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LigandPNGBDBM50214370(CHEMBL227134 | N-(4-{2-[[2-(4-methanesulfonylamino...)
Affinity DataKi:  0.390nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24226(1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxypheny...)
Affinity DataKi:  2.90nMAssay Description:Binding affinity at hERG expressed in HEK293 cells by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

LigandPNGBDBM50214364(11-ethyl-1-(3-{[2-(4-methanesulfonylamino-phenoxy)...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50031720((Dofetilide) N-[4-(2-{[2-(4-Methanesulfonylamino-p...)
Affinity DataKi:  6.40nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

LigandPNGBDBM50214372(24-{[(6-{[2-(4-methanesulfonamidophenoxy)ethyl][2-...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50031720((Dofetilide) N-[4-(2-{[2-(4-Methanesulfonylamino-p...)
Affinity DataKi:  7.70nMAssay Description:Binding affinity at hERG expressed in HEK293 cells by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

LigandPNGBDBM50214373(24-{5-[(6-{[2-(4-methanesulfonamidophenoxy)ethyl][...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50214369(24-{[(5-{[2-(4-methanesulfonamidophenoxy)ethyl][2-...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24226(1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxypheny...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

LigandPNGBDBM50214376(3,6-dihydroxy-N-(6-{[2-(4-methanesulfonamidophenox...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50214371(24-{[(4-{[2-(4-methanesulfonamidophenoxy)ethyl][2-...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117930((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50214374(24-{2-[(6-{[2-(4-methanesulfonamidophenoxy)ethyl][...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117930((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Affinity DataKi:  19nMAssay Description:Binding affinity at hERG expressed in HEK293 cells by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50214366(3,6-bis(dimethylamino)-N-(6-{[2-(4-methanesulfonam...)
Affinity DataKi:  89nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50214368(24-{[(3-{[2-(4-methanesulfonamidophenoxy)ethyl][2-...)
Affinity DataKi:  160nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM78577(BEPRIDIL HYDROCHLORIDE | Bepridil | MLS000028456 |...)
Affinity DataKi:  184nMAssay Description:Binding affinity at hERG expressed in HEK293 cells by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117922((1S,2S)-2-(2-((3-(1H-benzo[d]imidazol-2-yl)propyl)...)
Affinity DataKi:  190nMAssay Description:Binding affinity at hERG expressed in HEK293 cells by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM78577(BEPRIDIL HYDROCHLORIDE | Bepridil | MLS000028456 |...)
Affinity DataKi:  291nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50117922((1S,2S)-2-(2-((3-(1H-benzo[d]imidazol-2-yl)propyl)...)
Affinity DataKi:  353nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50214375(3',6'-dihydroxy-N-[2-(4-methanesulfonamidophenoxy)...)
Affinity DataKi:  980nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50214367((2-(N-ethylamidomethyl)-6,7,9,10,16,18-hexahydro-1...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50214363(3',6'-bis(dimethylamino)-N-[2-(4-methanesulfonamid...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  3.08E+3nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  4.06E+3nMAssay Description:Binding affinity at hERG expressed in HEK293 cells by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50214365(24-{[(2-{[2-(4-methanesulfonamidophenoxy)ethyl][2-...)
Affinity DataKi:  7.30E+3nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24855(4-{1,2-dihydrospiro[indole-3,4'-piperidine]}-7H-py...)
Affinity DataIC50:  2.40nMpH: 7.5 T: 22°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50214370(CHEMBL227134 | N-(4-{2-[[2-(4-methanesulfonylamino...)
Affinity DataIC50: <3nMAssay Description:Blockade of hERG expressed in HEK293 cells by whole-cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24848(5-fluoro-1-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-d...)
Affinity DataIC50:  3.10nMpH: 7.5 T: 22°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24853(1-{5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-d...)
Affinity DataIC50:  4.80nMpH: 7.5 T: 22°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24847(5-chloro-1-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-d...)
Affinity DataIC50:  4.80nMpH: 7.5 T: 22°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24846(1-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-dihydrospi...)
Affinity DataIC50:  5.30nMpH: 7.5 T: 22°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24852(1-{5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-d...)
Affinity DataIC50:  5.80nMpH: 7.5 T: 22°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50031720((Dofetilide) N-[4-(2-{[2-(4-Methanesulfonylamino-p...)
Affinity DataIC50:  9.20nMAssay Description:Blockade of hERG expressed in HEK293 cells by whole-cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

LigandPNGBDBM24849(1'-methyl-1-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-...)
Affinity DataIC50:  12.7nMpH: 7.5 T: 22°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24845(5-chloro-4-{3H,4H,5H,6H,7H-imidazo[4,5-c]pyridin-5...)
Affinity DataIC50:  42nMpH: 7.5 T: 22°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
LigandPNGBDBM24841(N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-py...)
Affinity DataIC50:  151nMpH: 7.5 T: 22°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
LigandPNGBDBM50152728(farnesyl methylenediphosphonate)
Affinity DataIC50:  160nMAssay Description:Inhibition of FarnesyltransferaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM24842(N-[4-chloro-2-(5-methyl-4H-1,2,4-triazol-3-yl)phen...)
Affinity DataIC50:  171nMpH: 7.5 T: 22°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24837(N-[2-(4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3...)
Affinity DataIC50:  210nMpH: 7.5 T: 22°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24844(5-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-3H,4H,5H,6H,7H...)
Affinity DataIC50:  294nMpH: 7.5 T: 22°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50214372(24-{[(6-{[2-(4-methanesulfonamidophenoxy)ethyl][2-...)
Affinity DataIC50:  310nMAssay Description:Blockade of hERG expressed in HEK293 cells by whole-cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24840(5-chloro-N-[2-(4H-1,2,4-triazol-3-yl)phenyl]-7H-py...)
Affinity DataIC50:  318nMpH: 7.5 T: 22°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24839(5-methyl-N-[2-(4H-1,2,4-triazol-3-yl)phenyl]-7H-py...)
Affinity DataIC50:  425nMpH: 7.5 T: 22°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24854(1-{5-benzyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-d...)
Affinity DataIC50:  1.33E+3nMpH: 7.5 T: 22°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24850(1-(5-fluoro-1-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,...)
Affinity DataIC50:  2.79E+3nMpH: 7.5 T: 22°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24851(5-fluoro-1'-methanesulfonyl-1-{7H-pyrrolo[2,3-d]py...)
Affinity DataIC50:  3.19E+3nMpH: 7.5 T: 22°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24838(7-methyl-N-[2-(4H-1,2,4-triazol-3-yl)phenyl]-7H-py...)
Affinity DataIC50: >1.00E+4nMpH: 7.5 T: 22°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24843(N-[5-chloro-2-(5-methyl-4H-1,2,4-triazol-3-yl)phen...)
Affinity DataIC50: >1.00E+4nMpH: 7.5 T: 22°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed