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Found 641 with Last Name = 'romano' and Initial = 'm'
TargetMu-type opioid receptor(GUINEA PIG)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50069559(Biphalin Analogue | CHEMBL2371057)
Affinity DataKi:  0.790nMAssay Description:Compound was tested for binding affinity towards mu opioid receptor in guinea pig brain homogenates using [3H]-CTOP as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50069560(Biphalin Analogue | CHEMBL2371080)
Affinity DataKi:  0.910nMAssay Description:Compound was tested for binding affinity towards mu opioid receptor in guinea pig brain homogenates using [3H]-CTOP as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM50193455(CHEMBL3966143)
Affinity DataKi:  0.950nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM50000296(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to KOR (unknown origin) assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(GUINEA PIG)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50069562(2-Amino-N-((S)-1-{[((R)-1-{N'-[(R)-2-(2-{(S)-2-[2-...)
Affinity DataKi:  1.30nMAssay Description:Compound was tested for binding affinity towards mu opioid receptor in guinea pig brain homogenates using [3H]-CTOP as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity to MOR (unknown origin) assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
University of Trieste

Curated by ChEMBL
LigandPNGBDBM50502547(CHEMBL4581662)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]-di-o-tolylguanidine from sigma2 receptor in rat liver membranes in the presence of sigma1 receptor ligand (+)-pentazocine incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50069563(Biphalin Analogue | CHEMBL2371079)
Affinity DataKi:  1.70nMAssay Description:Compound was tested for binding affinity towards mu opioid receptor in guinea pig brain homogenates using [3H]-CTOP as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
University of Trieste

Curated by ChEMBL
LigandPNGBDBM50502547(CHEMBL4581662)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]ifenprodil from GluN1a/GluN2B (unknown origin) expressed in mouse L(tk-) cell membranes after 120 mins by solid scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity to sigma 1 receptor (unknown origin) assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM50370067(CHEMBL1237164)
Affinity DataKi:  2.5nMAssay Description:Binding affinity to DOR (unknown origin) assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM50193445(CHEMBL3964384)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50069558(2-Amino-N-((S)-1-{[(2-{N'-[2-(2-{(S)-2-[2-amino-3-...)
Affinity DataKi:  2.80nMAssay Description:Compound was tested for binding affinity towards mu opioid receptor in guinea pig brain homogenates using [3H]-CTOP as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM50193443(CHEMBL3954990)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University of Arizona

Curated by ChEMBL
LigandPNGBDBM50069561(2-Amino-N-((S)-1-{[((S)-1-{N'-[(S)-2-(2-{(S)-2-[2-...)
Affinity DataKi:  3nMAssay Description:Compound was tested for binding affinity towards mu opioid receptor in guinea pig brain homogenates using [3H]-CTOP as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50176493((S)-3-((S)-2-((S)-3-methyl-2-(4-(quinoxalin-2-ylam...)
Affinity DataKi:  4nMAssay Description:Inhibitory activity against human Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50176494((3S)-3-(6-(3-methyl-4-(quinoxalin-2-ylamino)benzam...)
Affinity DataKi:  4nMAssay Description:Inhibitory activity against human Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM50001028((+)-PENTAZOCINE | (-)-pentazocine | (2R,6R,11R)-6,...)
Affinity DataKi:  4.70nMAssay Description:Binding affinity to sigma 1 receptor (unknown origin) assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
University of Trieste

Curated by ChEMBL
LigandPNGBDBM50502554(CHEMBL4533030)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]ifenprodil from GluN1a/GluN2B (unknown origin) expressed in mouse L(tk-) cell membranes after 120 mins by solid scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
University of Trieste

Curated by ChEMBL
LigandPNGBDBM50502557(CHEMBL4459690)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]ifenprodil from GluN1a/GluN2B (unknown origin) expressed in mouse L(tk-) cell membranes after 120 mins by solid scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50176495((3S)-4-oxo-3-(2-phenyl-6-(4-(quinoxalin-2-ylamino)...)
Affinity DataKi:  5nMAssay Description:Inhibitory activity against human Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50176510((S)-4-oxo-3-(2-((4-(quinoxalin-2-ylamino)benzamido...)
Affinity DataKi:  5nMAssay Description:Inhibitory activity against human Caspase 1More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM50193441(CHEMBL3955644)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50176496((3S)-3-(6-(4-(6-methylquinoxalin-2-ylamino)benzami...)
Affinity DataKi:  5nMAssay Description:Inhibitory activity against human Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM50193437(CHEMBL3975617)
Affinity DataKi:  5.20nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM50069558(2-Amino-N-((S)-1-{[(2-{N'-[2-(2-{(S)-2-[2-amino-3-...)
Affinity DataKi:  5.20nMAssay Description:Compound was tested for binding affinity towards Opioid receptor delta 1 in guinea pig brain homogenates using [3H]-[p-Cl-Phe]-DPDPE as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
University Of Bari &Quot;Aldo Moro&Quot

