antigen 4 (VLA-4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323607(CHEMBL1209596 | rac-N-((2S,3S)-3-(3-bromophenyl)-4...)
Affinity DataIC50:  0.590nMAssay Description:Displacement of [3H]CP55490 from human recombinant cannabinoid CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144792((S)-2-(2,6-Dichloro-benzoylamino)-3-[2-(2,6-dichlo...)
Affinity DataIC50:  0.690nMAssay Description:Inhibition of Mn2+ activated state of very late antigen 4 (VLA-4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50373120(CHEMBL260977 | MK-0364)
Affinity DataIC50:  0.740nMAssay Description:Displacement of [3H]CP-55940 from human wild type CB1R expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144789((S)-2-{[(S)-1-(3,5-Dichloro-benzenesulfonyl)-azeti...)
Affinity DataIC50:  0.740nMAssay Description:Inhibition of Mn2+ activated state of very late antigen 4 (VLA-4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50200841(CHEMBL220360 | MK-0364 | MK-0634 | N-((2S,3S)-4-(4...)
Affinity DataIC50:  0.740nMAssay Description:Displacement of [3H]CP55490 from human recombinant cannabinoid CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144787((S)-2-(2,6-Dichloro-benzoylamino)-3-[2-(2,6-dichlo...)
Affinity DataIC50:  0.790nMAssay Description:Inhibition of Mn2+ activated state of very late antigen 4 (VLA-4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144788((S)-2-{[(S)-1-(3,5-Dichloro-benzenesulfonyl)-azeti...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of Mn2+ activated state of very late antigen 4 (VLA-4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144786((S)-2-{[(S)-1-(3,5-Dichloro-benzenesulfonyl)-azeti...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of [Ca2+]/Mg2+ unactivated state of very late antigen 4 (VLA-4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144792((S)-2-(2,6-Dichloro-benzoylamino)-3-[2-(2,6-dichlo...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of Mn2+ activated state of alpha4-beta7 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM21279(1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N...)
Affinity DataIC50:  3.5nMAssay Description:Displacement of [3H]CP-55940 from human wild type CB1R expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144789((S)-2-{[(S)-1-(3,5-Dichloro-benzenesulfonyl)-azeti...)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of [Ca2+]/Mg2+ unactivated state of very late antigen 4 (VLA-4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144791((S)-3-[2-(2,6-Dichloro-phenyl)-benzooxazol-5-yl]-2...)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of Mn2+ activated state of alpha4-beta7 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50104229(CHEMBL310780 | N-{(S)-2-(3-Chloro-phenyl)-4-[4-(3-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50104224(1'-[3-(3-chlorophenyl)-4-methyl(phenyl)sulfonamido...)
Affinity DataIC50:  5nMAssay Description:Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144787((S)-2-(2,6-Dichloro-benzoylamino)-3-[2-(2,6-dichlo...)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of Mn2+ activated state of alpha4-beta7 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158202(CHEMBL434526 | Correloid derivative)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against voltage-gated potassium channel subunit Kv1.3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096540((2S)-2-(3-chlorophenyl)-1-[(N-methyl-N-phenylsulfo...)
Affinity DataIC50:  10nMAssay Description:Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158200(Aceticacid(R)-1-{(4R,4aR,5S,6R,6aR,11bS)-4,5,6-tri...)
Affinity DataIC50:  11nMAssay Description:Inhibition of voltage-gated potassium channel subunit Kv1.3 in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158213(Aceticacid(R)-1-{(4R,4aR,5S,6R,6aR,11bS)-4,5,6-tri...)
Affinity DataIC50:  12nMAssay Description:Inhibition of voltage-gated potassium channel subunit Kv1.3 in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158214(Aceticacid(R)-1-[(4R,4aR,5S,6R,6aR,11bS)-4,5,6-tri...)
Affinity DataIC50:  12nMAssay Description:Inhibition of voltage-gated potassium channel subunit Kv1.3 in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158218(Aceticacid(R)-1-{(4R,4aR,5S,6R,6aR,11bS)-4,5,6-tri...)
Affinity DataIC50:  12.3nMAssay Description:Inhibitory activity against voltage-gated potassium channel subunit Kv1.3 of human T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105372((S)-2-{[(S)-1-(3,5-Dichloro-benzenesulfonyl)-2-met...)
Affinity DataIC50:  14nMAssay Description:Inhibition of Mn2+ activated state of alpha4-beta7 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158233(Aceticacid(R)-1-{(4R,4aR,5S,6R,6aR,11bS)-4,5,6-tri...)