Curated by ChEMBL
LigandPNGBDBM50442068(CHEMBL2441057)
Affinity DataKi:  6nMAssay Description:Inhibition of bovine thrombin using D-Phe-Pip-Arg-p-NA as substrate by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Bos taurus (Bovine))
University Of Bari &Quot;Aldo Moro&Quot

Curated by ChEMBL
LigandPNGBDBM50442068(CHEMBL2441057)
Affinity DataKi:  6nMAssay Description:Inhibition of bovine thrombin using D-Phe-Pip-Arg-p-NA as substrate by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes incubated for 120 mins by solid scintillation counting...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]-(+)pentazocine from sigma-1 receptor in guinea pig brain membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM50069559(Biphalin Analogue | CHEMBL2371057)
Affinity DataKi:  6.40nMAssay Description:Compound was tested for binding affinity towards Opioid receptor delta 1 in guinea pig brain homogenates using [3H]-[p-Cl-Phe]-DPDPE as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  6.60nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetCaspase-1(Homo sapiens (Human))
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50176500((3S)-4-oxo-3-(6-(4-(quinoxalin-2-ylamino)benzamido...)
Affinity DataKi:  7nMAssay Description:Inhibitory activity against human Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM50069563(Biphalin Analogue | CHEMBL2371079)
Affinity DataKi:  7.40nMAssay Description:Compound was tested for binding affinity towards Opioid receptor delta 1 in guinea pig brain homogenates using [3H]-[p-Cl-Phe]-DPDPE as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM50193444(CHEMBL3894798)
Affinity DataKi:  7.70nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM50069560(Biphalin Analogue | CHEMBL2371080)
Affinity DataKi:  7.80nMAssay Description:Compound was tested for binding affinity towards Opioid receptor delta 1 in guinea pig brain homogenates using [3H]-[p-Cl-Phe]-DPDPE as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50176509((3S)-3-(2-(2-fluorophenyl)-6-(4-(quinoxalin-2-ylam...)
Affinity DataKi:  8nMAssay Description:Inhibitory activity against human Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50176519((S)-3-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methy...)
Affinity DataKi:  8nMAssay Description:Inhibitory activity against human Caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM50540585(CHEMBL4639180)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]-(+)pentazocine from sigma-1 receptor in guinea pig brain membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
University of Trieste

Curated by ChEMBL
LigandPNGBDBM50502558(CHEMBL4449269)
Affinity DataKi:  8.10nMAssay Description:Displacement of [3H]ifenprodil from GluN1a/GluN2B (unknown origin) expressed in mouse L(tk-) cell membranes after 120 mins by solid scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
University of Trieste

Curated by ChEMBL
LigandPNGBDBM50502548(CHEMBL4446466)
Affinity DataKi:  8.20nMAssay Description:Displacement of [3H]ifenprodil from GluN1a/GluN2B (unknown origin) expressed in mouse L(tk-) cell membranes after 120 mins by solid scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM50193450(CHEMBL3966773)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM50193436(CHEMBL3946295)
Affinity DataKi:  9.30nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma intracellular receptor 2(Homo sapiens (Human))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM50592398(CHEMBL5169420)
Affinity DataKi:  9.90nMAssay Description:Binding affinity to sigma 2 receptor (unknown origin) assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
University of Trieste

Curated by ChEMBL
LigandPNGBDBM50083351((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]ifenprodil from GluN2B (unknown origin) expressed in mouse L(tk-) cell membranes co-expressing GluN1a incubated for 120 mins by s...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
University of Trieste

Curated by ChEMBL
LigandPNGBDBM50502555(CHEMBL4445874)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]ifenprodil from GluN1a/GluN2B (unknown origin) expressed in mouse L(tk-) cell membranes after 120 mins by solid scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM50069561(2-Amino-N-((S)-1-{[((S)-1-{N'-[(S)-2-(2-{(S)-2-[2-...)
Affinity DataKi:  11nMAssay Description:Compound was tested for binding affinity towards Opioid receptor delta 1 in guinea pig brain homogenates using [3H]-[p-Cl-Phe]-DPDPE as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM50592398(CHEMBL5169420)
Affinity DataKi:  12nMAssay Description:Binding affinity to sigma 1 receptor (unknown origin) assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
University of Trieste

Curated by ChEMBL
LigandPNGBDBM50502553(CHEMBL4439170)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]ifenprodil from GluN1a/GluN2B (unknown origin) expressed in mouse L(tk-) cell membranes after 120 mins by solid scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Trieste

Curated by ChEMBL
LigandPNGBDBM50193435(CHEMBL3895475)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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