Affinity DataIC50:  14nMAssay Description:Inhibition of voltage-gated potassium channel subunit Kv1.3 in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158224(Aceticacid(R)-1-{(4R,4aR,5S,6R,6aR,11bS)-4,5,6-tri...)
Affinity DataIC50:  14nMAssay Description:Inhibition of voltage-gated potassium channel subunit Kv1.3 in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158233(Aceticacid(R)-1-{(4R,4aR,5S,6R,6aR,11bS)-4,5,6-tri...)
Affinity DataIC50:  14.7nMAssay Description:Inhibitory activity against voltage-gated potassium channel subunit Kv1.3 of human T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50096559(1'-[3-(3-chlorophenyl)-4-methyl(phenyl)sulfonamido...)
Affinity DataIC50:  15nMAssay Description:Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158228(Aceticacid(R)-1-{(4R,4aR,5S,6R,6aR,11bS)-4,5,6-tri...)
Affinity DataIC50:  17nMAssay Description:Inhibition of voltage-gated potassium channel subunit Kv1.3 in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158227(Aceticacid1-[4,5,6-triacetoxy-1-hydroxy-2,4a,11b-t...)
Affinity DataIC50:  19nMAssay Description:Inhibition of voltage-gated potassium channel subunit Kv1.3 in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158195(Aceticacid(R)-1-[(4R,4aR,5S,6R,6aR,11bS)-4,5,6-tri...)
Affinity DataIC50:  19nMAssay Description:Inhibition of voltage-gated potassium channel subunit Kv1.3 in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158210(Aceticacid(R)-1-{(4R,4aR,5S,6R,6aR,11bS)-4,5,6-tri...)
Affinity DataIC50:  19nMAssay Description:Inhibition of voltage-gated potassium channel subunit Kv1.3 in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144791((S)-3-[2-(2,6-Dichloro-phenyl)-benzooxazol-5-yl]-2...)
Affinity DataIC50:  21nMAssay Description:Inhibition of [Ca2+]/Mg2+ unactivated state of very late antigen 4 (VLA-4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158226(Aceticacid(R)-1-[(4R,4aR,5S,6R,6aR,11bS)-4,5,6-tri...)
Affinity DataIC50:  21nMAssay Description:Inhibition of voltage-gated potassium channel subunit Kv1.3 in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158209(Aceticacid(R)-1-{(4R,4aR,5S,6R,6aR,11bS)-4,5,6-tri...)
Affinity DataIC50:  21nMAssay Description:Inhibition of voltage-gated potassium channel subunit Kv1.3 in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323608(CHEMBL1209597 | rac-(S)-N-(3-(3-bromophenyl)-4-(4-...)
Affinity DataIC50:  22nMAssay Description:Displacement of [3H]CP55490 from human recombinant cannabinoid CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144792((S)-2-(2,6-Dichloro-benzoylamino)-3-[2-(2,6-dichlo...)
Affinity DataIC50:  22nMAssay Description:Inhibition of [Ca2+]/Mg2+ unactivated state of very late antigen 4 (VLA-4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144790((S)-2-{[(S)-1-(3,5-Dichloro-benzenesulfonyl)-azeti...)
Affinity DataIC50:  22nMAssay Description:Inhibition of Mn2+ activated state of alpha4-beta7 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158197(Aceticacid(R)-1-{(4R,4aR,5S,6R,6aR,11bS)-4,5,6-tri...)
Affinity DataIC50:  24nMAssay Description:Inhibition of voltage-gated potassium channel subunit Kv1.3 in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323610(CHEMBL1209668 | N-(3-(3-bromophenyl)-4-(4-chloroph...)
Affinity DataIC50:  25nMAssay Description:Displacement of [3H]CP55490 from human recombinant cannabinoid CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50323610(CHEMBL1209668 | N-(3-(3-bromophenyl)-4-(4-chloroph...)
Affinity DataIC50:  25nMAssay Description:Displacement of [3H]CP55490 from human recombinant cannabinoid CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50104218(CHEMBL83957 | N-{(S)-2-(3-Chloro-phenyl)-4-[4-(4-f...)
Affinity DataIC50:  25nMAssay Description:Inhibition of [125I]-MIP-1 alpha binding to human CCR5 receptor expressed in Chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50158217(Aceticacid1-{(R)-4,5,6-triacetoxy-1-[2-(2-ethyl-ph...)
Affinity DataIC50:  25.5nMAssay Description:Inhibitory activity against voltage-gated potassium channel subunit Kv1.3 of human T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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